McBride, Christopher, Levine, Barry, Xia, Yi, Bellamacina, Cornelia, Machajewski, Timothy, Gao, Zhenhai, Renhowe, Paul, Antonios-Mccrea Jr., Bill, Barsanti, Paul, Brinner, Kristin, Costales, Abran, Doughan, Brandon, Lin, Xiaodong, Louie, Alicia, McKenna, Maureen, Mendenhall, Kris, Poon, Daniel, Rico, Alice, Wang, Michael, Williams, Teresa, Abrams, Tinya, Fong, Susan, Hendrickson, Thomas, Lei, Dachuan, Lin, Julie, Menezes, Daniel Lopes De, Pryer, Nancy, Taverna, Pietro, Zhou, Yasheen and Shafer, Cynthia (2014) Design, Structure Activity Relationship and in vivo Characterization of the Clinical Candidate NVP-HSP990. Journal of Medicinal Chemistry, 57 (21). pp. 9124-9129. ISSN 0022-26231520-4804

Abstract

From a commercial hit (1), a novel dihydroquinazolinone scaffold was developed. The SAR of the series was developed which led to the selection of NVP-HSP990 as a clinical candidate.

Item Type:	Article
Date Deposited:	02 May 2016 23:45
Last Modified:	02 May 2016 23:45
URI:	https://oak.novartis.com/id/eprint/21284