Synthesis of mucin-type O-glycan probes ready to be immobilized to glycoarray platforms.
Smith, Nichola, Benito-Alifonso, David, Jones, Rachel A, Tran, Anh-Tuan, Woodward, Hannah and Galan, M Carmen (2013) Synthesis of mucin-type O-glycan probes ready to be immobilized to glycoarray platforms. Beilstein Journal of Organic Chemistry.
Abstract
The chemical synthesis of a series of mucin-type oligosaccharide fragments 2-7 containing an αlinked amino-propyl spacer ready for glyco-array attachment is reported. A highly convergent and stereoselective strategy that employs two different orthogonal protected galactosamine building blocks was used to access all of the targets. A tandem deprotection sequence, that did not require chromatography-based purification between steps, was employed to globally unmask all protecting groups and all final targets were isolated in good to excellent yields
Item Type: | Article |
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Date Deposited: | 26 Apr 2016 23:46 |
Last Modified: | 26 Apr 2016 23:46 |
URI: | https://oak.novartis.com/id/eprint/10560 |