Improving the plausibility of success with inefficient metrics
Tools
Shultz, Michael (2014) Improving the plausibility of success with inefficient metrics. ACS Medicinal Chemistry Letters, 5 (1). pp. 2-5. ISSN 1948-5875
Official URL: http://pubs.acs.org/doi/abs/10.1021/ml4004638
Abstract
To increase the probability of success in drug discovery, the concept of drug-like properties was introduced. Efficiency metrics that normalize potency against these properties could help reach drug-like space more efficiently. Potential reasons for the inefficient use of metrics and suboptimal decision making are discussed. © 2013 American Chemical Society.
Item Type: | Article |
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Keywords: | decision making drug-likeness efficiency metrics fragment-based drug design Ligand efficiency (LE) lipophilic efficiency (LipE) |
Date Deposited: | 30 Nov 2017 00:45 |
Last Modified: | 25 Jan 2019 00:46 |
URI: | https://oak.novartis.com/id/eprint/20303 |