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Resveratrol inhibits firefly luciferase.

Bakhtiarova, Adel and Taslimi, Paul and Elliman, Stephen and Kosinski, Penelope and Hubbard, Brian and Kavana, Michael and Kemp, Daniel (2006) Resveratrol inhibits firefly luciferase. Biochemical and Biophysical Research Communications, 351 (2). pp. 481-484. ISSN 0006-291X

Abstract

The potential therapeutic value of resveratrol in age-related disease settings including cancer, diabetes, and Alzheimer's has emerged from a rapidly growing body of experimental evidence. Protection from oxidative stress appears to be a common feature of resveratrol that may be mediated through SirT1, though more specific molecular mechanisms by which resveratrol mediates its effects remain unclear. This has prompted an upsurge in cell-based mechanistic studies, often incorporating reporter assays for pathway elucidation in response to resveratrol treatment. Here, we report that resveratrol potently inhibits firefly luciferase with a K(i) value of 2microM, and caution that this confounding element may lead to compromised data interpretation.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Resveratrol; Firefly luciferase; SirT1; Therapeutic; Drug; Cancer; Neurodegeneration
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Date Deposited: 14 Dec 2009 13:57
Last Modified: 14 Dec 2009 13:57
URI: https://oak.novartis.com/id/eprint/580

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