Cole, Andrew G, Metzger, Axel, Brescia, Marc-Raleigh, Qin, Lan-Ying, Appell, Kenneth C, Brain, Christopher, Hallett, Allan, Ganju, Pam, Denholm, Alastair, Wareing, James, Ritchie, Tim, Drake, Gillian, Bevan, Stuart, MacGloinn, Aisling, Mcbryde, Andrew, Patel, Viral, Oakley, Paul, Nunez, Ximena, Gstach, Hubert, Schneider, Peter, Baldwin, John J, Dolle, Roland E, McDonald, Edward and Henderson, Ian (2009) Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 19 (1). pp. 119-122. ISSN 1464-3405

Abstract

The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a approximately 60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit K(i) values of approximately 10nM.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Bradykinin; Sulfonamide; Combinatorial chemistry; ECLiPSTM
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 13:48
Last Modified:	14 Dec 2009 13:48
URI:	https://oak.novartis.com/id/eprint/1452