Noble, Christian Guy and Shi, Pei-Yong (2013) Difficulties and advancements in developing drugs for the treatment of dengue fever. Expert Opinion on Orphan Drugs, 1 (12). pp. 947-949. ISSN 2167-8707

Abstract

Dengue fever is caused by infections with dengue virus, the most prevalent mosquito-borne viral pathogen in humans. There are no drugs available to treat dengue virus infection and we discuss the strategies available to develop novel drugs against it. Treating the disease pathology is hindered by a lack of understanding of the disease progression and the causes of disease symptoms such as vascular leakage. Most drug-discovery efforts have concentrated on viral targets, which have their own particular challenges. Ultimately, the only way to know whether a direct-acting antiviral will be a viable approach for treating dengue patients is to test safe compounds with demonstrated antiviral activity in human trials.

Item Type:	Article
Date Deposited:	26 Apr 2016 23:46
Last Modified:	26 Apr 2016 23:46
URI:	https://oak.novartis.com/id/eprint/20040