Wu, Baogen, Kuhen, Kelli, Ngoc Nguyen, Truc, Ellis, David, Anaclerio, Beth, He, Xiaohui, Yang, Kunyong, Karanewsky, Donald, Yin, Hong, Wolff, Karen, Bieza, Kimberly, Caldwell, Jeremy and He, Yun (2006) Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (13). pp. 3430-3433. ISSN 0960-894X

Abstract

The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	author can archive post-print (ie final draft post-refereeing)
Keywords:	Antiviral; HIV; NNRTI; Pyrrolidinone
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 14:04
Last Modified:	31 Jan 2013 01:26
URI:	https://oak.novartis.com/id/eprint/151