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Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization

Linton, Steven D, Karanewsky, Donald S, Ternansky, Robert J, Chen, Ning, Guo, Xian, Jahangiri, Kathy G, Kalish, Vincent J, Meduna, Steven P, Robinson, Edward D, Ullman, Brett R, Wu, Joe C, Pham, Brian, Kodandapani, Lalitha, Smidt, Robert, Diaz, Jose-Luis, Fritz, Lawrence C, von Krosigk, U, Roggo, Silvio, Schmitz, Albert and Tomaselli, Kevin J (2002) Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorganic & Medicinal Chemistry Letters, 12 (20). pp. 2973-2975. ISSN 0960-894X


A new structural class of broad spectrum caspase inhibitors was optimized for its activity against caspases 1, 3, 6, 7, and 8. The most potent compound had low nanomolar broad spectrum activity, in particular, single digit nanomolar inhibitory activity against caspase 8.

Item Type: Article
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Additional Information: Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 29 Apr 2010 23:45
Last Modified: 01 Feb 2013 00:49


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