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Article

Abend, Johanna, Sathe, Atul, Changala, Marguerite, Casey, Fergal, Kistler, Amy, Chandran, Sindhu, Howard, Abigail and Wojciechowski, David (2016) Correlation of BK Virus Neutralizing Serostatus with the Incidence of BK Viremia in Kidney Transplant Recipients. Transplantation. p. 1. ISSN 0041-1337

Abramowski, Dorothee and Staufenbiel, Matthias (2016) Co-expression of truncated and full-length tau induces severe neurotoxicity. Mol Psychiatry. ISSN 1359-4184

Accart Gris, Nathalie, Dawson King, Janet, Kramer, Ina, Kolbinger, Frank and Beckmann, Nicolau (2016) NON-INVASIVE IMAGING DEMONSTRATES CLINICAL FEATURES OF THE PATHOLOGY IN A RAT ADJUVANT MODEL FOR ANKYLOSING SPONDYLITIS. European journal of histochemistry : EJH., 60 (4). p. 2667. ISSN 2038-8306

Achichi, Manel, Chetham, Michelle, Dragisic, Zlatan, Euzenat, Jerome, Faria, Daniel, Ferrara, Alfio, Flouris, Giorgios, Fundulaki, Irini, Harrow, Ian, Ivanova, Valentina, Jimenez-Ruiz, Ernesto, Kuss, Elena, Lambrix, Patrick, Leopold, Henrik, Meilicke, Christian, Montanelli, Stefano, Pesquita, Catia and Saveta, Tzanina (2016) Results of the Ontology Alignment Evaluation Initiative 2016. CEUR Proceedings, 1766. pp. 73-129. ISSN 1613-0073

Agarinis, Claudia, Orsini, Vanessa, Megel, Philippe, Abraham, Yann, Yang, Haidi, Mickanin, Craig, Bouwmeester, Antonius, Tchorz, Jan and Parker, Christian (2016) Activation of Yap Directed Transcription by Knock-down of Conserved Cellular Functions. Journal of Biomolecular Screening.

Agarinis, Claudia, Orsini, Vanessa, Megel, Philippe, Abraham, Yann, Yang, Haidi, Mickanin, Craig, Myer, Vic, Bouwmeester, Antonius, Tchorz, Jan and Parker, Christian (2016) Activation of Yap Directed Transcription by Knock-down of Conserved Cellular Functions. Journal of Biomolecular Screening.

Akahane, Koshi, Sanda, Takaomi, Mansour, Marc R., Radimerski, Thomas, Weinstock, David M., Letai, Anthony and Look, Thomas (2016) HSP90 Inhibition Leads to Degradation of the TYK2 Kinase and Apoptotic Cell Death in T-Cell Acute Lymphoblastic Leukemia. Leukemia, 30 (1). pp. 219-228. ISSN 1476-5551; 0887-6924

Akahori, Mizuki, Ayalasomayajula, Surya, Langenickel, Thomas Heiko, Pal, Parasar and Sunkara, Gangadhar (2016) Pharmacokinetics after single ascending dose, food effect, and safety of sacubitril/valsartan (LCZ696), a novel angiotensin receptor and neprilysin inhibitor, in healthy Japanese subjects. European Journal of Drug Metabolism and Pharmacokinetics, Epub a (NA). NA-NA. ISSN 2107-0180

Alper, Phillip and Ratnikov, Max (2016) GNF portion of an NSF GOALI grant proposal on flow photochemistry to be submitted with Professor Gary Molander from U Penn. NSF Review Committee, None (None). pp. 1-85. ISSN None

Althof, Erwin and Nijholt, Ralf (2016) Novartis & SiLA—Partners in Simplifying Lab Automation Implementations. Novartis & SiLA—Partners in Simplifying Lab Automation Implementations.

Altmann, Eva, Schlierf, Anita, Jefferson, AB, Renatus, Martin, Jones, Matthew, Hassiepen, Ulrich, Assenberg, Rene, Schaefer, Michael, Quancard, Jean, Kiffe, Michael, Weiss, Andreas, Wiesmann, Christian, Sedrani, Richard, Eder, Joerg and Martoglio, Bruno (2016) A first-in-class small molecule inhibitor of the COP9 signalosome subunit 5 for the treatment of cancer. Nature communications, 7. pp. 13166-13175. ISSN 2041-1723

Amaral, Adam, Saran, Chitra, Amin, Jakal and Hatsis, Panagiotis (2016) A Comparison of LC-MS/MS and a Fully Integrated Autosampler/Solid Phase Extraction System for the Analysis of Protein Binding Samples. Journal of Biomolecular Screening. ISSN 1552-454X

Anders, Gerd, Hassiepen, Ulrich, Theisgen, Stephan, Heymann, Stephan, Muller, Lionel, Panigada, Tania, Huster, Daniel and Samsonov, Sergey (2016) The Intrinsic Pepsin Resistance of Interleukin-8 Can be Explained from a Combined Bioinformatical and Experimental Approach. IEEE TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, PP (99). p. 1. ISSN 1545-5963

Andersen, ND, Nielsen, BE, Corradi, J, Tolosa, MF, Feuerbach, Dominik, Arias, HR and Bouzat, C (2016) Exploring the Positive Allosteric Modulation of Human α7 Nicotinic Receptors from a Single-Channel Perspective. Neuropharmacology.

Arenas-Amirez, Natalia, Zou, Chao, Popp, Simone, Zingg, Daniel, Brannetti, Barbara, Wirth, Emmanuelle, Calzascia, Thomas, Kovarik, Jiri, Sommer , Lukas, Zenke, Gerhard, Woytschak, Janine, Regnier, Catherine, Katopodis, Andreas and Boyman, Onur (2016) Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2. Science Translational Medicine, 8 (367). ISSN 1946-62341946-6242

Argikar, Upendra, Bushee, Jennifer and Dunne, Christine (2016) An in vitro approach to investigate ocular metabolism: Part I - Levobunolol. Drug metabolism and disposition, 44 (8). pp. 1304-1312. ISSN 1521-009X

Argikar, Upendra, Potter, Phil, Matthew, Hutzler and Punit, Marathe (2016) Challenges and Opportunities with Non-CYP Enzymes Aldehyde oxidase, Carboxyl esterase and UDP-glucuronosyl transferase. Focus on Reaction Phenotyping and Prediction of Human Clearance. AAPS Journal, 18 (6). pp. 1391-1405. ISSN N/A

Arias, HR, Ravazzini, F, Targowska-Duda, KM, Kaczor, AA, Feuerbach, Dominik, Boffi, JC, Draczkowski, P, Montag, D, Brown, BM, Elgoyhen, AB, Jozwiak, K and Puia, G (2016) Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. The International Journal of Biochemistry & Cell Biology.

Ashok, Yashwanth and Jaakola, Veli-Pekka (2016) Nanodisc-Tm: Rapid functional assessment of nanodisc reconstituted membrane proteins by CPM assay. MethodsX, 3. pp. 212-218. ISSN 22150161

Atienzar, Franck, Blomme, Eric, Chen, Minjun, Hewit , Philip, Kenna, Gerry, Labbe, Gilles, LeCluyse, Edward, Moulin, Frederic, Pognan, Francois, Roth, Adrian, Suter-Dick, Laura, Ukairo, Okechukwu, Weaver, Richard, Will, Yvonne and Dambach, Donna (2016) Key challenges and opportunities associated with the use of in vitro models to detect human DILI: integrated risk assessment and mitigation plans. BioMed Research International, 2016 (-). pp. 1-20. ISSN 10.1155

Auberson, Yves, Briard, Emmanuelle, Sykes, David, Reilly, John and Healy, Mark (2016) The Ligand Specific Efficiency (LSE) index for PET tracer optimization, illustrated with tracer candidates for imaging the prostacyclin receptor. ChemMedChem, 11 (13). pp. 1415-1427. ISSN don't know

Auld, Douglas (2016) Doug Auld—Interview for November 2016 issue of Assays and Drug Dev. Technologies (Mary Ann Liebert Inc., publishing). Assay and drug development technologies, 14 (9). pp. 518-523.

Auld, Douglas, Busby, Scott, Chen, Kiki, Jimenez, Marta, Yue, Qing, Bowes, Scott, Wendel, Gregory, Smith, Thomas and Zhang, Ji (2016) Matrix-Based Activity Pattern Classification as a Novel Method for the Characterization of Enzyme Inhibitors Derived from High-Throughput Screening. Journal of Biomolecular Screening, 21 (10). pp. 1075-1089. ISSN 1552-454X

Ayalasomayajula, Surya, Langenickel, Thomas Heiko, Priya, Chandra, Wolfson, Edward, Albrecht, Diego, Zhou, Wei, Pal, Parasar, Rajman, Iris and Sunkara, Gangadhar (2016) Effect of food on the oral bioavailability of the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan (LCZ696) in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics, 54 (12). pp. 1012-1018. ISSN 0946-1965

Bacioglu, Mehtap, Maia, Luis, Schelle, Juliane, Kaeser, Stephan, Schweighauser, Manuel, Shimshek, Derya, Neumann, Ulf, Preische, Oliver, Kahle, Philipp, Staufenbiel, Matthias, Neumann, Manuela, Kuhle, jens and Jucker, Mathias (2016) Neurofilament light chain in blood and CSF as marker of disease progression in mouse models of neurodegenerative diseases. Neuron, 91 (1). pp. 56-66. ISSN 08966273

Bakker, Maarten H., Lee, Cameron, Meijer, E. W., Dankers, Patricia Y. W. and Albertazzi, Lorenzo (2016) Supramolecular multicomponent BTA polymers as a modular platform for intracellular delivery. ACS Nano, 10 (2). pp. 1845-1852. ISSN 1936-08511936-086X

Balko, Justin M and Arteaga, Carlos L (2016) Tumors with amplifications of JAK2 at the 9p24 loci in TNBC demonstrate JAK2-specific dependency. Sci Transl Med., 8 (334). pp. 334-353. ISSN 1946-6242

Bastakoty, Dikshya , Saraswati, Sarika , Atkinson, James , Feoktistov, Igor, Liu, Jun, Harris, Jennifer and Young, Pampee (2016) Temporary, Systemic Inhibition of the WNT/β- Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, Stem cells and Regenerative Medicine, 2 (2). pp. 1-13. ISSN 2472-6990

Bauer, Daniel, Soon, Rachel, Kulmatycki, Kenneth, Chen, Yuming, Noe, Adele, Chen, Jin, Dosik, Jonathan and Meyers, Charles (2016) Photosensitizing potential of pradigastat in healthy subjects: a randomized controlled trial using three defined sunlight exposure conditions. Photochem. Photobiol. Sci., 15 (9). pp. 1155-1162. ISSN 1474-905X1474-9092

Bautista Mercader, Manuel, Tosini, Federico, Schneider, Marcel and Steigmiller, Stefan (2016) Transmission Raman Spectroscopy (TRS): how far can we go with the analysis of capsule based Dry Powder Inhalers? European Pharmaceutical Review, 21 (6). pp. 6-10.

Beckmann, Nicolau, Doelemeyer, Arno, Zurbruegg, Stefan, Bigot, Karine, Theil, Diethilde, Frieauff, Wilfried, Kolly, Carine, Neddermann, Daniel, Kreutzer, Robert, Perrot, Ludovic, Brzak, Irena, Jacobson, Laura, Staufenbiel, Matthias, Neumann, Ulf and Shimshek, Derya (2016) Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice. Neurobiology of Aging, 45. pp. 50-60. ISSN 01974580

Ben M'Barek, Mohamed, Redrup, Michael J, Igarashi, Harue , Schaefgen, Jay , Lin, Jenny , Geisler, Lisa , Ramachandran, Subramanian , Cardoso, Thales and Hillewaert, Vera (2016) Sample Management: Recommendation for best practices and harmonization from the Global Bioanalysis Consortium Harmonization Team. The AAPS Journal, Volume (Issue ). pp. 290-293. ISSN 1550-7416

Bende, Girish, Biswal, Shibadas, Bhad, Prafulla, Chen, Yuming, Salunke, Atish Azad, Winter, Serge, Wagner, Robert and Sunkara, Gangadhar (2016) Relative bioavailability of diclofenac potassium from softgel capsule versus powder for oral solution and immediate-release tablet formulation. Clinical Pharmacology in Drug Development, 5 (1). pp. 76-82. ISSN 2160-7648

Benoit, Roger, Ostermeier, Christian, Geiser, Martin, Widmer, Hans, Auer, Manfred and Li, Julia Su Zhou (2016) Seamless insert-plasmid assembly at high efficiency and low cost. PLOS ONE, April . pp. 1-13.

Berg, Daniela, Godau, Jana, Trenkwalder, Claudia, Eggert, Karla, Csoti, Ilona, Storch, Alexander, Huber, Heiko, Morelli-Canelo, Monica, Stamelou, Maria, Ries, Vincent, Wolz, Martin, Schneider, Christine, Di Paolo, Thérèse, Gasparini, Fabrizio, Hariry, Sam, Vandemeulebroecke, Marc, Gomez-Mancilla, Baltazar, Abi-Saab, Walid, Johns, Donald and Cooke, Katy (2016) AFQ056 treatment of levodopa-induced dyskinesias: results of two randomized controlled trials. Movement Disorders, 26 (7). pp. 1243-1250.

Bergeron, Sophie and Grant, James (2016) Validity Studies - Enhancing Patent Searches. Pharmaceutical patent analyst, Unknow (Unknow). XX-YY. ISSN 2046-8954

Berghausen, Joerg, Seiler, Frank Hans, Gobeau, Nathalie and Faller, Bernard (2016) Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range. ADMET&DMPK.

Bergsdorf, Christian, Fiez-Vandal, Cedric, Sykes, David, Bernet, Pascal, Aussenac, Sonia, Charlton, Steven, Schopfer, Ulrich, Ottl, Johannes and Duckely, Myriam (2016) An alternative thiol-reactive dye to analyze ligand interactions with the chemokine receptor CXCR2 using a new thermal shift assay format. Journal of Biomolecular Screening, 21 (3). pp. 243-251. ISSN 1087-05711552-454X

Bernasconi-Elias, Paula, Hu, Tiancen, Jenkins, David, Firestone, Brant, Gans, Sara, Kurth, Esther, Capodieci, Paola, Deplazes-Lauber, Joelle, Petropoulos, Konstantin, Thiel, Phillip, Ponsel, Dirk, Choi, Sung Hee, Lemotte, Peter, London, Anne, Goetcshkes, Margaret, Nolin, Erin, Jones, Michael, Slocum, Kelly, Kluk, Michael, Weinstock, David, Christodoulou, Alexandra, Weinberg, Olga, Jaehrling, Jan, Ettenberg, Seth, Buckler, Alan, Blacklow, Stephen, Aster, Jon and Fryer, Christy (2016) Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. ISSN 0950-92321476-5594

Beverly, Michael, Dell, Amy, Parmar, Parul and Houghton, Leslie (2016) Label-free analysis of mRNA capping efficiency using RNAse H probes and LC-MS. Analytical and Bioanalytical Chemistry, 408 (18). pp. 5021-5030. ISSN 1618-2650

Bhoumik, Priyasma, Del Rio Espinola, Alberto, Hahne, Florian, Moggs, Jonathan and Grenet, Olivier (2016) Translational Safety Genetics - Leveraging Genetic Variation for Enhanced Safety Assessment. Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Bhowmik, Shiva, Chiu, Hsien-Po, Jones, David, Chiu, Hsiu-Ju, Miller, Mitchell, Xu, Qingping, Farr, Carol Lynn, Ridlon, Jason M., Wells, James E., Elsliger, Marc-Andre, Wilson, Ian A., Hylemon, Phillip B. and Lesley, Scott (2016) Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis. Proteins: Structure, Function and Bioinformatics, 84 (3). pp. 316-331. ISSN 10970134

Bidinosti, Michael, Botta, Paolo, Moreira Ramos Proenca, Catia, Stoehr, Natacha, Bernhard, Mario, Fruh, Isabelle, Mueller, Matthias, Bonenfant, Debora, Voshol, Johannes, Carbone, Walter, Neal, Sarah, Mctighe, Stephanie, Roma, Guglielmo, Dolmetsch, Ricardo, Porter, Jeffrey, Caroni, Pico, Bouwmeester, Antonius, Lüthi, Andreas and Galimberti, Ivan (2016) CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency. Science.

Bigaud, Marc, Dincer, Zuhal, Bollbuck, Birgit, Dawson King, Janet, Beckmann, Nicolau, Beerli, Christian, Cavelti, Gina, Nahler, Michaela, Angst, Daniela, Janser, Philipp, Otto, Heike, Rosner, Elisabeth, Hersperger, Rene, Bruns, Christian and Quancard, Jean (2016) Pathophysiological consequences of a break in S1P1-dependent homeostasis of vascular permeability revealed by S1P1 competitive antagonism. PLOS ONE.

Biosse Duplan, Martin, Komla-Ebri, Davide, Heuzé, Yann, Estibal, Valentin, Gaudas, Emilie, Kaci, Nabil, Benoist-Lasselin, Catherine, Zerah, Michel, Kramer, Ina, Kneissel, Michaela, Graus Porta, Diana, Di Rocco, Federico and Legeai-Mallet, Laurence (2016) Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible. Human molecular genetics. ISSN 1460-2083; 0964-6906

Bojkovic, Jade, Richie, Daryl, Six, David, Rath, Christopher, Sawyer, William, Hu, Daniel and Dean, Charles (2016) Characterization of an Acinetobacter baumannii lptD deletion strain: Permeability defects and response to inhibition of lipopolysaccharide and fatty acid biosynthesis. Journal of Bacteriology, 198 (4). pp. 731-741. ISSN 1098-5530

Bottos, Alessia, Gill, Jason W, Tzankov, Alexander, Wodnar-Filipowicz, Aleksandra and Hynes, Nancy E (2016) Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nature communications, 7 (12258). pp. 1-12. ISSN 2041-1723

Bottos, Alessia, Gotthardt, Dagmar, Gill, Jason W, Gattelli, Albana, Frei, Anna, Tzankov, Alexandar, Sexl, Veronika, Wodnar-Filipowicz, Aleksandra and Hynes, Nancy E (2016) Decreased NK cell-mediated anti-tumor immunity consequent to JAK pathway inhibition enhances metastasis in preclinical models of breast cancer. Nat Commun., 7 (12258). pp. 1-12. ISSN 2041-1723

Bouchez, Laure, Gerbeaux, Cyril, rusch, marion, Livendahl, madeleine, Patoor, Maude and Press, Neil (2016) Wake Up Call of A Sleeping Beauty”: Straightforward Synthesis of Functionalized β-(2-Pyridyl) Ketones from 2,6-Lutidine. Synlett.

Brandl, Trixi, Simic, Oliver, Skaanderup, Philip, Namoto, Kenji, Berst, Frederic, Ehrhardt, Claus, Schiering, Nikolaus, Mueller, Irene Renate and Woelcke, Julian (2016) Trypsin inhibitors for the treatment of pancreatitis. Bioorganic & Medicinal Chemistry Letters.

Brasa, Sarah, Rozenberg, Izabela, Zollinger, Tulipan, Hahne, Florian, Peters, Thomas, Manzella, Liliana, Decker, Jerry, He, Yunsheng, Johnson, Keith, Mccormack, Christine, Gasparini, Fabrizio, Chibout, Salah-Dine, Grenet, Olivier, Moggs, Jonathan, Gomez-Mancilla, Baltazar, Terranova, Remi and Jacquemont, Sebastien (2016) Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome. Clinical Epigenetics, 8 (1). ISSN 18687083

Brasa, Sarah, Sebastien, Jacquemont, Hahne, Florian, Rozenberg, Izabela, Peters, Thomas, He, Yunsheng, Mccormack, Christine, Gasparini, Fabrizio, Chibout, Salah-Dine, Grenet, Olivier, Moggs, Jonathan, Gomez-Mancilla, Baltazar and Terranova, Remi (2016) Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in Fragile X syndrome. Clinical Epigenetics (http://www.clinicalepigeneticsjournal.com/).

Brecht, Karin, Riebel, Virginie, Couttet, Philippe, Paech, Franziska, Wolf, Armin, Chibout, Salah-Dine, Pognan, Francois, Krähenbühl, Stephan and Uteng, Marianne (2016) Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin. Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin, 40. pp. 55-65.

Brian, William, Tremaine, Larry M., Arefayene, Million, de Kanter, Ruben, Evers, Raymond, Guo, Yingying, Kalabus, James, Lin, Wen, Loi, Cho-Ming and Xiao, Guangqing (2016) Assessment of Drug Metabolism Enzyme and Transporter Pharmacogenetics in Drug Discovery and Early Development: Perspectives of the I-PWG. Pharmacogenomics, 17. pp. 615-631. ISSN 1744-8042

Brown, Alan, Drew, Philip, Knight, Brian, Marc, Philippe, Troth, Sean, Wuersch, Kuno and Zandee, Joyce (2016) Graphical display of histopathology data from toxicology studies for drug discovery and development: an industry perspective. Regulatory toxicology and pharmacology, 82. pp. 167-172.

Brunschweiger, Andreas, Gebert, Luca F. R., Lucic, Matije, Pradère, Ugo, Jahns, Hartmut, Hunziker, Juerg and Hall, Jonathan (2016) Site-specific conjugation of drug-like fragments to anti-miRNA oligonucleotides: pros and cons of targeting miRNAs in RISC. Angewandte Chemie International Edition, 52 (1). pp. 156-159. ISSN 1359-73451364-548X

Brykczynska Kunzmann, Urszula, Vrieseling Pecho, Eline, Thiemeyer, Anke, Klein, Jessica, Fruh, Isabelle, Doll, Thierry, Manneville, Carole, Iazeolla, Mariavittoria, Beibel, Martin, Roma, Guglielmo, Naumann, Ulrike, Kelley, Nicholas, Oakeley, Edward James, Mueller, Matthias, Gomez-Mancilla, Baltazar, Buehler, Marc, Tabolacci, Elisabetta, Chiruazzi, Pietro, Neri, Giovanni, Bouwmeester, Antonius, Di Giorgio, Francesco and Fodor, Barna (2016) CGG Repeat-Induced FMR1 Silencing Depends on the Expansion Size in Human iPSCs and Neurons Carrying Unmethylated Full Mutations. Stem Cell Reports, 7 (6). pp. 1059-1071. ISSN 22136711

Brykczynska Kunzmann, Urszula, Vrieseling Pecho, Eline, Thiemeyer, Anke, Klein, Jessica, Fruh, Isabelle, Doll, Thierry, Manneville, Carole, Iazeolla, Mariavittoria, Beibel, Martin, Roma, Guglielmo, Naumann, Ulrike, Kelley, Nicholas, Oakeley, Edward James, Mueller, Matthias, Gomez-Mancilla, Baltazar, Buehler, Marc, Tabolacci, Elisabetta, Chiruazzi, Pietro, Neri, Giovanni, Bouwmeester, Antonius, Di Giorgio, Francesco and Fodor, Barna (2016) Human neurons carrying FMR1 unmethylated full mutations require large CGG repeat expansions for silencing and display neurodegenerative features. Cell Stem Cell.

Brzeszczyńska, Joanna, Johns, Neil, Schilb, Alain, Degen, Simone, Degen, Martin, Langen, Ramon, Schols, Annemie, Glass, David, Roubenoff, Ronenn, Greig, Carolyn A., Jacobi, Carsten, Fearon, Kenneth C.H. and Ross, James A. (2016) Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not healthy elderly. Clinical Cancer Research, 8 (7). pp. 1-12. ISSN 1945-4589

Burmester, Gerd, Durez, Patrick, Shestakova, Galena, Genovese, Mark, Schulze-Koops, Hendrik, Li, Yue, Wang, Amanda, Lewitzky, Steven, Koroleva, Irina, Agarwal-Berneis, Anni, Lee, David M and Hueber, Wolfgang (2016) Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis. Rheumatology (United Kingdom), 55 (1). pp. 49-55. ISSN 14620332

Calonder, Claudio, Polus, Florine, Woessner, Ralph, Loesche, Christian, Cheng, Yi, Dragatin, Christian, Bodenlenz, Manfred, Aigner, Birgit, Tiffner, K, Mader , J, Ratzer , M, Pieber, Thomas, Bruin, Gerardus and Sinner, Frank (2016) Secukinumab Distributes into Dermal Interstitial Fluid of Psoriatic Patients as Demonstrated by Open Flow Microperfusion. Experimental dermatology, 25 (2). pp. 157-159. ISSN 09066705

Camenisch, Gian P. (2016) Drug disposition classification systems in discovery and development: A comparative review of the BDDCS, ECCS and ECCCS concepts. Pharmaceutical Research.

Campbell, Katie, Solovieff, Nadia, Morrissey, Michael, Leary, Rebecca, Mahan, Scott, Adamovich, Wendy, Murphy, Leon, Mirzaa, Ghayda, Jansen, Laura, Timms, Andrew, Conti, Valerio, Adams, Carissa, boyle, Evan, Collins, Sarah, ishak, gisele, poliachik, sandra, girisha, katta, yeung, kit san, chung, brain hon yin, rahikkala, elisa, gunter, sonya, martin, beth, weaver, molly, doerschner, michael, shendure, jay, saneto, russell, novotny, edward, hevner, robert, ojemann, jeffrey, guerrini, renzo, Sellers, William and dobyns, william (2016) Association of MTOR mutations with developmental brain disorders, including megalencephaly, focal cortical dysplasia, and pigmentary mosaicism. JAMA Neurology, 73 (7). pp. 836-845. ISSN 21686149

Caravatti, Giorgio, Guagnano, Vito, Aichholz, Reiner, Blanz, Joachim, Blasco, Francesca, Wipfli, Peter, Fritsch, Christine, Maira, Sauveur-Michel, Schnell, Christian and Seiler, Frank Hans (2016) Increasing metabolic stability via the deuterium kinetic isotope effect: an example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (19). pp. 4729-4734. ISSN 0960-894X

Carita, Guillaume, Frisch Dit Leitz, Estelle, Dahmani, Ahmed, Raymondie, Chloe, Cassoux, Nathalie, Piperno-Neumann, Sophie, Nemati, Fariba, Roman-Roman, Sergio, Wylie, Andrew, Emery, Caroline, Schoumacher, Marie and Decaudin, Didier (2016) Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma. Oncotarget, 7 (23). pp. 33542-33556. ISSN 1949-2553 (Electronic); 1949-2553 (Linking)

Carstens, Nadia, Williams, Sue, Goolam, Saadiah, Carmichael, Trevor, Zou, Chao, Cheung, Chi Ming, Buechmann-Moller, Stine, Sultan, Marc, Staedtler, Frank, Rice, Dennis, Lacoste, Arnaud, Paes, Kim, Swart, Peter and Ramsay , Michele (2016) Novel mutation in the CHST6 gene causes macular corneal dystrophy in a black South African family. BMC medical genetics, 17 (1). p. 47. ISSN 1471-2350

Cejka, Daniel, Parada-Rodriguez, Diego, Pichler, Stefanie, Marculescu, Rodrig, Kramer, Ina, Kneissel, Michaela, Gross, Thomas, Reisinger, Andreas, Pahr, Dieter, Monier-Faugere, Marie-Claude, Haas, Martin and Malluche, Hartmut H. (2016) Sclerostin knock-out does not protect from uremia-induced bone loss in a murine model of chronic renal failure. Kidney International.

Chaker, A, Shamji, MH, Dumitru, A, Calderon, M, Scadding, G, Makatsori, M, Jones, Ieuan, He, Ally, Subramanian, Kulandayan, Arm, Jonathan, Durham, SR and Schmidt-Weber, CB (2016) Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: a randomised controlled trial. Journal of Allergy and Clinical Immunology.

Chandra, Abhishek, Lin, Tiao, Young, Tiffany, Tong, Wei, Ma, Xiaoyuan, Tseng, Wei-Ju, Kramer, Ina, Kneissel, Michaela, Levine, Michael A., Zhang, Yejia, Cengel, Keith, Liu, X. Sherry and Qin, Ling (2016) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of Bone & Mineral Research, 16. ISSN 1523-4681

Chapman, Victoria, Terranova, Remi, Moggs, Jonathan, Kimber, Ian and Dearman, Rebecca (2016) Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens. Toxicology, 340. pp. 17-26. ISSN 1879-3185

Chen, Chao, Zhu, Hugh, Stauffer, Frederic, Caravatti, Giorgio, Vollmer, Susanne, Machauer, Rainer, Holzer, Philipp, Moebitz, Henrik, Scheufler, Clemens, Klumpp, Martin, Tiedt, Ralph, Beyer, Kim, Calkins, Keith, Kiffe, Michael, Guthy, Daniel Alexander, Zhang, Jeff and Gaul, Christoph (2016) The Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Chen, Xiao-Hui, Hatsis, Panagiotis, Judge, Joyce, Argikar, Upendra, Ren, Xiaojun, Sarber, Jason, Mansfield, Keith, Liang, Guiqing, Adamal, Adam , Catoire, Alexandre, Bentley, Adam, Ramos, Luis, Moench, Paul, Hintermann, Samuel, Carcache, David, Glick, Jim and Flarakos, Jimmy (2016) Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry. Analytical Chemistry, 88 (23). pp. 11813-11820. ISSN 0003-27001520-6882

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Chitnis, Shripad, Han, Yi, Yamaguchi, Masayuki, Nozaki, Sachiko, Zhao, Rong, Kulmatycki, Kenneth and Sunkara, Gangadhar (2016) Population pharmacokinetic modeling and noncompartmental analysis demonstrated bioequivalence between metformin component of metformin/vildagliptin fixed-dose combination products and metformin immediate-release tablet sourced from various countries. Clinical Pharmacology in Drug Development, 5 (1). pp. 40-51. ISSN 2160-7648

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Dickson, Callum, Hornak, Viktor, Pearlstein, Robert, Mckay, Daniel, Velez-Vega, Camilo, Duca, Jose, Sandham, David, Shaw, Duncan, Fairhurst, Robin, Reilly, John, Charlton, Steven and Sykes, David (2016) Uncoupling the structure-activity relationships of β2 adrenergic receptor ligands from membrane binding. Journal of Medicinal Chemistry, 59 (12). pp. 5780-5789. ISSN 0022-26231520-4804

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Dole, Kiran, Segal, Florencia, Feire, Adam, Magnusson, Baldur, Rondon, Juan C, Vemula, Janardhana Rao, Yu, Jing, Pang, Yinuo and Pertel, Peter (2016) A first-in-human study to assess the safety and pharmacokinetics of monoclonal antibodies against human cytomegalovirus in healthy volunteers. Antimicrobial Agents and Chemotherapy, 60 (5). pp. 2881-2887. ISSN 0066-4804; 1098-6596

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Donner, Lili, Fälker, Knut, Klinker, Stefan, Gremer, Lothar, Pagani, Giulia, Gohlke, Holger, Willbold, Dieter, Lang, Florian, Grenegard, Magnus and Elvers, Margitta (2016) Blood platelets contribute to the formation of Amyloid deposits in cerebral vessels via integrin. Science Signaling, 9 (429). ra52-56. ISSN 1945-08771937-9145

Dovala, Dustin, Rath, Christopher, Hu, Qijun, Sawyer, William, Shia, Steven, Elling, Robert, Knapp, Mark and Metzger Iv, Louis (2016) Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism. Proceedings of the National Academy of Sciences of the United States of America, 28. ISSN 1091-6490

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Ekmark-Lewen, S, Fridgeirsdottir, A, Kiwanuka, O, Hanell, A, Meyerson , B, Mir, Anis Khusro, Gram, Hermann, Lewen , A, Clausen, F, Hillered, L and Marklund, N (2016) Complex behavioral alterations after diffuse traumatic axonal injury in mice are normalized by post-injury neutralization of interleukin-1β. European Journal of Neuroscience, 43 (8). pp. 1016-1033. ISSN 0953816X

El Mouelhi, Mohamed and Roubenoff, Ronenn (2016) Drug Development and Challenges for Neuromuscular Clinical Trials. Journal of Molecular Neuroscience, 58 (3). pp. 374-378. ISSN 1559-1166

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Erpenbeck, Veit, Popov, Todor A, Miller, David, Weinstein, Steven F, Spector, Sheldon, Magnusson, Baldur, Osuntokun, Wande, Goldsmith, Paul, Weiss, Markus and Beier, Jutta (2016) The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma. Pulmonary pharmacology & therapeutics, 39. pp. 54-63. ISSN 1522-9629; 1094-5539

Erpenbeck, Veit, Weiss, Markus, Sandham, David and Neelakantham, Srikanth Raju (2016) Pharmacokinetics, safety, and tolerability of QAW039 (fevipiprant), a novel CRTh2 receptor antagonist: Results from two randomized, phase I, placebo-controlled studies in healthy volunteers. Clinical Pharmacology in Drug Development.

Fabrice, Andre, Hurvitz, Sara, Fasolo, Angelica, Tseng, Ling-Ming, Jerusalem, Guy, Wilks, Sharon, O'Regan, Ruth, Isaacs, Claudine, Toi, Masakazu, Burris, Howard, He, Wei, Riester, Markus, Taran, Tetiana, Chen, David and Slamon, Dennis (2016) Molecular Alterations and Everolimus Efficacy in HER2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3. JCO, 34 (18). pp. 2115-2124. ISSN 1527-7755

Faulkner, Lee, Gibson, Andrew, Sullivan, Andrew, Tailor, Arun, Usui, Toru, Alfirevic, Ana, Pirmohamed, Munir, Naisbitt, Dean J. and Park, B. Kevin (2016) Detection of primary T cell responses to drugs and chemicals in HLA-typed volunteers: implications for the prediction of drug immunogenicity. Toxicological Sciences, 154 (2). pp. 416-429. ISSN 1096-60801096-0929

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Fouche, Marianne, Schaefer, Michael, Berghausen, Joerg, Desrayaud, Sandrine and Roth, Hans-Joerg (2016) Pharmacokinetic Studies around the Mono- and Difunctionalization of a Bioavailable Cyclic Decapeptide Scaffold. ChemMedChem.

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Furet, Pascal, Masuya, Keiichi, Kallen, Joerg, Valat, Therese-Marie, Guagnano, Vito, Holzer, Philipp, Mah, Robert, Stutz, Stefan, Vaupel, Andrea, Chene, Patrick, Jeay, Sebastien, Ruetz, Stephan and Schlapbach, Achim (2016) Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument. Bioorganic and Medicinal Chemistry Letters, 26 (19). pp. 4837-4841. ISSN 1464-3405

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Gallagher, Iain, Jacobi, Carsten, Tardif, Nicolas and Fearon, Kenneth (2016) Systems biology and cancer cachexia. Special Issue of SCDB .

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Gampe, Christian, Hollis-Symynkywicz, Micah and Zecri, Frederic (2016) Covalent Chemical 5'-Functionalization of RNA with Diazo Reagents. Angewandte Chemie. International edition, 55 (35). pp. 10283-10286. ISSN 14337851

Gan, Lu, Jiang, Xuemin, Mendonza, Anisha, Swan, Therese, Reynolds, Christine, Nguyen, Joanne, Pal, Parasar, Neelakantham, Srikanth Raju, Dahlke, Marion, Langenickel, Thomas Heiko, Rajman, Iris, Akahori, Mizuki and Sunkara, Gangadhar (2016) Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects. Clinical Pharmacology in Drug Development, 5 (1). pp. 27-39. ISSN 2160-7648

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Gan, Lu, Langenickel, Thomas Heiko, Petruck, Jesika, Kode, Kiran Kumar, Rajman, Iris, Chandra, Priyamvada, Zhou, Wei, Rebello, Sam and Sunkara, Gangadhar (2016) Effects of age and gender on the pharmacokinetics of LCZ696, an angiotensin receptor neprilysin inhibitor. Journal of Clinical Pharmacology , 56 (1). pp. 78-86. ISSN 00912700

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Garcia Fortanet, Jorge, Chen, Christine, Chen, Zhuoliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao Bin, Karki, Rajesh, Kato, Mitsunori, Keen, Nicholas, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Shultz, Michael, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah, Zhang, Ji, Lamarche, Matthew and Sellers, William (2016) Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

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Gentile, Antonietta, Musella, Alessandra, Bullitta, Silvia, Fresegna, Diego, De Vito, Francesca, Piras, Eleanora, Gargano, Francesca, Borsellino, Giovanna, Battistini, Luca, Schubart Wellensiek, Anna, Mandolesi, Georgia and Centonze, Diego (2016) EFFECTS OF SIPONIMOD (BAF312) ON SYNAPTIC NEURODEGENERATIVE DAMAGE IN EXPERIMENTAL MULTIPLE SCLEROSIS. J Neuroinflammation, 13 (1). p. 207. ISSN 1742-2094

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Glowienke, Susanne (2016) Intermediates mutagenicity data sharing for 2017. Intermediates data sharing.

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Riccardi, Sabrina, Bergling, Sebastian, Sigoillot, Frederic, Beibel, Martin, Werner, Annick, Leighton-Davies, Juliet, Knehr, Judith, Bouwmeester, Antonius, Parker, Christian, Roma, Guglielmo and Kinzel, Bernd (2016) Mir-210 promotes sensory hair cell formation in the organ of Corti. BMC Genomics, 17 (309). pp. 1-14. ISSN 1471-2164

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Roessle, Matthias, Cathomas, Gieri, Bonapace, Laura, Sachs, Melanie, Dehler, Silvia, Storz, Martina, Huber, Gerhard, Moch, Holger, Junt, Tobias and Mertz, Kirsten D. (2016) Interleukin-33 expression indicates a favorable prognosis in malignant salivary gland tumors. Int J Surg Pathol.

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Roffe, Gavin, Boonseng, Sarote, Baltus, Christine, Coles, Simon, Day, Iain, Jones, Rhiannon, Press, Neil, Ruiz, Mario, Tizzard, Graham, Cox, Hazel and Spencer, John (2016) A Synthetic, Catalytic and Theoretical Investigation of an Unsymmetrical SCN Pincer Palladacycle. Royal Society Open Science, 3 (4). p. 150656. ISSN 2054-5703

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Rokka, Johanna, Snellman, Anniina, Kaasalainen, Martti, Salonen, Jarno, Zona, Critiano, La Ferla, Barbara, Re, Francesca, Masserini, Massimo, Forsback, Sarita, Lopez-Picon, Francisco, Rinne, Joha O, Haaparanta Solin, Merja and Solin, Olof (2016) Synthesis and preclinical evaluation of functionalized 18F-nanoliposomes for Alzheimer’s disease. European Journal of Pharmaceutical Sciences.

Rubic-Schneider, Tina, Carballido-Perrig, Nicole, Regairaz Kalenga Kapiamba, Camille, Raad, Layla, Jost, Sandra, Christen, Brigitte, Wieczorek, Grazyna, Kreutzer, Robert, Dawson King, Janet, Lametschwandner, Guenther, Littlewood-Evans, Amanda and Carballido, Jose (2016) GPR91 deletion enhances mast cell activation while preventing arthritic disease. Allergy, DO - (DO - ). pp. 1-9. ISSN 1398-9995

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Sedelmeier, Joerg Mathias, Sedelmeier, Gottfried, Schenkel, Berthold, Lima, Fabio, Kabeshov, Mikhail, Tran, Duc, Battilocchio, Claudio and Ley, Steven (2016) Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)–C(sp3) Cross-Couplings in Flow. Angew Chem Int Ed, 55 (55). pp. 1-6. ISSN 1055-0143

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Shakeri-Nejad, Kasra, Aslanis, Vassilios, Veldandi, Uday Kiran, Zaehringer, Andreas, Dodman, Angela, Su, Frank and Legangneux, Eric (2016) Pharmacokinetics, safety, and tolerability of siponimod (BAF312) in subjects with different levels of hepatic impairment: a single-dose, open-label, parallel-group study. Journal of Clinical Pharmacology.

Shaw, Duncan, Baig, Ferheen, Bruce, Ian, Chamoin, Sylvie, Collingwood, Stephen, Cross, Sarah, Dayal, Satish, Drueckes, Peter, Furet, Pascal, Furminger, Vikki, Haggart, Deborah, Hussey, Martin, Konstantinova, Irena, Loren, Jon, Molteni, Valentina, Roberts, Sonia, Reilly, John, Saunders, Alex, Stringer, Rowan, Sviridenko, Lilya, Thomas, Matthew, Thomson, Christopher, Tomlins, Christine, Wen, Ben, Yeh, Vince and Pearce, Andrew (2016) Optimization of PDGFR inhibitors for duration of action, as an inhaled therapy for lung remodeling in pulmonary arterial hypertension. Journal of Medicinal chemistry, 59 (17). pp. 7901-7914. ISSN DOI: 10.1021/acs.jmedchem.6b00703

Shimshek, Derya, Jacobson, Laura, Kolly, Carine, Zamurovic Ribrioux, Natasa, Balavenkatraman, Kamal Kumar, Morawiec, Laurent, Kreutzer, Robert, Schelle, Juliane, Jucker, Mathias, Bertschi, Barbara, Theil, Diethilde, Heier, Annabelle, Bigot, Karine, Beltz, Karen, Machauer, Rainer, Brzak, Irena, Perrot, Ludovic and Neumann, Ulf (2016) Pharmacological BACE1 and BACE2 inhibition induces hair hypopigmentation by inhibiting PMEL17 processing in mice. Scientific Reports, 6. p. 21917. ISSN 2045-2322

Smith, M. C., Mader, M. M., Cook, J. A., Iversen, P., Ajamie, R., Perkins, E., Bloem, L., Yip, Y. Y., Barda, D. A., Waid, P. P., Zeckner, D. J., Young, D. A., Sanchez-Felix, M., Donoho, G. P. and Wacheck, V. (2016) Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth. Molecular Cancer Therapeutics. ISSN 1535-7163

Smith, Troy, Sprague, Elizabeth, Wang, Kate, Mathieu, Simon, Chen, Zhuoliang, Mishina, Yuji, Feng, Yun, Shakya, Subarna, Chen, Dongshu, Meyer, Matthew, Brazell, Tres, Straub, Christopher, Sage, David, Wright, Kirk, Chen, Xin, Duca, Jose, Kim, Sean, Tian, Li, Martin, Eric, Hurov, Kristen, Shao, Wenlin and Yan-Neale, Yan (2016) Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. Journal of Medicinal Chemistry, 59 (10). pp. 4711-4723. ISSN 1520-4804

Soutter, Holly H., Centrella, Paolo, Clark, Matthew A., Cuozzo, John, Dumelin, Christoph, Guie, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Kennedy, Kaitlyn, Sigel, Eric, Troast, Dawn, Zhang, Ying, Ferguson, Andrew, Davies, Gareth, Stead, Eleanor, Breed, Jason, Madhavapeddi, Prashanti and Read, Jon A. (2016) Discovery of novel, co-factor specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology. Proceedings of the National Academy of Sciences.

Stauffer, Frederic, Jacob, Sandra, Scheufler, Clemens and Furet, Pascal (2016) Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors. Bioorganic & Medicinal Chemistry Letters, 26. pp. 2065-2067.

Stauffer, Frederic, Scheufler, Clemens, Moebitz, Henrik, Gaul, Christoph, Ragot, Christian, Be, Celine, Fernandez, Cesar, Beyer, Kim and Tiedt, Ralph (2016) Optimization of a fragment-based screening hit towards potent DOT1L inhibitors interacting in an induced binding pocket. ACS Medicinal Chemistry Letters, 7 (8). pp. 730-734. ISSN DOI: 10.1021/acsmedchemlett.6b00168

Steffek, Micah (2016) Characterization of PPAT Resistance Mutants and Identification of Small Molecule Binders at the PPAT ATP site. Independent Research Project Johns Hopkins University.

Steffek, Micah (2016) Evaluation of PPAT Phosphopantetheine Site Inhibitors and Identification of Small Molecule Binders at the PPAT ATP site. Johns Hopkins Independent Research Proposal.

Stewart, Neil J, Horn, Felix C, Norquay, Graham, Collier, Guilhem J, Yates, Denise, Lawson, Rod, Marshall, Helen and Wild, Jim M (2016) Reproducibility of Quantitative Indices of Lung Function and Microstructure from 129Xe Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy. Magnetic Resonance in Medicine, 000 (000). pp. 1-7. ISSN 10.1002/mrm.26310

Stringer, Rowan, Rose, Jonathan, Ferreira, Suzie and Ronseaux, Sebastien (2016) Application of osmotic pumps for sustained release of 1-aminobenzotriazole and inhibition of cytochrome P450 enzymes in mice: Model comparison with the hepatic P450 reductase null mouse. Drug Metabolism and Disposition, 44 (8). pp. 1213-1216. ISSN 0090-9556; 1521-009X

Strobelt, Hendrik, Alsallakh, Bilal, Botros, Joseph, Peterson, Brant, Borowsky, Mark, Lex, Alexander and Pfister, Hanspeter (2016) Vials: Visualizing Alternative Splicing of Genes. IEEE transactions on visualization and computer graphics, 22 (1). pp. 399-408. ISSN 1941-0506

Strobelt, Hendrik, Alsallakh, Bilal, Botros, Joseph, Peterson, Brant, Borowsky, Mark, Lex, Alexander and Pfister, Hanspeter (2016) Vials: Visualizing Alternative Splicing of Genes. IEEE transactions on visualization and computer graphics, 22 (1). pp. 399-408. ISSN 1941-0506

Stuart, Webb, Gabrelow, Chase, Pierce, James, Edwin , Gibb and Elliott, Jimmy (2016) Retinoic Acid Receptor (RAR) signaling preserves tendon stem cells characteristics and prevents spontaneous differentiation in vitro. Stem Cell Research and Therapy.

Stuart, Webb, Gabrelow, Chase, Pierce, James, Edwin , Gibb and Elliott, Jimmy (2016) Retinoic Acid Receptor (RAR) signaling preserves tendon stem cells characteristics and prevents spontaneous differentiation in vitro. Stem Cell Research and Therapy, 7 (45). pp. 1-11. ISSN 10.1186/s13287-016-0306-3

Sugiyama, Ikuo, Murayama, Norie, Kuroki, Ayaka, Kota, Jagannath, Iwano, Shunsuke, Yamazaki, Hiroshi and Hirota, Takashi (2016) Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells. Xenobiotica, 46 (9). pp. 765-774. ISSN 1366-5928

Sun, Haiying, Machineni, Surendra Kumar, Ting, Lillian, Praestgaard, Jens, Kuemmell, Andreas, Stein, Daniel, Sunkara, Gangadhar, Kovacs, Steven, Villano, Stephen and Tanaka, Ken (2016) A Randomized, Open-label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects. Antimicrobial Agents and Chemotherapy, Online (Online). pp. 1-22. ISSN 1098-6596

Sun, Yishan and Dolmetsch, Ricardo (2016) How induced pluripotent stem cells (iPSCs) are changing drug discovery in psychiatry. Swiss Medical Weekly.

Sun, Yishan, Pasca, Sergiu P., Portmann, Thomas, Goold, Carleton, Worringer, Katie, Guan, Wendy, Chan, Karen C., Gai, Hui, Vogt, Daniel, Chen, Ying-Jiun J., Mao, Rong, Chan, Karrie, Rubenstein, John L.R., Madison, Daniel V., Hallmayer, Joachim, Froehlich-Santino, Wendy M., Bernstein, Jon A. and Dolmetsch, Ricardo (2016) A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients. eLife, 5 (e13073). pp. 1-26. ISSN 2050-084X

Surya , Ayalasomayajula, Schuehly, Uwe, Langenickel, Thomas Heiko, Pal, Parasar, Chen, Fabian, Chen, Zhen, Zhou, Wei and Sunkara, Gangadhar (2016) Effect of renal function on the pharmacokinetics of LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor. European Journal of Clinical Pharmacology, 72 (9). pp. 1065-1073. ISSN 1432-1041

Sutton, James, Mitra, Partha, Yang, Ren-Ming, Ramsay, Robert G. and Gonda, Thomas J (2016) CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression. Oncotarget, 7 (8). pp. 9069-9083. ISSN 1949-2553

Swann, Justine, plouffe, David, Winzeler, Elizabeth and Meister, Stephan (2016) A high-­‐throughput luciferase-­‐based assay for the discovery of therapeutics that prevent malaria. ACS Infectious Diseases.

Swart, Pieter Jacob, Lozac'H, Frederic, Faller, Thomas, Van De Kerkhof, Esther, Krauser, Joel, Natt, Francois, Hunziker, Juerg, Catoire, Alexandre, Garnier, Maxime, litherland, karine and christensen, Jesper (2016) ADME studies of [5-3H]-2′-O-methyluridine nucleoside in mice: A building block in siRNA therapeutics. Pharmacology Research and Perspectives, 4 (1). ISSN 2052-1707

Sykes, David, Bradley, Michelle, Reilly, John, Bauer, Carsten, Watson, Simon, Sandham, David, Dubois, Gerald and Charlton, Steven (2016) Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology, 89 (5). pp. 593-605. ISSN 1521-0111

Tang, Hai-Ming, Ju, Haisong, Zhao, Shufang, Laduke, Carrie, Hahn, Suzette, Glick, Jim, Carey, Cynthia and Friedrichs, Gregory (2016) Translational assessment of cardiac contractility by echocardiography in the telemetered rat. Journal of Pharmacological Toxicololgical Methods, 77. pp. 24-32. ISSN 1056-8719

Tarselli, Mike (2016) NEXT CRO quick-reference guide. NEXT, NA (NA). pp. 1-6. ISSN NA

Tarselli, Mike (2016) Response to Science Magazine NextGen special issue, 20 May. Science NextGen 20 May 2016, 352 (6288). pp. 886-889. ISSN 0036-80751095-9203

Tarselli, Mike (2016) Tarselli Response to Science Mag InGenuity Survey, Nov 2016. Science, 354 (6315). pp. 964-966.

Thomas, Jason, Harrington, Edmund, Murphy, Jason, Jain, Rishi, Schirle, Markus, Gower, Carrie, Chang, Matthew and Maly, Dustin (2016) GENERATION OF BIVALENT KINASE INHIBITORS STARTING FROM A SINGLE POLYPHARMACOLOGICAL COMPONENT FOR SELECTIVE TARGET MODULATION IN VIVO. ACS Chemical Biology.

Thomson, JP, Ottaviano, R, Unterberger, E, Lempiainen, H, Mueller, Arne, Terranova, Remi, Illingworth, RS, Webb, S, Kerr, AR, Drake, A, Lyall, M, Wolf, CR, Moggs, Jonathan, Schwarz, M and Meehan, R (2016) Loss of Tet1 associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer. Cancer Research.

Tian, Hua, Maciazek, Dawid, Postawa, Zbigniew, Garrison, Barbara and Winograd, Nicholas (2016) CO2-Cluster SIMS. Journal of American Society of Mass Spectrometry, 27 (9). pp. 1476-1482. ISSN 1879-1123

Tian, Hua, Wucher, Andrea and Winograd, Nicholas (2016) Reducing the matrix effect in organic cluster SIMS using dynamic reactive ionization. Journal of the American Society for Mass Spectrometry, 27 (2). pp. 2014-2024. ISSN 1879-1123

Tomic, Ivana, Vidis Millward, Ana, Mueller-Zsigmondy, Martin and Cardot, Jean-Michel (2016) Setting accelerated dissolution test for PLGA microspheres containing peptide, investigation of critical parameters affecting drug release rate and mechanism. International journal of pharmaceutics, 505 (1-2). pp. 42-51. ISSN 1873-3476

Torene, Rebecca, Nirmala, Nanguneri, Obici, Laura, Meini, Antonella, Tormey, Vincent, Caorsi, R., Starck-Schwertz, Sandrine, Letzkus, Martin, Hartmann, Nicole, Abrams, Ken, Lachmann, Helen and Gattorno, Marco (2016) Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome. Annals of the Rheumatic Diseases, 29. ISSN 1468-2060

Toris, Carol, McLaughlin, Marsha, Dworak, Douglas, Fan, Shan, Havens, Shane, Zhan, Guilin, Horan, Nicholas and Prasanna, Ganesh (2016) Effects of rho kinase inhibitors on intraocular pressure and aqueous humor dynamics in nonhuman primates and rabbits. Journal of Ocular Pharmacology and Therapeutics, 32 (6). pp. 355-364. ISSN 1557-7732

Townsend, Elizabeth, Cooke, Vesselina, Firestone, Brant, Gao, Hui, Lees, Emma and Weinstock, David (2016) The Public Repository of Xenografts (ProXe) enables discovery and randomized phase II-like trials in mice. molecular cell.

Trendelenburg, Anne-Ulrike (2016) Frailty in mouse ageing: A conceptual approach. Mechanisms of Ageing and Development, 160. pp. 34-40. ISSN 18726216

Trenkwalder, Claudia , Berg, Daniela, Eggert, Karla , Oehlwein, Christian , Ceballos-Baumann, Andres , Feigin, Andrew, Coorvol, Jean Christophe , Rascol, Olivier, Stocchi, Fabrizio , Linazasoro, Gurutz, Di Paolo, Thérèse , Maruff, Paul, Feuerbach, Dominik, Sovago, Judit, Weiss, Markus, Rozenberg, Izabela, Johns, Donald and Gomez-Mancilla, Baltazar (2016) A multi-centre, randomized, double-blind, placebo-controlled, parallel-group, multiple oral dose study to assess the efficacy, safety and tolerability of AQW051 in Parkinson’s patients with L-dopa induced dyskinesias. Movement Disorders.

Umehara, Ken-Ichi, Zollinger, Markus, Kigondu, Elizabeth, Witschi, Marc, Juif, Claire, Huth, Felix, Schiller, Hilmar, Chibale, Kelly and Camenisch, Gian P. (2016) Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors. Xenobiotica. pp. 1-6. ISSN 0049-82541366-5928

Urban, Laszlo, Nagy, Istvan, Varga, Angelika, Selvarajah, Srikumaran, Jenes, Agnes, Kulik, Akos, Brain, Susan, Baker, David, Valente, Joao, White, John, Mackie, Kenneth and Chen, Jie (2016) CAPSAICIN- AND ANANDAMIDE-SENSITIVITY OF PRIMARY SENSORY NEURONS IS CONTROLLED BY VARIOUS COMPONENTS OF CROSSTALK BETWEEN THE CANNABINOID TYPE 1 AND THE CAPSAICIN RECEPTORS. Scientific reports, 6 (33307). pp. 1-18. ISSN 2045-2322

Uteng, Marianne, Mahl, Joerg Andreas, Beckmann, Nicolau, Piaia, Alessandro, Ledieu, David, Dubost, Valerie, Tritto, Elaine, Wolf, Armin, Moulin, Pierre, Li, Li, Chibout, Salah-Dine and Pognan, Francois (2016) Comparative renal safety assessment of the hepatitis B drugs, adefovir, tenofovir, telbivudine and entecavir in rats. Comparative renal safety assessment of the hepatitis B drugs, adefovir, tenofovir, telbivudine and entecavir in rats, 155 (1). pp. 283-297.

Vaidya, Soniya, Khindri, Sanjeev, Calder, Nicole, Hara, Hisanori, Majumdar, Tapan, Salvatore, Febbraro, Rainard , Fuhr and Woessner, Ralph (2016) Pharmacokinetics of indacaterol acetate and mometasone furoate delivered alone or in a free or fixed dose combination in healthy volunteers. Pulmonary Pharmacology and Therapeutics, 37. pp. 30-36. ISSN 10945539

Vaidya, Soniya, Khindri, Sanjeev, Maahs, Suzanne, Machineni, Surendra Kumar, Hara, Hisanori, Juan, Axel and Kaiser, Guenther (2016) Lung Delivery of Indacaterol and Mometasone Furoate Following Inhalation of QMF149 via the Twisthaler® Device in Healthy Volunteers. Clinical Pharmacology in Drug Development. ISSN 2160763X

Van, Linh, Floch, David, Jiang, Xuemin, Klein, Ulf, Abrams, Ken and Sunkara, Gangadhar (2016) Pharmacokinetic and Pharmacodynamics of Canakinumab in Patients with Systemic Juvenile Idiopathic Arthritis. The Journal of Clinical Pharmacology, Online (0(0)). pp. 1-12. ISSN 10.1002/jcph:754

Van Eldik, LJ, Carrillo, M, Cole, PE, Feuerbach, Dominik, Greenberg, BD, Hendrix, J, Kennedy, M, Kozauer, N, Mueller, R, Ransohoff, R, Wilcock, DM, Bain, L and Bales, K (2016) The Roles of Inflammation and Immune Mechanisms in Alzheimer's Disease. Alzheimers Dementia, 2 (2). pp. 99-100. ISSN http://dx.doi.org/10.1016/j.trci.2016.05.001

Vicini, P, Fields, O, Lai, E, Litwack, E D, Martin, A-M, Morgan, T M, Pacanowski, M A, Papaluca, M, Perez, O D, Ringel, M S, Robson, M, Sakul, H, Vockley, J, Zaks, T, Dolsten, M and Søgaard, M (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical pharmacology and therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Vicini, Paolo, Fields, Owen, Lai, Eric, Litwack, David, Martin, Anne-Marie, Morgan, Thomas, Pacanowski, Michael, Papaluca, Marisa, Perez, Omar, Ringel, Michael, Robson, Matthew, Sakul, Hakan, Vockley, Joseph, Zaks, Tal and Sogaard, Morten (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical Pharmacology and Therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Vicini, Paolo, Fields, Owen, Lai, Eric, Litwack, David, Martin, Anne-Marie, Morgan, Thomas, Pacanowski, Michael, Papaluca, Marisa, Perez, Omar, Ringel, Michael, Robson, Matthew, Sakul, Hakan, Vockley, Joseph, Zaks, Tal and Sogaard, Morten (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical Pharmacology and Therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Voegtle, Markus and Leforestier, Baptiste (2016) Safe Generation and Direct Use of Chlorine Azide in Flow Chemistry – 1,2‐Azidochlorination of Olefins and Access to Triazoles. Synlett, 27 (-). pp. 1957-1962. ISSN 0936-5214

Vrieseling Pecho, Eline (2016) Hunting cellular mechanisms underlying the spreading of misfolded protein pathology in the brain. Neuropathology and Applied Neurobiology, 42 (2). pp. 135-136. ISSN 1365-2990

Vuichoud, Basile, Bornet, Aurélien, de Nanteuil, Florian, Milani, Jonas, Canet, Estel, Ji, Xiao, Mieville, Pascal, Weber, Emmanuelle, Kurzbach, Dennis, Flamm, Andrea, Konrat, Robert, Gossert, Alvar, Jannin, Sami and Bodenhausen, Geoffrey (2016) Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins. Chemistry - a European journal, 22 (41). pp. 14696-14700. ISSN 09476539

Walker, Dana and Ramiah, Shashi (2016) Veterinary Pathologists in Translational Pharmacology and Biomarker Integration in Drug Discovery and Development. Toxicologic Pathology.

Walles, Markus, Rudolph, Bettina, Peraus, Gisela, Wolf, Thierry, Bourgailh, Julien, Suetterlin, Martina, Moenius, Thomas, Heudi, Olivier, Elbast, Walid, Lanshoeft, Christian and Bilic, Sanela (2016) New Insights in Tissue Distribution, Metabolism and Excretion of [3H]-labeled Antibody Maytansoid Conjugates in Female Tumor Bearing Nude Rats. Drug Metabolism and Disposition.

Wang, Hui, Lu, Bo, Castillo, Johnny, Yang, Zinger, Mcallister, Gregory, Reece-Hoyes, John, Tallarico, John, Russ, Carsten, Hoffman, Gregory, Schirle, Markus and Cong, Feng (2016) Tankyrase inhibitor sensitizes lung cancer cells to endothelial growth factor receptor (EGFR) inhibition via stabilizing angiomotins and inhibiting yap signaling. Journal of Biological Chemistry, 291 (29). pp. 15256-15266. ISSN 1083-351X

Wang, Yuan, Cornett, Allen, King, Frederick, Mao, Yi, Nigsch, Florian, Paris, Greg, Mcallister, Gregory and Jenkins, Jeremy (2016) Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery. Cell Chemical Biology, 23 (7). pp. 862-874. ISSN 24519456

Wassermann, Anne, Borowsky, Mark, Partl, Christian, Lex, Alexander, Streit, Marc, Pfister, Hanspeter and Schmalstieg, Dieter (2016) Caleydo Entourage: analyzing experimental data across multiple pathways. IEEE Trans Vis Comput Graph. , 19 (12). pp. 2536-2545. ISSN 1077-2626

Weaver, Margaret, Blak Grossi, Anette , Parish, Joanna , Schützsack, Jorgen , Løgsted, Jeanet , Brück Bøgh, Ingrid , Cameron, David , Harvey, Warren , Festag, Matthias , Downes, Noel , Venturella, Silvana , Schlichtiger, Julia , Mhedhbi, Sofiene , Ross, Vanessa , Kissner, Thomas , Stark, Claudia , Milano, Stephane , Heining, Peter and Sanchez-Felix, Manuel (2016) Vehicle Systems and Excipients Used in Minipig Drug Development Studies. Toxicologic Pathology, 44 (3). pp. 367-372. ISSN 1533-1601

Weaver, Margaret, Grossi, AB, Schuetzsack, J, Parish , J, Loegsted, J, Boegh, IB, Cameron , D, Harvey, W, Festag, M, Downes, N, Venturella, S, Schlichtiger, J, Heining, Peter and Sanchez-Felix, Manuel (2016) Vehicle Systems and Excipients Used in Minipig Drug Development Studies. Toxicology Pathology.

Webster, Carl I., Bryson, Christine J., Cloake, Edward A., Jones, Tim D., Austin, Mark J., Karle, Anette, Spindeldreher, Sebastian, Lowe, David C. and Baker, Matthew P. (2016) A comparison of the ability of the human IgG1 allotypes Gm1(3) and Gm1(1,17) to stimulate T-cells responses from allotype matched and mismatched donors. mAbs.

Weehuizen, T, Lankelma, J, de Jong, K, de Boer, O, Roelofs, J, Day, N, Gram, Hermann, de vos, j and Wiersinga, J (2016) THERAPEUTIC ADMINISTRATION OF A MONOCLONAL ANTI-IL-1Β ANTIBODY PROTECTS AGAINST EXPERIMENTAL MELIOIDOSIS. Shock : molecular, cellular, and systemic pathobiological aspects and therapeutic approaches : the official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies., 46. pp. 566-574. ISSN 1540-0514

Wehmeyer, Corinna, Frank, Svetlana, Beckmann, Denise, Böttcher, Martin, Cromme, Christoph, König, Ulrich, Fennen, Michelle, Held, Annelena, Paruzel, Peter, Hartmann, Christine, Stratis, Athanasios, Korb-Pap, Adelheid, Kramer, Ina, van den Berg, Wim, Kamradt, Thomas, Kneissel, Michaela, Pap, Thomas and Dankbar, Berno (2016) Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Science translational medicine. ISSN 1946-6242; 1946-6234

Weiskopf, Kipp, Anderson, Katie, Ito, Daisuke, Schnorr, Peter, Tomiyasu, Hirotaka, Ring, Aaron, Bloink, Kristin, Efe, Jem, Rue, Sarah, Lowery, David, Barkal, Amira, Prohaska, Susan, McKenna, Kelly, Cornax, Ingrid, O'Brien, Timothy, O'Sullivan, Gerard, Weissman, Irving and Modiano, Jaime (2016) Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20. Cancer immunology research, 4 (12). pp. 1072-1087. ISSN 2326-6074; 2326-6066

Wetzel, Kristie and Capodieci, Paola (2016) Dual ISH-IHC. Publication on website acdbio.com/dual-ISH-IHC.

Wharton Jr, Keith, Quigley, Catherine, Themeles, Marian, Dunstan, Robert W., Doyle, Kathryn, Cahir-McFarland, Ellen, Wei, Jing, Buko, Alex, Reid, Carl E., Sun, Chao, Carmillo, Paul, Sur, Gargi, Carulli, John P., Mansfield, Keith, Westmoreland, Susan V., Staugaitis, Susan M., Fox, Robert J., Meier, Werner and Goelz, Susan (2016) JC polyomavirus abundance and distribution in progressive multifocal leukoencephalopathy brain tissue implicates myelin sheath in intracerebral dissemination of infection. PLoS One.

Whibley, Natasha, Tritto, Elaine, Traggiai, Elisabetta, Kolbinger, Frank, Moulin, Pierre, Brees, Dominique, Coleman, Bianca M., Mamo, Anna J., Garg, Abhishek V., Jaycox, Jillian R., Siebenlist, Ulrich, Kammueller, Michael and Gaffen, Sarah L. (2016) IL-17A is the dominant IL-17-family cytokine required for immunity to acute murine oral mucosal candidiasis. Journal of Leukocyte Biology, 99 (?). ?.

White, John, P.M, Cibelli , Mario, Urban, Laszlo, Nilius, Bernd, McGeown, Graham and Nagy, Istvan (2016) TRPV4: MOLECULAR CONDUCTOR OF A DIVERSE ORCHESTRA. Physiological reviews, 96 (96). pp. 911-973. ISSN 1522-1210; 0031-9333

White, Nicholas, Thanh, Duong Tran, Uthaisin, Chirapong, Nosten, Francois, Phyo, Aung Pyae, Pukrittayakamee, Sasithon, Jittamala, Podjanee, Chuthasmit, Kittiphum, Cheung, Nicole, Feng, Elie, Li, Ruobing, Magnusson, Baldur, Sultan, Marc, Wieser, Daniela, Xun, Xiaolei, Zhao, Rong, Diagana, Thierry Tidiane, Pertel, Peter and Leong, Franz Joel Wen (2016) The novel imidazolopiperazine KAF156 clears parasitemia rapidly in falciparum and vivax malaria. New England journal of medicine : NEJM., 375 (12). pp. 1152-1160. ISSN 0028-4793

Whitebread, Steven, Dumotier, Berengere, Armstrong, Duncan, Fekete, Alexander, Chen, Shanni, Hartmann, Andreas, Mueller, Patrick and Urban, Laszlo (2016) Secondary Pharmacology: Screening and Interpretation of Off-target Activities – Focus on translation. Drug Discovery Today. ISSN 13596446

Wilcken, Rainer and Srinivas, Honnappa (2016) Mutational analysis of SGPL1: In silico modelling (The analysis results will be shared with Prof. Friedhelm Hildebrandt, Harvard medical school, Division of Nephrology Boston Children's Hospital). These results ( were approved in OAK before), that were shared with Prof. Friedhelm Hildebrandt is now a part of full manuscript for publication with Prof. Friedhelm Hildebrandt as corresponding author . Honnappa Srinivas and Rainer Wilken are the co-authors from NIBR. Please find attached the full manuscript. SGPL1 mutations cause nephrosis with ichthyosis and adrenal insufficiency.

Willadt, Silvia, Nash, Mark and Slater, Clarke (2016) Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragm. Scientific reports, 6. ISSN 2045-2322

Willard, Elizabeth, Sykes, David, Dubois, Gerald, Bradley, Michelle, Riddy, Darren, Sandham, David, Watson, Simon, Bauer, Carsten and Charlton, Steven (2016) Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology, 89 (5). pp. 593-605. ISSN 15210111

Winkler, Gian Christian, Lovsin Barle, Ester and Mirwald, Jens (2016) Tiered Banding Concept for Pharmaceutical Intermediates. Chimica oggi; chemistry today, 34 (4). pp. 32-36. ISSN ISSN 0392-839X, EISSN 1973-8250

Witek, Jagna, Keller, Bettina G., Blatter, Markus, Meissner, Axel, Wagner, Beatrix and Riniker, Sereina (2016) Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States. Journal of Chemical Information & Modeling, 56 (8). pp. 1547-1562. ISSN 1549-960X

Xiuning, Le, Rajee, Anthony, Pedram, Razavi, Daniel J, Treacy, Flora, Luo, Mahmoud, Ghandi, Jose, Baselga and Levi A, Garraway (2016) Systematic functional characterization of resistance to PI3K inhibition in breast cancer. Cancer discovery, 6 (10). pp. 1134-1147. ISSN 2159-8290; 2159-8274

Xu, Jing, Li, Li, Xiong, Jie, Dekker, Aaron den, Ye, Andrew, Karatas , Hacer, Liu, Liu, Wang, He, Qin, Zhaohui S., Wang, Shaomeng and Dou, Yali (2016) MLL1 and MLL1 fusion proteins play distinct roles in regulating leukemic transcription program. Cell discovery.

Yang, Yang (2016) Expedient Synthesis of 4-Aryl Quinazoline Analogues via Direct Nucleophilic Arylation of 2-Chloroquinazoline. Synthesis, 48 (14). pp. 2255-2262. ISSN 0039-7881

Yokokawa, Fumiaki, Noble, Christian Guy, Lim, Siew Pheng, Rao, Ranga Rao K.R., Tania, Stefani, Wang, Gang, Lee, Gladys, Hunziker, Juerg, Karuna, Ratnaningrum, Manjunatha, Ujjini Havaldar, Nilar, Shahul, Shi, Pei-Yong and Smith, Paul (2016) Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase From a Fragment Hit Using Structure-Based Drug Design. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Yu, Vionnie and Scadden, David (2016) Heterogeneity of the bone marrow niche. Current Opinion in Hematology, 23 (4). pp. 331-338. ISSN 2016 Jul;23(4):331-8

Yu, Yanyan, chen , Jiajia, Gao, Jun, Liao, Rijing, Oyang, Counde, Li, En, Jin, Hong, Yang, Pengyuan, Zhou, Shaolian and Yi, Wei (2016) A methodology paper for histone variant peptide quantitation. Quantitative Profiling of Combinational K27/K36 Modifications on Histone H3 Variants in Mouse Organs..

Zeeman, Anne-Marie, Lakshminarayana, Suresh Bangalore, van der Werff, Nicole, Klooster, Els, Kondreddi, Ravinder Reddy, Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan King Sing, Diagana, Thierry Tidiane and Kocken, Clemens (2016) PI4K is a prophylactic, but not radical curative target in Plasmodium vivax-type malaria parasites. Antimicrobial Agents and Chemotherapy (AAC) .

Zhai, Yufeng, Chen, Kaisheng, Zhong, Yang, Zhou, Bin, Ainscow, Edward, Wu, Ying-Ta and Zhou, Yingyao (2016) An Automatic Quality Control Pipeline for High-throughput Screening Hit Identification. Journal of Molecular Screening, 21 (8). pp. 832-841. ISSN 10870571

Zhang, Jin, Heimbach, Tycho, Barve, Avantika, Li, Wenkui and He, Handan (2016) Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies with PBPK Modeling. Journal of Pharmaceutical Sciences, 105 (4). pp. 1398-1404. ISSN 1520-6017

Zhu, Andrew, Chen, David, He, Wei, Kanai, Masayuki, Voi, Maurizio, Chen, Li-Tzong, Daniele, Bruno, Vogel, Arndt and Chiang, Derek (2016) Integrative Biomarker Analyses Indicate Etiological Variations in c-Met and Tsc2 Alterations in Hepatocellular Carcinoma. Journal of Hepatology, 65 (2). pp. 296-304. ISSN 1600-0641

Zhu, Kaichuan, Xiang, Xianyuan, Dorostkar, Mario, Filser, Severin, Crux, Sophie, Marinkovic, Petar, Neumann, Ulf, Shimshek, Derya, Rammes, Gerhard, Haass, Christian, Lichtenthaler, Stefan and Herms, Jochen (2016) Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biological Psychiatry. ISSN 18732402

Zielman, Ronald, Postma, Rudmer, Verhoeven, Aswin, Bakels, Floor, van Oosterhout, Willebrordus P J, Meissner, Axel, van den Maagdenberg, Arn M J M, Terwindt, Gisela M, Mayboroda, Oleg A and Ferrari, Michel D (2016) Metabolomic changes in CSF of migraine patients measured with (1)H-NMR spectroscopy. Molecular bioSystems, 12 (12). pp. 3674-3682. ISSN 1742-2051

de Zwart, Marcel, Lausecker, Berthold, Globig, Susanne, Neddermann, Daniel, Le Bras, Bruno, Guenzi, Alberto, White, Stephen, Scheel-Fjording, Marianne and Timmerman, Philip (2016) Co-medication and interference testing in bioanalysis: a European Bioanalysis Forum Recommendation. Bioanalysis, 8 (19). pp. 2065-2070. ISSN 1757-6180

van Overbeek, Megan, Capurso, Daniel, Carter, Mathew M., Thompson, Mathew S., Frias, Elizabeth, Reece-Hoyes, John, Nye, Christopher, Gradia, Scott, Vidal, Bastien, Zheng, Jiashun, Hoffman, Gregory, Fuller, Christopher K. and May, Andrew P. (2016) DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks. Molecular Cell, 63 (4). pp. 633-646. ISSN 1097-4164

van Overbeek, Megan , Capurso, Daniel , Carter, Matthew , Thompson, Matthew M. , Frias, Elizabeth, Russ, Carsten, Reece-Hoyes, John, Nye, Christopher , Gradia, Scott, Vidal, Bastien , Zheng, Jiashun, Hoffman, Gregory, Fuller, Christopher K. and May, Andrew P. (2016) DNA repair outcomes at Cas9-mediated double-strand breaks are non-random and sequence-dependent. Science.

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