Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.

Enz, Albert and Feuerbach, Dominik and Frederiksen, Mathias and Gentsch, Conrad and Hurth, Konstanze and Müller, Werner and Nozulak, Joachim and Roy, Bernard Lucien (2009) Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists. Bioorganic & Medicinal Chemistry Letters, 19 (5). pp. 1287-1291. ISSN 1464-3405

Abstract

A novel class of alpha7 nicotinic acetylcholine receptor (nAChR) agonists has been discovered through high-throughput screening. The cis gamma-lactam scaffold has been optimized to reveal highly potent and selective alpha7 nAChR agonists with in vitro activity and selectivity and with good brain penetration in mice.

Item Type: Article
Related URLs:
Additional Information: Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: γ-Lactams; α7; Nicotinic; nAChR
Related URLs:
Date Deposited: 22 Feb 2010 11:50
Last Modified: 22 Feb 2010 11:50
URI: https://oak.novartis.com/id/eprint/1744

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.