Furet, Pascal, Gerspacher, Marc and Pissot Soldermann, Carole (2010) Design of Two New Chemotypes for Inhibiting the Janus Kinase 2 by Scaffold Morphing. Bioorganic & Medicinal Chemistry Letters, 20 (6). pp. 1858-1860. ISSN 0960-894X

Abstract

JAK2 is a target of high interest in chronic myeloproliferative disorders drug research. Starting from a screening hit, two new JAK2 inhibitor chemotypes were designed by scaffold morphing. The prototype compounds of these new series showed nanomolar inhibition of the kinase.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Scaffold morphing; Kinase inhibitor design
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	13 Oct 2015 13:16
Last Modified:	13 Oct 2015 13:16
URI:	https://oak.novartis.com/id/eprint/2154