B

Bal, Gobardhan (2026) Evaluation of food effects on two anticancer drugs in humans: Application of physiologically based pharmacokinetic modeling as a surrogate strategy to minimize In-Vivo studies in drug development. Pharmacological Research - Reports, 5. ISSN 2950-2004

Beckmann, Nicolau (2026) Editorial for "Associations Between Hippocampal Transverse Relaxation Time and Amyloid PET in Cognitively Normal Aging Adults". Journal of magnetic resonance imaging : JMRI, 63 (1). pp. 181-182. ISSN 1522-2586

C

Chen, Ziyi, Ly, Duc, Kanda, Yuzuru, Mykhailiuk, Pavel, Musaev1, Djamaladdin and Davies, hUW (2026) Asymmetric C-H Functionalization of Bicyclo[2.1.1]hexanes and Their 2-Oxa- and 2-Aza Derivatives via Rhodium Carbene Intermediates. Journal of the American Chemical Society. ISSN 1520-5126

D

De Caro, Liberato, Stoll, Thibaud, Grandeury, Arnaud, Gozzo, Fabia and Giannini, Cinzia (2026) Characterization of VitE-TPGS Micelles linked to Poorly Soluble Compounds for Pharmaceutical Applications exploiting the Pair Distribution Function’s Moments. Pharmaceutics, 17 (431).

G

Ge, Xiaobin-1, Yuan, Lijun, Sun, Qiqi, Lin, Ting, Chen, Weihao-1, Sun, Ji-1, Yu, Huangchao, Jin, Jian, Liu, Feng, He, Hui, Xu, Guoqiang, Gallou, Fabrice, Ye, Ning, Mo, Yiming and Shen, Xiaodong (2026) Minute-scale Alkylation of Heteroarenes via Photo-Fenton Mechanism in Continuous Flow. Green chemistry. ISSN 1463-9270; 1463-9262

Glowienke, Susanne (2026) Assessment and Control of Host Cell Proteins in Biologics: Survey of Industry Practices and a Vision for Harmonization. Biotechnology and bioengineering. ISSN 1097-0290

K

KAWAKITA, YASUNORI, MATSUMOTO, KAYOKO, HIRANO, MASARU, INOUE, SATORU, TAWARA, HIROKI and SATO, MIKA (2026) Reimagining Early-Phase Clinical Development in Japan: From Regulatory Obligation to Global Acceleration. Clinical and translational science, 19 (1). e70467. ISSN 1752-8062

L

Liu, Chang, Li, Wenyuan, Li, Renzhe, Marchant, Rohan, Kanda, Yuzuru and Qin, Tian (2026) Propellane-Free Access to Bicyclo[1.1.1]pentanes. Nature communications.

M

Muehlenbroich, Angela, Schultz-Heienbrok, R, Baumann, S, Böhm, R, Bonertz, A, Breithaupt-Groegler, K, Buckpesch-Heberer, U, Coenen, M, Erb-Zohar, K, Faisst, N, Grass, G, Höchel, J, Kovar, A, Rengelhausen, J, Riedel, C, Schug, B, Sudhop, T, Warnke, A and Ziegele, B (2026) Designing integrated early-phase protocols to reduce substantial modifications, including considerations for patient cohorts – a multi-stakeholder consensus view for a practical approach in Germany. Frontiers in pharmacology, 16. ISSN 1663-9812

N

Naouar, Ikbel, Pangan, Andrei, Zuo, Michelle, Champagne-Jorgens, Kevin, Patel, Jyot, Wang, Angela, Pu, Annie, Ward, Lesley, Ahn, Jennifer, Cenni, Bruno, Nuesslein-Hildesheim, Barbara, Probstel, Anne-Katrin, Gommerman, Jennifer and Ramaglia, Valeria (2026) Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury. Nature immunology, 27 (1). pp. 48-60. ISSN 1529-2916

P

Parrondo, Raquel, Lanini, Jessica and Rodriguez Perez, Raquel (2026) Uncertainty Quantification in Molecular Machine Learning for Property Predictions under Data Shifts. Journal of chemical information and modeling. ISSN 1549-960X

Primi, Marina C, Tavares, Mauricio T, Hatcher, John M, Kang, Hyelim, Kresina, Thomas, Leroy, Emilie, Schmoker, Anna, Scott, David and Eck, Michael (2026) Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain. European journal of medicinal chemistry, 302 (Pt 1). p. 118274. ISSN 1768-3254

R

Rene, Olivier, Saldivia Concepcion, Manuel Alejand-1, Dauphinais, Maxime, Zhang, Lei-9, Hollingsworth, Scott, Jiricek, Jan, Koester, Dennis, Miller, Sarah, Williams, Sarah, Ng, Pearly, Patra, Debjani, Baxley, Grace, Osborne, Colin, Chen, Ying-Bo, Chen, Yen-Liang-1, Cheung, Harry, Lakshminarayana, Suresh, Galarneau, Jean-Rene, Diagana, Thierry, Sarko, Christopher, Rao, Srinivasa and Jumani, Rajiv (2026) Discovery of IID432: A Highly Efficacious and Safe Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II for Short-Duration Curative Treatment of Chagas Disease. Journal of medicinal chemistry.

S

Schaub, Daniela / D.S., von Haugwitz, Gerlis / G.v.H., Meyer, Fabian, Scheuermann, Jörg / J.S. and Buller, Rebecca / R.B. (2026) Toward the Chemoenzymatic Synthesis of DNA-Encoded Libraries. ACS central science.

Sechaud, Romain, Peters, Thomas, Gu, Helen, Rahmanzadeh, Gholamreza, Sharma, Gopal Krishna, Guichard, Nathalie and Menssen, Hans (2026) Pharmacogenomic, pharmacokinetic, and safety analysis of CYP3A4/CYP3A5 polymorphisms of midostaurin in patients with acute myeloid leukemia. European journal of clinical pharmacology, 82 (1). p. 19. ISSN 1432-1041

Shahrukh, Muhammad, Del Rio, Tony, Sweeney, Julianne and Ozsolak, Fatih (2026) Supplementary Information: Metadata Assessment of Preclinical Non-Human Primate Studies of AAV9 Uncovers Potential Tissue Specific Variation in Expression Efficiency. Gene therapy. ISSN 1476-5462; 0969-7128

Shahrukh, Muhammad, Sweeney, Julianne, Del Rio, Tony and Ozsolak, Fatih (2026) Metadata Assessment of Preclinical Non-Human Primate Studies of AAV9 Uncovers Potential Tissue Specific Variation in Expression Efficiency. Gene therapy. ISSN 1476-5462; 0969-7128

Shahrukh, Muhammad, Sweeney, Julianne, Del Rio, Tony and Ozsolak, Fatih (2026) Metadata assessment of non-human primate studies of AAV9 uncovers potential tissue specific variation in expression efficiency. Gene therapy, 32 (6). pp. 1476-5462. ISSN 1476-5462

Z

Zhang, Juan, Hatakeyama, Shinji, Grove, Kerri, Muller, Alban, Kreider, Julie, Santos, Camille, Hoque, Shaila, Bidinosti, Michael and Christen, Isabelle (2026) Charcot–Marie–Tooth Type 1 A (CMT1A) is a hereditary neuropathy caused by a duplication of the peripheral myelin protein 22 (PMP22) gene. Emerging evidence suggests that lipid metabolism plays a central role in CMT1A pathology. This study investigated metabolic profiles in sciatic nerve tissue and plasma of PMP22 transgenic (TG) and wild-type (WT) rats at 2, 4, and 6 months of age. Utilizing targeted metabolomics, more than 600 metabolites covering central metabolic pathways and major lipid classes were analyzed, revealing distinct age-dependent changes in metabolic pathways. Alterations that emerged early and became increasingly pronounced with age were observed in sphingolipids and glycerophospholipids, while changes in other metabolic pathways, such as amino acids, storage lipids, bile acids, and nucleotide metabolism, were age-specific. Notably, in contrast to these age-dependent adaptive changes, three lipid signatures were identified that remained stable from the earliest age examined. These include: (1) an elevated ratio of hydroxylated to nonhydroxylated sphingolipids, (2) a reduced ratio of monounsaturated-containing to saturated fatty acid containing phosphatidylcholines, and (3) a decreased ratio of hexosylceramides to ceramides. Imaging mass spectrometry analyses confirmed disruptions in sphingolipid metabolism. These findings suggest a key regulatory role of PMP22 in lipid metabolism, as demonstrated by the early stabilization of specific lipid signatures compared to other metabolic changes that occurred in an age-dependent and adaptive manner. These observations provide valuable insights into the pathogenic mechanisms underlying CMT1A. Scientific reports, 16 (2036).