Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways
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Garcia-Echeverria, Carlos (2009) Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways. Purinergic Signalling, 5 (1). pp. 117-125. ISSN 1573-9538
Abstract
The identification and characterization of the components of individual signal transduction cascades, and advances in our understanding on how these biological signals are integrated in cancer initiation and progression, have provided new strategies for therapeutic intervention in solid tumors and hematological malignancies. To this end, pharmaceutical efforts have been directed to target different components of the Ras/Raf/MEK and PI3K/PKB pathways. This review article covers recent salient achievements in the identification and development of Raf, MEK, and PI3K inhibitors.
| Item Type: | Article |
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| Additional Information: | Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | Cancer; Drug design; Kinase; MEK; PI3K; Raf; Targeted therapy |
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| Date Deposited: | 22 Feb 2010 11:50 |
| Last Modified: | 31 Jan 2013 00:50 |
| URI: | https://oak.novartis.com/id/eprint/1761 |