Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.

Epple, Robert, Azimioara, Mihai, Russo, Ross, Bursulaya, Badry, Tian, Shin-Shay, Gerken, Andrea and Iskandar, Maya (2006) 1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists. Bioorganic & Medicinal Chemistry Letters, 16 (11). pp. 2969-2973. ISSN 0960-894X


A series of highly potent and selective PPARdelta agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 microM, making it a useful tool in studying the biological effects of selective PPARdelta activation.

Item Type: Article
Related URLs:
Additional Information: author can archive post-print (ie final draft post-refereeing)
Keywords: Nuclear receptors; Peroxisome proliferator-activated receptor delta; PPAR agonists; Virtual docking
Related URLs:
Date Deposited: 14 Dec 2009 14:04
Last Modified: 31 Jan 2013 01:26