Chemical proteomics identifies unanticipated targets of clinical kinase inhibitors.
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Peters, Eric and Gray, Nathanael (2007) Chemical proteomics identifies unanticipated targets of clinical kinase inhibitors. ACS Chemical Biology, 2 (10). pp. 661-664. ISSN 1554-8937
Official URL: http://pubs.acs.org/doi/abs/10.1021/cb700203j
Abstract
Kinases represent one of the most important target classes of current drug discovery efforts. However, because the vast majority of potential small-molecule therapeutics is directed toward the highly conserved ATP-binding cleft, kinase inhibitors often exhibit significant unintended off-target effects. A recent report describes a chemical proteomics methodology that enables the simultaneous in vivo quantification of the on- and off-binding targets of kinase inhibitors across hundreds of nucleotide-dependent enzymes.
| Item Type: | Article |
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| Date Deposited: | 14 Dec 2009 14:05 |
| Last Modified: | 31 Jan 2013 01:28 |
| URI: | https://oak.novartis.com/id/eprint/102 |