Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks.
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Schleker, Thomas, Nagai, Shigeki and Gasser, Susan (2009) Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks. DNA Repair. ISSN 1568-7864
Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Abstract
DNA damage during replication requires an integration of checkpoint response with replication itself and distinct repair pathways, such as replication pausing, recombination and translesion synthesis. Here we focus on recent advances in our understanding of how protein posttranslational modifications contribute to the maintenance of fork integrity. In particular, we examine the role of histone modifications and chromatin remodeling complexes in this process.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | Replication; Checkpoint; Histone modification; Repair; Chromatin remodeling |
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| Date Deposited: | 14 Dec 2009 13:50 |
| Last Modified: | 31 Jan 2013 01:00 |
| URI: | https://oak.novartis.com/id/eprint/1020 |