Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents.

Coppola, Gary and Damon Ii, Robert and Eskesen, J and France, Dennis and Paterniti, James (2006) Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 113-117. ISSN 0960-894X

Abstract

A series of 1-alkyl-3-phenylthiourea analogues were prepared and evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Several derivatives were superior to gemfibrozil. The optimal analogue (HDL376) was shown to raise HDL cholesterol in the rat, hamster, dog, and monkey models.

Item Type: Article
Related URLs:
Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Related URLs:
Date Deposited: 14 Dec 2009 13:59
Last Modified: 14 Dec 2009 13:59
URI: https://oak.novartis.com/id/eprint/496

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.