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Number of items: 97.


Adachi, Yuichiro and Fu, Fumin and Pietropaolo, Michael and Pandit, Shilpa and Li, Weiyan and Murakami, Yutaka and Grewal, Pam and Lussier, Jen and Deyneko, Galina and Turner, Gordon and Shetty, Suraj and Tarnavski, Oleg and Liu, Jing and Cui, Lei and Taggart, Andrew and Waters, Gerry and Coughlin, Shaun (2022) Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models. PloS one, 17 (1). e0256512. ISSN 1932-6203

Allmendinger, Thomas and Furet, Pascal and Denay, Regis and Kotoni, Dorina and Bixel, Dominique and Anokwah, Daniel K. (2022) 9-epi-Artemisinin - How a single stereo center affects chemical reactivity and activity. Helvetica Chimica Acta. ISSN 0018-019X1522-2675

Axelsson, Gisli Thor and Gudmundsson, Gunnar and Aspelund, Thor and Putman, Rachel and Gudmundsson, Elias F and Hatabu, Hiroto and Gudmundsdottir, Valborg and Gudjonsson, Alexander and Launer, Lenore J and Jennings, Lori and Hunninghake, Gary M and Emilsson, Valur and Gudnason, Vilmundur (2022) The Proteomic Profile of Interstitial Lung Abnormalities. American journal of respiratory and critical care medicine. ISSN 1535-4970


Badaoui, Magd and Buigues, Pedro J. and Berta, Dénes and Mandana, Gaurav M. and Kato, Mitsunori and Dickson, Callum and Hornak, Viktor and Molteni, Carla and Parsons, Simon D. and Rosta, Edina (2022) Combined Free-Energy Calculation and Machine Learning Methods for Understanding Ligand Unbinding Kinetics. Journal of chemical theory and computation. ISSN 1549-9626

Badee, Justine Marine (2022) Current Practices, Gap Analysis and Proposed Roadmaps for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective. CPT: pharmacometrics & systems pharmacology..

Barabas, Amanda J. and Robbins, Lindsey A. and Gaskill, Brianna N. (2022) Home cage measures of Alzheimer's disease in the rTg4510 mouse model. Genes, Brain and Behavior, 21 (2). ISSN 1601-1848

Bassand, Celine and Verin, Jeremy and Lamatsch, Martin and Siepmann, Florence and Siepmann, Juergen (2022) How agarose gels surrounding PLGA implants limit swelling and slow down drug release. Journal of controlled release : official journal of the Controlled Release Society, 343. pp. 255-266. ISSN 1873-4995

Bechtold-Peters, Karoline (2022) Industry Perspective on the use and Characterization of Polysorbates for Biopharmaceutical Products Part 1: Survey Report on Current State and Common Practices for Handling and Control of Polysorbates. Journal of pharmaceutical sciences, 111 (5). pp. 1280-1291. ISSN 00223549

Beckmann, Nicolau (2022) Editorial for "Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study”. Journal of Magnetic Resonance Imaging. ISSN 1053-18071522-2586

Betschart, Claudia and Faller, Michael and Zink, Florence and Hemmig, Rene and Blank, Jutta and Vangrevelinghe, Eric and Bourrel, Marjorie and Glatthar, Ralf and Behnke, Dirk and Barker, Kerstin and Heizmann, Andreas and Angst, Daniela and Nimsgern, Pierre and Jacquier, Sebastien and Junt, Tobias and Collignon Zipfel, Geraldine and Ruzzante, Giulia and Loetscher, Pius and Limonta, Sarah and Hawtin, Stuart and Andre, Cedric Bernard and Boulay, Thomas and Feifel, Roland and Knoepfel, Thomas (2022) Structure-based optimization of a fragment like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Bluemel, Oliver and Bechtold-Peters, Karoline and Anuschek, Moritz and Buecheler, Jakob and Hoelzl, Georg and Friess, Wolfgang (2022) The effect of mAb and excipient cryoconcentration on long-term frozen storage stability - Part 1: Higher molecular weight species and subvisible particle formation. International journal of pharmaceutics: X, 4. p. 100108. ISSN 2590-1567

Bluemel, Oliver and Buecheler, Jakob and Hauptmann, Astrid and Hoelzl, Georg and Bechtold-Peters, Karoline and Friess, Wolfgang (2022) The effect of mAb and excipient cryoconcentration on long-term frozen storage stability - part 2: Aggregate formation and oxidation. International journal of pharmaceutics: X, 4. p. 100109. ISSN 2590-1567

Bluemel, Oliver and Friess, Wolfgang and Rodrigues, Miguel and Geraldes, Vitor and Bechtold-Peters, Karoline and Buecheler, Jakob and Hauptmann, Astrid and Hoelzl, Georg (2022) Evaluation of Two Novel Scale-Down Devices for Testing Monoclonal Antibody Aggregation During Large-Scale Freezing. Journal of pharmaceutical sciences. ISSN 1520-6017

Bowman, Christopher and Barrow, Paul and Erkman, Linda and Muller, Mireille (2022) Science-based approach to harmonize contraception recommendations in clinical trials and pharmaceutical labels. Clinical pharmacology and therapeutics. ISSN 1532-6535

Bray, Mark and Durand, Eric and de Weck, Antoine and Fang, Jian and Gabriel, Daniela and Janssens, Rens and Moutsatsos, Ioannis and Spiegel, Stephan and Zhang, Xian (2022) High-content cellular screen image analysis benchmark study. bioRxiv.

Bruin, Gerardus and Walles, Markus (2022) Absorption, Distribution, Metabolism, and Excretion (ADME) of Therapeutic Proteins: A White Paper on Current Industry Practices and Future Perspectives. Drug metabolism and disposition. ISSN doi: 10.1124/dmd.121.000461

Bunc, Marko and Boncina, Matjaz and Graf, Christian and Hadži , San and Lah, Jurij (2022) Aggregation Time Machine: A Platform for the Prediction and Optimization of Long-Term Antibody Stability Using Short-Term Kinetic Analysis. Journal of Medicinal Chemistry, 65 (3). pp. 2623-2632. ISSN 0022-26231520-4804

Böttinger, Katharina and Paul, Katrin and Esser-Skala, Wolfgang and Segl, Marius and Herwig, Christoph and Huber, Christian (2022) At-line quantitative profiling of monoclonal antibody products during bioprocessing using HPLC-MS. Analytica chimica acta, 1207. p. 339813. ISSN 1873-4324


Casado-García, Ana and Isidro-Hernández, Marta and Oak, Ninad and Mayado, Andrea and Mann-Ran, Christine and Raboso-Gallego, Javier and Alemán-Artega, Silvia and Buhles, Alexandra and Sterker, Dario and Blanco, Oscar and Orfao, Alberto and Alonso-López, Diego and De Las Rivas, Javier and Riesco, Susana and Prieto-Matos, Pablo and Criado, Francisco Javier García and Cenador, María Begoña García and Radimerski, Thomas and Ramírez-Orellana, Manuel and Cobaleda, César and Yang, Jun J and Vicente-Dueñas, Carolina and Weiss, Andreas and Nichols, Kim E and Sánchez-García, Isidro (2022) Transient JAK/STAT pathway inhibition prevents natural occurring B-ALL development in genetically predisposed Pax5+/- mice. Cancer research, Epub a (canres). ISSN 1538-7445; 0008-5472

Charmont, Stephane and Sangana, Ramachandra and Valentin, Marie-Anne (2022) Development, validation and application of a liquid chromatography-tandem mass spectrometry method for the activity and inhibition of DPP-4. Bioanalysis, 14 (6). pp. 369-378. ISSN 1757-6199

Chen, Jin and Gu, Jessie and Shah, Bharti and Stringer, Rowan and Reis da Silva Torrao, Leonel and Hackling, Melissa and Nidamarthy, Prasanna and Prince, William and Woessner, Ralph (2022) Pharmacokinetics of Tropifexor, a Potent Farnesoid X Receptor Agonist, in Participants With Varying Degrees of Hepatic Impairment. Journal of clinical pharmacology, 62 (4). pp. 520-531. ISSN 1552-4604

Clark, Kirk and Kulathila, Raviraj and Wright, Kirk and Isome, Yuko and Sage, David and Yang, Yi and Christodoulou, Constantina (2022) Crystal structure of 2-PG bound to BPGM. RCSB Protein Data Bank.


Davis, Haley J. and Barabas, Amanda J. and Gaskill, Brianna N. (2022) Titrating the preferences of altered lighting against temperature in female CD-1 laboratory mice, Mus musculus. Applied Animal Behaviour Science, 246. p. 105541. ISSN 01681591

Dawson King, Janet and Accart Gris, Nathalie and Obrecht, Michael and Lambert, Christian and Flueckiger, Manuela and Kreider, Julie and Hatakeyama, Shinji and Richards, Peter and Beckmann, Nicolau (2022) Degenerative joint disease induced by repeated intra-articular injections of monosodium urate crystals in rats as investigated by translational imaging. Scientific reports, 12 (1). p. 157. ISSN 2045-2322

Dhandapani, Rahul and Neri, Marilisa and Bernhard, Mario and Brzak, Irena and Schweizer, Tatjana and Rudin, Stefan and Stefanie, Joller and Berth, Ramon and Kernen, Jasmin and Neuhaus, Anna and Waldt, Annick and Cuttat-Theurillat, Rachel and Naumann, Ulrike and Gubser Keller, Caroline and Roma, Guglielmo and Feuerbach, Dominik and Shimshek, Derya and Ulf, Neumann and Gasparini, Fabrizio and Galimberti, Ivan (2022) Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease. Cell reports, 39 (9). ISSN 2211-1247

DiDominick, Sarah and Abozeid, Ahmed M and Chen, Xueying and Stammberger, Uz and Santoro, Armando and Su, Wu-Chou and Navarro, Alejandro and Simonelli, Matteo and Yang, James CH and Ardizzoni, Andrea and Barlesi, Fabrice and Kang, Jin Hyoung and Felip, Enriqueta (2022) Phase Ib/II study of ceritinib in combination with ribociclib in patients with ALK-rearranged non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 166. pp. 170-177. ISSN 1872-8332

Dickson, Callum and Walker, Ross and Gould, Ian (2022) Lipid21: Complex Lipid Membrane Simulations with AMBER. Journal of chemical theory and computation. ISSN 1549-9626

Duca, Matteo and Lim, Darren Wan-Teck and Subbiah, Vivek and Takahashi, Shunji and Sarantopoulos, John and Varga, Andrea and D'Alessio, Tony and Abrams, Tinya and Sheng, Qing and Tan, Eugene and Cintrao Dos Santos Rosa, Maria and Gonzalez Maffe, Juan and Sand Dejmek, Janna and Fabre, Claire and Martin, Miguel (2022) A First-in-Human, Phase 1, Multicenter, Open-label, Dose-Escalation Study of PCA062, an Antibody-Drug Conjugate Targeting P-Cadherin, in Adult Patients with Solid Tumors. Molecular cancer therapeutics, 21 (4). pp. 625-634. ISSN 1535-7163

de Esch, Iwan J P and Erlanson, Daniel A and Jahnke, Wolfgang and Johnson, Christopher N and Walsh, Louise (2022) Fragment-to-Lead Medicinal Chemistry Publications in 2020. Journal of medicinal chemistry, 65 (1). pp. 84-99. ISSN 1520-4804


Ebersbach, Hilmar and Jascur, Julia and Keshvari, Sahar and Genz, Berit and Teakle, Ngari and Caruso, Melanie and Cestari, Michele F and Patkar, Omkar L and Tse, Brian WC and Sokolowski, Kamil A and MacDonald, Kelly P.A. and Miller, Gregory and Ramm, Grant A and Pettit, Allison R and Clouston, Andrew D and Powell, Elizabeth E and Hume, David A and Irvine, Katharine M (2022) Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease models & mechanisms. ISSN 1754-8411

Eichler, Gabriel and Imbert, Georges and Branson, Janice and Balibey, Rene and Laramie, Jason and Hersch, Greg and Askin, Scott and Kauffmann, Audrey and Speyer, Peter and Cochrane, Andrew and Mannan, Haripriya and Rudolph, Amy and Asakiewicz, Christopher and McGovern, Patricia and Ramanathan, Krishnan and Ballard, Mary (2022) Democratizing data at Novartis through clinical trial data access. Drug discovery today. ISSN 1878-5832


Forest, Thomas and Aeffner, Famke and Bangari, Dinesh and Bawa, Bhupinder and Carter, Jonathan and Fikes, James and High, Wanda and Hayashi, Shim-mo and Jacobsen, Matthew and McKinney, LuAnn and Rudmann, Daniel and Steinbach, Thomas and Schumacher, Vanessa and Turner, Oliver and Ward, Jerrold and Willson, Cynthia (2022) Scientific and Regulatory Policy Committee Points to Consider*: Primary Digital Histopathology Evaluation and Peer Review for Good Laboratory Practice (GLP) Nonclinical Toxicology Studies. Toxicologic pathology.

Francotte, Eric and Huynh, Dan (2022) Immobilization of 3,5-Dimethylphenyl Carbamate of Cellulose and Amylose on Silica by Photochemical and Thermal Radical Processes. Immobilization of 3,5-dimethylphenyl carbamate of cellulose and amylose on silica by photochemical and thermal radical processes, 2022. pp. 1-21. ISSN 1520-636X

Freedman, Benjamin R and Kuttler, Andreas and Beckmann, Nicolau and Nam, Sungmin and Kent, Daniel and Farshad, Ramazani and Schuleit, Michael and Accart Gris, Nathalie and Rock, Anna and Li, Jianyu and Kurz, Markus and Fisch, Andreas and Ullrich, Thomas and Hast, Michael W and Tinguely, Yann and Weber, Eckhard and Mooney, David J (2022) Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity. Nature Biomedical Engineering.


Gallou, Fabrice (2022) Phosphine Ligand-Free Bimetallic Ni(0)Pd(0) Nanoparticles as a Catalyst for Facile, General, Sustainable, and Highly Selective 1,4-Reductions in Aqueous Micelles. ACS Appl. Mater. Interfaces, 14 (5). pp. 6754-6761.

Gallou, Fabrice (2022) Selectivity Arising from Synergy Between Two Metals and Aqueous Micelle: Nickel-Palladium Bimetallic Nanoparticles for Facile and Highly Selective 1,4-Reduction of Chalcones. ACS Appl. Mater. Interfaces, 14 (5). pp. 6754-6761.

Gallou, Fabrice (2022) Water: An Underestimated Solvent for Amide Bond-Forming Reactions. ACS Sustainable Chemistry & Engineering, 10 (16). pp. 5299-5306.

Gallou, Fabrice and Grandeury, Arnaud and Jones, Graham (2022) Cultural Diversity Drives Innovation: Does Institutional Residence Time Impact Behaviors? Journal of Innovation Management, 9 (9). pp. 1-9. ISSN 2183-0606

Garcia, Francisco and Hoopes, Caleb and Sarkar, Akash and Kuehl, Nicholas and Barkan, Dave and Collins, Nicole and Bramhall, Taylor and Meister, Glenna and Hsu, Chien-Hsiang and Jones, Michael and Schirle, Markus and Taylor, Michael (2022) Donor-Acceptor Pyridinium Salts for Photo-Induced Electron-Transfer-Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes Using Visible Light. Journal of the American Chemical Society. ISSN 1520-5126

Garcia, Francisco and Hoopes, Caleb and Sarkar, Akash and Kuehl, Nicholas and Barkan, Dave and Collins, Nicole and Meister, Glenna and Bramhall, Taylor and Hsu, Chien-Hsiang and Jones, Michael and Schirle, Markus and Taylor, Michael (2022) Donor-Acceptor Pyridinium Salts for Photo-Induced Electron-Transfer-Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes Using Visible Light. Journal of the American Chemical Society, 144 (14). pp. 6227-6236. ISSN 1520-5126

Gudjonsson, Alexander and Gudmundsdottir, Valborg and Gudmundsson, Elias F and Jonsson, Brynjolfur G and Launer, Lenore J and Lamb, John R and Jennings, Lori and Aspelund, Thor and Emilsson, Valur and Gudnason, Vilmundur (2022) A genome-wide association study of serum proteins reveals shared loci with common diseases. Nature communications.

Guerini, Danilo (2022) STING agonists/antagonists: their potential as therapeutics and future developments. Cells., 11. p. 1159.

Guillon, Antoine and Diakite, Deborah and Cezard, Adeline and Baranek, Thomas and Bourgeais, Jérôme and Picou, Frédéric and Hervé, Virginie and Carballido, Jose and Desbarats, Lydie Nadal and Auvet, Adrien and Dingli, Florent and Turtoi, Andrei and Le Gouellec, Audrey and Fauvelle, Florence and Crépin, Thibaut and Hiemstra, Pieter S and Paget, Christophe and Loew, Damarys and Herault, Olivier and Naffakh, Nadia and Le Goffic, Ronan and Si-Tahar, Mustapha (2022) Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein. The EMBO journal, 41 (12). e108306. ISSN 1460-2075

Gurtan, Allan and Dominy, John and Khalid, Shareef and Vong, Linh and Caplan, Shari and Currie, Treeve and Richards, Sean and Lamarche, Lindsey and Denning, Daniel and Rasheed, Asif and Hameed, Shahid and ul-Asar, Zameer and Saleem, Imran and Jalal, Anjun and Abbas, Shahid and Rasheed, Syed and Memon, Fazal-ur-Rehman and Ishaq, Mohammad and Frossard, Philippe and Saleheen, Danish (2022) Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index. PLoS genetics, 18 (4). e1010093. ISSN 1553-7404


Hahaut, Vincent and Pavlinic, Dinko and Cowan, Cameron and Schuierer, Sven and Carbone, Walter and Roma, Guglielmo and Picelli, Simone (2022) Lightning Fast and Highly Sensitive Full-Length Single-cell sequencing using FLASH-Seq. Nature biotechnology, 40. ISSN 1087-0156

Henning, Nathaniel and Boike, Lydia and Spradlin, Jessica and Ward, Carl and Zhang, Erika and Belcher, Bridget and Brittain, Scott and Hesse, Matthew and Dovala, Dustin and McGregor, Lynn and Valdez Misiolek, Rachel and Wingert Plasschaert, Lindsey and Rowlands, David and Wang, Feng and fuller, daniel and Estes, Abigail and Frank, Andreas and Randal, Katelyn and Panidapu, Anoohya and McKenna, Jeffrey and Tallarico, John and Schirle, Markus and Nomura, Daniel and Liu, Gang (2022) Deubiquitinase-targeting chimeras for targeted protein stabilization. Nature chemical biology. ISSN 1552-4469

Hoch, Matthias and Huth, Felix and SATO, MASAHIKO and Sengupta, Tirtha and Quinlan, Michelle and Dodd, Stephanie and Kapoor, Shruti and Hourcade-Potelleret, Florence (2022) Pharmacokinetics of asciminib in the presence of CYP3A or P-gp inhibitors, CYP3A inducers, and acid-reducing agents. Clinical and Translational Science. ISSN 1752-80541752-8062

Hoch, Matthias and Sengupta, Tirtha and Hourcade-Potelleret, Florence (2022) Pharmacokinetic Drug Interactions of Asciminib With the Sensitive Cytochrome P450 Probe Substrates Midazolam, Warfarin and Repaglinide in Healthy Volunteers. Clinical and translational science. ISSN 1752-8062; 1752-8054

Horvath, Courtney (2022) People of TM: Video of Courtney Horvath. LinkedIn.

Huang, Ying and Zhang, Jeff and Sendzik, Martin and Gao, Zhenting and Sun, Yongfeng and Wang, Long and Zhang, Lijun and Blanz, Joachim and Dubost, Valerie and Chen, Zijun and Fang, Douglas and Gu, Justin and Kiffe, Michael and Li, Ling and Luo, Fangjun and Luo, Xiao and Mistry, Prakash and Pearson, David and Piaia, Alessandro and Qi, Wei and Scheufler, Clemens and Terranova, Remi and Weiss, Andreas and Yu, Zhengtian and Zeng, Jue and Zhang, Hailong and Zhang, Jiangwei and Zhang, Qiong and Zhao, Kehao and Zhao, Mengxi and Atadja, Peter and Dillon, Michael and Jeay, Sebastien Jeay and Li, En and Moggs, Jonathan and Pissot Soldermann, Carole and Oyang, Counde and Lingel, Andreas (2022) Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. Journal of Medicinal Chemistry, 65 (7). pp. 5317-5333. ISSN 0022-26231520-4804


Jennings, Lori (2022) SomaScan Proteomics Profiling - An Overview for (potential) External Collaborators. general distribution.

Ji, Yan and Huang, Pai-Hsi and Woolfenden, Stephen and Myers, Andrea (2022) Model-based dose selection to inform translational clinical oncology development of WNT974, a first-in-class Porcupine inhibitor. Clinical and translational science. ISSN 1752-8062


Kroemer, Markus and Ostermeier, Daniela (2022) Tackling Challenging Targets with High-Throughput Biophysical Screening at Novartis. Scaling Up Surface Plasmon Resonance-Based Screens to Increase Novel Hit Finding.


Lanshoeft, Christian and Lozac'h, Frederic and Higton, David (2022) Use of predicted versus measured CCS values from different instrument platforms, and isomer separation on the SELECT SERIES Cyclic IMS. Waters Application Note.

Lara, Zentsche and Jessica, Yazarians and Suman, Chakrabarty and Meagan, Hinze and April, Lukowski and Leo, Joyce and Alison, Narayan (2022) Biaryl bond formation through biocatalytic oxidative cross-coupling reactions. Nature, 603. pp. 79-85. ISSN

Lee, Judy (2022) Formulated oligonucleotide APIs: Regulatory aspects. Therapeutic innovation & regulatory science, 2022 (56). pp. 386-393. ISSN 2168-4790; 2168-4804

Lehmann, Hansjoerg and Knoepfel, Thomas and Ruppen, Thomas (2022) Scale-up of Diazonium Salts and Azides in a Three-step Continuous Flow Sequence. Organic Process Research & Development.

Lenz, Jan and Fuest, Frederik and Finek, Jan Hendrik and Bunjes, Heike and Kwade, Arno and Juhnke, Michael (2022) Tablet disintegration and dispersion under in vivo-like hydrodynamic conditions. Pharmaceutics, 14 (n.a.). pp. 1-25. ISSN 1999-4923

Linker, Stephanie and Schellhaas, Christian and Ries, Benjamin and Roth, Hans-Joerg and Fouche, Marianne and Rodde, Stephane and Riniker, Sereina (2022) Polar/Apolar Interfaces Modulate the Conformational Behavior of Cyclic Peptides with Impact on Their Passive Membrane Permeability. RSC advances, 12 (10). pp. 5782-5796.

Lopez, John and Bucher, Christoph and Beck, Janina and Berthelmann, Arne and Spyridon, Markos and Eisser, Stefan (2022) THE MISSING LINK: ENABLING LOADING OF 2-CHLOROTRITYL CHLORIDE RESIN IN N-BUTYLPYRROLIDINONE AS A GREEN SOLVENT. Organic Process Research & Development, 26 (5). pp. 1450-1457. ISSN 1083-61601520-586X

Loryan, Irena and Reichel, Andreas and Feng, Bo and Bundgaard, Christopher and Shaffer, Christopher and Kalvass, Cory and Bednarczyk, Dallas and Morrison, Denise and Lesuisse, Dominique and Hopper, Edmund and Terstappen, Georg and Fischer, Holger and Di, Li and Colclough, Nicola and Summerfield, Scott and Buckley, Stephen and Maurer, Tristan and Friden, Markus (2022) Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development. Pharmaceutical research. ISSN 1573-904X

Lüönd, Fabiana and Pirkl, Martin and Hisano, Mizue and Prestigiacomo, Vincenzo and Kalathur, Ravi Kr and Beerenwinkel, Niko and Christofori, Gerhard (2022) Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching. Life science alliance, 5 (2). ISSN 2575-1077


Madren, Seth and McElroy, Will and Schultz-Kuszak, Kristin and Boumajny, Boris and Shu, Yao and Sautter, Sabine and Zhao, Helen C and Schadock-Hewitt, Abby and Chumsae, Chris and Ball, Nancy and Xiaoying, Zhang and Rish, Kimberly and Shukui, Zhang and Wurm, Christine and Cai, Sumin and Bauer, Scott P and Stella, Cinzia and Zheng, Laura and Roper, Brian and Michels, David A and Wu, Gang and Kocjan, Bostjan and Birk, Matej and Erdmann, Simon Erik and He, Xiaoping and Whittaker, Brad and Song, Yvonne and Barrett, Hannah and Strozyk, Kevin and Jing, Ye and Huang, Long and Mhatre, Vishal and McLean, Paul and Yu, Tiantian and Yang, Huijuan and Mattila, Minna (2022) Global intercompany assessment of ICIEF platform comparability for the characterization of therapeutic proteins. Electrophoresis.

Mann, Greg and Stanger, Frederic and Peschke, Theo and Schroer, Kirsten and Nguyen Trung, Nhat Quang and Burrer, Nathalie and Grassinger, Franziska and Piccioni, Lorenzo and Erdogan, Oemer and Heimburger, Jeremy and Koehl, Herve and Ertle, Heike and Denay, Regis and Dreier, Philippe and Schlama, Thierry (2022) Biocatalytic assembly of chemically modified oligonucleotides. Tetrahedron letters. ISSN 00404039

McKenna, Jeffrey and Schirle, Markus and Tallarico, John and Brittain, Scott and Scholz, Spencer and Near, Katherine and Page, Annika and Spradlin, Jessica and Nomura, Daniel and Toste, F Dean (2022) Photo-Brook rearrangement of acyl silanes as a new tool for photoaffinity probes design. Chem Sci.

Meseck, Emily and Mansfield, Keith and Hudry, Eloise and McElroy, Cameron and Guibinga, Ghiabe (2022) Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaques. Toxicologic pathology.

Moebitz, Henrik and Gruenenfelder, Bjoern and Kiffe, Michael and Ramos, Rita and Ramulu, Poddutoori and Kiran, Aithal and Mark, Bock and Sanjeev, BS and Shekar, Chelur and T S, Devaraja and Sreevalsam, Gopinath and Andrea, Gerken and Charamanna , KB and Maithreyi, Krishnaswami and John, Langowski and Sudarshan, Madapa and Kishore, Narayanan and Ravi Kumar , P and Chetan, Pandit and Sunil Kumar, Panigrahi and Mark, Perrone and Murali, Ramachandra and Anuradha, Ramanathan and Susanta, Samajdar and Hosahalli, Subramanya and Eleni, Venetsanakos (2022) Discovery of MAP855, an efficacious and selective MEK1/2 inhibitor with ATP-competitive mode of action. Journal of Medicinal Chemistry.


Parmentier, Michael and Li, Wei and Steven, Alan (2022) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development. ISSN 1083-61601520-586X

Pearson, David and Jin, Yi and Romeo, Andrea and Birlinger, Bertrand-Luc and Schiller, Hilmar and Ji, Yan and Gunduz, Mithat and Baldoni, Daniela and Walles, Markus (2022) Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation. Xenobiotica. pp. 1-12. ISSN 0049-82541366-5928

Pearson, David and Jin, Yi and Romeo, Andrea and Birlinger, Bertrand-Luc and Schiller, Hilmar and Ji, Yan and Gunduz, Mithat and Baldoni, Daniela and Walles, Markus (2022) Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation. Xenobiotica; the fate of foreign compounds in biological systems. pp. 1-12. ISSN 1366-5928

Pivk-Lukancic, Petra and Drčar, Tjaša and Bruccoleri, Robert and Crnugelj, Martin and Mrak, Peter (2022) Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064. Applied microbiology and biotechnology. ISSN 1432-0614

Prabhath, Anupama and Vernekar , Varadraj N and Esdaille, Caldon J and Eisenberg , Ellen and Lebaschi , Amir and Badon , Mary and Seyedsalehi, Amir and Dzidotor , Godwin and Tang, Xiaoyan and Dyment , Nathaniel and Thomopoulos , Stavros and Kumbar , Sangamesh G and Deymier, Alix and Weber, Eckhard and Laurencin , Cato T (2022) Pegylated insulin-like growth factor-1 biotherapeutic delivery promotes rotator cuff regeneration in a rat model. Journal of biomedical materials research. Part A. ISSN 1552-4965

Pretre, Vincent and Papadopoulos, Dimitrios and Regard, Jean and Pelletier, Marc and Woo, Janghee (2022) Interleukin-1 (IL-1) and the inflammasome in cancer. Cytokine, 153. ISSN 1043-4666


Quintavalle, Cristina and Meyer-Schaller, Nathalie and Roessler, Stephanie and Calabrese, Diego and Marone, Romina and Riedl, Tobias and Picco-Rey, Silvia and Panagiotou, Orestis A and Uzun, Sarp and Piscuoglio, Salvatore and Boldanova, Tuyana and Bian, Chaoran B and Semela, David and Jochum, Wolfram and Cathomas, Gieri and Mertz, Kirsten D and Diebold, Joachim and Mazzucchelli, Luca and Koelzer, Viktor H and Weber, Achim and Decaens, Thomas and Terracciano, Luigi M and Heikenwalder, Mathias and Hoshida, Yujin and Andersen, Jesper B and Thorgeirsson, Snorri S and Matter, Matthias S (2022) miR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver. Hepatology communications. ISSN 2471-254X


Rawat, Manoj and Natasha , Manners and Vishnu, Priya and Abhishesh Kumar , Mehata and Madaswamy S, Muthu (2022) Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives. Pharmaceuticals, 15 (4). p. 441. ISSN 1424-8247

Reddy, K. Raja and Totrov, Maxim and Lomovskaya, Olga and Griffith, David C. and Tarazi, Ziad and Clifton, Matt and Hecker, Scott J. (2022) Broad-spectrum cyclic boronate β-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability. Bioorganic & medicinal chemistry, 62. p. 116722. ISSN 1464-3391

Reilly, Dorothy and Alharbi, Ebtisam and Gadiya, Yojana and Henderson, David and Zaliani, Andrea and Delfin-Rossaro, Alejandra and Cambon-Thomsen, Anne and Witt, Gesa and Welter, Danielle and Juty, Nick and Jay, Caroline and Goble, Carol and Satagopam, Venkata and Ioannidis, Vassilios and Gu, Wei and Gribbon, Phil (2022) Selection of datasets for FAIRification in Drug Discovery and Development: Which, Why, and How? Drug discovery today. ISSN 1878-5832

Rodriguez Perez, Raquel and Miljkovic, Filip and Bajorath, Jürgen (2022) Machine Learning in Chemoinformatics and Medicinal Chemistry. Annual review of biomedical data science. ISSN 2574-3414


Salvi, Amrita and Young, Alexandria N. and Huntsman, Andrew C. and Pergrande, Melissa and Korkmaz, Melissa A. and Mize, Brittney K. and Zhang, Xiaoli and Ratia, Kiira and Shelton IV, Claude and Brittain, Scott and Schirle, Markus and Thomas, Jason and Aldritch, Leslie N. and Cologna, Stephanie M. and Fuchs, James R. and Burdette, Joanna E. (2022) PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. Cell death & disease, 13 (1). p. 45. ISSN 2041-4889

Schiller, Hilmar and Huth, Felix and Schuhler, Carole and Drollmann, Anton Franz and Kaul, Martin and Woessner, Ralph and Shah, Bharti and Weis, Wendy and End, Peter (2022) Novel Bruton’s tyrosine kinase inhibitor remibrutinib: Assessment of drug-drug interaction potential as a perpetrator of cytochrome P450 enzymes and drug transporters and the impact of covalent binding on possible drug interactions. European journal of pharmaceutical sciences, 172. ISSN 09280987

Schoeberl, Birgit and Kearns, Jeff (2022) Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making. Frontiers in pharmacology, 13. p. 860881. ISSN 1663-9812

Schwab, Nathalie and Nienhold, Ronny and Henkel, Maurice and Baschong, Albert and Graber, Anne and Frank, Angela and Mensah, Nadine and Koike, Jacqueline and Hernach, Claudia and Sachs, Melanie and Willi, Niels and Zsikla, Veronika and Junt, Tobias and Mertz, Kirsten (2022) COVID-19 Autopsies Reveal Underreporting of SARS-CoV-2 Infection and Scarcity of Co-infections. Frontiers in medicine, 9. p. 868954. ISSN 2296-858X

Scorrano, Fabrizio (2022) A New Feeder Device to Provide Cleaner and Accessible Diet Gel to Laboratory Mice. Laboratory Animal Science Professional. pp. 50-52.

Seror, Raphaele and Baron, Gabriel and Camus, Marine and Cornec, Divi and Perrodeau, Elodie and Bowman, Simon and Bombardieri, Michele and Bootsma, Hendrika and Gottenberg, Jaccques-Eric and Fisher, Benjamin and Hueber, Wolfgang and van Roon, Joel and Devauchelle-Pensec, Valerie and Gergely, Peter and Mariette, Xavier and Porcher, Raphael (2022) Development and preliminary validation of the Sjögren’s Tool for Assessing Response (STAR): a consensual composite score for assessing treatment effect in primary Sjögren’s syndrome. Annals of the rheumatic diseases : ARD, Online (Online). Online-Online. ISSN Online ahead of print

Skolnik, Suzanne and Barrett, Jaclyn and Yang, Wenzhan and Belliveau, Lisa and Patros, Kellyn (2022) Discovery solubility measurement and assessment with drug development in mind. Drug discovery today. ISSN 13596446

Snyder, Jennifer (2022) We Support each other to Develop and Grow at Novartis. Biopharma Asia / also published in Biopharma Careers .

Spencer, Sarah and Chung, Jessie R. and Belongia, Edward A. and Sundaram, Maria and Meece, Jennifer and Coleman, Laura A. and Zimmerman, Richard K. and Nowalk, Mary Patricia and Moehling Geffel, Krissy and Ross, Ted and Carter, Chalise E. and Shay, David and Levine, Min and Liepkalns, Justine and Kim, Jin Hyang and Sambhara, Suryaprakash and Thompson, Mark G. and Flannery, Brendan (2022) Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults. Influenza and Other Respiratory Viruses, 16 (3). pp. 562-567. ISSN 1750-2640


Taskar, Kunal and Yang, Xinning and Neuhoff, Sibylle and Patel, Mitesh and Yoshida, Kenta and Paine, Mary and Brouwer, Kim and Chu, Xiaoyan and Sugiyama, Yuichi and Cook, Jack and Polli, Joseph and Hanna, Imad and Lai, Yurong and Zamek-Gliszczynski, Maciej (2022) Clinical relevance of hepatic and renal P-gp/BCRP inhibition of drugs: An International Transporter Consortium perspective. Clinical pharmacology and therapeutics. ISSN 1532-6535

Tassano, Erika and Moore, Charles and Dussauge, Solene and Vargas, Alexandra and Snajdrova, Radka (2022) Discovery of novel Fe(II)/α-ketoglutarate-dependent dioxygenases for oxidation of L-proline. Organic Process Research & Development. ISSN 1083-61601520-586X

Tia , Byer and Richter, Susanne (2022) Future Directions for Accelerated Upstream Bioprocessing. Cell Content hub:, n.a. (n.a.). n.a.-n.a.. ISSN n.a.

Tin, Adrienne and Jennings, Lori and Gudnason, Vilmundur and Mosley, Thomas H (2022) Proteomic analysis identifies circulating proteins associated with plasma amyloid βeta and incident dementia. Biological Psychiatry Global Open Science. ISSN 26671743


Ullrich, Thomas and Teixeira-Fouchard, Sylvie and Broennimann, Valerie and Stiefl, Nikolaus and Head, Victoria and Kramer, Ina and Guth-Gundel, Sabine and Arista, Luca and Weiler, Sven (2022) Discovery of a novel 2-aminopyrazine-3-carboxamide as a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2) for the treatment of fibrodysplasia ossificans progressiva. Bioorganic & medicinal chemistry letters. ISSN 1464-3405

Ungricht, Rosemarie and Guibbal, Laure and Lasbennes-Eckerlen, Marie-Christine and Orsini, Vanessa and Beibel, Martin and Waldt, Annick and Cuttat-Theurillat, Rachel and Carbone, Walter and Basler, Anne and Roma, Guglielmo and Nigsch, Florian and Tchorz, Jan and Hoepfner, Dominic and Hoppe, Philipp (2022) Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis. Cell stem cell, 29 (1). p. 160. ISSN 19345909


Walles, Markus (2022) A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation. Drug metabolism and disposition, June.

Wargenau, Manfred and Reidemeister, Sibylle and Klingmann, Ingrid and Klingmann , Viviane (2022) A composite endpoint for acceptability evaluation of oral drug formulations in the pediatric population. Therapeutic Innovation & Regulatory Science (TIRS) , 2022.

Wolf, Babette and Piksa, Mateusz and Voedisch, Bernd and Patoux, Agnes and Besson, Thierry and Schindler, Patrick and Cordier, Valerie and Perrot, Ludovic and Brees, Dominique and Kammueller, Michael (2022) Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity. Immunology. ISSN 1365-2567


Zevnik, Branko and Jerchow, Boris and Buch, Thorsten (2022) 3R Measures in facilities for the production of genetically modified rodents. Lab animal, 51 (6). pp. 162-177. ISSN 1548-4475; 0093-7355

This list was generated on Wed Jun 29 10:16:32 2022 UTC.


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