Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Items where Year is 2021

Group by: Creators | Item Type | No Grouping
Number of items: 331.

Aeffner, Famke, Turner, Oliver and Sing, Tobias (2021) Special Issue on Digital Pathology, Tissue Image Analysis, Artificial Intelligence, and Machine Learning: Approximation of the Effect of Novel Technologies on Toxicologic Pathology. Toxicologic Pathology, Volume (4). pp. 705-708. ISSN 15331601

Aksenov, Sergey, Roberts, John, Ganesh, Mugundu, Thudium-Mueller, Karen, Bhattacharya, Indranil and Tortorici, Michael (2021) Rational prediction of human dose for gene therapy based on translational dose-response studies. Clinical Pharmacology & Therapeutics. ISSN 0009-92361532-6535

Alave Reyes-Furrer, Angela, De Andrade, Sonia, Bachmann, Domininc, Jeker, Heidi, Steinmann, Martin, Accart Gris, Nathalie, Dunbar, Andrew W., Rausch, Martin, Bono, Epifania, Rimann, Markus and Keller, Hansjoerg (2021) Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses. Communications biology, 4. p. 1183. ISSN 2399-3642

Albanese, F, Mercatelli, D, Finetti, L, Lamonaca, G, Pizzi, S, Shimshek, Derya, Bernacchia, G and Morari, M (2021) Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo. Neurobiology of Disease, 159. ISSN 1095953X

Allam, Ahmed, Feuerriegel, Stefan, Rebhan, Michael and Krauthammer, Michael (2021) Analyzing patient trajectories with artificial intelligence. Journal of medical internet research, 23 (12). ISSN 1438-8871; 1439-4456

Anderka, Oliver, Graf, Tobias, Seisenberger, Christina, Wiedmann, Michael and Wohlrab, Stefanie (2021) Best practices on critical reagent characterization, qualification, and life cycle management for HCP immunoassays. Biotechnology and Bioengineering. ISSN 0006-35921097-0290

Auberson, Yves (2021) Reflections on 2018-2020. EFMC Yearbook, 2021. pp. 3-4.

Auberson, Yves, Benfatti, Fides, Jaeschke, Georg and Zumbrunn, Cornelia (2021) News from the DMCCB - Congress Report from the Virtual EFMC-ISMC 2021. Chimia, 75 (12). pp. 1048-1050. ISSN 0009-4293

Auberson, Yves and Missbach, Martin (2021) Perspectives and Opportunities in Medicinal Chemistry: A View from the Novartis Institute for BioMedical Research in Basel, Switzerland. Chimia., 75 (12). pp. 1091-1095. ISSN 0009-4293

Auld, Douglas, Jenkins, Jeremy and Concannon, John (2021) Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38. Developmental cell. ISSN 1878-1551

Axelsson, Erik, Ljungvall, I, Bhoumik, Priyasma, Conn, LB, Muren, E, Ohlsson, A, Ohlsen, LH, Engdahl, K, Hagman, R, Hanson, J, Kryvokhyzha, D, Pettersson, M, Grenet, Olivier, Moggs, Jonathan, Del Rio Espinola, Alberto, Epe, C, Taillon, B, Tawari, N, Mane, S, Hawkins, T, Hedhammar, A, Gruet, P, Haggstrom, J and Lindblah-Toh, Kerstin (2021) The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels. PLoS genetics, 17 (9). e1009726. ISSN 1553-7404

Axford, Jake, Briner, Karin, Cheung, Atwood, Dales, Natalie, Hurley, Timothy, Jain, Monish, Sung, Moo, Manchester, John, Hamann, Lawrence, Chin, Donovan, Shin, Youngah and Sivasankaran, Rajeev (2021) Use of Intramolecular 1,5-sulfur-oxygen and 1,5-sulfur-halogen interactions in the design of N-methyl-5-aryl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 splicing modulators. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Babu, Charles, Phulera, Swastik, Hao, Qin, Wall, Daniel, Nettleton, David, Pathak, Tejas and Siuti, Piro (2021) Biosynthetic production and evaluation of knotted peptide topology and characteristics. ACS Omega, 6 (44). pp. 29555-29566. ISSN 2470-13432470-1343

Baczyk, Paulina, Wyss, Brigitte, Widmer, Jasmin, Hartmann, Steffen, Wassmann, Paul, Lobo, Susana, Jesus, Lídia , Gomes, Joana and Batista, Ana (2021) Stability liabilities of biotherapeutic proteins: early assessment as mitigation strategy. Journal of pharmaceutical and biomedical analysis, 192. pp. 1-15. ISSN 1873-264X; 0731-7085

Barabas, Amanda J, Soini, Helena A, Novotny, Milos V, Williams, David R, Desmond, Jacob A, Lucas, Jeffrey R, Erasmus, Marisa A, Cheng, Heng-Wei and Gaskill, Brianna N (2021) Compounds from plantar foot sweat, nesting material, and urine show strain patterns associated with agonistic and affiliative behaviors in group housed male mice, Mus musculus. PloS one, 16 (5). e0251416. ISSN 1932-6203

Barabas, Amanda J., Dijak, Stephanie R., Yatcilla, Jane F., Walker, Danielle N. and Gaskill, Brianna N. (2021) Modulating captive mammalian social behavior: a scoping review on olfactory treatments. Applied Animal Behaviour Science, 244. p. 105489. ISSN 01681591

Baran, Szczepan, Lim, Maria A., Do, Johnny P., Stolyar, Polina, Rabe, Mark D., Schaevitz, Laura R. and Cadena, Samuel (2021) Digital biomarkers enable automated, longitudinal monitoring in a mouse model of aging. The journals of gerontology. Series A, Biological sciences and medical sciences. ISSN 1758535X

Bartels, Christian and Dumortier, Thomas (2021) Inverse probability of censoring weighting for visual predictive checks of time-to-event models with time-varying covariates. Pharmaceutical Statistics. ISSN 1539-16041539-1612

Bartels, Christian, Jain, Monish, Yu, Jing, Tillmann, Hanns-Christian and Vaidya, Soniya (2021) Population Pharmacokinetic Analysis of Indacaterol/Glycopyrronium/Mometasone Furoate After Administration of Combination Therapies Using the Breezhaler® Device in Patients with Asthma. European Journal of Drug Metabolism and Pharmacokinetics, 46 (4). pp. 487-504. ISSN 21070180

Barth, Melanie, Bacioglu, Mehtap, Tanriöver, Gaye, Schwarz, Niklas, Novotny, Renata, Brandes, Janine, Welzer, Marc, Mazzitelli, Sonia, Häsler, Lisa, Schweighauser, Manuel, Kronenberg-Versteeg, Deborah, Fog, Karina, Ambjørn, Malene, Bousset, Luc, Melki, Ronald, Shimshek, Derya, Koch, Henner and Jucker, Mathias (2021) Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures. Molecular Neurodegeneration, 16 (1). ISSN 17501326

Bashkar, Varun, Desogus, Jessica, Graff-Meyer, Alexandra, Schenk, Andreas, Cavadini, Simone and Chao, Jeffrey A (2021) Dynamic association of human Ebp1 with the ribosome. RNA (New York, N.Y.), 27 (4). pp. 411-419. ISSN 1469-9001

Bastien, Julie, Menon, Sue, Messa, Mirko and Nyfeler, Beat (2021) Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders. Molecular aspects of medicine, 82. p. 101018. ISSN 1872-9452

Bauer, Daniel, Buckley , Lorrene A. , Delafoy , Laure, Ellinger-Ziegelbauer , Heidrun, Fellows , Mick D. , Gerets , Helga H. J., Howe , Jonathan, Kaijser , Gerry , Nicolette , John, Pettersen , Betty A. and Schimpf , Brian (2021) A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10. Regulatory toxicology and pharmacology : RTP, 125. p. 105017. ISSN 1096-0295

Bauer, Sebastian, Demetri, George, Jeay, Sebastien, Dummer, Reinhard , Guerreiro, Nelson, Tan, Daniel, Jullion, Astrid, Meille, Christophe, Ferretti, Stephane Raymond, Van Bree, Laurence, Halilovic, Ensar, Hourcade-Potelleret, Florence, Fabre, Claire, Wuerthner, Jens and Cassier, Philippe A. (2021) First-in-Human, Phase I Dose-Escalation Study of CGM097, a HDM2 Inhibitor in Adult Patients With p53 Wild-type Advanced Solid Malignancies. British journal of cancer : BJC, 125. pp. 687-698. ISSN 1532-1827

Bednarczyk, Dallas (2021) Passive influx and ion trapping are more relevant to the cellular accumulation of highly permeable low molecular weight acidic drugs than is Organic Anion Transporter 2 (OAT2). Drug metabolism and disposition: the biological fate of chemicals. ISSN 1521009X

Begum, Alaybeyoglu, Ho Wa, Cheng, Kshama, Doshi, Vishruti, Makani and Stein, Andrew (2021) Estimating drug potency in the competitive target mediated drug disposition (TMDD) system when the endogenous ligand is included. Journal of Pharmacokinetics and Pharmacodynamics, 48 (4). pp. 447-464. ISSN 15738744

Belcher, Bridget, Ward, Carl and Nomura, Daniel (2021) Ligandability of E3 Ligases for Targeted Protein Degradation Applications. Biochemistry. ISSN 1520-4995

Bellot, Muriel, Luetjens, C Marc, Bagger, Morten, Horvath, Courtney, Sutter, Esther, DeLise, Anthony, Brees, Dominique, Carballido, Jose, Pingili, Ratnakar, Ramanathan, Krishnan, Kieseier, Bernd and Hellwig, Kerstin (2021) Effect of ofatumumab on pregnancy, parturition, and lactation in cynomolgus monkeys. Reproductive toxicology (Elmsford, N.Y.), 108. pp. 28-34. ISSN 1873-1708

Bieberich, Andrew, Rajwa, Bartek, Irvine, Allison, Fatig, Raymond, Fekete, Alexander, Jin, Hong, Kutlina, Elena and Urban, Laszlo (2021) Acute Cell Stress Screen with Supervised Machine Learning in Association with in vitro Pharmacological Profiling Predicts Cytotoxicity of Excipients. Journal of Pharmacological and Toxicological Methods, e-pub. pp. 1-15.

Biering, Scott B., Van Dis, Erik, Yamashiro, Livia H., Nguyenla, Xammy , Wehri, Eddie, Dugast-Darzacq, Claire , Graham, Thomas G.W., Stroumza, Julian , Golovkine, Guillaume , Roberts, Allison W., Fines, Daniel M. , Fox, Douglas M., Ward, Carl, Spradlin, Jessica, Dovala, Dustin, Schaletzky, Julia and Stanley, Sarah A. (2021) Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2. ACS infectious diseases. ISSN 23738227

Bigaud, Marc, Rudolph, Bettina, Briard, Emmanuelle, Beerli, Christian, Hofmann, Andreas, Hermes, Erwin, Muellershausen, Florian, Schubart Wellensiek, Anna and Gardin, Anne (2021) Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights. Multiple sclerosis journal - experimental, translational and clinical, 7 (4). p. 20552173211049168. ISSN 2055-2173

Bill, Anke, Espinola, Sheryll, Guthy, Daniel Alexander, Lu, Min, Marelli, Anthony, Mendiola, Angelica, Miraglia, Loren, Taylor, Brandon, Haling, Jake, Vargas, Leonardo, Orth, Anthony, King, Frederick and Lanter, Mylene (2021) EndoBind - Real-time detection of endogenous protein-protein interactions. Nature communications Biology.

Bleu, Melusine, Grass, Verena, Mermet-Meillon, Fanny Anne-Marie, Barys, Louise, Holzer, Laura, Marques Lopes, Rui, Barbosa, Ines, Delmas, Cecile, Hinniger, Alexandra, Chau, Suzanne, Kaufmann, Markus, Haenni, Simon, Berneiser, Karolin Fiona, Wahle, Maria, Moravec, Ivana, Vissieres, Alexandra, Poetsch, Tania, Ahrne, Erik, Carte, Nathalie, Voshol, Johannes, Fischer, Matteo, Stachyra, Therese-Marie, Freuler, Felix, Gutmann, Sascha, Fernandez, Cesar, Naumann, Ulrike, Roma, Guglielmo, Schuebeler, Dirk, Nieto-Oberhuber, Cristina, Cobos-Correa, Amanda, Ferretti, Stephane Raymond and Galli, Giorgio (2021) PAX8 and MECOM are interaction partners driving Ovarian Carcinogenesis. Nature communications, 12. p. 2442. ISSN 2041-1723

Bluemel, Oliver, Friess, Wolfgang, Bechtold-Peters, Karoline, Hoelzl, Georg, Hauptmann, Astrid and Buecheler, Jakob (2021) Scaling Down Large-Scale Thawing of Monoclonal Antibody Solutions: 3D Temperature Profiles, Changes in Concentration, and Density Gradients. Pharmaceutical research, 38 (11). pp. 1977-1989. ISSN 1573-904X

Bolje, Aljoša (2021) Project report (for Faculty of Pharmacy): Structural characterization of proteins in solid pharmaceutical forms. Project report published on the Faculty of Pharmacy's web page.

Booler, Helen, Lejeune, Typhaine, Sorden, Steve, Schafer, Kenneth, Short, Brian, Farman, Cindy, Ramos, Margaret, Bennett, Bindu, Krishna, Yekkala, Atzpodien, Elke-Astrid, Turner, Oliver, Brassard, Jaqueline, Gruebbel, Margarita and Foley, George (2021) Scientific and Regulatory Policy Committee Points to Consider*: Fixation, Trimming and Sectioning of Non-Rodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies. Toxicologic pathology. ISSN 1533-1601; 0192-6233

Boyle, Molly, Bennet, Bindu, Houle, Christopher D., Sura, Radhakrishna, Colman, Karyn, Romeike, Annette, Frisk, Anna-Lena, Garcia, Begonya and Elmore, Susan A. (2021) Publication Categories in Toxicologic Pathology. Toxicologic Pathology. ISSN 15331601

Brase, Jan Christoph, Robert, Walter, Savchenko, Alexander, Gusenleitner, Daniel, Garrett, James, Schimming, Tobias , Varaljai, Renata, Castelletti, Deborah, Kim, Ju, Dakappagari, Naveen, Schultz Gonzaga, Kenneth, Robert, Caroline, Long, Georgina V, Nathan, Paul, Ribas, Antoni, Flaherty, Keith, Karaszewska, Boguslawa, Schachter, Jacob, Sucker, Antje, Schmid, Kurt W, Zimmer, Lisa, Livingstone, Elisabeth, Tan, Sartika, Schadendorf, Dirk and Roesch, Alexander (2021) Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib. Clinical cancer research : an official journal of the American Association for Cancer Research. ISSN 15573265

Briggs, Katahrine, Camara, Tima, Diaz, Carlos, Drew, Phil, Drewe, Will, Kors, Jan, van Mulligen, Erik, Pognan, Francois, Quintana, Jordi Ramon, Sarntivijai, Sirarat and Steger-Hartmann, Thomas (2021) Guidelines for FAIR sharing of preclinical safety and off-target pharmacology data. ALTEX, 38 (2). pp. 187-197. ISSN 1868596X

Brightling, Christopher E, Kulkarni, Swarupa, Lambrecht, Bart, Sandham, David, Weiss, Markus and Altman, Pablo (2021) The pharmacology of the prostaglandin D2 receptor 2 (DP2) receptor antagonist, fevipiprant. Pulmonary Pharmacology and Therapeutics, 68. p. 102030. ISSN 15229629

Brogdon, Jennifer, Pruteanu-Malinici, Iulian, Melenhorst, J. Joseph, June, Carl H., Fraietta, Joseph A., Young, Regina M., Levine, Bruce L. and Lacey, Simon F. (2021) Decade-long Remissions of Leukemia Sustained by the Persistence of Activated CD4 CAR T Cells. Science translational medicine.

Buechel, David, Sugiyama, Nami, Rubinstein, Natalia, Saxena, Meera, Kalathur, Ravi K R, Lüönd, Fabiana, Vafaizadeh, Vida, Valenta, Tomas, Hausmann, George, Cantù, Claudio, Basler, Konrad and Christofori, Gerhard (2021) Parsing β-catenin's cell adhesion and Wnt signaling functions in malignant mammary tumor progression. Proceedings of the National Academy of Sciences of the United States of America, 118 (34). ISSN 1091-6490

Campbell, John M. , Foti, Chris, Wang, Chloe, Adams, Neal, Allain, Leonardo R., Araujo, Gabriela, Azevedo, Renan , Ribeiro Franca, Juçara , Hicks, Simon R. , Hostyn, Steven , Jansen, Patrick J. , Kotoni, Dorina, Kuemmell, Andreas, Marden, Stacey , Rullo, Gregory, Santos, Ana Cláudia O. , Sluggett, Gregory W., Zelesky, Todd and Baertschi, Steven W. (2021) Assessing the Relevance of Solution Phase Stress Testing of Solid Dosage Form Drug Products: A Cross-Industry Benchmarking Study. Journal of Pharmaceutical Sciences. ISSN 15206017

Canham, Steve, Jenkins, Jeremy, Forrester, William, Hild, Marc, Ambrose, Jessi, Sigoillot, Frederic, Gleim, Scott, Cobos-Correa, Amanda, Wang, Ying, Eggimann, Fabian, Moore, Charles, Mapa, Felipa, Burks, Heather, Roma, Guglielmo, Krastel, Philipp, Tallarico, John, Nomura, Daniel, Fisher, David, Zhang, Lydia, Cho, Hyelim, Shen, Qiong, Okumura, Mikiko, Kawakami, Akinori, Miller, Howard, Dix, Ina and Ross, Nathan (2021) CYP27A1 dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism. Cell chemical biology. ISSN 24519456

Carballido, Jose and Spits, Hergen (2021) Legends of allergy and immunology: Jan E. de Vries. Allergy. ISSN 13989995

Carbonneau, Seth, Sharma, Sujata, Peng, Liaomin, Rajan, Vaisakh, Hainzl, Dominik, Henault, Martin, Yang, Chian, Hale, Jacob, Shulok, Janine, Tallarico, John, Porter, Jeffrey, Brogdon, Jennifer, Dranoff, Glenn, Bradner, Jay, Hild, Marc and Guimaraes, Carla (2021) An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity. Cell Chemical Biology. ISSN 24519448

Carstensen, Saskia, Gress, Christina, Erpenbeck, Veit, Kazani, Shamsah, Hohlfeld, Jens, Sandham, David and Mueller, Meike (2021) Prostaglandin D2 metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP2 receptor. Respiratory research, 22 (1). p. 262. ISSN 1465-993X

Cassaro, A, Grillo, G, Esposito, I, Reda, G, Cairoli, R, Beghini, A, Notaro, M, Gliozzo, J, Trojani, A, Valentini, G and Di Camillo, B (2021) FZD6 triggers Wnt–signalling driven by WNT10BIVS1 expression and highlights new targets in T cell acute lymphoblastic leukemia. Hematological oncology. ISSN 1099-1069

Chen, Heller, Cui, Xiaoming, Pognan, Nathalie, Quinlan, Michelle, Kapoor, Shruti, Rahmanzadeh, Gholamreza, Giovannini, Monica and Marbury, Thomas (2021) Pharmacokinetics of capmatinib in participants with hepatic impairment: A phase 1, open-label, single-dose, parallel-group study. British Journal of Clinical Pharmacology. ISSN 13652125

Chen, Wentao, Luo, Jian, Ye , Yuan, Hoyle, Ryan, Liu, Wei, Borst, Rowie, Kazani, Shamsah, Shikatani, Eric, Erpenbeck, Veit, Pavord, Ian, Klenerman, Paul, Sandham, David and xue, luzheng (2021) Prostaglandin D2 drives tissue remodelling functions and prostaglandin D2 autocrine production in type 2 cytotoxic T cells. The journal of immunology, 206. pp. 2714-2724. ISSN 1550-6606

Chen, Xinhui, Cui, Xiaoming, Pognan, Nathalie, Quinlan, Michelle, Kapoor, Shruti, Rahmanzadeh, Gholamreza, Giovannini, Monica and Marbury, Thomas C (2021) Pharmacokinetics of capmatinib in participants with hepatic impairment: A phase 1, open-label, single-dose, parallel-group study. British journal of clinical pharmacology. ISSN 1365-2125

Chiang, Chih-Yuan, Zhong, Yang, Ward, Michael M, Lane, Douglas J, Kenny, Tara, Rosario-Acevedo, Raysa, Eaton, Brett P, Trevino, Sylvia R, Chance, Taylor B, Worsham, Patricia L, Waag, David M, Moore, Richard T, Cazares, Lisa H, Cote , Christopher K, Zhou, Yingyao and Panchal, Rekha G (2021) Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis. Frontiers in Microbiology, 12. ISSN 1664302X

Christian, Lohasz, Loretan, Jacqueline, Goerlach, Ekkehard, Sterker, Dario, Kasper, Renggli, Paul, Argast, Olivier, Frey, Wiesmann, Marion, Wartmann, Markus, Rausch, Martin and Andreas, Hierlemann (2021) A Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues. Frontiers in pharmacology, 12. p. 785851. ISSN 1663-9812

Christler, Anna, Scharl, Theresa, Sauer, Dominik Georg, Koeppl, Johannes, Tscheließnig, Anne, Toy, Cabir, Melcher, Michael, Jungbauer, Alois and Dürauer, Astrid (2021) Technology transfer of a monitoring system to predict product concentration and purity of biopharmaceuticals in real‐time during chromatographic separation. Biotechnology and Bioengineering. pp. 1-12. ISSN 0006-3592

Christophe, Pellefigues, Karmella, Naidoo, Palak, Mehta, Alfonso , Schmidt, Ferdinand, Jagot, Roussel, Elsa, Cait, Alissa, Bibek, Yumnam, Sally, Chappell, Meijlink, Kimberly, Mali, Chamberis, Jean, Jiang, Gavin, Painter, Filbey, Kara, Uluckan, Ozge, Olivier, Gasser and Graham, LeGros (2021) Basophils promote barrier dysfunction and resolution in the atopic skin. Journal of Allergy and Clinical Immunology. ISSN 10976825

Colman, Karyn, Andrews, Rachel A, Atkins, Hannah, Boulineau, Theresa, Bradley, Alys, Braendli-Baiocco, Annamaria, Capobianco, Raffaella, Caudell, David, Cline, Mark, Doi, Takuya, Ernst, Rainer, Everitt, Jeffrey, Fant, Pierluigi, Gruebbel, Margarita, Mecklenberg, Lars, Miller, Andrew D, Nikula, Kristin, Satake, Shigeru, Schwartz, Julie, Shimoi, Akihito, Sobry, Cecile, Taylor, Ian, Van Esch, Eric, Vemireddi, Vimala, Vidal, Justin, Wood, Charles and Vahle, John (2021) International harmonization of nomenclature and diagnostic criteria (INHAND): Non-proliferative and proliferative lesions of the non-human primate (M. fascicularis). Journal of Toxicologic Pathology, 34. pp. 1-182. ISSN 09149198

Conlon, Kevin, Watson, Dionysios C, Waldmann, Thomas A, Valentin, Antonio, Bergamaschi, Cristina, Felber, Barbara K, Peer, Cody J, Figg, William D, Potter, E. Lake, Roederer, Mario, McNeel, Douglas G, Thompson, John A , Gupta, Sumati, Leidner, Rom, Wang-Gillam, Andrea, Parikh, Nehal, Long, Debby, Kurtulus-Aksoylar, Sema, Lee, Lang Ho, Roy Chowdhury, Niladri, Bender, Florent and Pavlakis, George N (2021) Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors. Journal for immunotherapy of cancer, 9 (11). ISSN 2051-1426

Corey, Kathleen E, Pitts, Rebecca, Lai, Michelle, Loureiro, Joe, Masia, Ricard, Osganian, Stephanie A, Gustafson, Jenna L, Hutter, Matthew M, Gee, Denise W, Meireles, Ozanan R, Witkowski, Elan R, Richards, Shola, Jacob, Jaison, Finkel, Nancy, Ngo, Debby, Wang, Thomas J, Gerszten, Robert E, Ukomadu, Chinweike and Jennings, Lori (2021) ADAMTSL2 protein and a soluble biomarker signature identify significant and advanced fibrosis in adults with NAFLD. Journal of hepatology. ISSN 1600-0641

Cremer, Malika, Rooks, Daniel, Fretault, Nathalie, Schubert-Tennigkeit, Agnes Annette and Papanicolaou, Dimitris (2021) Bimagrumab to Improve Recovery after Hip Fracture in the Elderly: A Randomised, Double-Blind, Placebo-Controlled Phase 2a/b Study. The Lancet Healthy Longevity, 2 (5). E263-E274.

Dawson King, Janet and Vogelsanger, Melanie (2021) Cantharidin-induced skin blister as an in vivo model of inflammation. Current Protocols in Pharmacology , 1 (e49). pp. 1-14.

De Maria, D, Fahrni, S, Ramrath, D, Lozac'H, Frederic, Marvalin, Cyrille and Synal, HA (2021) GAS MEASUREMENTS AT LEA Performance and analysis of labelled biomedical compounds. Annual report of ETH Zurich university.

Delgado, Pete, Glass, Raoul Julian, Geraci, Gina, Duvadie, Rohit, Majumdar, Dyuti, Robinson, Richard, Elmaarouf, Imran, Mikus, Malte and Tan, Kian (2021) Use of Green Solvents in Metallaphotoredox Cross-Electrophile Coupling Reactions Utilizing a Lipophilic Modified Dual Ir/Ni Catalyst System. Journal of Organic Chemistry, 86 (23). 17428-17436. ISSN 1520-6904

Di Marco, Fiammetta, Berger, Thomas, Esser-Skala, Wolfgang, Rapp, Erdmann, Regl, Christof and Huber, Christian (2021) Simultaneous Monitoring of Monoclonal Antibody Variants by Strong Cation-Exchange Chromatography Hyphenated to Mass Spectrometry to Assess Quality Attributes of Rituximab-Based Biotherapeutics. International journal of molecular sciences, 22 (16). ISSN 1422-0067

Di Nanni, Noemi, Reyes Quiroz, Alejandro, Ho, Daniel, Durand, Eric, de Weck, Antoine, Ihry, Robert and Kauffmann, Audrey (2021) TRAWLING: a Transcriptome Reference Aware of spLIciNG events. biorxiv.

Dickson, Callum, Hornak, Viktor and Duca, Jose (2021) Relative Binding Free-Energy Calculations at Lipid-Exposed Sites: Deciphering Hot Spots. Journal of chemical information and modeling. ISSN 1549-960X

Diener, John, Mowbray, Sarah, Huang, WaanJeng, Yowe, David, Xu, Jian, Caplan, Shari, Misra, Abhay, Kapur, Ankur, Shapiro, Jeffrey, Ke, Xiaoling, Wu, Xiaoping, Bose, Avirup, Panza, Darrell, Chen, Min, Beaulieu, Valerie and Gao, Jiaping (2021) FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction. bioRxiv. pp. 1-19. ISSN https://doi.org/10.1101/2021.01.04.425295

Dispas, Amandine, Guillarme, Davy, Hubert, Philippe, Clarke, Adrian and Grand-Guillaume-Perrenoud, Alexandre (2021) Interlaboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities: evaluation of multi-systems reproducibility. Journal of pharmaceutical and biomedical analysis, 203 (Articl). ISSN 07317085

Dittrich, Birger (2021) On modelling disordered crystal structures through restraints from molecule-in-cluster computations,and distinguishing static and dynamic disorder. IUCrJ, International Union of Crystallography Journal , 8. pp. 305-318. ISSN 2052-2525

Dodd, Stephanie (2021) Use of PBPK Modeling for Predicting Drug-Food Interactions: Successful prediction using a middle-out approach. AAPS PharmSci, 23 (12). ISSN 1550-7416/21/0000-0001/0

Dorgau, Birthe, Georgiou, Maria, Chaudhary, Alexander, Moya-Molina, Marina, Collin, Joseph, Queen , Rachel, Hilgen, Gerrit, Davies, Tracey, Hewitt, Philip, Schmitt, Michael, Kusterman, Stefan, Pognan, Francois, Steel, David, Sernagor, Evelyne, Armstrong, Lyle and Lako, Majlinda (2021) Human iPSC-derived retinal organoid model for in vitro toxicity screening. Toxicology letters, 350. ISSN 1879-3169; 0378-4274

Dovala, Dustin, Fischer, Christian and Trauner, Dirk (2021) De novo Design of SARS-CoV-2 Main Protease Inhibitors. De novo Design of SARS-CoV-2 Main Protease Inhibitors.

Duca, Maria, Gillingham, Dennis, Olsen, Christian Adam, Sbardella, Gianluca, Skaanderup, Philip, van der Stelt, Mario, Vauzeilles, Boris, Vazquez, Ollala and Auberson, Yves (2021) The Chemical Biology-Medicinal Chemistry continuum: EFMC's vision. ChemBioChem, 22.

Elo, Petri, Li, Xiang-Guo, Liljenbäck, Heidi, Gardberg, Maria, Moisio, Olli, Miner, Maxwell, Virta, Jenni, Saraste, Antti, Srinivasarao, Madduri, Pugh, Michael, Low, Philip, Knuuti, Juhani, Jalkanen, Sirpa, Airas, Laura, Lu, June and Roivainen, Anne (2021) Efficacy and tolerability of a folic acid derivative of aminopterin in a rat focal model of multiple sclerosis. J Neuroinflammation, 18 (30).

Emmenegger, M, De Cecco, E, Hruska-Plochan, M, Eininger, T, Schneider, MM, Barth, M, Tantardini, E, de Rossi, P, Langston, RG, Kaga-novich, A, Gonzalez-Guerra, A, Avar, M, Heinzer, D, Reimann, R, Häsler, LM, Herling, TW, Matharu, NS, Landeck, N, Luk, K, Melki, R, Kahle, PJ, Hornemann, S, Knowles, TP, Cookson, MR, Polymenidou, M, Jucker, M and Aguzzi, A (2021) LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. EMBO Molecular Medicine. ISSN 17574684

Emperador-Melero, Javier, Wong, Man Yan, Wang, Shan Shan H, de Nola, Giovanni, Nyitrai, Hajnalka, Kirchhausen, Tom and Kaeser, Pascal S (2021) PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure. Nature communications, 12 (1). p. 3057. ISSN 2041-1723

Ertl, Peter (2021) NP Navigator: A New Look at the Natural Product Chemical Space. Molecular informatics, 40 (9). e2100068. ISSN 1868-1751

Ertl, Peter, Lewis, Richard, Sirockin, Finton, Stiefl, Nikolaus, Tosco, Paolo, Muenkler, Hagen, Gerebtzoff, Gregori and Schneider, Nadine (2021) Chemical Reactivity Prediction: Current Methods and Different Application Areas. Molecular informatics, 41. e2100277. ISSN 1868-1751

Estoppey, David, Schutzius, Gabi, Kolter, Christian, Salathe, Adrian, Wunderlin, Tiffany, Meyer, Amandine, Hoepfner, Dominic and Bouwmeester, Antonius (2021) CRISPR-Cas9 screen identifies mechanisms of BET bromodomain inhibitor sensitivity including manganese. iScience, 24 (11). p. 103323.

Evans, Tiffany R, Giridharan, Thejaswini, Singel, Kelly L, Khan, ANM Nazmul , Ricciuti, Jason, Howard, Kaitlyn, Silva-Del Toro, Stephanie L, Debreceni, Ivy L, Aarts, Cathelijn E. M. , Suzuki, Sora, Kuijpers, Taco W, Brouwer, Mieke C, Lee-Ann H, Allen, Viviana P, Ferreira, Schubart Wellensiek, Anna, Eder, Joerg, Holland, Steven M, Ram, Sanjay, Lederer, James A, Eng, Kevin H, Moysich, Kirsten B, Odunsi, Kunle, Yaffe, Michael B, Zsiros, Emese and Segal, Brahm H (2021) Mechanisms driving neutrophil-induced t-cell immunoparalysis in ovarian cancer. Cancer Immunology Research, 9 (7). pp. 790-810. ISSN 23266074

Even, Caroline , Li, Hung-Ming , Ngan, Roger , Dechaphunkul, Arunee , Zhang, Li , Jui Yen, Chia , Chan, Po Chung , Chakrabandhu, Somvilai , Ma, Brigette , Tanasanvimon, Suebpong , Lee, Victor , Lou, Pei-Jen , Li, Zujun , Spira, Alexander , Ammar , Sukari, Guigay, Joël , McCune, Steven , Lim, Darren Wan-Teck, Szpakowski, Sebastian, Yao, Yao, Liang, Coco, Mataraza, Jennifer, Sechaud, Romain and Manenti , Luigi (2021) Phase II, randomized study of spartalizumab (PDR001), an anti-PD-1 antibody, vs chemotherapy in patients with recurrent/metastatic nasopharyngeal cancer. Clinical cancer research. ISSN 1557-3265; 1078-0432

Evers, Felix, Cabrera-Orefice, Alfredo, Elurbe, Dei M, Kea-Te Lindert, Mariska, Niederwieser, Sylwia, Voss, Till S, Huynen, Martijn A, Brandt, Ulrich and Kooij, Taco W A (2021) Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum. Nature communications, 12 (1). p. 3820. ISSN 2041-1723

Fanale, Salvatore, Emmons, Kayla and Gunderson, Andrew (2021) WDII Unpacking and Startup Video. N/A, n/a (n/a). n/a-n/a. ISSN n/a

Fang, Li Tai, Zhu, Bin, Zhao, Yongmei, Chen, Wanqiu, Yang, Zhaowei, Kerrigan, Liz, Langenbach, Kurt, de Mars, Maryellen, Lu, Charles, Idler, Kenneth, Jacob, Howard, Yu, Ying, Ren, Luyao, Zheng, Yuanting, Jaeger, Erich, Schroth, Gary, Abaan, Ogan, Lack, Justin, Shen, Tsai-Wei, Talsania, Keyur, Chen, Zhong, Stanbouly, Seta, Shetty, Jyoti, Kumar, Primal, Bettridge, John, Tran, Bao, Meerzaman, Daoud, Nguyen, Cu, Petitjean, Virginie, Sultan, Marc, Cam, Margaret, Hung, Tiffany, Peters, Eric, Kalamegham, Rasika, Sahraeian, Sayed Mohammad Ebrahim , Mohiyuddin, Marghoob, Yunfei, Guo, Yao, Liking, Song, Lei, Lam, Hugo YK, Drabek, Jiri, Maestro, Roberta, Polano, Maurizio , Kõks, Sulev , Reimann, Ene, Scherer, Andreas, Nordlund, Jessica, Liljedahl, Ulrika, Jensen, Roderick V, Pirooznia, Mehdi, Li, Zhipan, Xiao, Chunlin, Sherry, Steve , Kusko, Rebecca, Moos, Malcolm, Wang, Jing , Donaldson, Eric, Tezak, Zivana, Ning, Baitang, Tong, Weida, Li, Jing, Duerken-Hughes, Penelope, Hong, Huixiao, Shi, Leming, Wang, Charles and Xiao, Wenming (2021) Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing. Nature biotechnology, 39 (9). pp. 1151-1160. ISSN 1546-1696

Fanous, Marina, Bitar, Malak, Gold, Sarah, Sobczuk, Adam, Hirsch, Stefan, Ogorka, Joerg and Imanidis, Georgios (2021) Immediate Release 3D-Printed Dosage Forms for Poorly Soluble Drugs: Development and Exploration of Morphology-Dissolution Relationship. International journal of pharmaceutics, 26. p. 120417. ISSN DOI: 10.1016/j.ijpharm.2021.120417

Faris, Jason, Bialucha, Carl, Ruan, Shiling, Zhu, Xu, DiDominick, Sarah, Wagner, Joel, Mansfield, Keith, Origuchi, Shizuka, Tran, Ben, Schoffski, Patrick, Concin, Nicole, Suarez, Cristina, Subbiah, Vivek and Ando, Yuichi (2021) A phase 1 study of a CDH6-Targeting antibody-drug conjugate in patients with advanced solid tumors with evaluation of inflammatory and neurological adverse events. Oncology Research and Treatment, 44 (10). pp. 547-556. ISSN 22965262

Filipponi, Paolo, Martin, Benjamin, Knochel, Paul, Heinz, Benjamin and Djukanovic, Dimitrije (2021) Regioselective Difunctionalization of Pyridines via 3,4-Pyridynes. Chemical Science, 12. pp. 6143-6147. ISSN https://doi.org/10.1039/D1SC01208H

Forenzo, Patrick and Quinlan, Michelle (2021) A Practical Discussion on Estimating Shelf Life Through Tolerance Intervals. AAPS PharmSciTech, 22 (8). p. 273. ISSN 1530-9932

Frederiksen, Mathias (2021) The kinase chemogenomic set (KCGS): An open science resource for kinase vulnerability identification. International Journal of Molecular Sciences, 22 (2). pp. 1-18. ISSN 14220067

Freund, Ernst, Meyer, Daniel, Schneider, Nadine, Lozac'h, Marie-Anne, Schroeder, Harald, Cynar, Cagatay, Schlotterbeck, Goetz and Wagner, Beatrix (2021) Automated chiral method screening – Evaluation of generated chromatographic data sets to further optimize screening efficiency. Journal of Chromatography A, 1644. ISSN 0021-9673

Gallou, Fabrice (2021) α-Arylation of (Hetero)aryl Ketones in Aqueous Surfactant Media. Green chemistry, 23. pp. 4858-4865.

Gallou, Fabrice (2021) Chemistry in bulk water. Challenges and opportunities ahead of us. Current opinion in colloid & interface science. ISSN 1879-0399; 1359-0294

Gallou, Fabrice (2021) Greening up nitro group reductions. 1-Pot sequences and applications to syntheses of pharmaceutical intermediates. Organic letters, 23 (20). pp. 8114-8118. ISSN 1523-7052; 1523-7060

Gallou, Fabrice (2021) Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to U.N. Sustainable Development Goal 12. ACS Sustainable Chem. Eng.

Gallou, Fabrice (2021) La chimie verte comme catalyseur de l'innovation ! l'actualite chimique, 463. pp. 17-21.

Gallou, Fabrice (2021) Late-stage cyanation of aryl/heteroaryl halides using ppm levels of a bidentate phosphine-derived palladacycle in water. ChemCatChem., 13 (1). pp. 212-216. ISSN 1867-3899; 1867-3880

Gallou, Fabrice (2021) Mild and robust Stille reactions in water using ppm levels of a new triphenylphosphine-based palladacycle. Angewandte Chemie. International edition, 60 (9). pp. 4158-4163.

Gallou, Fabrice (2021) Nanochannels in Photoactive Cu(I) Polymer for Selective Oxidations in Aqueous Micelles. ACS Sustainable Chem. Eng, 9 (7). pp. 2854-2860.

Gallou, Fabrice (2021) Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water. Chem Comm, 57. pp. 11847-11850.

Gallou, Fabrice (2021) Photoassisted Decomposition of DMF for Facile and Selective N,NDimethylamination of Arenes. ChemSusChem, 14. p. 2704.

Gallou, Fabrice (2021) Safe, Scalable, Inexpensive, and Mild Nickel-Catalyzed Migita-like C–S Cross-Couplings in Recyclable Water. Angewandte Chemie. International edition, 60 (7). pp. 3708-3713.

Gallou, Fabrice (2021) “TPG-lite”: A new, simplified “designer” surfactant for general use in synthesis under micellar catalysis conditions in recyclable water. Tetrahedron.

Gallou, Fabrice (2021) Visible Light mediated micellar one-pot Triazole formation. ChemSusChem, 14. pp. 2704-2710. ISSN 1864-564X; 1864-5631

Gallou, Fabrice (2021) Water in organic chemistry:from our worst enemy to our best friend. Chemical science, 12. pp. 4237-4266.

Gallou, Fabrice (2021) Water-Sculpting of a Heterogeneous Nanoparticle Pre-catalyst for Mizoroki-Heck Couplings Under Micellar Catalysis Conditions. Journal of the American Chemical Society JACS., 143 (9). pp. 3373-3382.

Gallou, Fabrice (2021) A roadmap towards sustainable chemical products and processes for Switzerland. Chimia, 75 (7/8). pp. 697-699.

Gallou, Fabrice and Plummer, Scott (2021) Nanochannels in Photoactive Polymeric Cu(I) Compatible for Efficient Micellar Catalysis: Sustainable Aerobic Oxidations of Alcohols in Water. ACS Sustainable Chem. Eng., 9 (7). pp. 2854-2860.

Glowienke, Susanne (2021) Use of less-than-lifetime (LTL) durational limits for nitrosamines: Case study of N-Nitrosodiethylamine (NDEA). Regulatory Toxicology and Pharmacology, 123. ISSN 10960295

Glowienke, Susanne and Udovic, Erika (2021) Calculating qualified non-mutagenic impurity levels: Harmonization of approaches. Regulatory Toxicology and Pharmacology, 126. ISSN 10960295

Goebel, Mathias, Dos Reis Rodrigues, Rui Claudio, Pampel, Lars, Rapp, Johanna, Shultz, Joseph and Cui, Huanchun (2021) Flow management strategies for a connected purification process. Biotechnology and bioengineering. ISSN 10970290

Goldfine, Allison (2021) INNODIA Four Trial Comparison. https://www.innodia.eu/.

Golosov, Andrei, Flyer, Alec, Amin, Jakal, Babu, Charles, Gampe, Christian, Li, Jingzhou, Liu, Eugene, Nakajima, Katsumasa, Nettleton, David, Patel, Tej, Reid, Patrick, Yang, Lihua and Monovich, Lauren (2021) Design of thioether cyclic peptide scaffolds with passive permeability and oral exposure. Journal of medicinal chemistry, 64 (5). pp. 2622-2633.

Grass, Verena, Begue, Damien, Cordo, Valentina, Holzer, Laura, Martinuzzi-Duboc, Laetitia, Buhles, Alexandra, Kerr, Grainne, Barbosa, Ines, Naumann, Ulrike, Piquet, Michelle, Ruddy, David, Tordella, Luca, Weiss, Andreas, Ferretti, Stephane Raymond, Almeida, Reinaldo, Bonenfant, Debora and Galli, Giorgio (2021) Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms. ACS Pharmacology and Translational Sciences.

Guan, Mingxing, Tian, Yingtao, Zhao, Jibin, Gu, Wayne, Jiang, Xigui, Wang, Xufan, Zhang, Yongbo and Zhang, Xingmin (2021) Safe Scale-Up of a NBS-Involved Bromination Reaction: Thermal Safety Analysis Contributes to Process Optimization. Organic process research & development, 25 (6). pp. 1375-1382.

Guerreiro, Nelson, Jullion, Astrid, Ferretti, Stephane Raymond, Fabre, Claire and Meille, Christophe (2021) Translational Modeling of Anticancer Efficacy to Predict Clinical Outcomes in a First-in-Human Phase 1 Study of MDM2 Inhibitor HDM201. AAPS Journal, 23 (2). ISSN 15507416

Gurinovich, Anastasia, Song, Zeyuan, Zhang, William, Federico, Anthony, Monti, Stefano, Anderson, Stacy L, Jennings, Lori, Barzilai, Nir, Millman, Sofiya, Perls, Thomas T and Sebastian, Paola (2021) Effect of longevity genetic variants on the molecular aging rate. GeroScience. ISSN 25092723

Hadjikyriacou, Andrea, Concannon, John, Sigoillot, Frederic, Antczak, Christophe, Jenkins, Jeremy, Nyfeler, Beat, Jain, Rishi, Tallarico, John and Canham, Steve (2021) Multi-Species Phenotypic Screening across Disease Models of Mucolipidosis Type IV. BioRxiv.

Hadjikyriacou, Andrea, Concannon, John, Sigoillot, Frederic, Antczak, Christophe, Jenkins, Jeremy, Nyfeler, Beat, Jain, Rishi, Tallarico, John and Canham, Steve (2021) Multi-Species Phenotypic Screening across Disease Models of Mucolipidosis Type IV. BioRxiv.

Hall, Peter, Flandre, Thierry, Piaia, Alessandro, Colman, Karyn, Tarnow, Inge, Price, Mark, Haworth, Richard, Vahle, John, Cary, Maurice, Jones, David and Cauvin, Annick (2021) BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics. Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Hall, Peter, Vahle, John and Colman, Karyn (2021) Inspiration and Exasperation: The Challenges of Inhaled Biologics. Toxicologic Pathology. ISSN 15331601

Harlacher, Cornelius, Galli, Bruno, Meinel, Lorenz, Schlauersbach, Jonas, Hanio, Simon , Lenz, Bettina, Vemulapalli, Sahithya, Griesinger, Christian and Pöppler, Ann-Christin (2021) Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection. Journal of Controlled Release, 330. pp. 36-48. ISSN 18734995

Hartmann, Andreas, Darribat, Katy, Doelemeyer, Arno, Valdez, Reginald, Schneider, Marilynn, Sivasankaran, Rajeev and Theil, Diethilde (2021) Orally administered branaplam does not impact neurogenesis in juvenile mice, rats, and dogs. Biol Open, Volume (Issue ).

Hartung, Whitney, Schalago, John, Rossi, Claudio and Pavkov, Richard (2021) Software as medical device for connected drug-device combination products. Pharmaceutical engineering.

Hauptmann, Astrid, Hoelzl, Georg and Loerting, Thomas (2021) Optical cryomicroscopy and differential scanning calorimetry of buffer solutions containing cryoprotectants. European Journal of Pharmaceutics and Biopharmaceutics, Volume. pp. 127-140. ISSN 09396411

Heiser, Diane, Rubert, Joelle, Unterreiner, Adeline, Maurer, Claudine, Kamke, Marion, Bodendorf, Ursula, Farady, Christopher, Roediger, Ben and Bornancin, Frederic (2021) Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation. PloS one, 16 (11). e0248668. ISSN 1932-6203

Hendriks, Bart and Venkatakrishnan, Karthik (2021) Essential (and Largely Untaught) Skills for Clinical Pharmacology in Oncology Drug Development. Clinical Pharmacology and Therapeutics. ISSN 15326535

Henning, Nathaniel, Manford, Andrew, Spradlin, Jessica, Brittain, Scott, Zhang, Erika, McKenna, Jeffrey, Tallarico, John, Schirle, Markus, Rape, Michael and Nomura, Daniel (2021) Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. Journal of the American Chemical Society, 144 (2). pp. 701-708. ISSN 0002-7863

Heusser, Carolyn, Garad, Sudhakar, Sanchez-Felix, Manuel and Ganish, Ahil (2021) Patient-centric design for systemic peptide delivery: Trends in routes of administration and advancement in drug delivery technologies. Medicine in Drug Discovery.

Heymsfield, Steven, Coleman, Laura, Miller, Ram, Rooks, Daniel, Laurent, Didier, Petricoul, Olivier, Praestgaard, Jens, Swan, Therese, Wade, Thomas, Perry, Robert, Goodpaster, Bret and Roubenoff, Ronenn (2021) Bimagrumab, an Activin Type II Receptor Antagonist, for the Treatment of Obesity and Type 2 Diabetes: A Randomized ClinicalTrial. Journal of the American Medical Association.

Hinterholzer, Arthur, Stanojlovic, Vesna, Huber, Christian, Cabrele, Chiara and Schubert, Mario (2021) Detecting aspartate isomerization and backbone cleavage after aspartate in intact proteins by NMR spectroscopy. Journal of Biomolecular NMR, 75 (1). pp. 71-82. ISSN 15735001

Hoch, Matthias, SATO, MASAHIKO, Zack, Julia, Quinlan, Michelle, Sengupta, Tirtha, Allepuz Palau, Alejandro Javier, Aimone, Paola Daniela and Hourcade-Potelleret, Florence (2021) Pharmacokinetics of asciminib in individuals with hepatic or renal impairment. Journal of Clinical Pharmacology .

Hoch, Matthias, Zack, Julia, Quinlan, Michelle, Huth, Felix, Forte, Sofia, Dodd, Stephanie, Aimone, Paola Daniela and Hourcade-Potelleret, Florence (2021) The effects of imatinib and food on the pharmacokinetics of asciminib. Clinical Pharmacology in Drug Development. ISSN 2160-763X2160-7648

Hodoscek, Milan, Kralj, Sebastjan, Podobnik, Barbara, Kunej , Tanja and Konc, Janez (2021) Full therapeutic IgG1 antibody complex with FcγIIa/b and FcγIIIa receptors examined using all-atom molecular dynamics simulations. Frontiers in Chemistry, 9. ISSN 2296-2646

Humbeck, Lina, Morawietz, Tobias, Sturm, Noe, Zalewski, Adam, Harnqvist, Simon, Heyndrickx, Wouter, Holmes, Matthew and Beck, Bernd (2021) Don’t overweight weights: Evaluation of weighting strategies for multi-task bioactivity classification models. Don’t Overweight Weights: Evaluation of Weighting Strategies for Multi-Task Bioactivity Classification Models, 26 (22). p. 6959. ISSN 1420-3049

Huth, Felix, Domange, Norbert, Poller, Birk, Vapurcuyan, Natasha, Durrwell, Alexandre, Hanna, Imad and Faller, Bernard (2021) Predicting Oral Absorption for Compounds Outside the Rule of Five Property Space. Journal of pharmaceutical sciences, 110 (6). pp. 2562-2569. ISSN 00223549

Huth, Felix, Schiller, Hilmar, Jin, Yi, Poller, Birk, Schuhler, Carole, Weis, Wendy, Woessner, Ralph, Drollmann, Anton Franz and End, Peter (2021) Novel Bruton’s Tyrosine Kinase inhibitor remibrutinib: Drug-drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling. Clinical and Translational Science, 15 (1). pp. 118-129. ISSN 17528062

INOUE, SATORU, Vaidya, Soniya, Tillmann, Hanns-Christian, SAKITA, YOHEI, Machineni, Surendra Kumar, Heudi, Olivier and Furihata, Kenichi (2021) Pharmacokinetics of indacaterol, glycopyrronium and mometasone furoate administered as an inhaled fixed-dose combination in Japanese and Caucasian healthy subjects. BMC Pulmonary Medicine, 21 (1). p. 18. ISSN 14712466

Ilaria, Romito, Manuela, Porru, Maria Rita, Braghini, Luca, Pompili, Nadia, Panera, Annalisa, Crudele, Daniela, Gnani, Cristiano, De Stefanis, Marco, Scarsella, Silvia, Pomella, Stefano Levi, Mortera, Emmanuel, de Billy, Adrian Libenzio, Conti, Valeria, Marzano, Lorenza, Putignani, Manlio, Vinciguerra, Clara, Balsano, Anna, Pastore, Rossella, Rota, Marco, Tartaglia, Carlo, Leonetti and Anna, Alisi (2021) Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects. Journal of experimental & clinical cancer research. ISSN 1756-9966; 0392-9078

Ispasanie, Emma, Muri, Lukas, Schubart Wellensiek, Anna, Thorburn, Christine, Zamurovic Ribrioux, Natasa, Kammueller, Michael and Pluschke, Gerd (2021) Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals. Frontiers in immunology, 12. p. 732146. ISSN 1664-3224

Israel, Laura, Glueck, Anton, Berger, Marjorie, Coral, Marine, Ceci, Melanie, Unterreiner, Adeline, Rubert, Joelle, Bardet, Maureen, Ginster, Stefanie, Ochsenbein, Alexandra, Martin, Kea, Hoyler, Thomas, Calzascia, Thomas, Wieczorek, Grazyna, Hillenbrand, Rainer, Ferretti, Stephane Raymond, Ferrero, Enrico and Bornancin, Frederic (2021) CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo. Oncogenesis, 6 (10 (4)). p. 32. ISSN 2157-9024

Iurlaro, Mario, Galli, Giorgio, Jagani, Zainab, Stadler, Michael and Schuebeler, Dirk (2021) Mammalian SWI/SNF continuously restores local accessibility to chromatin. Nature Genetics. ISSN 15461718

Iurlaro, Mario, Stadler, Michael, Galli, Giorgio, Jagani, Zainab and Schuebeler, Dirk (2021) Mammalian SWI/SNF continuously restores local accessibility to chromatin. Nature Genetics. ISSN 15461718

Iyer, Raman, Vesna, petrovska jovanovska, Sanchez-Felix, Manuel, Fabiani, Flavio, Harlacher, Cornelius, Huzjak, Tilen, Berginc, Katja and Jaklič, Miha (2021) Amorphous Solid Dispersions (ASDs) – “The influence of material properties, manufacturing processes and technologies in drug product development". Pharmaceutics Journal, 13(10) (10). pp. 1682-1696.

Jennings, Lori, Loureiro, Joe, Orth, Anthony and Hillenbrand, Rainer (2021) SomaScan Novartis proteins (construct, domain, expression) used in development of SomaScan, for PUBLIC disclosure on SomaLogic website. Somalogic.com.

Johansson, David, Rauld, Celine, Roux, Julien, Regairaz Kalenga Kapiamba, Camille, Galli, Edoardo, Callegari, Ilaria, Raad, Layla, Waldt, Annick, Cuttat-Theurillat, Rachel, Roma, Guglielmo, Diebold, Martin, Becher, Burkhard, Kuhle, Jens, Derfuss, Tobias, Carballido, Jose and Sanderson, Nicholas (2021) Mass Cytometry of CSF Identifies an MS-Associated B-cell Population. Neurology(R) neuroimmunology & neuroinflammation, 8 (2). ISSN 23327812

Jones, Graham (2021) Scales, belts, and pyramids: Back to the future of digital healthcare. International Journal of Family and Community Medicine, 5 (4). pp. 139-142. ISSN eISSN: 2577-8269

Jones, Graham, Chirino-Chace, Bernardita and Wright, Justin (2021) How Team Diversity Drives Innovation: Modeling in the Global Pharmaceutical Industry. International Journal of Innovation Science, 13 (2). pp. 133-144. ISSN 1757-2223

Jordaan, Pierre, Abi-Gerges, Najah, Dumotier, Berengere, Ghetti, Andrea, Urban, Laszlo and Miler, Paul (2021) Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in adult Human Primary Cardiomyocytes. Toxicological Sciences, e-pub (e-pub). pp. 1-13. ISSN 1096-60801096-0929

Joseph, Boen, Wagner, Joel and Di Nanni, Noemi (2021) Inferring copy number variation from gene expression data: methods, comparisons, and applications to oncology. bioRxiv.

Julie, Corliss (2021) Post-traumatic stress disorder: When fear strikes the heart. Harvard Heart Letter, 32 (3). p. 6.

Keller, Steve, Quiroz, Jorge, Christopher, Dave, Wickremsinhe, Enaksha , Geng, Wanping, Hawthorne, Glen, James, Christopher, Katterle, Yvonne, Li, Wenkui, Liu, Guowen, Mayer, Andrew, Paton, Martin, Pav, Joseph, Potter, Julian, Vergis, James and Wang, Jonathan (2021) The effectiveness of quality control samples in pharmaceutical bioanalysis. Bioanalysis, 13 (3). pp. 135-145. ISSN 17576199

Khanna, Amit and Jones, Graham (2021) Envisioning Post-Pandemic Neurological, Psychiatric and Mental Health Care. Frontiers in Digital Health, 3 (803315). pp. 1-6. ISSN ISSN=2673-253X

Kholodar, Svetlana A., Lang, Geoffrey, Cortopassi, Wilian A., Iizuka, Yoshie, Brah, Harman S., Jacobson, Matthew P. and England, Pamela M. (2021) Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1. ACS Chemical Biology. ISSN 1554-8929

Kingsley, Laura, He, Xiaohui, McNeill, Matthew, Nelson, John, Nikulin, Victor, Ma, Zhiwei, Lu, Wenshuo, Zhou, Vicki, Manuia, Mari, Kreusch, Andreas, Gao, Mu-Yun, Witmer, Darbi, Vaillancourt, Mei Ting, Lu, Min, Greenblatt, Sarah, Lee, Christian, Bender, Steven, Spraggon, Glen, Michellys, Pierre, Jia, Yong, Haling, Jake and Lelais, Gerald (2021) Structure-based design of selective LONP1 inhibitors for probing in vitro biology. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Kingsley, Laura, He, Xiaohui, McNeill, Matthew, Nelson, John, Nikulin, Victor, Ma, Zhiwei, Lu, Wenshuo, Zhou, Vicki, Manuia, Mari, Kreusch, Andreas, Gao, Mu-Yun, Witmer, Darbi, Vaillancourt, Mei Ting, Lu, Min, Greenblatt, Sarah, Lee, Christian, Vashisht, Ajay, Bender, Steven, Spraggon, Glen, Michellys, Pierre, Jia, Yong, Haling, Jake and Lelais, Gerald (2021) Structure-based design of selective LONP1 inhibitors for probing in vitro biology. Journal of Medicinal Chemistry, 64 (8). pp. 4857-4869. ISSN 0022-26231520-4804

Kleinbeck-Riniker, Florian, Schlama, Thierry, Ruch, Thomas, Novick, Scott, Dellas, Nikki, Garcia, Ravi, Ching, Charlene, Bautista, Abby, Homan, David, Alvizo, Oscar and Entwistle, David (2021) Engineering an omega-Transaminase for the Efficient Production of a Chiral Sacubitril Precursor. ACS Catalysis, 11. pp. 3762-3770. ISSN 2155-54352155-5435

Kleinbeck-Riniker, Florian, Schlama, Thierry, Ruch, Thomas, Novick, Scott, Dellas, Nikki, Garcia, Ravi, Ching, Charlene, Bautista, Abby, Homan, David, Alvizo, Oscar and Entwistle, David (2021) Engineering an omega-Transaminase for the Efficient Production of a Chiral Sacubitril Precursor. ACS Catalysis, 11. pp. 3762-3770. ISSN 2155-54352155-5435

Klejbor, I, Shimshek, Derya, Klimaszewska-Łata, J, Velasco-Estevez, M, Moryś, J, Karaszewski, B, Szutowicz, A and Rutkowska, A (2021) EBI2 is expressed in glial cells in multiple sclerosis lesions and its knock-out modulates remyelination in the cuprizone model. European Journal of Neuroscience. ISSN 0953-816X1460-9568

Kolbinger, Frank, Di Padova, Franco E., Huppertz, Christine, Kuiper, Torsten, Carballido, Jose, Calonder, Claudio, Vogel, Beate Elisabeth, Rondeau, Jean-Michel, Bruin, Gerardus, Deodhar, Atul, Hawkes, Jason, McInnes, Iain B., Ritchlin, Christopher T., Rosmarin, David, Schett, Georg and Häusermann, Peter (2021) Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and safety. Pharmacology and Therapeutics. ISSN 1879016X

Krantz, Carsten (2021) Review of the Technical, Toxicological, and PKPD Considerations for Conducting Inhalation Toxicity Studies on Biologic Pharmaceuticals—The Outcome of a Cross-Industry Working Group Survey. Toxicologic Pathology. ISSN 15331601

Krell, Christoph and Gallou, Fabrice (2021) Water waste from surfactant chemistry: risk or opportunity? Organic process research & development, 25.

Kreutter, David , Schwaller, Philippe and Reymond, Jean-Louis (2021) Predicting Biotransformations with a Molecular Transformer. Chemical science, 12 (25). pp. 8573-8932. ISSN 2041-6539; 2041-6520

Kuemmel, Sherko, Campone, Mario, Loirat, Delphine, Lopez Lopez, Rafael, Beck, J.Thaddeus , De Laurentiis, Michelino, Im, Seock-Ah, Kim, Sung-Bae, Kwong, Ava, Steger, Guenther G, Adelantado, Esther Zamora, Duhoux, Francois P, Greil, Richard, Kuter, Irene, Lu, Yen-Shen, Tibau, Ariadna, Özgüroğlu, Mustafa, Scholz, Christian, Singer, Christian F. , Vega, Estela, Wimberger, Pauline, Zamagni, Claudio, Couillebault, Xuan-Mai, Fan, Liqiong, Guerreiro, Nelson, Mataraza, Jennifer, Sand Dejmek, Janna and Chan , Arlene (2021) A Randomized Phase II Study of Anti-CSF-1 Monoclonal Antibody Lacnotuzumab (MCS110) Combined with Gemcitabine and Carboplatin in Advanced Triple Negative Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. ISSN 1557-3265

Kuzman, Drago, Bunc, Marko, Reiter, Fritz, Boncina, Matjaz, Žagar, Lan and Ravnik , Miha (2021) Long-Term Stability Predictions of Therapeutic Monoclonal Antibodies in Solution Using Arrhenius Based Kinetics. Scientific reports, 11 (20534).

Kälin, RE, Cai, L, Li, Y, Zhang, H, Cheng, J, Zhang, W, Wu, Y, Eisenhut, K, Janssen, P, Schmitt, L, Enard, W, Michels, M, Flüh, C, Hou, M, Kirchleitner, SV, Siller, S, Schiemann, M, Andrä, I, Montanez, E, Giachino, C, Taylor, V, Synowitz, M, Tonn, J, von Baumgarten, L, Schulz, C, Hellmann, I and Glass, R (2021) Dangerous Air: How air pollution affects astrocyte functions. GLIA, 69 (SUPPL ). ISSN 10981136

Lapointe, Guillaume, Skepper, Colin, Holder, Lauren, Armstrong, Duncan, Bellamacina, Cornelia, Blais, Johanne, Bussiere, Dirksen, Bian, Jianwei, Cepura, Cody, Chan, Helen, Dean, Charles, De Pascale, Gianfranco, Dhumale , Bhavesh, Fisher, L. Mark, Fulsundar , Mangesh, Kantariya, Bhavin, Kim, Julie, King, Sean, Kossy, Lauren, Kulkarni, Upendra, Lakshman, Jay, Leeds, Jennifer, Ling, Xiaolan, Lvov, Anatoli, Ma, Sylvia, Malekar, Swapnil, Mckenney, David, Mergo, Wosenu, Metzger Iv, Louis, Mhaske, Keshav, Moser, Heinz, Mostafavi, Mina, Namballa, Sunil, Noeske, Jonas, Osborne, Colin, Patel, Ashish, Patel, Darshit, Patel, Tushar, Piechon, Philippe, Polyakov, Valery, Prajapati, Kruna, Prosen, Katie, Reck, Folkert, Richie, Daryl, Sanderson, Mark, Satasia, Shailesh, Savani, Bhautik, Selvarajah, Jogitha, Sethuraman, Vijay, Shu, Wei, Tashiro, Kyuto, Thompson, Katherine, Vaarla, Krishniah, Vala, Lakhan, Veselkov, Dennis, Vo, Jason, Vora, Bhavesh, Wagner, Beatrix, Wedel, Laura, Williams, Sarah, Yendluri, Satya, Yue, Qin, Yifru, Aregahegn, Zhang, Yong and Rivkin, Alexey (2021) Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity Against Fluoroquinolone-Resistant Gram-positive Bacteria. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Le Grand, Darren, Gosling, Martin, Baettig, Urs, Bahra, Parmjit, Bala, Kamlesh, Brocklehurst, Cara, Budd, Emma, Butler, Rebecca, Cheung, Atwood, Collingwood, Stephen, Cox, Brian, Danahay, Henry, Edwards, Lee, Everatt, Brian, Glaenzel, Ulrike, Hall, Edward, Hatto, Julia, Howsham, Catherine, Hughes, Glyn, King, Anna, Koehler, Julia, Kulkarni, Swarupa, Lightfoot, Megan, Nicholls, Ian Michael, Page, Christopher, Pergl-Wilson, Giles, Robinson, Richard, Rowlands, David, Steward, Oliver, Taylor, Roger, Tranter, Pamela, Wagner, Beatrix, Williams, Gareth, Wright, Penny and Sandham, David (2021) Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. Journal of Medicinal Chemistry, 64 (11). pp. 7241-7260. ISSN 0022-26231520-4804

Lebede, Maximilian, Di Marco, Fiammetta, Esser-Skala, Wolfgang, Rapp, Erdmann, Wohlschlager, Therese and Huber, Christian G. (2021) Exploring the Chemical Space of Protein Glycosylation in Noncovalent Protein Complexes: An Expedition along Different Structural Levels of Human Chorionic Gonadotropin by Employing Mass Spectrometry. Analytical chemistry, 93 (30). pp. 10424-10434. ISSN 1520-6882

Lee, Jung Seok, Han, Patrick, Chaudhury, Rabib, Khan, Shihan, Bickerton, Sean, McHugh, Michael D, Park, Hyun Bong, Siefert, Alyssa L, Rea, Gerald, Carballido, Jose, Horwitz, David A, Criscione, Jason, Perica, Karlo, Samstein, Robert, Rageb, Ragy, Kim, Dongin and Fahmy, Tarek M (2021) Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin. Nature Biomedical Engineering, 2021 (5). pp. 983-997.

Lee, Minkyoung, Betz, Charles, Yin, Jianmin, Paatero, Ilkka, Schellinx, Niels, Carte, Adam N, Wilson, Christopher W, Ye, Weilan, Affolter, Markus and Belting, Heinz-Georg (2021) Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip 1. Development (Cambridge, England). ISSN 1477-9129

Lemmens, Myriam, Fischer, Benoit, Rodrigues, Lindsey, Kerr, Grainne, Del Rio Espinola, Alberto, Schaeffer, Fanny, Maddalo, Danilo, Dubost, Valerie, Piaia, Alessandro, Mueller, Arne, Plappert Helbig, Ulla, Naumann, Ulrike, Haegele, Jasmin, Alex, Odermatt, Martus, Hans-Joerg and Libertini, Silvana (2021) In vitro transformation assays for non-clinical safety assessment of CRISPR/Cas9 genome-edited cells. Molecular therapy - methods and clinical development, 23. pp. 241-253. ISSN 2329-0501

Lenz, Jan, Bunjes, Heike, Kwade, Arno and Juhnke, Michael (2021) An Improved Method for the Simultaneous Determination of Water Uptake and Swelling of Tablets. International journal of pharmaceutics, 595 (n/a). p. 120229. ISSN 1873-3476; 0378-5173

Lenz, Jan, Bunjes, Heike, Kwade, Arno and Juhnke, Michael (2021) Tablet formulation development focusing on the functional behaviour of water uptake and swelling. International Journal of Pharmaceutics X, 3 (n/a). p. 100103. ISSN 2590-1567

Lewis, Richard (2021) Best practices for repurposing studies. Journal of computer-aided molecular design, 36 (1). pp. 1-5. ISSN 1573-4951

Li, Wenkui, Glick, Jim, Hatsis, Panagiotis, Fu, Yunlin, Chin, Harvey, Moench, Paul and Flarakos, Jimmy (2021) An integrated outsourcing practice of nonclinical LC-MS bioanalysis and toxicokinetics at Novartis small molecule drug development. Bioanalysis, 13 (12). pp. 1001-1010. ISSN 17576199

Lima, Fabio, Meisenbach, Mark, Schenkel, Berthold and Sedelmeier, Joerg Mathias (2021) Continuous Flow as an Enabling Technology: A Fast and Versatile Entry to Functionalized Glyoxal Derivatives. Organic & Biomolecular Chemistry. ISSN 1477-05201477-0539

Litchfield, Marcus, Wuest, Melinda, Glubrecht, Daryl, Briard, Emmanuelle, Auberson, Yves, McMullen, Todd, Brindley, David and Wuest, Frank (2021) PET Imaging of Autotaxin in Thyroid and Breast Cancer Models using [18F]PRIMATX. Molecular pharmaceutics.

Liu, Chen, Lu, Henry, Wang, Hongyun, Loo, Alice, Zhang, Xiamei, Yang, Guizhi, Kowal, Colleen, Delach, Scott, Wang, Ye, Goldoni, Silvia, Hastings, Bill, Wong , Karrie, Gao, Hui, Meyer, Matthew, Moody, Susan, LaMarche, Matthew, Engelman, Jeffrey, Williams, Juliet, Hammerman, Peter, Abrams, Tinya, Mohseni, Morvarid, Caponigro, Giordano and Hao, Huaixiang (2021) Combinations with allosteric SHP2 inhibitor TNO155 to block receptor tyrosine kinase signaling. Clinical Cancer Research, 27 (1). pp. 342-354. ISSN 15573265

Lopez, John, Albericio, Fernando, de la Torre, Beatriz and Ramkisson, Shaveer (2021) Refractive Index: The Ultimate Tool for Real-Time Monitoring of Solid-Phase Peptide Synthesis. Greening the Process. Organic process research & development, 25. pp. 1047-1053. ISSN 1520-586X; 1083-6160

Lopez, John, G. de la Torre1, Beatriz , Albericio, Fernando and Ramkisson, Shaveer (2021) Refractive Index: The Ultimate Tool for Real-Time Monitoring of Solid-Phase Peptide Synthesis. Greening the Process. Organic Process Research & Development, 25 (https:). pp. 1047-1053. ISSN 1520-586X.

Lu, Yasong, Yang, Shu, Ho, Yu-Yun and Ji, Yan (2021) Ribociclib Population Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Analysis of Neutrophils in Cancer Patients. Journal of Clinical Pharmacology. ISSN 15524604

Luo, Mai, Spradlin, Jessica, Boike, Lydia, Tong, Bingqi, Brittain, Scott, McKenna, Jeffrey, Tallarico, John, Schirle, Markus, Maimone, Thomas and Nomura, Dan (2021) Chemoproteomics-Enabled Ligand Screening Yields Covalent RNF114-Based Degraders that Mimics Natural Product Function. Cell chemical biology. ISSN 24519456

Lustenberger, Philipp, Mathes, Christian, Riss, Bernard, Hueber, Lukas, Dedic, Darija, den Reijer, Carolien, Koenigsberger, Kurt, Napp, Matthias, Schlama, Thierry, Rueegger, Ulrich and Fei, Zhongbo (2021) Using a Johnson-Claisen Rearrangement Strategy to Construct Azaindoles – A Streamlined and Concise Route for the Commercial Process of Fevipiprant. European Journal of Organic Chemistry, 2021 (31). pp. 4490-4494. ISSN 1434-193X1099-0690

Lüönd, Fabiana, Sugiyama, Nami, Bill, Ruben, Bornes, Laura, Hager, Carolina, Tang, Fengyuan, Santacroce, Natascha, Beisel, Christian, Ivanek, Robert, Bürglin, Thomas, Tiede, Stefanie, van Rheenen, Jacco and Christofori, Gerhard (2021) Distinct contributions of partial and full EMT to breast cancer malignancy. Developmental cell, 56 (23). 3203-3221.e11. ISSN 1878-1551

Lüönd, Fabiana, Tiede, Stefanie and Christofori, Gerhard (2021) Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression. British journal of cancer, 125 (2). pp. 164-175. ISSN 1532-1827

Machauer, Rainer, Lueoend, Rainer Martin, Hurth, Konstanze, Veenstra, Siem, Rueeger, Heinrich, Voegtle, Markus, Tintelnot-Blomley, Marina, Rondeau, Jean-Michel, Jacobson, Laura, Laue, Grit, Beltz, Karen and Neumann, Ulf (2021) Discovery of Umibecestat (CNP520): A Potent, Selective and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease. Journal of Medicinal Chemistry, 64 (20). pp. 15262-15279. ISSN 0022-26231520-4804

Manjunatha, Ujjini, Jumani, Rajiv Satish, Blais, Johanne, Tillmann, Hanns-Christian, Segal, Florencia, Wetty, Dean, Lakshman, Jay, Aziz, Natasha, Chandra, Richa, Ostermeier, Christian, Nuber, Natko, Chen, Wilbur, Chappell, Cynthia and Diagana, Thierry (2021) Opportunities and challenges in developing a Cryptosporidium controlled human infection model for testing novel anti-parasitic agents. ACS infectious diseases, 7. pp. 959-968. ISSN 2373-8227

Manjunatha, Ujjini, Rao, Srinivasa, Smith, Paul, Westhuyzen, Renier van der and Chibale, Kelly (2021) Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging. Journal of medicinal chemistry. ISSN 15204804

Marc, Philippe (2021) Data Science in R&D: it is about culture! Pharma Tech Outlook.

Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lueoend, Rainer Martin, Miltz, Wolfgang, Waelchli, Rudolf, Wolf, Romain, Hinrichs, Juergen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos, Klein, Kai, Wack, Nathalie, Jaeger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson King, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda and Roehn, Till (2021) Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase. Journal of medicinal chemistry.

Marques Lopes, Rui, Sprouffske, Kathleen, Sheng, Caibin, Esther, Ujittewaal, Adriana, Wesdorp, Jan, Dahinden, Simon, Wengert, Juan, Diaz Miyar, Umut, Yildiz, Rok, Krese, Bleu, Melusine, Grass, Verena, Mermet-Meillon, Fanny Anne-Marie, Mathias, Eder, Knehr, Judith, Walter, Carbone, Cuttat-Theurillat, Rachel, Waldt, Annick, Altorfer, Marc, Naumann, Ulrike, de Weck, Antoine, Kauffmann, Audrey, Roma, Guglielmo, Schuebeler, Dirk and Galli, Giorgio (2021) Systematic dissection of transcriptional regulatory networks by genome-scale and singlecell CRISPR screens. Science advances, 7. ISSN 2375-2548

Martin, Benjamin, Filipponi, Paolo, Mostarda, Serena, Mandrelli, Francesca, Knochel, Paul, Heinz, Benjamin and Djukanovic, Dimitrije (2021) Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene. Chemistry—A European Journal, 27. pp. 1-6. ISSN 15213765

Martin, Benjamin, Knochel, Paul, Heinz, Benjamin, Djukanovic, Dimitrije, Siemens, Fiona and Idriess, Mohamed (2021) Regioselective Amination or Alkoxylation of Halogenated Amino-, Thio- or Alkoxypyridines via Pyridyne Intermediates. Synthesis, 53. A-I.

Martin, Benjamin, Ladosz, Agnieszka and Battilocchio, Claudio (2021) Flow Chemistry Highlights column in Chimia (monthly contribution). Chimia : international journal for chemistry.

Martin, Eric, Bosc, Nicolas , Felix, Eloy, Saunders, Martin R., Green, Darren V. S. , Ochoada, Jason, Shelat, Anang A., Iyer, Preeti, Engkvist, Ola, Verras, Andreas, Duffy, James, Gardner, J. Mark. F. and Leach, Andrew R. (2021) MAIP: A prediction platform for predicting blood-stage malaria inhibitors. Journal of Cheminformatics , 13 (1). p. 13. ISSN 1758-2946

Martin, Eric and Zhu, Xiangwei (2021) Collaborative Profile-QSAR: A Natural Platform for Building Collaborative Models among Competing Companies. Journal of chemical information and modeling, 61 (4). pp. 1603-1616. ISSN 1549960X

Martinez Heredia, Lizbeth, Matero, Sanni, Neumuller, Julie, Juhnke, Michael and Camille, Adler (2021) Process analytical technology as a tool to optimize and accelerate pharmaceutical process development. American Pharmaceutical Review, 24 (4). pp. 28-34.

Martus, Hans-Joerg, Erkman, Linda, Maremanda, Nihal, Elhajouji, Azeddine and Hartmann, Andreas (2021) Comprehensive review of genotoxicity data for diclofenac. Mutation research..

Mathison, Casey, Yang, Yang, Nelson, John, Huang, Zhihong, Jiang, Jiqing, Chianelli, Donatella, Rucker, Paul, Roland, Jason, Xie, Yun, Epple, Robert, Bursulaya, Badry, Lee, Christian, Gao, Mu-Yun, Shaffer, Jennifer, Briones, Sergio, Sarkisova, Yelena, Galkin, Anna, Li, Lintong, Li, Nanxin, Li, Chun, Hua, Su, Kasibhatla, Shailaja, Kinyamu-Akunda, Jacqueline, Kikkawa, Rie, Molteni, Valentina and Tellew, John (2021) Antitarget selectivity and tolerability of novel pyrrolo[2,3-d]pyrimidine RET inhibitors. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Maziarz, Krzysztof, Jackson-Flux, Henry, Cameron, Pashmina, Sirockin, Finton, Schneider, Nadine, Stiefl, Nikolaus and Brockschmidt, Marc (2021) Learning to Extend Molecular Scaffolds with Structural Motifs. International Conference on Machine Learning.

McIntosh, Avery, Sverdlov, Alex, Yu, Li and Kaufmann, Petra (2021) Clinical design and analysis strategies for development of cell and gene therapies: quantitative drug development in the age of genetic medicine. Clinical pharmacology and therapeutics. pp. 1-9.

Meyer, Angelika, Ibebunjo, Chikwendu, Solovyeva, Elizaveta, Utzinger, Stephan, Eash, John, Dunbar, Andrew W., Demirci, Sabrina, Naumann, Ulrike, Zhang, Yunyu, Serluca, Fabrizio, Oberhauser, Berndt, Black, Frederique, Rausch, Martin, Trifilieff, Estelle, Hoersch, Sebastian and Trendelenburg, Anne-Ulrike (2021) New insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence. Mechanisms of Ageing and Development, 197 (111510). pp. 1-13. ISSN 18726216

Meyer, Arndt, Brocklehurst, Cara, Duckely, Myriam, Gallou, Fabrice, Lovelle, Lucie, Parmentier, Michael, Schlama, Thierry, Snajdrova, Radka and Auberson, Yves (2021) Fostering Research Synergies between Chemists in Swiss Academia and at Novartis. Chimia, 75 (11). pp. 936-942. ISSN 0009-4293

Meyer, Fabian, Frey, Raphael, Ligibel, Mathieu, Sager, Emine, Schroer, Kirsten, Snajdrova, Radka and Buller, Rebecca (2021) Modulating chemoselectivity in a Fe(II)/ alpha-ketoglutarate dependent oxygenase for the oxidative modification of a non-proteinogenic amino acid. ACS Catalysis , 11 (10). pp. 6261-6269.

Meyer, Robina M., Berger, Lukas, Nerkamp, Joerg, Scheler, Stefan, Nehring, Sebastian and Friess, Wolfgang (2021) Identification of Monoclonal Antibody Variants Involved in Aggregate Formation - Part 1: Charge Variants. European journal of pharmaceutics and biopharmaceutics, 158. pp. 123-131. ISSN 1873-3441

Meyer., Robina M., Berger, Lukas, Nerkamp, Joerg, Scheler, Stefan, Nehring, Sebastian and Friess, Wolfgang (2021) Identification of monoclonal antibody variants involved in aggregate formation – Part 2: Hydrophobicity variants. European Journal of Pharmaceutics and Biopharmaceutics, 160 (March ). pp. 134-142. ISSN 18733441

Miljković , Filip, Rodriguez Perez, Raquel and Bajorath, Jürgen (2021) Impact of Artificial Intelligence on Compound Discovery, Design, and Synthesis. ACS Omega.

Milton, Mark, Gorovits, Boris, Azedeh, Mitra, Buchlis, George, Harrisson, Travis, Havert, Mike, Jawa, Vibha, Long, Brian, McNally, Jim, Nelson, Robert, O'Dell, Mark, Richards, Karen, Vetterman, Christian and Wu, Bonnie (2021) Evaluation of the humoral response to viral-based Gene Therapy Modalities using Total Antibody assays. The AAPS journal, 23. p. 108. ISSN 1550-7416

Milton, Mark, Kroenke, Mark, Kumar, Seema, Bame, Eris and White, Joleen (2021) Immunogenicity Risk Assessment for Multi-specific Therapeutics. The AAPS journal, 23 (6). p. 115. ISSN 1550-7416

Mohamed, Weaam I, Schenk, Andreas, Kempf, Georg, Cavadini, Simone, Basters, Anja, Potenza, Alessandro, Abdul Rahman, Wassim, Rabl, Julius, Reichermeier, Kurt and Thomä, Nicolas H (2021) The CRL4 DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state. The EMBO Journal, 40 (22). ISSN 0261-41891460-2075

Moore, Charles, Siirola, Elina Maria, Ma, Eric, Kummer, Arkadij, Siegrist, Luca, Stoeckli, Markus, Bouquet, Caroline, Acker, Anne-Christine, Faller, Michael, Eggimann, Fabian, Ligibel, Mathieu, Freund, Ernst, Huynh, Dan, Cutler, Geoffrey, Lewis, Richard, Oakeley, Edward James and Snajdrova, Radka (2021) Simultaneous machine-directed evolution of an imine reductase for activity and stereoselectivity. ACS Catalysis, 11 (20). ISSN 2155-54352155-5435

Moreno, Victor, Greil, Richard, Yachnin, Jeffrey, Majem, Margarita, Wermke, Martin, Arkenau, Hendrik-Tobias, Basque, Jean-Rene, Nidamarthy, Prasanna, Kapoor, Shruti, Cui, Xiaoming and Giovannini, Monica (2021) Pharmacokinetics and safety of capmatinib with food in patients with MET-dysregulated advanced solid tumors. Clinical Therapeutics, 43 (6). p. 1092.

Mueller-Zsigmondy, Martin, Heimbach, Tycho, Novakovic, Jasmina, Suarez, Sandra, Mitra, Amitava, Kollipara, Sivacharan and Tausif, Ahmed (2021) Establishing the Bioequivalence Safe Space for Immediate-Release Oral Dosage Forms using Physiologically Based Biopharmaceutics Modeling (PBBM): Case Studies. Journal of pharmaceutical sciences, 110 (12). pp. 3896-3906. ISSN 1520-6017

Mueller-Zsigmondy, Martin and Kourentas, Alexandros (2021) The Case for Apex Vessels. Pharmacopeial forum, 47 (6). ISSN 0363-4655

Muri, Lukas, Ispasanie, Emma, Schubart Wellensiek, Anna, Thorburn, Christine, Zamurovic Ribrioux, Natasa, Kammueller, Michael and Pluschke, Gerd (2021) Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals. Frontiers in immunology, 12. ISSN 1664-3224

Nauwelaerts, Nina, Deferm, Neel, Smits, Anne, Bernardini, Chiara, Lammens, Bart, Gandia, Peggy, Panchaud, Alice, Nordeng, Hedvig, Bacci, Maria Laura, Forni, Monica, Ventrella, Domenico, Van Calsteren, Kristel, DeLise, Anthony, Huys, Isabelle, Bouisset-Leonard, Michele, Allegaert, Karel and Annaert, Pieter (2021) A comprehensive review on non-clinical methods to study transfer of medication into breast milk – A contribution from the ConcePTION project. Biomedicine and Pharmacotherapy, 136. p. 111038. ISSN 19506007

Neef, James, Hollingworth, Greg, Hall, Edward, Wuersch, Kuno, Lal, Ajay, Bellenie, Ben, Bruce, Ian, Spendiff, Matthew, Culshaw, Andrew, McDonald, Sara, Ambarkhane, Ameet, Chinn, Colin, Thomas, Matthew , Sarah , Marshall, Rosner, Elisabeth, Bracher, Marguerite , Nicklin, Paul , Marshall, Stephen , Coote, Julie , Cullen, Eva and Tessier, Clemence (2021) Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ. Journal of Medicinal Chemistry. ISSN 15204804

Niederwieser, Sylwia, Passecker, Armin, Alder, Arne, Carrington, Eilidh, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, van der Starre, Alex, Beck, Hans-Peter, Sauerwein, Robert W, Kooij, Taco W A, Brancucci, Nicolas M B, Proellochs, Nicholas I, Gilberger, Tim-Wolf and Voss, Till S (2021) CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research. Nature communications, 12 (1). p. 4806. ISSN 2041-1723

Norby, Ulrike, Cuppers, Benedikte-Noël , Hristoskova, Sashka Angelova, Desai, Monali, Harmark, Linda and Steel, Michael (2021) Online information discrepancies regarding safety of medicine use during pregnancy and lactation: a ConcePTION study. Expert Opinion on Drug Safety, https: (https:). pp. 1-8. ISSN https://doi.org/10.1080/14740338.2021.1935865

Novello, S, Mercatelli, D, Albanese, F, D’Aversa, E, Vantaggiato, S, Dovero, S, Murtaj, V, Presotto, L, Borgatti, M, Shimshek, Derya, Bezard, E, Moresco, RM, Belloli, S and Morari, M (2021) In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity. Neurobiology of disease, 162. p. 105579. ISSN 1095-953X

Nyquist, Michael D and et al, et al (2021) Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth. Journal of Clinical Investigation, 131 (10). pp. 1-15. ISSN 15588238

Nörpel, Julia, Cavadini, Simone, Schenk, Andreas, Graff-Meyer, Alexandra, Hess, Daniel, Seebacher, Jan, Chao, Jeffrey A and Bhaskar, Varun (2021) Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture. PLoS biology, 19 (7). ISSN 1545-7885

Ofori-Atta, Kwabena and Springer, Clayton (2021) The Price is Right: Predicting Reagent Prices. ChemRxiv.

Papadopoulou, Athena, Meierhofer, Jasmin, Meyer, Fabian, Hayashi, Takahiro, Schneider, Samuel, Sager, Emine and Rebecca, Buller (2021) Re-programming and optimization of a L-proline cis-4-hydroxylase for the cis-3-halogenation of its native substrate. ChemCatChem.. ISSN 1867-38801867-3899

Parmentier, Michael, Baudoin, Olivier, Antien, Kevin and Geraci, Andrea (2021) A New Dioxazolone for the Synthesis of 1,2-Aminoalcohols via Iridium(III)-Catalyzed C(sp3)–H Amidation. Angewandte Chemie International Edition. ISSN 1433-78511521-3773

Parmentier, Michael, Debrauwer, Vincent, Leito, Ivo, Lokov, Mart, Tshepelevitsh, Sofja, Blanchard , Nicolas and Bizet, Vincent (2021) Synthesis and Physico-Chemical Properties of 2-SF5-(Aza)Indoles, A New Family of SF5-Heterocycles. ACS Organic & Inorganic Au. ISSN 2694-247X2694-247X

Parmentier, Michael, Li, Wei, Dalton, Charlotte, Diorazio, Louis, Doerfler, Jaika, Engl, Olivier, Han, Zhengxu, Howell, Gareth, Hutchby, Marc, Latham, Jonathan, McLaws, Mark, Munday, Rachel, Navarro, Antonio, Pawlas, Jan, Roiban, Doru, Terrett, Jack, Treitler, Daniel, Zeng, Mingshuo and Steven, Alan (2021) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development. ISSN 1083-61601520-586X

Parmentier, Michael, Li, Wei and Steven, Alan (2021) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development. ISSN 1083-61601520-586X

Pavlova, Anna, Lynch, Diane, Diadone, Isabella, Zanetti-Polzi, Laura, Smith, Micholas Dean, Chipot, Chris, Kneller, Daniel, Kovalevsky, Andrey, Coates, Leighton, Velez-Vega, Camilo, Golosov, Andrei, Dickson, Callum, Duca, Jose, Vermaas, Josh, Pang, Yui Tik, Acharya, Atanu, Parks, Jerry, Smith, Jeremy and Gumbart, James (2021) Inhibitor binding influences the protonation states of histidines in SARS-CoV-2 main protease. Chemical science. ISSN 2041-6539; 2041-6520

Pepe, Felice, Bill, Marius , Papaioannou, Dimitrios, Karunasiri, Malith, Walker, Allison , Snyder, Katiri, Ranganathan, Parvathi, Dorrance, Adrienne , Garzon, Ramiro and Naumann, Eric (2021) Targeting Wnt signaling in acute myeloid leukemia stem cells. Haematologica. ISSN 15928721

Persaud, Avinash, Prag, Gali, Shusterman, Anna, Biswas, Sagnik, Elias, Sivan, Florentin, Amir, Levin-Kravets, Olga, Borisova, Ekaterina, Simpson-Lavy, Kobi, Kupiec, Martin, Kordonsky, Alina, Yariv, Elon, Avishid, Reut, Sror, Mor, Almog, Ofir, Marshanski, Tal, Kadosh, Shira, David, Nichole, Manori, Bar, Fischer, Zohar, Lilly, Jeremiah, Ambrozkiewicz, Mateusz, Tarabykin, Victor, Rotin, Daniela and Thaker, Maulik (2021) Split chloramphenicol acetyl-transferase assay reveals self-ubiquitylation-dependent regulation of UBE3B. Journal of molecular biology, 433 (23). ISSN 00222836

Pikman, Yana, Tasian, Sarah K, Sulis, Maria Luisa, Stevenson, Kristen, Blonquist, Traci M, Apsel Winger, Beth, Cooper, Todd M, Pauly, Melinda, Maloney, Kelly W, Burke, Michael J, Brown, Patrick A, Gossai, Nathan, McNeer, Jennifer L, Shukla, Neerav N, Cole, Peter D, Kahn, Justine M, Chen, Jing, Barth, Matthew J, Magee, Jeffrey A, Gennarini, Lisa, Adhav, Asmani A, Clinton, Catherine M, Ocasio-Martinez, Nicole, Gotti, Giacomo, Li, Yuting, Lin, Shan, Imamovic, Alma, Tognon, Cristina E, Patel, Tasleema, Faust, Haley L, Contreras, Cristina F, Cremer, Anjali, Cortopassi, Wilian A, Garrido Ruiz, Diego, Jacobson, Matthew P, Dharia, Neekesh V, Su, Angela, Robichaud, Amanda L, Saur Conway, Amy, Tarlock, Katherine, Stieglitz, Elliot, Place, Andrew E, Puissant, Alexandre, Hunger, Stephen P, Kim, Annette S, Lindeman, Neal I, Gore, Lia, Janeway, Katherine A, Silverman, Lewis B, Tyner, Jeffrey W, Harris, Marian H, Loh, Mignon L and Stegmaier, Kimberly (2021) Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium. Cancer discovery. ISSN 2159-8290

Pikman, Yana, Tasian, Sarah K., Sulis, Maria Luisa, Stevenson, Kristen, Blonquist, Traci M., Apsel Winger, Beth, Cooper, Todd M., Pauly, Melinda, Maloney, Kelly W., Burke, Michael J., Brown, Patrick A., Gossai, Nathan, McNeer, Jennifer L., Shukla, Neerav N., Cole, Peter D., Kahn, Justine M., Chen, Jing, Barth, Matthew J., Magee, Jeffrey A., Gennarini, Lisa, Adhav, Asmani A., Clinton, Catherine M., Ocasio-Martinez, Nicole, Gotti, Giacomo, Li, Yuting, Lin, Shan, Imamovic, Alma, Tognon, Cristina E., Patel, Tasleema, Faust, Haley L., Contreras, Cristina F., Cremer, Anjali, Cortopassi, Wilian A., Garrido Ruiz, Diego, Jacobson, Matthew P., Dharia, Neekesh V., Su, Angela, Robichaud, Amanda L., Saur Conway, Amy, Tarlock, Katherine, Stieglitz, Elliot, Place, Andrew E., Puissant, Alexandre, Hunger, Stephen P., Kim, Annette S., Lindeman, Neal I., Gore, Lia, Janeway, Katherine A., Silverman, Lewis B., Tyner, Jeffrey W., Harris, Marian H., Loh, Mignon L. and Stegmaier, Kimberly (2021) Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium. Cancer Discovery, 11 (6). pp. 1424-1439. ISSN 2159-8274

Pinch, Benika, Buckley, Dennis, Gleim, Scott, Brittain, Scott, Tandeske, Laura, D'Alessandro, Pier Luca, Hauseman, Zachary , Lipps, Jennifer, Xu, Lei, Harvey, Edward , Schirle, Markus, Sprague, Elizabeth, Forrester, William, Dovala, Dustin, McGregor, Lynn and Thoma, Claudio (2021) A Strategy to Assess the Cellular Activity of E3 Ligase Components against Neo-Substrates using Electrophilic Probes. Cell chemical biology. ISSN 24519456

Pistorius, Dominik, Buntin, Kathrin, Weber, Eric, Richard, Etienne, Bouquet, Caroline and Wollbrett, Severine (2021) Genetic engineering of Chromobacterium vaccinii DSM 25150 for improved production of FR900359. ChemRxiv (https://chemrxiv.org/).

Pistorius, Dominik, Buntin, Kathrin, Weber, Eric, Richard, Etienne, Bouquet, Caroline, Wollbrett, Severine, Regenass, Hugo, Peon, Victor, Boehm, Marcel, Kessler, Regis, Gempeler, Thomas, Haberkorn, Anne, Wimmer, Laurin, Lanshoeft, Christian, Davis, John, Hainzl, Dominik, D'Alessio, Tony, Manchado Robles, Eusebio and Petersen, Frank (2021) Promoter-driven overexpression in Chromobacterium vaccinii facilitates access to FR900359 and yields novel low abundance analogs. Chemistry A European Journal.

Plummer, Scott, Robinson, Richard, Smith, Marie, Chang, Jim, Lipschutz, Bruce, Wood, Alex and Gallou, Fabrice (2021) Continuous Slurry Plug Flow Fe/ppm Pd Nanoparticle-Catalyzed Suzuki-Miyaura Couplings in Water Utilizing Novel Solids Handling Equipment. Green Chemistry, 23 (19). pp. 7724-7730. ISSN 1463-92621463-9270

Prabhath , Anupama , Vernekar , Varadraj N, Vasu , Vignesh , Badon, Mary , Avochinou , Jean-Emmanuel, Asandei , Alexandru D, Kumbar , Sangamesh G, Weber, Eckhard and Laurencin , Cato T (2021) In Vitro Kinetic Degradation and In Vivo Biocompatibility Evaluation of Polycaprolactone-Based Growth Factor Delivery Matrices in the Rotator Cuff. Journal of Biomedical Materials Research Part A. ISSN 1549-32961552-4965

Quancard, Jean, bach, anders, cox, brian, craft, russel, finsinger, dirk, gueret , stephanie, hartung, ingo, laufer, stefan, messinger, josef, sbardella, gianluca and koolman, hannes (2021) The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery. ChemMedChem : chemistry enabling drug discovery.

Rader, Daniel, Maratos-Flier, Terry, Nguyen, Amanda, Hom, Douglas, Ferriere, Michael, Li, Yifang, Kompa, Jill, Martic, Miljen, Hinder, Markus, Basson, Craig, Yowe, David, Diener, John and Goldfine, Allison (2021) LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in obese persons with modestly elevated triglycerides: A 12 Week Randomized Double Blind Placebo Controlled Study. Journal of Clinical Endocrinology and Metabolism.

Rader, Daniel, Maratos-Flier, Terry, Nguyen, Amanda, Hom, Douglas, Ferriere, Michael, Li, Yifang, Kompa, Jill, Martic, Miljen, Hinder, Markus, Basson, Craig, Yowe, David, Diener, John and Goldfine, Allison (2021) LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in obese persons with modestly elevated triglycerides: A 12 Week Randomized Double Blind Placebo Controlled Study. Journal of Clinical Endocrinology and Metabolism.

Rago, Florencia, Rodrigues, Lindsey, Bonney, Megan, Sprouffske, Kathleen, Kurth, Esther, Elliott, GiNell, Ambrose, Jessi, Aspesi Jr, Peter, Oborski, Justin, Chen, Julie, McDonald III, Earl, Mapa, Felipa, Ruddy, David, Kauffmann, Audrey, Abrams, Tinya, Bhang, Hyo-eun and Jagani, Zainab (2021) Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia. BioRxiv.

Reilly, Dorothy (2021) FAIRification at Novartis, published as one section in Why FAIR?: A course module for the IMI FAIRplus Fellowship training program. The FAIRplus Fellowship Programme. ISSN https://ilias.fraunhofer.de/ilias.php?baseClass=ilSAHSPresentationGUI&ref_id=17151

Remillard, David, Savage, Nik, Kedves, Alexia, Paulk, Josh, Chen, Xin, Garcia, Francisco, Romanowski, Michael, Horton, Patricia, Murphy, Jason, Maxwell, Matthew, Pham, Helen, Maksimovic, Igor, Thomas, Jason and Forrester, William (2021) Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8. ACS Chemical Biology.

Risitano, Antonio, Röth, Alexander, Soret, Juliette, Frieri, Camilla, Sicre de Fontbrune, Flore, Marano, Luana, Alashkar, Ferras, Rozenberg, Izabela, Milojevic, Julie, End, Peter, Nidamarthy, Prasanna, Junge, Guido and Peffault de Latour, Regis (2021) Addition of iptacopan, an oral factor B inhibitor, to eculizumab in patients with paroxysmal nocturnal haemoglobinuria and active haemolysis: an open-label, single-arm, phase 2, proof-of-concept trial. The Lancet. Haematology. ISSN 2352-3026

Robbins, Jeremy M, Peterson, Bennet, Schranner, Daniela, Tahir, Usman A, Keyes, Michelle, Katz, Daniel, Jean Beltran, Pierre M, Barber, Jacob L, Baumgartner, Christian, Carr, Steven A, Ghosh, Sujoy, Jennings, Lori, Shen, Changyu, Sarzynski, Mark A, Bouchard, Claude and Gerszten , Robert E (2021) Human plasma proteomic profiles indicative of cardiorespiratory fitness. Nature Metabolism. ISSN 25225812

Robbins, Lindsey A., Green-Miller, Angela R., Johnson, Jay S. and Gaskill, Brianna N. (2021) One Is the Coldest Number: How Group Size and Body Weight Affect Thermal Preference in Weaned Pigs (3 to 15 kg). Animals, 11 (5). p. 1447. ISSN 2076-2615

Rodon, Jordi, Argiles, Guillem, Connolly, Roisin, Vaishampayan, Ulka, de Jonge, Maja, Garralda, Elena, Giannakis, Marios, Smith, David C., Dobson, Jason, McLaughlin, Margaret, Seroutou, Abdelkader, Ji, Yan, Morawiak, Jennifer, Moody, Susan and Janku, Filip (2021) Phase I study of single-agent WNT974 a first-in-class Porcupine inhibitor, in patients with advanced solid tumors. British journal of cancer : BJC, 125. pp. 28-37. ISSN 1532-1827

Rodriguez Perez, Raquel and Bajorath, Jürgen (2021) Explainable Machine Learning for Property Predictions in Compound Optimization. Journal of medicinal chemistry, 64 (24). pp. 17744-17752. ISSN 1520-4804

Rodriguez Perez, Raquel and Bajorath, Jürgen (2021) Feature importance correlation from machine learning indicates functional relationships between proteins and similar compound binding characteristics. Scientific reports, 11.

Rodriguez Perez, Raquel and Gerebtzoff, Gregori (2021) Identification of bile salt export pump inhibitors using machine learning: Predictive safety from an industry perspective. Artificial Intelligence in the Life Sciences, 1. ISSN 26673185

Roehle, Kevin, Qiang, Li, Ventre, Katherine, Heid , Daniel, Ali, Lestat, Lenehan, Patrick, Heckler, Max, Crowley, Stephanie, Stump, Courtney, Ro, Gabrielle, Godicelj, Anze, Bhuiyan, Aladdin, Yang, Annan, Quiles del Rey, Maria, Biary, Tamara, Luoma, Adrienne, Bruck, Patrick, Tegethoff, Jana, Nopper, Svenja, Li, Jinyang, Byrne, Katelyn, Pelletier, Marc, Wucherpfennig , Kai, Stanger , Ben, Akin, James, Mancias, Joe, Agudo, Judith, Dougan, Michael and Dougan, Stephanie (2021) cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Science translational medicine, 13. ISSN 1946-6242

Roggo, Yves, Pellegatti, Laurent and Krumme, Markus (2021) Towards real-time release of pharmaceutical tablets: 100% in-line control via near-infrared spatially resolved spectroscopy and 3D microwave resonance technology. Journal of pharmaceutical and biomedical analysis. ISSN 07317085

Rowlands, Marianna, Segal, Florencia and Hartl, Dominik (2021) Myeloid-Derived Suppressor Cells as a Potential Biomarker and Therapeutic Target in COVID-19. Frontiers in immunology, 12. ISSN 1664-3224

Rueeger, Heinrich, Lueoend, Rainer Martin, Machauer, Rainer, Veenstra, Siem, Holzer, Philipp, Hurth, Konstanze, Voegtle, Markus, Frederiksen, Mathias, Rondeau, Jean-Michel, Tintelnot-Blomley, Marina, Jacobson, Laura, Staufenbiel, Matthias, Laue, Grit and Neumann, Ulf (2021) Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360. Journal of Medicinal Chemistry, 64 (8). pp. 4677-4696. ISSN 0022-26231520-4804

SEBASTIANI, PAOLA, MONTI, STEFANO, FEDERICO, ANTHONY, Morris, Melody, GURINOVICH, ANASTASIA, TOSHIKO, TANAKA, BHUTKAR, APARNA, ANDERSON, STACY L, FERRUCCI, LUIGI, Glass, David, Jennings, Lori and PERLS, THOMAS T (2021) Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans. Aging Cell. ISSN 14749726

Samant, Tanay, Yang, Shu, Miller, Michelle and Ji, Yan (2021) Pharmacokinetics of Ribociclib in Subjects With Hepatic Impairment. Journal of Clinical Pharmacology, 61 (8). pp. 1001-1009. ISSN 15524604

Sanchez, Carlos, Acker, Chris, Gray, Audrey, Varadarajan, Malini, An, Shaojian, Paula, Steve, Lindeman, Alicia, Alford, John, Reece-Hoyes, John, Russ, Carsten, Cochran, Nadire, McAllister, Gregory, Craig, Lucas, Capre, Ketthsy, Doherty, Christian and Elwood, Fiona (2021) Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons. Communications biology, 4 (1). p. 736. ISSN 23993642

Sanchez-Felix, Manuel (2021) Forming Partnerships and Meeting the Needs of Patient Populations. Partnership Opportunities in Drug Delivery Newletter. pp. 1-17.

Sanchez-Felix, Manuel (2021) Introduction video for Manuel Sanchez-Felix. Control Release Society. p. 1.

Sanchez-Felix, Manuel, Li, Yimeng , Ariotti, Nicholas , Aghaei-Ghareh-Bolagh, Behnaz , Pandzic, Elvis, Ganda, Sylvia , Willcox, Marc and Stenzel, Martina (2021) Inhibitive S. aureus Infection to HUVECs Induced by Trehalose and Glucose-functionalized Gold Nanoparticles. Angewandte Chemie.

Sanchez-Felix, Manuel, Zulick, Elizabeth, Sadler, Lauren-Ash and Bladon, Mariluci (2021) Education Pathway to Diversify STEM Workforce: A Call to Action for a Collaborative Ecosystem. American Association of Pharmaceutical Science Newsmagazine, August (1).

Santandrea, Ernesto, Waldraff, Christine, Gerber, Gilles, Moreau, Mael and Beney, Pascal (2021) Development of the late-phase manufacturing process to ZPL389: control of process impurities by enhanced process knowledge. Organic process research & development.

Saravanan, Chandrassegar, Flandre, Thierry, Hodo, Carolyn, Lewis, Anne, Mecklenburg, Lars, Romeike, Annette, Turner, Oliver and Yen, Hsi-Y (2021) Research Relevant Conditions and Pathology in Nonhuman Primates. ILAR Journal. ISSN 1084-20201930-6180

Schmelzer, Bernhard, Mischo, André and Innerbichler, Franz (2021) Statistically significant versus practically relevant trend in stability data. PDA journal of pharmaceutical science and technology. ISSN 19482124

Schneider, Anselm, Hackenberger, Christian, Kallen, Joerg, Ottl, Johannes, Reid, Patrick, Ripoche, Sebastien, Ruetz, Stephan, Stachyra, Therese-Marie, Hintermann, Samuel, Dumelin, Christoph and Marzinzik, Andreas (2021) Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors. RSC Chemical Biology. ISSN 2633-0679

Schuhmacher, Alexander, Brieke, Clara, Gassmann, Oliver, Hinder, Markus and Hartl, Dominik (2021) Systematic risk identification and assessment using a new risk map in pharmaceutical R&D. Drug discovery today, 21. S1359--6446.

Schuhmacher, Alexander, Wilisch, Lukas, Kandelbauer, Andreas, Hinder, Markus and Gassmann, Oliver (2021) R&D efficiency of leading pharmaceutical companies - a 20-year analysis. Drug Discovery Today, 2021 M (S1359-). pp. 36-41.

Schuhmacher, Alexander, Wilisch, Lukas, Kandelbauer, Andreas, Hinder, Markus and Gassmann, Oliver (2021) R&D efficiency of leading pharmaceutical companies — a 20-year analysis. Drug discovery today, May 20.

Schustak, Joshua, Twarog, Michael, Wu, Xiaoqiu, Wu, Henry, Huang, Qian and Bao, Yi (2021) Mechanism of nucleic acid sensing in retinal pigment epithelium (RPE): RIG-I mediates type I interferon response in human RPE. Journal of Immunology Research, 2021. pp. 1-14. ISSN 2314-71562314-8861

Schutten, Melissa, Knoblaugh, Sue, Salas , Elisa, Edmondson, Elijah, Cossic, Brieuc, Everitt, Jeffrey, Saravanan, Chandrassegar, Schmidt, Sarah, Schumacher, Vanessa and Zimmerman, Kurt (2021) Letter to the Editor Regarding “Pathology Informatics Education Committee of the American College of Veterinary Pathologists (ACVP)”. Toxicologic pathology, 49 (4). pp. 709-710. ISSN 1533-1601; 0192-6233

Schutzius, Gabi, Hauer, Christian, Bergling, Sebastian, Tortelli, Federico, Fuchs, Florian, Renner, Steffen, Guagnano, Vito, Cotesta, Simona, Rueeger, Heinrich, Faller, Michael, Bouchez, Laure, Salathe, Adrian, Nigsch, Florian, Richards, Shola, Louis, Malvina Caroline, Gruber, Viktoria, Aebi, Alexandra, Turner, Jonathan, Grandjean, Frederic, Li, Jun, Dimitri, Christopher, Thomas, Jason, Schirle, Markus, Blank, Jutta, Drueckes, Peter, Vaupel, Andrea, Tiedt, Ralph, Manley, Paul, Klopp, Julia, Hemmig, Rene, Zink, Florence, Leroy, Nelly, Carbone, Walter, Roma, Guglielmo, Gubser Keller, Caroline, Dales, Natalie, Beyerbach, Armin, Zimmerlin, Alfred Gilbert, Bonenfant, Debora, Terranova, Remi, Berwick, Amy, Sahambi, Sukhdeep, Reynolds, Aimee, Jennings, Lori, Ruffner, Heinz, Tarsa, Peter, Bouwmeester, Antonius, Driver, Vickie, Frederiksen, Mathias, Lohmann, Felix and Kirkland, Susan (2021) BET bromodomain inhibitors regulate keratinocyte plasticity. Nature Chemical Biology, 17 (3). pp. 280-290. ISSN 15524469

Sedlmayer, Ferdinand, Woischnig, Anne-Kathrin, Unterreiner, Vincent, Fuchs, Florian, Baeschlin, Daniel, Khanna, Nina and Fussenegger, Martin (2021) 5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice. Nucleic Acids Research. ISSN 0305-10481362-4962

Seidel, Jonathan, Goebel, Mathias, Dos Reis Rodrigues, Rui Claudio, Kaup, Nora, Rapp, Johanna, Frauenschuh, Achim, Shultz, Joseph and Cui, Huanchun (2021) Continuous Capture scale down model comparison of a continuous and a discrete approach. Biotechnology and Bioengineering. pp. 1-7.

Seo, Hyungseok, González-Avalos, Edahí, Zhang, Wade, Ramchandani, Payal, Yang, Chao, Lio, Chan-Wang J, Rao, Anjana and Hogan, Patrick G (2021) BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells. Nature immunology. ISSN 1529-2916

Seo, Hyungseok, González-Avalos, Edahí, Zhang, Wade, Ramchandani, Payal, Yang, Chao, Lio, Chan-Wang J., Rao, Anjana and Hogan, Patrick G. (2021) BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells. Nature Immunology. ISSN 1529-2908

Simm, Jaak, Humbeck, Lina, Zalewski, Adam, Sturm, Noe, Heyndrickx, Wouter, Moreau, Yves, Beck, Bernd and Schuffenhauer, Ansgar (2021) Splitting chemical structure data sets for federated privacy-preserving machine learning. Journal of cheminformatics, 13 (1). p. 96. ISSN 1758-2946

Sing, Tobias, Hoefling, Holger, Hossain, Imtiaz, Boisclair, Julie, Doelemeyer, Arno, Flandre, Thierry, Piaia, Alessandro, Romanet, Vincent, Santarossa, Gianluca, Saravanan, Chandrassegar, Spiegel, Stephan, Sutter, Esther, Turner, Oliver, Wuersch, Kuno and Moulin, Pierre (2021) HistoNet: A Deep Learning-Based Model of Normal Histology. Toxicologic Pathology, 49 (4). pp. 784-797. ISSN 15331601

Singh, Ashish Kumar, Schauer, Tamas, Pfaller, Lena, Straub, Tobias and Mueller-Planitz, Felix (2021) The biogenesis and function of nucleosome arrays. bioRxiv.

Song, Shuang, Cao, Chun, Choukrallah, Mohamed-Amin, Tang, Fengyuan, Christofori, Gerhard, Kohler, Hubertus, Wu, Fabian, Fodor, Barna, Frederiksen, Mathias, Willis, Simon N., Jackson, Jacob, Nutt, Stephen L., Dirnhofer, Stefan, Stadler, Michael and Matthias, Patrick (2021) OBF1 and Oct factors control the germinal center transcriptional program. Blood, 137 (21). pp. 2920-2934. ISSN 15280020

Spencer, Sarah, Chung, Jessie R., Belongia, Edward A., Sundaram, Maria, Meece, Jennifer, Coleman, Laura A., Zimmerman, Richard, Nowalk, Mary Patricia, Moehling, Krissy K., Ross, Ted, Carter, Chalise E., Shay, David, Levine, Min, Liepkalns, Justine, Kim, Jin Hyang, Sambhara, Suryaprakash, Thompson, Mark and Flannery, Brendan (2021) Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults. Influenza and other respiratory viruses. ISSN 1750-2659; 1750-2640

Stančič, Metka, Cvijic, Tamara, Kuzman, Drago, Mravljak, Rok, Gunčar, Gregor and Podgornik, Aleš (2021) Application of lectin immobilized on polyHIPE monoliths for bioprocess monitoring of Fc-fusion surface glycosylated protein. Journal of chromatography B : biomedical sciences and applications.

Straube, Frank and Cirera Salinas, Daniel (2021) Membrane-tethered mucins and lubricin mediate the interfacial properties of model ocular epithelial surfaces. Advanced Science. ISSN 2198-38442198-3844

Streffer, Johannes, Treyer, Valerie, Buck, Alfred, Ametamey, Simon, Blagoev, Milen, Schmidt, Mark, Gautier, Aurelie, Maguire, Paul, Auberson, Yves, Vranesic, Ivan-Toma, Gomez-Mancilla, Baltazar and Gasparini, Fabrizio (2021) Regional brain mGluR5 receptor occupancy following single oral doses of mavoglurant as measured by [11C]-ABP688 PET imaging in healthy volunteers. NeuroImage, 230. ISSN 10538119

Streubel-Gallasch, L, Giusti, V, Sandre, M, Tessari, I, Plotegher, N, Giusto, E, Masato, A, Iovino, L, Battisti, I, Arrigoni, G, Shimshek, Derya, Greggio, E, Tremblay, ME, Bubacco, L, Erlandsson, A and Civiero, L (2021) Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance. Molecular Neurobiology. ISSN 15591182

Sukseree, Supawadee, Bakiri, Latifa, Paloma-Irigoyen, Marta, Uluckan, Ozge, Petzelbauer, Peter and Wagner, Erwin (2021) Sequestosome 1/p62 enhances chronic skin inflammation. The Journal of allergy and clinical immunology. ISSN 10976825

Sverdlov, Alex, Curcic, Jelena, Hannesdottir, Kristin, De Luca, Valeria, Ambrosetti, Francesco , Zhang, Bingsong, Praestgaard, Jens, Vallejo, Vanessa, Dolman, Andrew, Gomez-Mancilla, Baltazar, Biliouris, Konstantinos, Deurinck, Mark, Cha, Jang-Ho, Cormack, Francesca, Anderson, John J., Bott, Nicholas, T., Peremen, Ziv, Issachar, Gil, Joachim, Dale, Kas , Martien, Zhuparris, Ahnjili and Jacobs, Gabriel (2021) A study of new exploratory tools, digital technologies and biomarkers to characterize depression. Frontiers in psychiatry, 12. ISSN 1664-0640

Tan, Susanne, Schellenberg, Doerte, Morton, Kayce, Dokras, Anuja, Seufert, Joachim, Zwanziger, Denise, Dunschen, Karin, Zakaria, Marjorie, Huseinovic, Neda, Basson, Craig, Fuhrer, Dagmar and Hinder, Markus (2021) Licogliflozin versus placebo in women with polycystic ovary syndrome: A randomized, double-blind, phase 2 trial. Diabetes, Obesity and Metabolism. pp. 1-5. ISSN 14631326

The SEQC-II consortium, - and Petitjean, Virginie (2021) Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing. Nature biotechnology, 39 (9). pp. 1141-1150. ISSN 1546-1696

Theut Riis, Peter, Loft , Isabella C, Yazdanyar, Shiva, Kjærsgaard Andersen, Rune, Pedersen, Ole B, Ring, Hans Christian, Huber, Roland, Sultan , Marc, Loesche, Christian, Saunte, Ditte ML and Jemec, Gregor BE (2021) Full exome sequencing of 11 families with Hidradenitis suppurativa. Full exome sequencing of 11 families with Hidradenitis suppurativa. , 35 (5). pp. 1203-1211. ISSN 0926-9959 , 1468-3083

Thomas, Ranjeny, Carballido, Jose, Wesley, Johnna D and Ahmed, Simi (2021) Overcoming obstacles in the development of antigen-specific immunotherapies for type 1 diabetes. Frontiers in immunology, 12. ISSN 1664-3224

To, Jeremy, Quackenbush, Doug, Rowell, Emily, Li, Lilin, Lo, Frederick and Horman, Shane (2021) A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function. Communications biology, 4. p. 56. ISSN 2399-3642

Tong, Bingqi, Belcher, Bridget, Nomura, Daniel and Maimone, Thomas (2021) Chemical Investigations of Gymnastatin and Dankastatin Alkaloid Biosynthesis. Frontiers of Chemical Science and Engineering, 12 (25). pp. 8884-8891. ISSN 2041-65202041-6539

Tsai, Wan-Chen, Aleem, Ansari Mukhtar, Whittington, Chris, Cortopassi, Wilian A., Kalyanaraman, Chakrapani, Baroz, Angel, Iavarone, Anthony T., Skrzypczak-Jankun, Ewa, Jacobson, Matthew P., Offenbacher, Adam R. and Holman, Theodore (2021) Mutagenesis, Hydrogen–Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase. Biochemistry, 60 (10). pp. 802-812. ISSN 0006-2960

Tummino, Tia, Rezelj, Veronica, Fischer, Benoit, Fischer, Audrey, o'Donnel, Henry, Monel, Blandine, Vallet, Thomas, Zhang, Ziyang, Alon, Assaf, Lyu, Jiankun, Schadt, Heiko, White, Kris, o'Meara, Matthew, Krogan , Nevan, Shokat, Kevan, Urban, Laszlo, Kruse, Andrew, Garcia-Sastre, Adolfo, Schwarz, Olivier, Moretti, Francesca, Vignuzzi, Marco, Pognan, Francois and Shoichet, Brian (2021) Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science. ISSN 0036-8075

Turner, Oliver, Rudmann, Daniel, Knight, Brian, Zuraw, Aleksandra and Litjens, Geert (2021) Mini Review: The Last Mile—Opportunities and Challenges for Machine Learning in Digital Toxicologic Pathology. Toxicologic pathology.

Unterreiner, Adeline, Rubert, Joelle, Kauffmann, Muriel, Fruhauf, Alice, Heiser, Diane, Erbel, Paulus, Schlapbach, Achim, Eder, Joerg, Bodendorf, Ursula, Boettcher, Andreas, Farady, Christopher and Bornancin, Frederic (2021) Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1. Biochemical and biophysical research communications : BBRC, 545. pp. 177-182. ISSN 0006291X

Valencia, Jessica, Megnin, Michelle, Collyar, Deborah, Guerreiro, Debra, Kashuba, Maureen, Klim, Lotte, Murray, Caragh, Patrick, Susan, Schindler, Thomas and Vashisht, Vidhi (2021) Presenting secondary endpoints in plain language clinical trial result summaries: Considerations for emerging practice. 'Medical Writing' - Quarterly publication produced by European Medical Writers Association , Volume (Issue ). pp. 58-67. ISSN 2047-4814

Velasco-Estevez, M, Koch, N, Klejbor, I, Laurent, Stephane, Dev, K, Szutowicz, A, Sailer, Andreas and Rutkowska, A (2021) Ebi2 is temporarily upregulated in mo3.13 oligodendrocytes during maturation and regulates remyelination in the organotypic cerebellar slice model. International Journal of Molecular Sciences, 22 (9). ISSN 14220067

Ventrella, Domenico, Ashkenazi, Nurit, Elmi, Alberto, Allegaert, Karel, Aniballi, Camilla, DeLise, Anthony, Devine, PJ, Smits, Anne, Steiner, Lilach, Forni, Monica, Bouisset-Leonard, Michele and Bacci, Maria Laura (2021) Animal models for in vivo lactation studies: anatomy, physiology and milk compositions in the most used non-clinical species, a contribution from the ConcePTION project. Animals, 11 (3). pp. 714-733. ISSN 2076-2615

Vermeulen, Koen, Cools, Romy, Briard, Emmanuelle, Auberson, Yves, Schoepfer, Joseph, Koole, Michel, Cawthorne, Christopher and Bormans, Guy (2021) Preclinical evaluation of [11C]YC-72-AB85 for in vivo visualisation of heat shock protein 90 in brain and cancer with positron emission tomography. Molecular Pharmaceutics, 18 (9). pp. 3352-3364. ISSN 1543-83841543-8392

Vidal, Justin, Colman, Karyn, Bhaskaran, Manoj, de Rijk, Eveline, Fegley, Darren, Haplern, Wendy, Jacob, Binod, Kandori, Hitoshi, Manickam, Balasubramanian, McKeag, Sean, Parker, George A., Regan, Karen S., Sefing, Benjamin, Thibodeau, Michael, Vemireddi, Vimala, Werner, Jonathan and Zalewska, Aleksandra (2021) Scientific and Regulatory Policy Committee Best Practices*: Documentation of Sexual Maturity by Microscopic Evaluation in Nonclinical Safety Studies. Toxicologic Pathology. ISSN 15331601

Vittal, Shivva, Fink, Martin and Lowe, Philip J (2021) Improving priors for human monoclonal antibody linear pharmacokinetic parameters by using half-lives from non-human primates. Journal of Pharmacokinetics and Pharmacodynamics. ISSN 15738744

Vorherr, Thomas (2021) Important considerations related to permeability of peptides. Chimia., 75 (6). pp. 522-524.

Vulpetti, Anna and Dalvit, Claudio (2021) Hydrogen Bond Acceptor Propensity of different Fluorine Atom Types: An Analysis of Experimentally- and Computationally-derived Parameters. Chemistry (Weinheim an der Bergstrasse, Germany), 27 (34). pp. 8764-8773. ISSN 15213765

Waehle, Verena, Ungricht, Rosemarie, Hoppe, Philipp and Betschinger, Joerg (2021) The tumor suppressor WT1 drives progenitor cell progression and epithelialization to prevent Wilms tumorigenesis in human kidney organoids. Stem cell reports, 16. pp. 1-11. ISSN 2213-6711

Walker, Keenan A., Chen, Jingsha, Zhang, Jingning, Fornage, Myriam, Tin, Adrienne, Daya, Natalie, Hoogeveen, Ron C, Wu, Aozhou, Sullivan, Kevin J, Ganz, Peter, Zeger, Scott L, Yang, Yunju, Gudmundsson, Elias F, Emilsson, Valur, Launer, Lenore J, Jennings, Lori, Gudnason, Vilmundur, Chatterjee, Nilanjan, Gottesman, Rebecca F, Mosley, Thomas H, Boerwinkle, Eric, Ballantyne, Christie M, Coresh, Josef, Zhou, Linda and Grams, Morgan E (2021) Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk. Nature Aging.

Walles, Markus (2021) Meeting report of the first European Biotransformation Workshop. Xenobiotica. pp. 1-6. ISSN 34284691

Walles, Markus and Hainzl, Dominik (2021) Risk-Based Pharmacokinetic and Drug-Drug Interaction Characterization of Antibody-Drug Conjugates in Clinical Development: An IQ Consortium Perspective. Clinical pharmacology and Therapeutics. ISSN 34657311

Wang, Hui-Qin, Mulford, Iain, Sharp, Fiona, Liang, Jinsheng, Kurtulus-Aksoylar, Sema, Trabucco, Gina, Quinn, David, Longmire, Tyler, Patel, Nidhi, Shirley, Matt, Chen, Yan, Wang, Hao, Ruddy, David, Fabre, Claire, Williams, Juliet, Hammerman, Peter, Mataraza, Jennifer, Platzer, Barbara and Halilovic, Ensar (2021) Inhibition of MDM2 promotes antitumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment. Cancer Research, 81 (11). pp. 3079-3091. ISSN 15387445

Wang, Xinting, Bartels, Christian, Kulkarni, Swarupa, Sangana, Ramachandra, Jain, Monish, Zack, Julia and Yu, Jing (2021) Population Pharmacokinetic Analysis of Fevipiprant in Healthy Subjects and Asthma Patients using a Tukey's g-and-h Distribution. Drug Research. ISSN 21949387

Wang, Zhongyi, Keogh, Adrian, Waldt, Annick, Cuttat-Theurillat, Rachel, Neri, Marilisa, Zhu, Shanshan, Schuierer, Sven, Ruchti, Alexandra, Crochemore, Christophe, Knehr, Judith, Jourdain, Marie, Weber, Delphine, Bastien, Julie, Roma, Guglielmo, Ksiazek, Iwona, Ge, Hui, Wu, Jing, Sánchez-Taltavull, Daniel , Helliwell , Stephen , Stroka , Deborah and Nigsch, Florian (2021) Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis. Scientific reports, 11. ISSN 2045-2322

Wang-Lakshman, Lydia, Mendonza, Anisha, Huber, Roland, Walles, Markus, He, Yan-Ling and Jarugula, Venkateswar (2021) Pharmacokinetics, Metabolism, and Excretion of Licogliflozin, a Dual Inhibitor of SGLT1/2, in Rats, Dogs, and Humans. Xenobiotica.

Wang-Lakshman, Lydia, Zhuang, Miao, Wang, Lai, Gu, Helen, Gu, Jessie, McNamara, Elizabeth, Walles, Markus, Woessner, Ralph, Camenisch, Gian P., Einolf, Heidi and Chen, Jin (2021) Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1 mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependency of Tropifexor Metabolism. Drug metabolism and disposition, 49 (7). pp. 548-562. ISSN 1521-009X

Wasserbacher, Helmut and Spindler, Martin (2021) Machine learning for financial forecasting, planning and analysis: recent developments and pitfalls. Digital Finance.

Weiss, Markus, Cain, Meredith, Langenickel, Thomas, Kulkarni, Swarupa, Shah, Bharti, Rahmanzadeh, Gholamreza, Poller, Birk and Vemula, Janardhana Rao (2021) Clinical investigation of metabolic and renal clearance pathways contributing to the elimination of fevipiprant using probenecid as perpetrator. Drug metabolism and disposition, 49 (5). pp. 389-394. ISSN 1521-009X

Widmer, Hans (2021) Open innovation: the many shades of a promising road to scientific discoveries. NCCR TransCure newsletter .

Willemsen, Joschka, Hoyler, Thomas, Noir, Emma, Tessier, Clemence, Sarret, Sophie, Thorsen, Tara Nicole, Littlewood-Evans, Amanda, Zhang, Juan, Rush, James, Guerini, Danilo and Siegel, Richard (2021) TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis. Cell reports, 37 (6). p. 109977. ISSN 2211-1247

Woicke, Jochen, Al-Haddawi, Muthafar M, Bienvenu, Jean-Guy, Caverley Rae, Jessica M, Chanut, Franck J, Colman, Karyn, Cullen, John, Davis, Wendell, Fukuda, Ryo, Huisinga, Maike, Junker Walker, Ursula, Kai, Kiyonori, Kovi, Ramesh C, Macri, Nicholas P, Marxfeld, Heike-Antje, Nikula, Kristin J, Pardo, Ingrid D, Rosol, Thomas J, Sharma, Alok K, Singh, Bhanu P, Tamura, Kazutoshi, Thibodeau, Michael S, Vezzali, Enrico, Vidal, Justin D and Meseck, Emily (2021) International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog. Toxicologic Pathology, 49 (1). pp. 5-109. ISSN 15331601

Wolf, Babette, Jeliazkova-Mecheva, Valentina, Del Rio Espinola, Alberto, Cochin de Billy, Benjamin, Boisclair, Julie, Walker, Dana, Flaherty, Meghan and Flandre, Thierry (2021) An afucosylated anti-CD32b monoclonal antibody induced platelet-mediated adverse events in human Fcg receptor transgenic mouse model and its potential human translatability. Toxicological sciences. ISSN 1096-0929; 1096-6080

Wolf, Thomas, Meishammer, Aldo, Patissier, Celine, Reck, Marcel, Valente, Claudio and Reilly, John (2021) Achiral SFC for Purification of Pharmaceuticals. Chromatography Today , Nov 20. pp. 12-14.

Wong, Nicole N., Frias, Elizabeth, Sigoillot, Frederic, Letendre, Justin, Hild, Marc and Wong, Wilson W. (2021) Engineering digitizer circuits for chemical and genetic screens in human cells. Nature communications, 12 (1). p. 6150. ISSN 2041-1723

Wuensch, Isabell, Finke, Jan, John, Edgar, Juhnke, Michael and Kwade, Arno (2021) The influence of particle size on the application of compression and compaction models for tableting. International journal of pharmaceutics, 599 (n/a). 120424-n/a. ISSN 0378-5173

Wygant, Matthew and Kikuchi, Lena (2021) Reducing protein quantification bottlenecks by automating the Octet® HTX with a Hudson PlateCrane. Hudson Robotics Application Note.

Wünsch, Isabell, Michel, Stephanie, Finke, Jan Henrik, John, Edgar, Juhnke, Michael and Kwade, Arno (2021) How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression? European Journal of Pharmaceutics and Biopharmaceutics, 165 (n/a). pp. 203-218. ISSN 0939-6411

Xu, Huilei, Hon, Claudia, Kaiser, Sergio, Serrano Fernandez, Pablo, Hartmann, Nicole, Yates, Denise, Healey, Margaret, Gusev, Arkady, Laramie, Jason, Kennedy, Scott, Marc, Philippe, Paul, Ridker, Obeidat, Maen, Beste, Michael, Svensson, Eric and Madar, Aviv (2021) Coronary artery disease polygenic risk score identifies patients at higher risk for recurrent cardiovascular events in the CANTOS Trial. Circulation: Genomics and Precision Medicine.

Zhang, Zhe (2021) Solving Complex Biologics Truncation Problems by Top-Down Mass Spectrometry. Journal of the American Society for Mass Spectrometry. ISSN 1879-1123; 1044-0305

Zhao, Kangming, Ge, Xiaobin, Zheng, Yu, Shen, Xiaodong, Shi, Lei, Gallou, Fabrice, Cortes-Clerget, Margery , Louis Regnier, Morgan , Parmentier, Michael, Ye, Ning and Wu, Bin (2021) Micelle enabled C(sp2)–C(sp3) cross-electrophile coupling in water via synergistic nickel and copper catalysis†. Chemical Communications, 57 (62). pp. 7629-7632. ISSN 1359-73451364-548X

Zhao, Yongmei, Tai Fang, Li, Shen, Tsai-wei, Houdhari, Sulbha, Talsania, Keyur, Chen, Jack, Shetty, Jyoti, Kriga, Yuliya, Tran, Bao, Zhu, Bin, Chen, Zhong, Chen, Wanqiu, Wang, Charles, Jaeger, Erich, Meerzaman, Daoud, Lu, Charles, Idler, Kenneth, Zheng, Yuanting, Shi, Leming, Petitjean, Virginie, Sultan, Marc, Hung, Tiffany, Eric, Peters, Drabek, Jiri, Vojta, Petr, Maestro, Roberta, Gasparotto, Daniela, Koks, Sulev, Reimann, Ene, Scherer, Andreas, Nordlund, Jessica, Liljedahl, Ulrika, Foox, Jonathan, Mason, Christopher, Xiao, Chunlin and Xiao, Wenming (2021) Whole genome and exome sequencing reference datasets from a multi-center and cross-platform benchmark study. Scientific data, 8 (1). p. 296. ISSN 2052-4463

Zhou, Lili , Miller, Caitlyn , Miraglia, Loren, Mendiola, Angelica, Mure, Ludovic S. , Panda, Satchidananda , Xiao, Changchun and Kay, Steve (2021) A genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms. Proceedings of the National Academy of Sciences, 118 (1). ISSN 0027-84241091-6490

Zuo, Zhaorui, Wang, Penglei, Chen, Xiaowei, Tian, Li, Ge, Hui and Qian, Dahong (2021) SWnet: a deep learning model for drug response prediction from cancer genomic signatures and compound chemical structures. BMC bioinformatics, 22 (1). p. 434. ISSN 1471-2105

van Hoogevest, Peter, Tiemessen, Harry, Metselaar, Josbert and Fahr, Alfred (2021) The Use of Phospholipids to make Pharmaceutical Form Line Extensions. European Journal of Lipid Science and Technology. ISSN 1438-76971438-9312

This list was generated on Wed Aug 17 17:56:23 2022 UTC.

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.