Costales, Abran, Mathur, Michelle, Ramurthy, Savithri, Lan, Jiong, Subramanian, Sharadha, Jain, Rama, Atallah, Gordana, Setti, Lina, Lindvall, Mika, Appleton, Brent, Ornelas, Elizabeth, Feucht, Paul, Warne, Robert, Doyle, Laura, Basham, Stephen, Aronchik, Ida, Jefferson, A.B. and Shafer, Cynthia (2014) 2-Amino-7-Substitued Benzoxazole Analogs as Potent RSK2 Inhibitors. Bioorganic and Medicinal Chemistry Letters, 24 (6). pp. 1592-1596. ISSN 0960894X

Abstract

2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochemical properties.

Item Type:	Article
Date Deposited:	02 May 2016 23:45
Last Modified:	02 May 2016 23:45
URI:	https://oak.novartis.com/id/eprint/20358