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Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.

Osborne, Colin and Leitner, Ingrid and Hofbauer, Bettina and Fielding, Ceri A and Favre, Bertrand and Ryder, Neil (2006) Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. Antimicrobial Agents and Chemotherapy, 50 (6). pp. 2234-2236. ISSN 0066-4804

Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); but on personal or university-hosted websites only
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Date Deposited: 14 Dec 2009 14:00
Last Modified: 14 Dec 2009 14:00
URI: https://oak.novartis.com/id/eprint/406

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