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Entry into a new class of protein kinase inhibitors by pseudo ring design.

Furet, Pascal and Caravatti, Giorgio and Guagnano, Vito and Lang, Marc and Meyer, Thomas and Schoepfer, Joseph (2008) Entry into a new class of protein kinase inhibitors by pseudo ring design. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 897-900. ISSN 1464-3405

Abstract

A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Kinase; Scaffold morphing; Pseudo ring
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Date Deposited: 14 Dec 2009 13:51
Last Modified: 14 Dec 2009 13:51
URI: https://oak.novartis.com/id/eprint/918

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