Synthesis of 3-chloro-4-fluoro-7,8-dihydro-6H-isoquinolin-5-one and its derivatives.
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Velcicky, Juraj and Pflieger, Daniel (2010) Synthesis of 3-chloro-4-fluoro-7,8-dihydro-6H-isoquinolin-5-one and its derivatives. Synlett. pp. 1397-1401. ISSN 1437-2096
Official URL: https://www.thieme-connect.com/ejournals/pdf/synle...
Abstract
Synthesis of novel 3-Chloro-4-fluoro-7,8-dihydro-6H-isoquinolin-5-one and its derivatives using sequentional ortho-formylation/ortho-allylation reaction of 2-chloro-3-fluoropyridine and ring-closing metathesis is described.
| Item Type: | Article |
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| Keywords: | ortho-lithiation, ring-closing metathesis, fluoro pyridine, heterocycle, fused-ring system |
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| Date Deposited: | 13 Oct 2015 13:16 |
| Last Modified: | 13 Oct 2015 13:16 |
| URI: | https://oak.novartis.com/id/eprint/2219 |