Trompette, Aurelien, Gollwitzer, Eva, Yadava, Koshika, Sichelstiel, Anke K., Sprenger, Norbert, Ngom-Bru, Catherine, Blanchart, Carine G., Junt, Tobias, Nicod, Laurent P., Harris, Nicola L. and Marsland, Benjamin J. (2013) Dietary fiber influences the severity of allergic airway inflammation through GPR41 mediated host-microbial-metabolite cross-talk. Nature Medicine.

Abstract

Diet-induced dysbiosis of host-microbial mutualism has been linked with chronic intestinal diseases; however, less well established is whether diet and host microbe
interactions influence pulmonary inflammation. We have found that dietary fiber content changed the intestinal microbiota in mice, with consequent alterations in circulating levels of short-chain fatty acids (SCFA’s) and a reduced severity of allergic airway inflammation. Specifically, high-fiber fed mice exhibited elevated levels of SCFA’s in the serum and were protected against house dust
mite extract (HDM)-induced allergic airway inflammation, whilst the contrary was found under low fiber diet conditions. The protective effect of SCFA’s was dependent on a GPR41-mediated pathway. During the HDM-induced airway inflammation, SCFA’s led to enhanced generation of macrophage and dendritic cell precursors in the bone marrow and subsequent seeding of the lung by
dendritic cells with high phagocytic capacity but an impaired ability to mediate Thelper 2 cell effector function. Our results show that dietary fiber content and
SCFA’s can shape the immunological environment in the lung and influence the severity of allergic inflammation.

Item Type:	Article
Keywords:	GPR41, short chain fatty acid, dendritic cell
Date Deposited:	13 Oct 2015 13:13
Last Modified:	13 Oct 2015 13:13
URI:	https://oak.novartis.com/id/eprint/10743