Enz, Albert, Feuerbach, Dominik, Frederiksen, Mathias, Gentsch, Conrad, Hurth, Konstanze, Müller, Werner, Nozulak, Joachim and Roy, Bernard Lucien (2009) Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists. Bioorganic & Medicinal Chemistry Letters, 19 (5). pp. 1287-1291. ISSN 1464-3405

Abstract

A novel class of alpha7 nicotinic acetylcholine receptor (nAChR) agonists has been discovered through high-throughput screening. The cis gamma-lactam scaffold has been optimized to reveal highly potent and selective alpha7 nAChR agonists with in vitro activity and selectivity and with good brain penetration in mice.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... http://dx.doi.org/10.1016/j.bmcl.2009.01...
Additional Information:	Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	γ-Lactams; α7; Nicotinic; nAChR
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... http://dx.doi.org/10.1016/j.bmcl.2009.01...
Date Deposited:	22 Feb 2010 11:50
Last Modified:	22 Feb 2010 11:50
URI:	https://oak.novartis.com/id/eprint/1744