Koromilas, AE and Mounir, Z (2013) Control of oncogenesis by eIF2alpha phosphorylation: Implications in PTEN and PI3K-Akt signaling and tumor treatment. Future Oncology. pp. 1005-1015.

Abstract

mRNA translation plays an important role in tumor development and represents a valid target of pharmaceutical intervention in cancer. A key step in mRNA translation involves the regulation of initiation by the eukaryotic initiation factor eIF2. Eukaryotic cells respond to various forms of stress by inducing the phosphorylation of the alpha-subunit of eIF2 at S51, a modification that leads to protein synthesis inhibition. Phosphorylated eIF2alpha can act either as a promoter of cell survival or an inducer of cell death in response to distinct stimuli. Increased eIF2alpha phosphorylation has a cytoprotective function in response to genetic or pharmacological inhibition of the PI3K-Akt pathway but also exhibits a proapoptotic function downstream of the PTEN tumor suppressor, independent of PI3K-Akt signaling inhibition. The functional interplay between the PI3K-Akt and eIF2alpha phosphorylation pathways may have important implications in the design of anti-tumor therapies that depend on the cell fate decisions of phosphorylated eIF2alpha. 2013 Future Medicine Ltd

Item Type:	Article
Additional Information:	pubid: 56 nvp_institute: NIBR contributor_address: (Koromilas, Mounir) Lady Davis Institute, McGill University, Montreal, QC, H3T 1E2, Canada (Koromilas) Department of Oncology, Faculty of Medicine, McGill University, Montreal, QC, Canada (Mounir) Department of Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States
Date Deposited:	13 Oct 2015 13:13
Last Modified:	13 Oct 2015 13:13
URI:	https://oak.novartis.com/id/eprint/21904