Elliott, Luke D, Knowles , Jonathan P, Maskill, Kate G, Ralph, Michael J, Lejeune, Guillaume, Hook, Ben D A, Edwards, Lee, Robinson, Richard, Clemens, Ian, Cox, Brian, Pascoe, David, Koch, Guido, Eberle, Martin, Berry, Malcolm B and Booker-Milburn, Kevin I (2014) Batch vs. Flow Photochemistry: A Thorough Analysis of Yields and Productivities. Chemistry - a European journal, 20 (46). pp. 15226-15232. ISSN 09476539

Abstract

The use of flow photochemistry and its apparent superiority over batch has been reported by a number of groups over recent years. In order to rigorously determine whether flow does indeed have an advantage over batch, a broad range of synthetic photochemical transformations were optimized in both batch and flow and their yields and productivities compared. Although yields were essentially identical in all cases, 3-layer FEP flow reactors showed an average of 20% greater productivity. In most cases single layer flow reactors were marginally less productive than their batch counterparts. The utility of flow chemistry was demonstrated in the scale-up of the ring opening reaction of the potentially explosive bicyclo[1.1.1]pentane 26 with butane-2,3-dione.

Item Type:	Article
Date Deposited:	12 Oct 2016 00:45
Last Modified:	12 Oct 2016 00:45
URI:	https://oak.novartis.com/id/eprint/22204