3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1.
Epple, Robert, Russo, Ross, Azimioara, Mihai, Cow, Christopher, Xie, Yongping, Wang, Xing, Wityak, John, Karanewsky, Donald, Gerken, Andrea, Iskandar, Maya, Saez, Enrique, Seidel, Martin and Tian, Shin-Shay (2006) 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4376-4380. ISSN 0960-894X
Abstract
We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARdelta. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.
Item Type: | Article |
---|---|
Related URLs: | |
Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
Keywords: | PPARδ agonists; Metabolic syndrome; Energy homeostasis; Isoxazoles |
Related URLs: | |
Date Deposited: | 14 Dec 2009 14:04 |
Last Modified: | 31 Jan 2013 01:26 |
URI: | https://oak.novartis.com/id/eprint/148 |