Jiang, Tao, Kuhen, Kelli, Wolff, Karen, Yin, Hong, Bieza, Kimberly, Caldwell, Jeremy, Bursulaya, Badry, Tuntland, Tove, Zhang, Kanyin, Karanewsky, Donald and He, Yun (2006) Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2. Bioorganic & Medicinal Chemistry Letters, 16 (8). pp. 2109-2112. ISSN 0960-894X

Abstract

A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	author can archive post-print (ie final draft post-refereeing)
Keywords:	AIDS; HIV; Reverse transcriptase; Inhibitor; Oxindole; Heterocycle; SAR
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 14:04
Last Modified:	31 Jan 2013 01:25
URI:	https://oak.novartis.com/id/eprint/163