1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.
Tools
Epple, Robert, Azimioara, Mihai, Russo, Ross, Bursulaya, Badry, Tian, Shin-Shay, Gerken, Andrea and Iskandar, Maya (2006) 1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists. Bioorganic & Medicinal Chemistry Letters, 16 (11). pp. 2969-2973. ISSN 0960-894X
Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Abstract
A series of highly potent and selective PPARdelta agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 microM, making it a useful tool in studying the biological effects of selective PPARdelta activation.
Item Type: | Article |
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Additional Information: | author can archive post-print (ie final draft post-refereeing) |
Keywords: | Nuclear receptors; Peroxisome proliferator-activated receptor delta; PPAR agonists; Virtual docking |
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Date Deposited: | 14 Dec 2009 14:04 |
Last Modified: | 31 Jan 2013 01:26 |
URI: | https://oak.novartis.com/id/eprint/153 |