Pseudomonas aeruginosa increases formation of multidrug tolerant persister cells in response to quorum sensing signaling molecules
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Moeker, Nina, Dean, Charles and Tao, Jianshi (2010) Pseudomonas aeruginosa increases formation of multidrug tolerant persister cells in response to quorum sensing signaling molecules. Journal of Bacteriology, 192 (7). pp. 1946-1955. ISSN 0021-9193
Abstract
Bacterial persister cells constitute a small portion of a culture which is tolerant to killing by lethal doses of bactericidal antibiotics. These phenotypic variants are formed in numerous bacterial species, including those with clinical relevance like the opportunistic pathogen Pseudomonas aeruginosa. Although persisters are believed to contribute to the difficulties in the treatment of many infectious diseases, the underlying mechanisms affecting persister formation are not well understood. Here we show that even though P. aeruginosa cultures have a significantly smaller fraction of multidrug tolerant persister cells than cultures of Escherichia coli or Staphylococcus aureus, they can increase persister numbers in response to quorum sensing-related signalling molecules. The phenazine pyocyanin (and the closely related molecule paraquat), and acyl-homoserine lactone 3-OC12-HSL significantly increased the persister numbers in logarithmic P. aeruginosa PAO1 or PA14 cultures, but not in E. coli or S. aureus cultures.
| Item Type: | Article |
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| Additional Information: | Author can archive post-print (ie final draft post-refereeing); but on personal or university-hosted websites only |
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| Date Deposited: | 13 Oct 2015 13:17 |
| Last Modified: | 13 Oct 2015 13:17 |
| URI: | https://oak.novartis.com/id/eprint/1259 |