Peters, Eric and Gray, Nathanael (2007) Chemical proteomics identifies unanticipated targets of clinical kinase inhibitors. ACS Chemical Biology, 2 (10). pp. 661-664. ISSN 1554-8937

Abstract

Kinases represent one of the most important target classes of current drug discovery efforts. However, because the vast majority of potential small-molecule therapeutics is directed toward the highly conserved ATP-binding cleft, kinase inhibitors often exhibit significant unintended off-target effects. A recent report describes a chemical proteomics methodology that enables the simultaneous in vivo quantification of the on- and off-binding targets of kinase inhibitors across hundreds of nucleotide-dependent enzymes.

Item Type:	Article
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Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 14:05
Last Modified:	31 Jan 2013 01:28
URI:	https://oak.novartis.com/id/eprint/102