Article

Abend, Johanna, Sathe, Atul, Changala, Marguerite, Casey, Fergal, Kistler, Amy, Chandran, Sindhu, Howard, Abigail and Wojciechowski, David (2016) Correlation of BK Virus Neutralizing Serostatus with the Incidence of BK Viremia in Kidney Transplant Recipients. Transplantation. p. 1. ISSN 0041-1337

Abramowski, Dorothee and Staufenbiel, Matthias (2016) Co-expression of truncated and full-length tau induces severe neurotoxicity. Mol Psychiatry. ISSN 1359-4184

Accart Gris, Nathalie, Dawson King, Janet, Kramer, Ina, Kolbinger, Frank and Beckmann, Nicolau (2016) NON-INVASIVE IMAGING DEMONSTRATES CLINICAL FEATURES OF THE PATHOLOGY IN A RAT ADJUVANT MODEL FOR ANKYLOSING SPONDYLITIS. European journal of histochemistry : EJH., 60 (4). p. 2667. ISSN 2038-8306

Achichi, Manel, Chetham, Michelle, Dragisic, Zlatan, Euzenat, Jerome, Faria, Daniel, Ferrara, Alfio, Flouris, Giorgios, Fundulaki, Irini, Harrow, Ian, Ivanova, Valentina, Jimenez-Ruiz, Ernesto, Kuss, Elena, Lambrix, Patrick, Leopold, Henrik, Meilicke, Christian, Montanelli, Stefano, Pesquita, Catia and Saveta, Tzanina (2016) Results of the Ontology Alignment Evaluation Initiative 2016. CEUR Proceedings, 1766. pp. 73-129. ISSN 1613-0073

Agarinis, Claudia, Orsini, Vanessa, Megel, Philippe, Abraham, Yann, Yang, Haidi, Mickanin, Craig, Bouwmeester, Antonius, Tchorz, Jan and Parker, Christian (2016) Activation of Yap Directed Transcription by Knock-down of Conserved Cellular Functions. Journal of Biomolecular Screening.

Agarinis, Claudia, Orsini, Vanessa, Megel, Philippe, Abraham, Yann, Yang, Haidi, Mickanin, Craig, Myer, Vic, Bouwmeester, Antonius, Tchorz, Jan and Parker, Christian (2016) Activation of Yap Directed Transcription by Knock-down of Conserved Cellular Functions. Journal of Biomolecular Screening.

Akahane, Koshi, Sanda, Takaomi, Mansour, Marc R., Radimerski, Thomas, Weinstock, David M., Letai, Anthony and Look, Thomas (2016) HSP90 Inhibition Leads to Degradation of the TYK2 Kinase and Apoptotic Cell Death in T-Cell Acute Lymphoblastic Leukemia. Leukemia, 30 (1). pp. 219-228. ISSN 1476-5551; 0887-6924

Akahori, Mizuki, Ayalasomayajula, Surya, Langenickel, Thomas Heiko, Pal, Parasar and Sunkara, Gangadhar (2016) Pharmacokinetics after single ascending dose, food effect, and safety of sacubitril/valsartan (LCZ696), a novel angiotensin receptor and neprilysin inhibitor, in healthy Japanese subjects. European Journal of Drug Metabolism and Pharmacokinetics, Epub a (NA). NA-NA. ISSN 2107-0180

Alper, Phillip and Ratnikov, Max (2016) GNF portion of an NSF GOALI grant proposal on flow photochemistry to be submitted with Professor Gary Molander from U Penn. NSF Review Committee, None (None). pp. 1-85. ISSN None

Althof, Erwin and Nijholt, Ralf (2016) Novartis & SiLA—Partners in Simplifying Lab Automation Implementations. Novartis & SiLA—Partners in Simplifying Lab Automation Implementations.

Altmann, Eva, Schlierf, Anita, Jefferson, AB, Renatus, Martin, Jones, Matthew, Hassiepen, Ulrich, Assenberg, Rene, Schaefer, Michael, Quancard, Jean, Kiffe, Michael, Weiss, Andreas, Wiesmann, Christian, Sedrani, Richard, Eder, Joerg and Martoglio, Bruno (2016) A first-in-class small molecule inhibitor of the COP9 signalosome subunit 5 for the treatment of cancer. Nature communications, 7. pp. 13166-13175. ISSN 2041-1723

Amaral, Adam, Saran, Chitra, Amin, Jakal and Hatsis, Panagiotis (2016) A Comparison of LC-MS/MS and a Fully Integrated Autosampler/Solid Phase Extraction System for the Analysis of Protein Binding Samples. Journal of Biomolecular Screening. ISSN 1552-454X

Anders, Gerd, Hassiepen, Ulrich, Theisgen, Stephan, Heymann, Stephan, Muller, Lionel, Panigada, Tania, Huster, Daniel and Samsonov, Sergey (2016) The Intrinsic Pepsin Resistance of Interleukin-8 Can be Explained from a Combined Bioinformatical and Experimental Approach. IEEE TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, PP (99). p. 1. ISSN 1545-5963

Andersen, ND, Nielsen, BE, Corradi, J, Tolosa, MF, Feuerbach, Dominik, Arias, HR and Bouzat, C (2016) Exploring the Positive Allosteric Modulation of Human α7 Nicotinic Receptors from a Single-Channel Perspective. Neuropharmacology.

Arenas-Amirez, Natalia, Zou, Chao, Popp, Simone, Zingg, Daniel, Brannetti, Barbara, Wirth, Emmanuelle, Calzascia, Thomas, Kovarik, Jiri, Sommer , Lukas, Zenke, Gerhard, Woytschak, Janine, Regnier, Catherine, Katopodis, Andreas and Boyman, Onur (2016) Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2. Science Translational Medicine, 8 (367). ISSN 1946-62341946-6242

Argikar, Upendra, Bushee, Jennifer and Dunne, Christine (2016) An in vitro approach to investigate ocular metabolism: Part I - Levobunolol. Drug metabolism and disposition, 44 (8). pp. 1304-1312. ISSN 1521-009X

Argikar, Upendra, Potter, Phil, Matthew, Hutzler and Punit, Marathe (2016) Challenges and Opportunities with Non-CYP Enzymes Aldehyde oxidase, Carboxyl esterase and UDP-glucuronosyl transferase. Focus on Reaction Phenotyping and Prediction of Human Clearance. AAPS Journal, 18 (6). pp. 1391-1405. ISSN N/A

Arias, HR, Ravazzini, F, Targowska-Duda, KM, Kaczor, AA, Feuerbach, Dominik, Boffi, JC, Draczkowski, P, Montag, D, Brown, BM, Elgoyhen, AB, Jozwiak, K and Puia, G (2016) Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. The International Journal of Biochemistry & Cell Biology.

Ashok, Yashwanth and Jaakola, Veli-Pekka (2016) Nanodisc-Tm: Rapid functional assessment of nanodisc reconstituted membrane proteins by CPM assay. MethodsX, 3. pp. 212-218. ISSN 22150161

Atienzar, Franck, Blomme, Eric, Chen, Minjun, Hewit , Philip, Kenna, Gerry, Labbe, Gilles, LeCluyse, Edward, Moulin, Frederic, Pognan, Francois, Roth, Adrian, Suter-Dick, Laura, Ukairo, Okechukwu, Weaver, Richard, Will, Yvonne and Dambach, Donna (2016) Key challenges and opportunities associated with the use of in vitro models to detect human DILI: integrated risk assessment and mitigation plans. BioMed Research International, 2016 (-). pp. 1-20. ISSN 10.1155

Auberson, Yves, Briard, Emmanuelle, Sykes, David, Reilly, John and Healy, Mark (2016) The Ligand Specific Efficiency (LSE) index for PET tracer optimization, illustrated with tracer candidates for imaging the prostacyclin receptor. ChemMedChem, 11 (13). pp. 1415-1427. ISSN don't know

Auld, Douglas (2016) Doug Auld—Interview for November 2016 issue of Assays and Drug Dev. Technologies (Mary Ann Liebert Inc., publishing). Assay and drug development technologies, 14 (9). pp. 518-523.

Auld, Douglas, Busby, Scott, Chen, Kiki, Jimenez, Marta, Yue, Qing, Bowes, Scott, Wendel, Gregory, Smith, Thomas and Zhang, Ji (2016) Matrix-Based Activity Pattern Classification as a Novel Method for the Characterization of Enzyme Inhibitors Derived from High-Throughput Screening. Journal of Biomolecular Screening, 21 (10). pp. 1075-1089. ISSN 1552-454X

Ayalasomayajula, Surya, Langenickel, Thomas Heiko, Priya, Chandra, Wolfson, Edward, Albrecht, Diego, Zhou, Wei, Pal, Parasar, Rajman, Iris and Sunkara, Gangadhar (2016) Effect of food on the oral bioavailability of the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan (LCZ696) in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics, 54 (12). pp. 1012-1018. ISSN 0946-1965

Bacioglu, Mehtap, Maia, Luis, Schelle, Juliane, Kaeser, Stephan, Schweighauser, Manuel, Shimshek, Derya, Neumann, Ulf, Preische, Oliver, Kahle, Philipp, Staufenbiel, Matthias, Neumann, Manuela, Kuhle, jens and Jucker, Mathias (2016) Neurofilament light chain in blood and CSF as marker of disease progression in mouse models of neurodegenerative diseases. Neuron, 91 (1). pp. 56-66. ISSN 08966273

Bakker, Maarten H., Lee, Cameron, Meijer, E. W., Dankers, Patricia Y. W. and Albertazzi, Lorenzo (2016) Supramolecular multicomponent BTA polymers as a modular platform for intracellular delivery. ACS Nano, 10 (2). pp. 1845-1852. ISSN 1936-08511936-086X

Balko, Justin M and Arteaga, Carlos L (2016) Tumors with amplifications of JAK2 at the 9p24 loci in TNBC demonstrate JAK2-specific dependency. Sci Transl Med., 8 (334). pp. 334-353. ISSN 1946-6242

Bastakoty, Dikshya , Saraswati, Sarika , Atkinson, James , Feoktistov, Igor, Liu, Jun, Harris, Jennifer and Young, Pampee (2016) Temporary, Systemic Inhibition of the WNT/β- Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, Stem cells and Regenerative Medicine, 2 (2). pp. 1-13. ISSN 2472-6990

Bauer, Daniel, Soon, Rachel, Kulmatycki, Kenneth, Chen, Yuming, Noe, Adele, Chen, Jin, Dosik, Jonathan and Meyers, Charles (2016) Photosensitizing potential of pradigastat in healthy subjects: a randomized controlled trial using three defined sunlight exposure conditions. Photochem. Photobiol. Sci., 15 (9). pp. 1155-1162. ISSN 1474-905X1474-9092

Bautista Mercader, Manuel, Tosini, Federico, Schneider, Marcel and Steigmiller, Stefan (2016) Transmission Raman Spectroscopy (TRS): how far can we go with the analysis of capsule based Dry Powder Inhalers? European Pharmaceutical Review, 21 (6). pp. 6-10.

Beckmann, Nicolau, Doelemeyer, Arno, Zurbruegg, Stefan, Bigot, Karine, Theil, Diethilde, Frieauff, Wilfried, Kolly, Carine, Neddermann, Daniel, Kreutzer, Robert, Perrot, Ludovic, Brzak, Irena, Jacobson, Laura, Staufenbiel, Matthias, Neumann, Ulf and Shimshek, Derya (2016) Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice. Neurobiology of Aging, 45. pp. 50-60. ISSN 01974580

Ben M'Barek, Mohamed, Redrup, Michael J, Igarashi, Harue , Schaefgen, Jay , Lin, Jenny , Geisler, Lisa , Ramachandran, Subramanian , Cardoso, Thales and Hillewaert, Vera (2016) Sample Management: Recommendation for best practices and harmonization from the Global Bioanalysis Consortium Harmonization Team. The AAPS Journal, Volume (Issue ). pp. 290-293. ISSN 1550-7416

Bende, Girish, Biswal, Shibadas, Bhad, Prafulla, Chen, Yuming, Salunke, Atish Azad, Winter, Serge, Wagner, Robert and Sunkara, Gangadhar (2016) Relative bioavailability of diclofenac potassium from softgel capsule versus powder for oral solution and immediate-release tablet formulation. Clinical Pharmacology in Drug Development, 5 (1). pp. 76-82. ISSN 2160-7648

Benoit, Roger, Ostermeier, Christian, Geiser, Martin, Widmer, Hans, Auer, Manfred and Li, Julia Su Zhou (2016) Seamless insert-plasmid assembly at high efficiency and low cost. PLOS ONE, April . pp. 1-13.

Berg, Daniela, Godau, Jana, Trenkwalder, Claudia, Eggert, Karla, Csoti, Ilona, Storch, Alexander, Huber, Heiko, Morelli-Canelo, Monica, Stamelou, Maria, Ries, Vincent, Wolz, Martin, Schneider, Christine, Di Paolo, Thérèse, Gasparini, Fabrizio, Hariry, Sam, Vandemeulebroecke, Marc, Gomez-Mancilla, Baltazar, Abi-Saab, Walid, Johns, Donald and Cooke, Katy (2016) AFQ056 treatment of levodopa-induced dyskinesias: results of two randomized controlled trials. Movement Disorders, 26 (7). pp. 1243-1250.

Bergeron, Sophie and Grant, James (2016) Validity Studies - Enhancing Patent Searches. Pharmaceutical patent analyst, Unknow (Unknow). XX-YY. ISSN 2046-8954

Berghausen, Joerg, Seiler, Frank Hans, Gobeau, Nathalie and Faller, Bernard (2016) Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range. ADMET&DMPK.

Bergsdorf, Christian, Fiez-Vandal, Cedric, Sykes, David, Bernet, Pascal, Aussenac, Sonia, Charlton, Steven, Schopfer, Ulrich, Ottl, Johannes and Duckely, Myriam (2016) An alternative thiol-reactive dye to analyze ligand interactions with the chemokine receptor CXCR2 using a new thermal shift assay format. Journal of Biomolecular Screening, 21 (3). pp. 243-251. ISSN 1087-05711552-454X

Bernasconi-Elias, Paula, Hu, Tiancen, Jenkins, David, Firestone, Brant, Gans, Sara, Kurth, Esther, Capodieci, Paola, Deplazes-Lauber, Joelle, Petropoulos, Konstantin, Thiel, Phillip, Ponsel, Dirk, Choi, Sung Hee, Lemotte, Peter, London, Anne, Goetcshkes, Margaret, Nolin, Erin, Jones, Michael, Slocum, Kelly, Kluk, Michael, Weinstock, David, Christodoulou, Alexandra, Weinberg, Olga, Jaehrling, Jan, Ettenberg, Seth, Buckler, Alan, Blacklow, Stephen, Aster, Jon and Fryer, Christy (2016) Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. ISSN 0950-92321476-5594

Beverly, Michael, Dell, Amy, Parmar, Parul and Houghton, Leslie (2016) Label-free analysis of mRNA capping efficiency using RNAse H probes and LC-MS. Analytical and Bioanalytical Chemistry, 408 (18). pp. 5021-5030. ISSN 1618-2650

Bhoumik, Priyasma, Del Rio Espinola, Alberto, Hahne, Florian, Moggs, Jonathan and Grenet, Olivier (2016) Translational Safety Genetics - Leveraging Genetic Variation for Enhanced Safety Assessment. Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Bhowmik, Shiva, Chiu, Hsien-Po, Jones, David, Chiu, Hsiu-Ju, Miller, Mitchell, Xu, Qingping, Farr, Carol Lynn, Ridlon, Jason M., Wells, James E., Elsliger, Marc-Andre, Wilson, Ian A., Hylemon, Phillip B. and Lesley, Scott (2016) Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis. Proteins: Structure, Function and Bioinformatics, 84 (3). pp. 316-331. ISSN 10970134

Bidinosti, Michael, Botta, Paolo, Moreira Ramos Proenca, Catia, Stoehr, Natacha, Bernhard, Mario, Fruh, Isabelle, Mueller, Matthias, Bonenfant, Debora, Voshol, Johannes, Carbone, Walter, Neal, Sarah, Mctighe, Stephanie, Roma, Guglielmo, Dolmetsch, Ricardo, Porter, Jeffrey, Caroni, Pico, Bouwmeester, Antonius, Lüthi, Andreas and Galimberti, Ivan (2016) CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency. Science.

Bigaud, Marc, Dincer, Zuhal, Bollbuck, Birgit, Dawson King, Janet, Beckmann, Nicolau, Beerli, Christian, Cavelti, Gina, Nahler, Michaela, Angst, Daniela, Janser, Philipp, Otto, Heike, Rosner, Elisabeth, Hersperger, Rene, Bruns, Christian and Quancard, Jean (2016) Pathophysiological consequences of a break in S1P1-dependent homeostasis of vascular permeability revealed by S1P1 competitive antagonism. PLOS ONE.

Biosse Duplan, Martin, Komla-Ebri, Davide, Heuzé, Yann, Estibal, Valentin, Gaudas, Emilie, Kaci, Nabil, Benoist-Lasselin, Catherine, Zerah, Michel, Kramer, Ina, Kneissel, Michaela, Graus Porta, Diana, Di Rocco, Federico and Legeai-Mallet, Laurence (2016) Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible. Human molecular genetics. ISSN 1460-2083; 0964-6906

Bojkovic, Jade, Richie, Daryl, Six, David, Rath, Christopher, Sawyer, William, Hu, Daniel and Dean, Charles (2016) Characterization of an Acinetobacter baumannii lptD deletion strain: Permeability defects and response to inhibition of lipopolysaccharide and fatty acid biosynthesis. Journal of Bacteriology, 198 (4). pp. 731-741. ISSN 1098-5530

Bottos, Alessia, Gill, Jason W, Tzankov, Alexander, Wodnar-Filipowicz, Aleksandra and Hynes, Nancy E (2016) Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nature communications, 7 (12258). pp. 1-12. ISSN 2041-1723

Bottos, Alessia, Gotthardt, Dagmar, Gill, Jason W, Gattelli, Albana, Frei, Anna, Tzankov, Alexandar, Sexl, Veronika, Wodnar-Filipowicz, Aleksandra and Hynes, Nancy E (2016) Decreased NK cell-mediated anti-tumor immunity consequent to JAK pathway inhibition enhances metastasis in preclinical models of breast cancer. Nat Commun., 7 (12258). pp. 1-12. ISSN 2041-1723

Bouchez, Laure, Gerbeaux, Cyril, rusch, marion, Livendahl, madeleine, Patoor, Maude and Press, Neil (2016) Wake Up Call of A Sleeping Beauty”: Straightforward Synthesis of Functionalized β-(2-Pyridyl) Ketones from 2,6-Lutidine. Synlett.

Brandl, Trixi, Simic, Oliver, Skaanderup, Philip, Namoto, Kenji, Berst, Frederic, Ehrhardt, Claus, Schiering, Nikolaus, Mueller, Irene Renate and Woelcke, Julian (2016) Trypsin inhibitors for the treatment of pancreatitis. Bioorganic & Medicinal Chemistry Letters.

Brasa, Sarah, Rozenberg, Izabela, Zollinger, Tulipan, Hahne, Florian, Peters, Thomas, Manzella, Liliana, Decker, Jerry, He, Yunsheng, Johnson, Keith, Mccormack, Christine, Gasparini, Fabrizio, Chibout, Salah-Dine, Grenet, Olivier, Moggs, Jonathan, Gomez-Mancilla, Baltazar, Terranova, Remi and Jacquemont, Sebastien (2016) Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome. Clinical Epigenetics, 8 (1). ISSN 18687083

Brasa, Sarah, Sebastien, Jacquemont, Hahne, Florian, Rozenberg, Izabela, Peters, Thomas, He, Yunsheng, Mccormack, Christine, Gasparini, Fabrizio, Chibout, Salah-Dine, Grenet, Olivier, Moggs, Jonathan, Gomez-Mancilla, Baltazar and Terranova, Remi (2016) Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in Fragile X syndrome. Clinical Epigenetics (http://www.clinicalepigeneticsjournal.com/).

Brecht, Karin, Riebel, Virginie, Couttet, Philippe, Paech, Franziska, Wolf, Armin, Chibout, Salah-Dine, Pognan, Francois, Krähenbühl, Stephan and Uteng, Marianne (2016) Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin. Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin, 40. pp. 55-65.

Brian, William, Tremaine, Larry M., Arefayene, Million, de Kanter, Ruben, Evers, Raymond, Guo, Yingying, Kalabus, James, Lin, Wen, Loi, Cho-Ming and Xiao, Guangqing (2016) Assessment of Drug Metabolism Enzyme and Transporter Pharmacogenetics in Drug Discovery and Early Development: Perspectives of the I-PWG. Pharmacogenomics, 17. pp. 615-631. ISSN 1744-8042

Brown, Alan, Drew, Philip, Knight, Brian, Marc, Philippe, Troth, Sean, Wuersch, Kuno and Zandee, Joyce (2016) Graphical display of histopathology data from toxicology studies for drug discovery and development: an industry perspective. Regulatory toxicology and pharmacology, 82. pp. 167-172.

Brunschweiger, Andreas, Gebert, Luca F. R., Lucic, Matije, Pradère, Ugo, Jahns, Hartmut, Hunziker, Juerg and Hall, Jonathan (2016) Site-specific conjugation of drug-like fragments to anti-miRNA oligonucleotides: pros and cons of targeting miRNAs in RISC. Angewandte Chemie International Edition, 52 (1). pp. 156-159. ISSN 1359-73451364-548X

Brykczynska Kunzmann, Urszula, Vrieseling Pecho, Eline, Thiemeyer, Anke, Klein, Jessica, Fruh, Isabelle, Doll, Thierry, Manneville, Carole, Iazeolla, Mariavittoria, Beibel, Martin, Roma, Guglielmo, Naumann, Ulrike, Kelley, Nicholas, Oakeley, Edward James, Mueller, Matthias, Gomez-Mancilla, Baltazar, Buehler, Marc, Tabolacci, Elisabetta, Chiruazzi, Pietro, Neri, Giovanni, Bouwmeester, Antonius, Di Giorgio, Francesco and Fodor, Barna (2016) CGG Repeat-Induced FMR1 Silencing Depends on the Expansion Size in Human iPSCs and Neurons Carrying Unmethylated Full Mutations. Stem Cell Reports, 7 (6). pp. 1059-1071. ISSN 22136711

Brykczynska Kunzmann, Urszula, Vrieseling Pecho, Eline, Thiemeyer, Anke, Klein, Jessica, Fruh, Isabelle, Doll, Thierry, Manneville, Carole, Iazeolla, Mariavittoria, Beibel, Martin, Roma, Guglielmo, Naumann, Ulrike, Kelley, Nicholas, Oakeley, Edward James, Mueller, Matthias, Gomez-Mancilla, Baltazar, Buehler, Marc, Tabolacci, Elisabetta, Chiruazzi, Pietro, Neri, Giovanni, Bouwmeester, Antonius, Di Giorgio, Francesco and Fodor, Barna (2016) Human neurons carrying FMR1 unmethylated full mutations require large CGG repeat expansions for silencing and display neurodegenerative features. Cell Stem Cell.

Brzeszczyńska, Joanna, Johns, Neil, Schilb, Alain, Degen, Simone, Degen, Martin, Langen, Ramon, Schols, Annemie, Glass, David, Roubenoff, Ronenn, Greig, Carolyn A., Jacobi, Carsten, Fearon, Kenneth C.H. and Ross, James A. (2016) Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not healthy elderly. Clinical Cancer Research, 8 (7). pp. 1-12. ISSN 1945-4589

Burmester, Gerd, Durez, Patrick, Shestakova, Galena, Genovese, Mark, Schulze-Koops, Hendrik, Li, Yue, Wang, Amanda, Lewitzky, Steven, Koroleva, Irina, Agarwal-Berneis, Anni, Lee, David M and Hueber, Wolfgang (2016) Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis. Rheumatology (United Kingdom), 55 (1). pp. 49-55. ISSN 14620332

Calonder, Claudio, Polus, Florine, Woessner, Ralph, Loesche, Christian, Cheng, Yi, Dragatin, Christian, Bodenlenz, Manfred, Aigner, Birgit, Tiffner, K, Mader , J, Ratzer , M, Pieber, Thomas, Bruin, Gerardus and Sinner, Frank (2016) Secukinumab Distributes into Dermal Interstitial Fluid of Psoriatic Patients as Demonstrated by Open Flow Microperfusion. Experimental dermatology, 25 (2). pp. 157-159. ISSN 09066705

Camenisch, Gian P. (2016) Drug disposition classification systems in discovery and development: A comparative review of the BDDCS, ECCS and ECCCS concepts. Pharmaceutical Research.

Campbell, Katie, Solovieff, Nadia, Morrissey, Michael, Leary, Rebecca, Mahan, Scott, Adamovich, Wendy, Murphy, Leon, Mirzaa, Ghayda, Jansen, Laura, Timms, Andrew, Conti, Valerio, Adams, Carissa, boyle, Evan, Collins, Sarah, ishak, gisele, poliachik, sandra, girisha, katta, yeung, kit san, chung, brain hon yin, rahikkala, elisa, gunter, sonya, martin, beth, weaver, molly, doerschner, michael, shendure, jay, saneto, russell, novotny, edward, hevner, robert, ojemann, jeffrey, guerrini, renzo, Sellers, William and dobyns, william (2016) Association of MTOR mutations with developmental brain disorders, including megalencephaly, focal cortical dysplasia, and pigmentary mosaicism. JAMA Neurology, 73 (7). pp. 836-845. ISSN 21686149

Caravatti, Giorgio, Guagnano, Vito, Aichholz, Reiner, Blanz, Joachim, Blasco, Francesca, Wipfli, Peter, Fritsch, Christine, Maira, Sauveur-Michel, Schnell, Christian and Seiler, Frank Hans (2016) Increasing metabolic stability via the deuterium kinetic isotope effect: an example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (19). pp. 4729-4734. ISSN 0960-894X

Carita, Guillaume, Frisch Dit Leitz, Estelle, Dahmani, Ahmed, Raymondie, Chloe, Cassoux, Nathalie, Piperno-Neumann, Sophie, Nemati, Fariba, Roman-Roman, Sergio, Wylie, Andrew, Emery, Caroline, Schoumacher, Marie and Decaudin, Didier (2016) Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma. Oncotarget, 7 (23). pp. 33542-33556. ISSN 1949-2553 (Electronic); 1949-2553 (Linking)

Carstens, Nadia, Williams, Sue, Goolam, Saadiah, Carmichael, Trevor, Zou, Chao, Cheung, Chi Ming, Buechmann-Moller, Stine, Sultan, Marc, Staedtler, Frank, Rice, Dennis, Lacoste, Arnaud, Paes, Kim, Swart, Peter and Ramsay , Michele (2016) Novel mutation in the CHST6 gene causes macular corneal dystrophy in a black South African family. BMC medical genetics, 17 (1). p. 47. ISSN 1471-2350

Cejka, Daniel, Parada-Rodriguez, Diego, Pichler, Stefanie, Marculescu, Rodrig, Kramer, Ina, Kneissel, Michaela, Gross, Thomas, Reisinger, Andreas, Pahr, Dieter, Monier-Faugere, Marie-Claude, Haas, Martin and Malluche, Hartmut H. (2016) Sclerostin knock-out does not protect from uremia-induced bone loss in a murine model of chronic renal failure. Kidney International.

Chaker, A, Shamji, MH, Dumitru, A, Calderon, M, Scadding, G, Makatsori, M, Jones, Ieuan, He, Ally, Subramanian, Kulandayan, Arm, Jonathan, Durham, SR and Schmidt-Weber, CB (2016) Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: a randomised controlled trial. Journal of Allergy and Clinical Immunology.

Chandra, Abhishek, Lin, Tiao, Young, Tiffany, Tong, Wei, Ma, Xiaoyuan, Tseng, Wei-Ju, Kramer, Ina, Kneissel, Michaela, Levine, Michael A., Zhang, Yejia, Cengel, Keith, Liu, X. Sherry and Qin, Ling (2016) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of Bone & Mineral Research, 16. ISSN 1523-4681

Chapman, Victoria, Terranova, Remi, Moggs, Jonathan, Kimber, Ian and Dearman, Rebecca (2016) Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens. Toxicology, 340. pp. 17-26. ISSN 1879-3185

Chen, Chao, Zhu, Hugh, Stauffer, Frederic, Caravatti, Giorgio, Vollmer, Susanne, Machauer, Rainer, Holzer, Philipp, Moebitz, Henrik, Scheufler, Clemens, Klumpp, Martin, Tiedt, Ralph, Beyer, Kim, Calkins, Keith, Kiffe, Michael, Guthy, Daniel Alexander, Zhang, Jeff and Gaul, Christoph (2016) The Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Chen, Xiao-Hui, Hatsis, Panagiotis, Judge, Joyce, Argikar, Upendra, Ren, Xiaojun, Sarber, Jason, Mansfield, Keith, Liang, Guiqing, Adamal, Adam , Catoire, Alexandre, Bentley, Adam, Ramos, Luis, Moench, Paul, Hintermann, Samuel, Carcache, David, Glick, Jim and Flarakos, Jimmy (2016) Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry. Analytical Chemistry, 88 (23). pp. 11813-11820. ISSN 0003-27001520-6882

Chen, Ying-Nan P, LaMarche, Matthew J, Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, Acker, Michael G, Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhouliang, Cooke, Vesselina G, Dobson, Jason R, Deng, Zhan, Fei, Feng, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Grunenfelder, Denise, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, La Bonte, Laura R, Lenoir, Francois, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Price, Edmund, Quinn, Christopher, Shakya, Subarna, Shultz, Michael D, Slisz, Joanna, Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Ramsey, Timothy, Keen, Nicholas J, Sellers, William R, Stams, Travis and Fortin, Pascal D (2016) Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature, 535 (7610). pp. 148-152. ISSN 1476-4687

Cheng, Dai, Liu, Jun, Han, Dong, Zhang, Guobao, Hsieh, Hsin-I, Ng, Nicholas, Kasibhatla, Shailaja, Tompkins, Celin, Li, Jie, Steffy, Auzon, Seidel, Martin, Harris, Jennifer and Sun, Fangxian (2016) Discovery of a Novel Series of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med Chem Lett, 7 (7). pp. 676-680. ISSN 1948-5875

Chitnis, Shripad, Han, Yi, Yamaguchi, Masayuki, Nozaki, Sachiko, Zhao, Rong, Kulmatycki, Kenneth and Sunkara, Gangadhar (2016) Population pharmacokinetic modeling and noncompartmental analysis demonstrated bioequivalence between metformin component of metformin/vildagliptin fixed-dose combination products and metformin immediate-release tablet sourced from various countries. Clinical Pharmacology in Drug Development, 5 (1). pp. 40-51. ISSN 2160-7648

Christmann-Franck, Serge, van Westen, Gerard, Papadatos, George, Beltran Escudie, Fanny, Roberts, Alexander, Overington, John P and Domine, Daniel (2016) Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design? Journal of chemical information and modeling, asap (asap). 0-0. ISSN 1549-960X

Clark, Kirk (2016) Outcome of the first wwPDB/CCDC/D3R Ligand Validation Workshop. Structure, 24 (4). pp. 502-508. ISSN 09692126

Clark, Robert, Delise, Anthony and Youreneff, Maureen (2016) Developmental toxicity studies of lumefantrine and artemether in rats and rabbits. Birth defects research. Part B: developmental and reproductive toxicology, 107. pp. 243-257. ISSN 1542-9741; 1542-9733

Colleton, Curtis, Brewster, David, Chester, Anne, Clarke, David, Heining, Peter and Olaharski, Andrew (2016) THE USE OF MINIPIGS FOR PRECLINICAL SAFETY ASSESSMENT BY THE PHARMACEUTICAL INDUSTRY: Results of an IQ DruSafe Minipig Survey. THE USE OF MINIPIGS FOR PRECLINICAL SAFETY ASSESSMENT BY THE PHARMACEUTICAL INDUSTRY: Results of an IQ DruSafe Minipig Survey, 44 (3). pp. 458-466. ISSN 0192-62331533-1601

Colman, Karyn (2016) Impact of the Genetics and Source of Preclinical Safety Animal Models on Study Design, Results and Interpretation. Toxicologic pathology, ? (?). pp. 1-13. ISSN 1533-1601; 0192-6233

Cong, Feng, Hao, Huaixiang and Jiang, Xiaomo (2016) Control of Wnt receptor turnover by R-spondin-ZNRF3/RNF43 signaling module and its dysregulation in cancer. Cancers, 8 (6). ISSN 2072-6694

Corey, Victoria, Fuchs, Olivia, Meister, Stephan, Goldgof, Greg, Winzeler, Elizabeth, Istvan, Eva, Goldberg, Daniel, Coburn-Flynn, Olivia, Gnadig, Nina, Lee, Marcus, Fidock, David, Sakata-Kato, Tomoyo, Lukens, Amanda, Magistrado, Pamela, Wirth, Dyann, Linares, Maria, Franco, Virginia, Gracia, Maria, Gamo, Francisco, Zhou, Yingyao and Tanaseichuk, Olga (2016) Comprehensive analysis of resistance development in the malaria parasite. Nature communications, 7 (1). pp. 1-9. ISSN 2041-1723

Craven, Timothy W., Cho, Min-Kyu, Traaseth, Nathaniel J., Bonneau, Richard and Kirshenbaum, Kent (2016) A Miniature Protein Stabilized by a Cation−π Interaction Network. Journal of the American Chemical Society, 138 (5). pp. 1543-1550. ISSN 0002-7863

Crick, Peter, J., Griffiths, William, J., Zhang, Juan, Beibel, Martin, Abdel-Khalik, Jonas, Kuhle, Jens, Sailer, Andreas and Wang, Yuqin (2016) Reduced plasma levels of 25‐hydroxycholesterol and increased CSF levels of bile acid precursors in multiple sclerosis patients. Molecular Neurobiology. ISSN 0893-7648; 1559-1182

Crutcher, Emeline , May, Ali, Harrison, John, Schaaf, Christian , Sovago, Judit and Gomez-Mancilla, Baltazar (2016) Assessment of cognitive outcome measures in teenagers with 15q13.3 microdeletion syndrome. Genetics in Medicine.

Cytrynbaum, Cheryl, Chong, Karen, Hannig, Vickie, Choufani, Sanaa, Shuman, Cheryl, Steele, Leslie, Morgan, Thomas, Scherer, Stephen W, Stavropoulos, Dimitri J, Basran, Raveen K and Weksberg, Rosanna (2016) Genomic imbalance in the centromeric 11p15 imprinting center in three families: Further evidence of a role for IC2 as a cause of Russell-Silver syndrome. American journal of medical genetics. Part A, 170 (10). pp. 2731-2739. ISSN 1552-4833

D'Alessandro, Pier Luca, Furet, Pascal, Baysang, Frederic, Brunner, Reto, Vorherr, Thomas, Stachyra, Therese-Marie, Ottl, Johannes, Lizos, Dimitrios, Cobos-Correa, Amanda, Marzinzik, Andreas and Kaufmann, Markus (2016) Bioorthogonal Probes to study MDM2-p53 inhibitors in cells and to develop high content screening assays for drug discovery. Angewandte Chemie International Edition, 55 (52). pp. 16026-16030. ISSN 1433-7851

Dalvit, Claudio and Vulpetti, Anna (2016) Weak intermolecular hydrogen-bonds with fluorine: detection and implications for enzymatic/chemical reactions, for chemical physical properties and for ligand/protein fluorine NMR screening. Chemistry-a European Journal.

Daniels, Matthew and Tan, Kian (2016) Substrate and Catalyst Controlled Regioselective C-H Functionalization of Five-Membered Heterocycles. Organic Letters, 18 (14). pp. 3310-3313.

Dawson King, Janet (2016) GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis. no journal (9).

Deanna , Barch, Steve, Marder, Michael, Harms, Lars, Jarksog, Robert, Buchanan, Will, Cronenwett, Li-Shiun , Chen, Weiss, Markus, Maguire, Paul, Pezous, Nicole, Feuerbach, Dominik, Lopez Lopez, Cristina, Johns, Donald and Gomez-Mancilla, Baltazar (2016) Task-related fMRI responses to a nicotinic acetylcholine receptor agonist in schizophrenia: a randomized trial. Progress in Neuro-Psychiticpharmacology and Biol Psy.

Defontis, Myriam / MD, Cote, Serge and Ledieu, David (2016) A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety. Experimental and Toxicologic Pathology. ISSN 16181433

Dejesus, Rowena, Moretti, Francesca, Mcallister, Gregory, Wang, Zuncai, Bergman, Phil, Liu, Shanming, Frias, Elizabeth, Alford, John, Reece-Hoyes, John, Lindeman, Alicia, Kelliher, Jennifer, Russ, Carsten, Knehr, Judith, Carbone, Walter, Beibel, Martin, Roma, Guglielmo, Aylwin, Ng, Ramnik, Xavier, Mickanin, Craig, Murphy, Leon, Hoffman, Gregory and Nyfeler, Beat (2016) Functional CRISPR screening identifies the protein ufmylation pathway as a regulator of SQSTM1/p62. eLife, 5 (NA). NA-NA. ISSN 2050-084X

Delise, Anthony, Solomen, Howard M., Makris, Susan L., Alsaid, Hasan, Bermudex, Oscar, Beyer, Bruce K., Chen, Antong, Chen, Connie L., Chen, Zhou, Chmielewski, Gary, De Schaepdrijver, Luc, Dogdas, Belma, French, Julian, Harrouck, Waffa, Helfott, Jonathan, Henkelman, R. Mark, Hesterman, Jacob, Hew, Kok-Wah, Hoberman, Alan, Lo, Cecilia, McDougal, Andrew, Mink, Daniel, Scott, Lelia, Stewart, Jane, Sutherland, Vicki, Tatiparthi, Arun K., Winkelmann, Christopher T., Wise, L. David, Wood, Sandra L. and Ying, Xiaoyou (2016) Micro-CT Imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A Workshop Report. Regulatory Toxicology and Pharmacology, 77. pp. 100-108. ISSN 02732300

Descombes, Patrick and Oakeley, Edward James (2016) Landscape of Genomics Technology Platforms in Switzerland. International Journal for Chemistry (CHIMIA).

Diagana, Thierry Tidiane, Chavchich, Marina, Van Breda, Karin, Rowcliffe, Kerryn and Edstein, Michael (2016) The spiroindolone KAE609 does not induce dormant ring stages in Plasmodium falciparum parasites. Antimicrobial Agents and Chemotherapy, 60 (9). pp. 5167-5174. ISSN 1098-6596

Dickson, Callum, Hornak, Viktor, Pearlstein, Robert, Mckay, Daniel, Velez-Vega, Camilo, Duca, Jose, Sandham, David, Shaw, Duncan, Fairhurst, Robin, Reilly, John, Charlton, Steven and Sykes, David (2016) Uncoupling the structure-activity relationships of β2 adrenergic receptor ligands from membrane binding. Journal of Medicinal Chemistry, 59 (12). pp. 5780-5789. ISSN 0022-26231520-4804

Dodd, Stephanie, Sethuraman, Vijay, Panicucci, Riccardo, Garad, Sudhakar, Zhou, Liping and Capacci-Daniel, Christina (2016) Co-Crystal Formation Based on Structural Matching. European Journal of Pharmaceutical Sciences. ISSN 09280987

Dole, Kiran, Segal, Florencia, Feire, Adam, Magnusson, Baldur, Rondon, Juan C, Vemula, Janardhana Rao, Yu, Jing, Pang, Yinuo and Pertel, Peter (2016) A first-in-human study to assess the safety and pharmacokinetics of monoclonal antibodies against human cytomegalovirus in healthy volunteers. Antimicrobial Agents and Chemotherapy, 60 (5). pp. 2881-2887. ISSN 0066-4804; 1098-6596

Doll, Thierry, Fruh, Isabelle, Mueller, Matthias, Marcellin, David, Russell, Oliver, Rai, Pavendeep, Taylor, Robert, Lightowlers, Robert, Turnbull, Douglass, Bastien, Julie, Germain, Mitchel, Rygiel, Karolina, Majlinda, Lako and Amy, Reeve (2016) Unanticipated increase in mtDNA deletion heteroplasmy in an in vivo environment. Nature Genetics.

Donner, Lili, Fälker, Knut, Klinker, Stefan, Gremer, Lothar, Pagani, Giulia, Gohlke, Holger, Willbold, Dieter, Lang, Florian, Grenegard, Magnus and Elvers, Margitta (2016) Blood platelets contribute to the formation of Amyloid deposits in cerebral vessels via integrin. Science Signaling, 9 (429). ra52-56. ISSN 1945-08771937-9145

Dovala, Dustin, Rath, Christopher, Hu, Qijun, Sawyer, William, Shia, Steven, Elling, Robert, Knapp, Mark and Metzger Iv, Louis (2016) Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism. Proceedings of the National Academy of Sciences of the United States of America, 28. ISSN 1091-6490

Dovala, Dustin, Sawyer, William, Rath, Christopher and Metzger Iv, Louis (2016) Rapid analysis of protein expression and solubility with the SpyTag-SpyCatcher system. Protein Expr Purif, 117. pp. 44-51. ISSN 1096-0279 (Electronic); 1046-5928 (Linking)

Drollmann, Anton Franz, Lowe, Phil, Meiser, Karin and Arm, Jonathan (2016) Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. Journal of Allergy and Clinical Immunology, 138 (4). pp. 1051-1059. ISSN 1097-6825

Dryja, Ted (2016) Early Insight Into Neovascular Age-Related Macular Degeneration. JAMA Ophthalmology, 134 (11). pp. 1281-1282. ISSN 2168-6173

Dubiknov, Tatyana, Hoepfner, Dominic and Cohen, Ehud (2016) The Triage of Misfolded Prion Molecules to Aggresomes Occurs Within the Endoplasmic Reticulum. Journal of cell science, 129 (19). pp. 3635-3647. ISSN 1477-9137; 0021-9533

Einolf, Heidi, Chen, Jin, Meyers, Charles, Kulmatycki, Kenneth, Bretz, Angela, Wang, Lai, Palamar, Safet, Majumdar, Tapan and Tran, Phi (2016) Pradigastat disposition in humans: in vivo and in vitro investigations. Xenobiotica. ISSN 0049-8254

Ekmark-Lewen, S, Fridgeirsdottir, A, Kiwanuka, O, Hanell, A, Meyerson , B, Mir, Anis Khusro, Gram, Hermann, Lewen , A, Clausen, F, Hillered, L and Marklund, N (2016) Complex behavioral alterations after diffuse traumatic axonal injury in mice are normalized by post-injury neutralization of interleukin-1β. European Journal of Neuroscience, 43 (8). pp. 1016-1033. ISSN 0953816X

El Mouelhi, Mohamed and Roubenoff, Ronenn (2016) Drug Development and Challenges for Neuromuscular Clinical Trials. Journal of Molecular Neuroscience, 58 (3). pp. 374-378. ISSN 1559-1166

Eng , Christina, Wang, Zuncai, Tkach, Diane, Toral-Barzy, Lourdes, Ugwonali, Savuth, Liu, Shanming, Fitzgerald, Stephanie, George, Elizabeth, Frias, Elizabeth, Cochran, Nadire, Dejesus, Rowena, Mcallister, Gregory, Hoffman, Gregory, Bray, Kevin, Lemon, LuAnna, Lucas, Judy, Fantin, Valeria, Abraham, Robert, Murphy, Leon and Nyfeler, Beat (2016) Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. PNAS, 113 (1). pp. 182-187. ISSN 1091-6490

Erpenbeck, Veit, Popov, Todor A, Miller, David, Weinstein, Steven F, Spector, Sheldon, Magnusson, Baldur, Osuntokun, Wande, Goldsmith, Paul, Weiss, Markus and Beier, Jutta (2016) The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma. Pulmonary pharmacology & therapeutics, 39. pp. 54-63. ISSN 1522-9629; 1094-5539

Erpenbeck, Veit, Weiss, Markus, Sandham, David and Neelakantham, Srikanth Raju (2016) Pharmacokinetics, safety, and tolerability of QAW039 (fevipiprant), a novel CRTh2 receptor antagonist: Results from two randomized, phase I, placebo-controlled studies in healthy volunteers. Clinical Pharmacology in Drug Development.

Fabrice, Andre, Hurvitz, Sara, Fasolo, Angelica, Tseng, Ling-Ming, Jerusalem, Guy, Wilks, Sharon, O'Regan, Ruth, Isaacs, Claudine, Toi, Masakazu, Burris, Howard, He, Wei, Riester, Markus, Taran, Tetiana, Chen, David and Slamon, Dennis (2016) Molecular Alterations and Everolimus Efficacy in HER2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3. JCO, 34 (18). pp. 2115-2124. ISSN 1527-7755

Faulkner, Lee, Gibson, Andrew, Sullivan, Andrew, Tailor, Arun, Usui, Toru, Alfirevic, Ana, Pirmohamed, Munir, Naisbitt, Dean J. and Park, B. Kevin (2016) Detection of primary T cell responses to drugs and chemicals in HLA-typed volunteers: implications for the prediction of drug immunogenicity. Toxicological Sciences, 154 (2). pp. 416-429. ISSN 1096-60801096-0929

Fenaux, Martijn, Lin, Xiaodong, Yokokawa, Fumiaki, Sweeney, Zachary, Saunders, Oliver, Xie, Lili, Lim, Siew Pheng, Uteng, Marianne, Uehara, Kyoko, Warne, Robert, Jones, Christopher, Yendluri, Satya, Gu, Helen, Mansfield, Keith, Boisclair, Julie, Heimbach, Tycho, Catoire, Alexandre, Bracken, Kathryn, Weaver, Margaret, Moser, Heinz and Zhong, Weidong (2016) Antiviral nucleotide incorporation by recombinant human mitochondrial RNA polymerase is predictive of increased in vivo mitochondrial toxicity risk. Antimicrobial Agents and Chemotherapy, 60 (12). pp. 7077-7085. ISSN 1098-6596

Ferreira Antunes, Marcia, Eggimann, Fabian, Kittelmann, Matthias, Luetz, Stephan, Hanlon, Steven Paul, Wirz, Beat, Bachler, Thorsten and Winkler, Margit (2016) Human xanthine oxidase recombinant in E. coli: a whole cell catalyst for preparative drug metabolites synthesis. Journal of Biotechnology. ISSN 01681656

Fischer, Jerome (2016) Rapport du stage de 2eme annee. Rapport du stage de 2eme annee..

Flarakos, Jimmy, Du, Yancy, Bedman, Timothy, Chandra, Priya, Al-Share, Qusai, Jordaan, Pierre, Wang, Lai, Gu, Helen, Mangold, James, Albrecht, Diego and Lin, Tsu-Han (2016) Disposition and metabolism of [14C]LCZ696, an angiotensin receptor neprilysin inhibitor, in healthy volunteers. Xenobiotica.

Forrester, William, Chen, Sheng-hong and Lahav, Galit (2016) Schedule-dependent interaction between anticancer treatments. Science, 351 (6278). pp. 1204-1208. ISSN 1095-9203

Forrester, William, Paek, Andrew L., Liu, Julia C., Loewer, Alexander and Lahav, Galit (2016) Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell, 165 (3). pp. 631-642. ISSN 10974172

Fouche, Marianne, Roth, Hans-Joerg, Schaefer, Michael, Berghausen, Joerg, Desrayaud, Sandrine, Blatter, Markus, Piechon, Philippe, Dix, Ina and Martin Garcia, Aimar (2016) Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure. ChemMedChem.

Fouche, Marianne, Schaefer, Michael, Berghausen, Joerg, Desrayaud, Sandrine and Roth, Hans-Joerg (2016) Pharmacokinetic Studies around the Mono- and Difunctionalization of a Bioavailable Cyclic Decapeptide Scaffold. ChemMedChem.

Francotte, Eric (2016) Practical Advances in SFC for the Purification of Pharmaceutical Molecules. LCGC Europe.

Frommlet, Alexandra, Blechschmidt, Anke, Lingel, Andreas, Peng, Chen, Perez, Manuel, Cobas, Carlos and Dominguez, Santiago (2016) An Automated Software Tool for Efficient Processing and Analysis of Ligand-Observed 1H and 19F NMR Binding Data. Journal of Medicinal Chemistry, 59 (7). pp. 3303-3310. ISSN 0022-26231520-4804

Fu, Yunlin, Li, Wenkui, Flarakos, Jimmy and Tse, Francis (2016) LC-MS/MS determination of Pasireotide (SOM230), a cyclic peptide, in monkey plasma. Journal of Chromatography B.

Fu, Yunlin, Xia, Yuan-qing, Flarakos, Jimmy, Tse, Francis, Miller, Jeffrey, Jones, Elliott and Li, Wenkui (2016) Deferential Mobility Spectrometry Coupled with Multiple Ion Monitoring in Regulated LC-MS/MS Bioanalysis of a Therapeutic Cyclic Peptide in Human Plasma. Analytical Chemistry.

Furet, Pascal, Masuya, Keiichi, Kallen, Joerg, Valat, Therese-Marie, Guagnano, Vito, Holzer, Philipp, Mah, Robert, Stutz, Stefan, Vaupel, Andrea, Chene, Patrick, Jeay, Sebastien, Ruetz, Stephan and Schlapbach, Achim (2016) Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument. Bioorganic and Medicinal Chemistry Letters, 26 (19). pp. 4837-4841. ISSN 1464-3405

Gable, Jonathan , Lee, Gregory , Acker, Timothy , Hulce, Kaitlin , Gonzalez, Eric , Schweigler, Patrick, Melkko, Samu, Farady, Christopher and Craik, Charles (2016) Fragment-based protein-protein interaction antagonists of a viral dimeric protease. ChemMedChem.

Gadola, Stephan (2016) Primary Sjögren's Syndrome_Article for Patients (Lays) in German Language. Primäres Sjögren Syndrom.

Gallagher, Iain, Jacobi, Carsten, Tardif, Nicolas and Fearon, Kenneth (2016) Systems biology and cancer cachexia. Special Issue of SCDB .

Gallou, Fabrice (2016) A Deeper Shade of Green: Inspiring Sustainable Pharmaceutical API Manufacturing via the Green Aspiration Level. Green chemistry, 19. pp. 281-285.

Gallou, Fabrice (2016) EvanPhos. A New Ligand for ppm Level Pd-Catalyzed Suzuki-Miyaura Couplings in Either Organic Solvent or Water. Ang Chem Int Ed, 55 (16). pp. 4914-4918.

Gallou, Fabrice, Lipshutz, Bruce and Handa, Sachin (2016) The Evolution of Solvents in Organic Chemistry. ACS Sus. Chem., 4 (11). pp. 5838-5849.

Gallou, Fabrice, Parmentier, Michael, Lipshutz, Bruce and Gabriel , Christopher (2016) Sustainable and Scalable: Fe/ppm Pd Nanoparticle-catalyzed Nitro Group Reductions… in Water at Room Temperature. Org. Proc. Res. Dev..

Gampe, Christian, Hollis-Symynkywicz, Micah and Zecri, Frederic (2016) Covalent Chemical 5'-Functionalization of RNA with Diazo Reagents. Angewandte Chemie. International edition, 55 (35). pp. 10283-10286. ISSN 14337851

Gan, Lu, Jiang, Xuemin, Mendonza, Anisha, Swan, Therese, Reynolds, Christine, Nguyen, Joanne, Pal, Parasar, Neelakantham, Srikanth Raju, Dahlke, Marion, Langenickel, Thomas Heiko, Rajman, Iris, Akahori, Mizuki and Sunkara, Gangadhar (2016) Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects. Clinical Pharmacology in Drug Development, 5 (1). pp. 27-39. ISSN 2160-7648

Gan, Lu, Jiang, Xuemin, Mendonza, Anisha, Swan, Therese, Reynolds, Christine, Nguyen, Joanne, Pal, Parasar, Neelakantham, Srikanth Raju, Dahlke, Marion, Langenickel, Thomas Heiko, Rajman, Iris, Akahori, Mizuki, Zhou, Wei, Rebello, Sam and Sunkara, Gangadhar (2016) Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects. Clinical Pharmacology in Drug Development, 5 (1). pp. 27-39. ISSN 2160-7648

Gan, Lu, Langenickel, Thomas Heiko, Petruck, Jesika, Kode, Kiran Kumar, Rajman, Iris, Chandra, Priyamvada, Zhou, Wei, Rebello, Sam and Sunkara, Gangadhar (2016) Effects of age and gender on the pharmacokinetics of LCZ696, an angiotensin receptor neprilysin inhibitor. Journal of Clinical Pharmacology , 56 (1). pp. 78-86. ISSN 00912700

Gao, Jinhai, Wang, Bing and Rajan, Srinivasan (2016) In-tube Derivatization for the Determination of Absolute Configuration and Enantiomeric Purity of Chiral Compounds by NMR Spectroscopy. Magn Reson Chem.

Gao, Xinliu, Lin, Hui, Krantz, Carsten, Garnier, Arlette, Flarakos, Jimmy, Tse, Francis and Li, Wenkui (2016) Quantitative analysis of factor P (Properdin) in monkey serum using immunoaffinity capturing in combination with LC-MS/MS. Bioanalysis.

Garcia Fortanet, Jorge, Chen, Christine, Chen, Zhuoliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao Bin, Karki, Rajesh, Kato, Mitsunori, Keen, Nicholas, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Shultz, Michael, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah, Zhang, Ji, Lamarche, Matthew and Sellers, William (2016) Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Gauvreau, Gail M, Arm, Jonathan P, Boulet, Louis-Philippe, Leigh, Richard, Cockcroft, Donald W, Davis, Beth E, Mayers, Irvin, FitzGerald, J Mark, Dahlen, Barbro, Killian, Kieran J, Laviolette, Michel, Carlsten, Christopher, Lazarinis, Nikolaos, Watson, Richard M, Milot, Joanne, Swystun, Veronica, Bowen, Miranda, Hui, Linda, Lantz, Ann-Sofie, Meiser, Karin, Maahs, Suzanne, Lowe, Philip J, Skerjanec, Andrej, Drollmann, Anton and O'Byrne, Paul M (2016) Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. The Journal of allergy and clinical immunology, in pre (in pre). 00-00. ISSN 1097-6825

Gedeck, Peter, Lu, Yipin, Skolnik, Suzanne, Rodde, Stephane, Dollinger, Gavin, Jia, Weiping, Berellini, Giuliano, Vianello, Riccardo, Faller, Bernard and Lombardo, Franco (2016) The benefit of retraining pKa models studied using internally measured data. Journal of Chemical Information and Modeling.

Gentile, Antonietta, Musella, Alessandra, Bullitta, Silvia, Fresegna, Diego, De Vito, Francesca, Piras, Eleanora, Gargano, Francesca, Borsellino, Giovanna, Battistini, Luca, Schubart Wellensiek, Anna, Mandolesi, Georgia and Centonze, Diego (2016) EFFECTS OF SIPONIMOD (BAF312) ON SYNAPTIC NEURODEGENERATIVE DAMAGE IN EXPERIMENTAL MULTIPLE SCLEROSIS. J Neuroinflammation, 13 (1). p. 207. ISSN 1742-2094

Ghode, Pramila Baban, Ramachandran, Sarath , Bifani, Juan Pablo and Sivaraman, Jayaraman (2016) Structure and mapping of spontaneous mutational sites of PyrR from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications, 471 (4). pp. 409-415. ISSN 1090-2104

Glatthar, Ralf, Stojanovic, Aleksandar, Troxler, Thomas J., Mattes, Henri, Moebitz, Henrik, Beerli, Rene, Blanz, Joachim, Gassmann, Ernst, Drueckes, Peter, Fendrich, Gabriele, Gutmann, Sascha, Martiny-Baron, Georg, Spence, Fiona, Peel, John Edmondson and Sparrer, Helmut (2016) Discovery of imidazoquinolines as a novel class of potent, selective and in vivo efficacious COT kinase inhibitors. Journal of Medicinal Chemistry, 59 (16). pp. 7544-7560. ISSN 0022-2623

Glowienke, Susanne (2016) Aromatic amine data sharing for 2015. Aromatic amine data sharing, Not ap (Not ap). NA-NA. ISSN Not applicable

Glowienke, Susanne (2016) Assessing safety of extractables from materials and leachables in pharmaceuticals and biologics – current challenges and approaches. Regul Tox Pharm, 81 (?). pp. 201-211. ISSN not available

Glowienke, Susanne (2016) Intermediates mutagenicity data sharing for 2017. Intermediates data sharing.

Glowienke, Susanne (2016) "Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses". Regulatory Toxicology and Pharmacology .

Glowienke, Susanne (2016) Toxicological assessment report on excipients in xxx (formulation) for use in pediatric patients (age groups). Regulatory toxicology and pharmacology.

Glowienke, Susanne (2016) The new ICH M7 Guideline on the assessment and control of mutagenic impurities in pharmaceuticals – Implications on its practical use. PharmInd.

Glowienke, Susanne, Araya, Selene and Lovsin Barle, Ester (2016) Testing strategy for mutagenicity assessment for occupational exposure limit setting of pharmaceutical intermediates. Regul Tox Pharm.

Glowienke, Susanne and Parenty, Alexis (2016) Evaluation Of A Statistically-Based Ames Mutagenicity QSAR Model And Interpretation Of The Results Obtained. Regul Tox Pharm.

Glowienke, Susanne and Parenty, Alexis (2016) It’s difficult, but important, to make negative predictions. Regulatrory Toxicology and Pharmacology.

Gobeau, Nathalie, Stringer, Rowan, De Buck, Stefan, Tuntland, Tove and Faller, Bernard (2016) Evaluation of the GastroPlus™ Advanced Compartmental and Transit (ACAT) Model in Early Discovery. Pharmaceutical Research, 33 (9). pp. 2126-2139. ISSN 1573-904X

Gobeau, Nathalie, Stringer, Rowan, De Buck, Stefan, Tuntland, Tove and Faller, Bernard (2016) Evaluation of the Gastroplus Advanced Compartmental and Transit (ACAT) Model in Early Discovery. Pharmaceutical Research, 33 (9). pp. 2126-2139. ISSN 0724-8741

Goodnow, Robert A., Dumelin, Christoph and Keefe, Anthony D. (2016) DNA-encoded Chemistry: Enabling the deeper sampling of chemical space. Nature Reviews Drug Discovery. ISSN 1474-17761474-1784

Gossert, Alvar and Jahnke, Wolfgang (2016) NMR in drug discovery: A practical guide to identification and validation of ligands interacting with biological macromolecules. Progress in nuclear magnetic resonance spectroscopy, 97 (1). pp. 82-125. ISSN 00796565

Gotwals, Philip and Mataraza, Jennifer (2016) Recent advances in immuno-oncology and its application to urological cancers. BJU International, 118 (4). ISSN 1464-410X

Gram, Hermann (2016) Commentary: Preclinical characterization and clinical development of ILARIS (canakinumab) for the treatment of autoinflammatory diseases. Journal of Rare Diseases Research & Treatment.

Gram, Hermann (2016) Preclinical Characterization and Clinical Development of ILARIS® (canakinumab) for the Treatment of Autoinflammatory Diseases. Chemical Biology. ISSN 13675931

Grant, James and Bergeron, Sophie (2016) Validity Studies - Enhancing Patent Searches. Pharmaceutical Patent Analyst, 5 (6). pp. 373-379. ISSN 2046-8954

Greenidge, Paulette, Lewis, Richard and Ertl, Peter (2016) Boosting Pose Ranking Performance via Rescoring with MM-GBSA. Chemical Biology and Drug Design. ISSN 17470277

Grisouard, Jean, Romanet, Vincent, Murakami, Masato, Skoda, Radek and Radimerski, Thomas (2016) Mice expressing a JAK2 exon 12 mutation display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis. Blood, 2015-1 (2015-1). pp. 1-32. ISSN 27288519

Groot Kormelink, Paul, Ferrand, Sandrine, Kelley, Nicholas, Bill, Anke, Freuler, Felix, Imbert, Pierre-Eloi, Marelli, Anthony, Gerwin, Nicole, Sivilotti, Lucia G, Miraglia, Loren, Orth, Anthony, Oakeley, Edward James, Schopfer, Ulrich and Siehler Wagner, Sandra (2016) High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. PLOS One (Journal), 11 (9). e0163129-e0163129. ISSN 1011-2138

Gutierrez, Marcelo, Pillai, Goonaseelan, Felix, Sandra Daniela, Romero, Fernando, Onyango, Kevin, Owusu-Agyei, Seth, Asante, Kwaku Poku, Barnes, Karen, Sinxadi, Phumla, Abdulla, Salim, Masimirembwa, Collen, Munyoro, Michelle, Yimer, Getnet, Gebre-Mariam, Tsige, Spector, Jonathan and Ogutu, Bernhards (2016) Building capability for clinical pharmacology research in sub-Saharan Africa. Building capability for clinical pharmacology research in sub-Saharan Africa .

Gutierrez, Marcelo, Pillai, Goonaseelan, Felix, Sandra Daniela, Romero, Fernando, Onyango, Kevin, Owusu-Agyei, Seth, Barnes, Karen, Sinxadi, Phumla, Abdulla, Salim, Asante, Kwaku Poku, Masimirembwa, Collen, Munyoro, Michelle, Yimer, Getnet, Gebre-Mariam, Tsige, Spector, Jonathan and Ogutu, Bernhards (2016) Table 1: Building capability for clinical pharmacology research in sub-Saharan Africa. Building capability for clinical pharmacology research in sub-Saharan Africa .

Haffke, Matthias, Rummel, Gabriele, Boivineau, Jacques, Münch, Anna and Jaakola, Veli-Pekka (2016) nanoDSF: label-free thermal unfolding assay of G-protein-coupled receptors for compound screening and buffer composition optimization. Nanotemper Application Note NT-PR-007, - (NT-PR-). pp. 1-4. ISSN -

Hafner, Andreas, Filipponi, Paolo, Piccioni, Lorenzo, Meisenbach, Mark, Schenkel, Berthold, Venturoni, Francesco and Sedelmeier, Joerg Mathias (2016) A simple scale-up strategy for organolithium chemistry in flow mode: From feasibility to kilogram quantities. Organic process research & development.

Hafner, Andreas, Meisenbach, Mark and Sedelmeier, Joerg Mathias (2016) Flash Chemistry on Multigram-Scale: Continuous Flow Synthesis of Boronic Acids within a Second. Organic Letters. ISSN 1523-70601523-7052

Han, Wooseok, Ding , Yu, Xu, Yongjin, Pfister, Keith, Zhu, Shejin, Warne, Robert, Doyle, Mike, Aikawa, Mina, Amiri, Payman, Appleton, Brent, Stuart, Darrin, Fanidi, Abdallah and Shafer, Cynthia (2016) Discovery of A Selective and Potent Inhibitor of MNK Kinase 1/2 Utilizing Structure-Based Drug Design. Journal of Medicinal Chemistry, 59 (7). pp. 3034-3045. ISSN 0022-26231520-4804

Han, Wooseok, Menezes, Daniel L., Xu, Yongjin, Knapp, Mark, Elling, Robert, Burger, Matthew, Ni, Zhi-Jie, Smith, Aaron, Lan, Jiong, Pick, Teresa, Verhagen, Joel, Huh, Kay, Merritt, Hanne, Chan, John, Kaufman, Susan, Voliva, Charles F. and Pecchi, Sabina (2016) Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. Bioorg. Med. Chem. Lett., 26 (3). pp. 742-746. ISSN 0960894X

Hansen, Birgitte Bork (2016) Stability studies of isotope-labelled carboxamides and a palladium-catalysed carbonylative approach using imines to form 4-quinolones. Master Thesis, N/A (N/A). 0-0. ISSN N/A

Hao, Xueshi, Jin, Qihui, Va, Porino, Li, Chun, Shen, Weijun, Laffitte, Bryan and Wu, Tom (2016) Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules. ChemMedChem, 11 (11). pp. 1129-1132. ISSN 1860-7187

Hasan, Maroof and Yan, Nan (2016) Therapeutic potential for inhibiting TBK1 in autoimmune diseases and interferonopathies. Pharmacological Research, 111 (Invite). pp. 336-342. ISSN 1096-1186

Hatakeyama, Shinji, Summermatter, Serge, Jourdain, Marie, Melly, Stefan, Minetti, Giulia and Trifilieff, Estelle (2016) ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments. Skeletal Muscle.

Havrdova, Eva, Belova, Anna, Goloborodko, Alla, Tisserant, Anne, Wright, Andrew, Wallstroem, Erik, garren, hideki, Maguire, Paul and Johns, Donald (2016) Activity of secukinumab, an anti‒IL-17A antibody, on brain lesions in RRMS: Results from a randomized, proof-of-concept study. Journal of Neurology.

Hayes, Lilian, Carmalt, Claire, Tochter, Derek and Press, Neil (2016) The Crystalline Sponge Method: A Systematic Study of the Reproducibility of Simple Aromatic Molecule Encapsulation and Guest–Host Interactions. Crystal Growth And Design, 16 (6). pp. 3465-3472. ISSN 1528-74831528-7505

Helal, Kazi Yasin, Maciejewski, Mateusz, Gregori-Puigjane, Elisabet, Glick, Meir and Wassermann, Anne Mai (2016) Public domain HTS fingerprints: design and evaluation of compound bioactivity profiles from PubChem’s bioassay repository. Journal of Chemical Information and Modeling, 56 (2). pp. 390-398.

Helal, Kazi Yasin, Maciejewski, Mateusz , Gregori-Puigjane, Elisabet, Glick, Meir and Wassermann, Anne Mai (2016) Public domain HTS fingerprints: design and evaluation of compound bioactivity profiles from PubChem’s bioassay repository. Journal of Chemical Information and Modeling, 56 (2). pp. 390-398. ISSN 1549-95961549-960X

Heudi, Olivier, Barteau, Samuel, Picard, Franck and Kretz, Olivier (2016) Quantitative analysis of maytansinoid (DM1) in human serum by on-line solid phase extraction coupled with tandem liquid chromatography mass spectrometry - Method validation and its application to clinical samples. Journal of Pharmaceutical and Biomedical Analysis, 120. pp. 322-332. ISSN 07317085

Heusermann, Wolf, Hean, Justin, Trojer, Dominic, Steib, Emmanuelle, Von Bueren, Stefan, Graff-Meyer, Alexandra, Genoud, Christel, Martin, Katrin, Pizzato, Nicolas, Voshol, Johannes, Morrissey, David, ElAndaloussi, Samir, Wood, Matthew and Meisner Kober, Nicole-Claudia (2016) Exosomes surf on filopodia to enter cells at endocytic hot spots and shuttle within endosomes to scan the ER. Journal of Cell Biology, 213 (2). pp. 173-184. ISSN 1540-8140

Heusermann, Wolf, Hean, Justin, Trojer, Dominic, Von Bueren, Stefan, Graff-Meyer, Alexandra, Genoud, Christel, Martin, Katrin, Voshol, Johannes, Morrissey, David, ElAndaloussi, Samir, Wood, Matthew and Meisner Kober, Nicole-Claudia (2016) Exosomes surf on filopodia to enter cells at endocytic hot spots, and shuttle with endosomes to scan the endoplasmic reticulum – a highway to the cell. Journal of Cell Biology, 213 (2). pp. 173-184. ISSN DOI: 10.1083

Hinder, Markus and Schuhmacher, Alexander (2016) Changing R&D Models in Research-based Pharmaceutical Companies. J Translat Med.

Hinder, Markus, Schuhmacher, Alexander and Gassmann, Oliver (2016) Changing R&D Models in Research-based Pharmaceutical Companies. J Translat Med, 14 (195). pp. 1-11. ISSN DOI: 10.1186/s12967-016-0838-4

Hintermann, Samuel, Guntermann, Christine, Mattes, Henri, Carcache, David, Vulpetti, Anna, Dawson King, Janet, Kaupmann, Klemens, Kallen, Joerg, Stringer, Rowan, Orain, David, Wagner, Juergen and Billich, Andreas (2016) Synthesis and biological evaluation of new triazolo and imidazolopyridine RORγt inverse agonists. ChemMedChem : chemistry enabling drug discovery, 11 (24). pp. 2640-2678. ISSN 1860-7179

Hoegenauer, Klemens, Soldermann, Nicolas, Hebach, Christina, Hollingworth, Greg, Lewis, Ian, Von Matt, Anette, Smith, Alexander Baxter, Wolf, Romain, Wilcken, Rainer, Haasen, Dorothea, Burkhart, Christoph and Zecri, Frederic (2016) Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties. Bioorganic and medicinal chemistry letters, 26 (23). pp. 5657-5662. ISSN 0960-894X

Hoegenauer, Klemens, Soldermann, Nicolas, Stauffer, Frederic, Furet, Pascal, Graveleau, Nadege, Smith, Alexander Baxter, Hebach, Christina, Hollingworth, Greg, Lewis, Ian, Gutmann, Sascha, Rummel, Gabriele, Knapp, Mark, Wolf, Romain, Blanz, Joachim, Feifel, Roland, Burkhart, Christoph and Zecri, Frederic (2016) Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Hoffmann, Peter, Keselica, Michael, Gunson, Diane and Lapadula, Daniel (2016) Acute Toxicity of Vildagliptin: Differences in Sensitivity Between Cynomolgus Monkeys of Asian or Mauritian Origin. Toxicol Pathol, 45. pp. 76-83.

Hofmann, Irmgard, Ciferri, Claudio, Wen, Yingxia, Schulze, Axel, Fühner, Viola, Leong, Megan, Gerber, Andrea, Gerrein, Rachel, Nandi, Avishek, Lijla, Anders E. , Carfi, Andrea and Laux, Holger (2016) Expression of the Human Cytomegalovirus Pentamer Complex for vaccine use in a CHO system. Biotech Bioeng.

Honda, Ayako, Harrington, Edmund, Furet, Pascal, Knapp, Mark, Triantafellow, Ellen, Hamann, Lawrence, Firestone, Brant, Murphy, Leon and Keaney, Erin (2016) Potent, selective, and orally bioavailable inhibitors of VPS34 provide chemical tools to modulate autophagy in vivo. ACS Medicinal Chemistry Letters, 7 (1). pp. 72-76. ISSN 1948-58751948-5875

Honma, Wataru, Gautier, Aurelie, Paule, Ines, Yamaguchi, Masayuki and Lowe, Phil (2016) Ethnic sensitivity assessment of pharmacokinetics and pharmacodynamics of omalizumab with dosing table expansion. Drug Metabolism and Pharmacokinetics, 31 (3). pp. 173-184. ISSN 13474367

Hu, Qi-Ying (2016) Towards the next generation of biomedicines by site-selective conjugation. Chemical Society reviews, 45 (6). pp. 1691-1719. ISSN 1460-4744

Huang, Jiaqing, Bruin, Gerardus, Liang, Eric, Fox, Todd K, Reich, Kristian, Blauvelt, Andrew, Lloyd, Peter and Armstrong, April (2016) Secukinumab, an Anti–Interleukin-17A Monoclonal Antibody, Exhibits Minimal Immunogenicity in Subjects with Moderate to Severe Psoriasis. British journal of dermatology, online (xx). xx-xx. ISSN 1365-2133; 0007-0963

Hughes, James N, Aubert, Matthew, Heatlie, Jessica, Gardner, Alison, Gecz, Jozef, Morgan, Thomas, Belsky, Joseph and Thomas, Paul Q (2016) Identification of an IGSF1-specific deletion in a five-generation pedigree with X-linked Central Hypothyroidism without macroorchidism. Clinical endocrinology, 85 (4). pp. 609-615. ISSN 1365-2265

Hunziker, Juerg, Koch, Guido and Press, Neil (2016) Reaction: Synthesis in Drug Discovery – The Short and Long of It. Chem, 1 (3). pp. 336-338. ISSN 24519294

Huskey, Su-Er, Forseth, Ry, Li, Hongmei, Jian, Zhigang, Catoire, Alexandre, Zhang, Jin, Ray, Tapan, He, Handan, Flarakos, Jimmy and Mangold, James (2016) Utilization of stable isotope labeling to facilitate the identification of polar metabolites of KAF156, an antimalarial agent. Drug Metabolism and Disposition, 44 (10). pp. 1697-1708. ISSN 1521-009X

Huskey, Su-Er, Li, Hongmei, Catoire, Alexandre, Zhang, Jin, Jian, Zhigang, Flarakos, Jimmy and Mangold, James (2016) UTILIZATION OF STABLE ISOTOPE LABELING TO FACILITATE THE IDENTIFICATION OF VERY POLAR METABOLITES IN RAT URINE. Drug metabolism and disposition, 44 (1). pp. 1697-1708. ISSN 1521-009X

Huskey, Su-Er, Zhu, Chunqi, Forseth, Ry, Gu, Helen, Simon, Oliver, Eggimann, Fabian, Kittelmann, Matthias, Luneau, Alexandre, Vargas, Alexandra, Li, Hongmei, Wang, Lai, Einolf, Heidi, Zhang, Jin, Favara, Sarah, He, Handan and Mangold, James (2016) Identification of three novel ring expansion metabolites of KAE609 in rat, dog, and human, a new spiroindolone agent for the treatment of malaria. Drug metabolism and disposition, Identification of three novel ring expansion metabolites of KAE609 in rat, dog, and human, a new spiroindolone agent for the treatment of malaria, 44 (5). pp. 653-664. ISSN 1521-009X (Online)

Huskey, Su-Er, Zhu, Chunqi, Fredenhagen, Andreas, Kuehnoel, Juergen, Luneau, Alexandre, Jian, Zhigang, Yang, Ziping, Miao, Zhuang, Yang, Fan, Jain, Jay Prakash, Sunkara, Gangadhar, Mangold, James and Stein, Daniel (2016) KAE609 (Cipargamin), a new spiroindolone agent for the treatment of malaria: Evaluation of the Absorption, Distribution, Metabolism and Excretion of a single oral 300 mg dose of [14C]KAE609 in healthy male subjects. Drug Metabolism and disposition, DMD 44 (5). pp. 672-682. ISSN 1521-009X

Jacobson, LH, Sweeney, FF, Kaupmann, Klemens, OLeary, OFO, Gassmann, M, Bettler, B and Cryan, JF (2016) Differential Roles of GABAB1 Subunit Isoforms on Locomotor Responses to Acute and Repeated Administration of Cocaine. Behavioural Brain Research , 298 (Pt B). pp. 12-16. ISSN 1872-7549

Jahnke, Wolfgang, Erlanson, Daniel A, Fesik, Stephen W, Hubbard, Roderick E and Jhoti, Harren (2016) Twenty years on: the impact of fragments on drug discovery. Nature Reviews Drug Discovery, 1 (1). pp. 1-2. ISSN 1474-17761474-1784

Janowski, Pawel, Moriarty, Nigel, Kelley, Brian, Case, David, York, Darrin, Adams, Paul and Warren, Greg (2016) IMPROVED LIGAND GEOMETRIES IN CRYSTALLOGRAPHIC REFINEMENT USING AFITT IN PHENIX. Acta Crystallographica Section D, 72 (9). pp. 1062-1072. ISSN 2059-7983

Jenkins, Jeremy (2016) Future Medicinal Chemistry - Ask the Experts. Future Medicinal Chemistry special issue: computational chemistry and computer-aided drug discovery, 8 (15). pp. 1807-1813. ISSN 1756-8919

Jenkins, Jeremy (2016) What is the key best practice for collaborating with a computational biologist? Cell systems., 3 (1). pp. 7-11. ISSN 24054712

Jenkins, Jeremy and Schirle, Markus (2016) Identifying Compound Efficacy Targets in Phenotypic Drug Discovery. Drug Discovery Today.

Ji, Wenzhi, Liu, Yahu and Liao, Xuebin (2016) Transition-Metal-Free Synthesis of N-Hydroxy Oxindoles by an Aza- Nazarov-Type Reaction Involving Azaoxyallyl Cations. Angewandte Chemie. International edition, 55 (n/a). pp. 13286-13289. ISSN 1521-3773; 0570-0833; 1433-7851

Jia, Yong, Juarez, Jose, Li, Jie, Manuia, Mari, Niederst, Matthew, Tompkins, Celin, Timple, Noelito, Vaillancourt, Mei Ting, Pferdekamper, Annemarie, Lockerman, Elizabeth, Li, Chun, Anderson, Jennifer, Costa, Carlotta, Liao, Debbie, Murphy, Eric, Didonato, Michael, Bursulaya, Badry, Lelais, Gerald, Barretina, Jordi, Mcneill, Matthew, Epple, Robert, Marsilje, Thomas, Pathan, Nuzhat, Michellys, Pierre, Mcnamara, Peter, Harris, Jennifer, Bender, Steven, Engelman, Jeffrey and Kasibhatla, Shailaja (2016) EGF816, an irreversible mutant-selective EGFR inhibitor, is effective in NSCLC with both primary activating and T790M-mediated resistant EGFR mutations. Cancer Research, 76 (6). OF1-OF12. ISSN Cancer Res; 76(6) March 15, 2016

Jiang, Xiaomo and Cong, Feng (2016) Novel Regulation of Wnt Signaling at the Proximal Membrane Level. Trends in Biochemical Sciences, 41 (9). pp. 773-783. ISSN 1362-4326

Kalkman, HO and Feuerbach, Dominik (2016) Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders. Cellular and molecular life sciences.

Kalkman, HO and Feuerbach, Dominik (2016) Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders. Cellular and Molecular Life Sciences.

Kalkman, HO and Feuerbach, Dominik (2016) Promotion of microglial M2-polarization by antidepressants. Pharmacology and Therapeutics.

Kamptmann, Sonja (2016) Application note: High product purity in pressure reactions. Application note Mettler-Toledo, n.a. (n.a.). ISSN n.a.

Keller, Baerbel, Cseresnyes, Zoltan, Stumpf, Ina, Wehr, Claudia, Fliegauf, Manfred, Bulashevska, Alla, Usadel, Susanne, Grimbacher, Bodo, Rizzi, Marta, Eibel, Hermann, Niesner, Raluca and Warnatz, Klaus (2016) Disturbed canonical NF-kB signaling in B cells of CVID patients. Journal of Allergy and Clinical Immunology, none (none). pp. 1-20. ISSN 0091-6749

Kesisoglou, Filippos, Chung, John, van Asperen, Judith and Heimbach, Tycho (2016) Physiologically Based Absorption Modeling to Impact Biopharmaceutics and Formulation Strategies in Drug Development—Industry Case Studies. Journal of Pharmaceutical Sciences, 105 (9). pp. 2723-2734. ISSN 1520-6017

Khare, Shilpi, Nagle, Advait, Lai, Yin, Liang, Fang, Davis, Lauren, Barnes, Whitney, Mathison, Casey, Myburgh, Elamrie, Gao, Mu-Yun, Gillespie, Robert, Liu, Xianzhong, Tan, Jocelyn, Stinson, Monique, Rivera, Ianne, Ballard, Jaime, Yeh, Vince, Groessl, Todd, Federe, Glenn, Koh, Hazel, Venable, John, Bursulaya, Badry, Shapiro, Michael, Mishra, Pranab, Spraggon, Glen, Brock, Ansgar, Mottram, Jeremy, Buckner, Frederick, Rao, Srinivasa P.S., Wen, Ben, Walker, John, Tuntland, Tove, Molteni, Valentina, Glynne, Richard and Supek, Frantisek (2016) Parasite proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness. Nature, 537 (7619). pp. 229-233. ISSN 0028-0836

Kikkawa, Rie (2016) A Case of Drug-Induced Cutaneous Toxicity Observed in Cynomolgus Monkeys. Toxicologic Pathology .

Kim, Sean, La Bonte, Laura, Liang, Guiqing, Berellini, Giuliano and Lombardo, Franco (2016) Systematic Evaluation of Wajima Superposition (Css-MRT) in the Estimation of Human Intravenous Pharmacokinetic Profile. Journal of Pharmacological Science.

King, Frederick, Ainscow, Edward, Tuntland, Tove, Kim, Sunkyu, Grandinetti, Kathryn, Caponigro, Giordano, He, You Qun, Krupa, Shiva, Li, Nanxin, Harris, Jennifer, Wood, Andrew C., Krytska, Kateryna, Ryles, Hannah, Infarinato, Nicole, Sano, Renata, Hansel, Theodore, Hart, Lori, Mosse, Yael P. and Smith, Timothy R. (2016) Combination CDK4/6 and ALK inhibition demonstrates on-target synergy against neuroblastoma. Cancer Research, 74 (19). pp. 2856-2868. ISSN 00085472

King, Frederick, Ainscow, Edward, Tuntland, Tove, Kim, Sunkyu, Grandinetti, Kathryn, Caponigro, Giordano, He, You Qun, Krupa, Shiva, Li, Nanxin, Harris, Jennifer, Wood, Andrew C., Krytska, Kateryna, Ryles, Hannah, Infarinato, Nicole, Sano, Renata, Hansel, Theodore, Hart, Lori, Mosse, Yael P. and Smith, Timothy R. (2016) Combination CDK4/6 and ALK inhibition demonstrates on-target synergy against neuroblastoma. Clinical Cancer Research, 74 (19). pp. 2856-2868. ISSN 00085472

Knee, Deborah, Hewes, Becker and Brogdon, Jennifer (2016) Rationale for anti-GITR cancer immunotherapy. European journal of cancer, 67 (NA). pp. 1-10. ISSN 09598049

Kobalava, Zhanna, Kotovskaya, Yulia , Averkov, Oleg, Pavlikova, Elena, Moiseev, Valentine, Albrecht, Diego, Chandra, Priyamvada, Ayalasomayajula, Surya, Prescott, Margaret, Pal, Parasar, Langenickel, Thomas Heiko, Jordaan, Pierre and Rajman, Iris (2016) Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction. Cardiovascular Therapeutics, 34 (4). pp. 191-198. ISSN 1755-5922

Kobalava, Zhanna, Villevalde, Svetlana, Kotovskaya, Yulia, Hinrichsen, Holger, Petersen-Sylla, Marc, Zaehringer, Andreas, Pang, Yinuo, Rajman, Iris, Canadi Semadeni, Jasna, Dahlke, Marion, Lloyd, Peter and Halabi, Atef (2016) Pharmacokinetics of serelaxin in patients with hepatic impairment: A single-dose, open-label, parallel-group study. British Journal of Clinical Pharmacology.

Komla-Ebri, Davide, Dambroise, Emilie, Kramer, Ina, Benoist-Lasselin, Catherine, Kaci, Nabil, Le Gall, Cindy, Martin, Ludovic, Busca, Patricia, Barbault, Florent, Graus Porta, Diana, Munnich, Arnold, Kneissel, Michaela, Di Rocco, Federico, Biosse-Duplan, Martin and Legeai-Mallet, Laurence (2016) Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model. Journal of Clinical Investigation.

Korneeva, Nadejda , Song, Anren, Gram, Hermann, Edens, Mary and Rhoads, Robert (2016) INHIBITION OF MAP KINASE-INTERACTING KINASE (MNK) PREFERENTIALLY AFFECTS TRANSLATION OF mRNAs CONTAINING BOTH A 5’-TERMINAL CAP AND HAIRPIN. JBC, 291 (7). pp. 3455-3467. ISSN 0021-92581083-351X

Krantz, Carsten (2016) 2016 White Paper on Recent Issues in Bioanalysis: Focus on Biomarker Assay Validation (BAV) (Part 2 – Hybrid LBA/LCMS and Input from Regulatory Agencies). Bioanalysis, 8 (23). pp. 2457-2474. ISSN bio-2016-4988

Krantz, Carsten (2016) Bioanalysis spotlight on Hybrid LBA/LC–MS Commentary: Carsten Krantz. published online: http://www.bioanalysis-zone.com/2016/05/18/hybrid-lbalc-ms-developments-benefits-hybrid-lba-lcms/, NA (NA). NA-MA. ISSN NA

Kraynov, Eugenia, Kamath, Amrita, Walles, Markus, Tarcsa, edit, Deslandes, Antoine, Datta, Amita, Siraman, Priya, Bairlein, Michaela, Yang, Johnny, Barfield, Matthew, Xiao, Guangchin, Escandon , Enrique, Wang, Weiron, Rock, Dan and Moore, David (2016) Assessment of the Current Approaches for ADME Characterization of Antibody-Drug Conjugates and Recommendations for Best Practices: An Industry White Paper. Drug Metabolism and Disposition.

Krepl, Miroslav, Clery, Antoine, Blatter, Markus, Allain, Frederic H.T. and Sponer, Jiri (2016) Synergy between NMR measurements and MD simulations of protein/RNA complexes: Application to the RRMs, the most common RNA Recognition Motifs. Nucleic acids research, 44 (13). pp. 6452-6470. ISSN 1362-4962; 0305-1048

Krepler, Clemens, Xiao, Min, Sproesser, Katrin, Brafford, Patricia, Shannan, Batool, Beqiri, Marilda, Liu, Qin, Xu, Wei, Garman, Bradley, Nathanson, Katherine, Xu, Xiaowei, Giorgos, Karakousis, Mills, Gordon, Lu, Yiling, Ahmed, Tamer, Poulikos, Poulikakos, Caponigro, Giordano, Boehm, Markus, Peters, Malte, Schuchter, Lynn, Weeraratna, Ashani and Meenhard, Herlyn (2016) Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models identify second line combination therapies. Clinical Cancer Research, 22 (7). pp. 1592-1602. ISSN 1078-0432

Kullak-Ublick, Gerd, Merz, Michael and End, Peter (2016) Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut.

Küffer, Alexander, Lakkaraju, Asvin , Doucerain, Cédric , Monnard, Arnaud , Schiavi, Carmen , Airich, Kristina , Grosshans, Bianka, Hornemann, Simone , Bassilana, Frederic and Aguzzi, Adriano (2016) The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature, 536 (7617). pp. 464-468. ISSN 14764687

LaMonte, Gregory , Lim, Michelle, Wree, Melanie , Nachon, Marie , Corey, Victoria , Plouffe, David, Gedeck, Peter, Du, Alan , Figueroa, Nelissa , Yeung, Bryan King Sing, Bifani, Juan Pablo and Winzeler, Elizabeth (2016) Mutations in the P. falciparum Cyclic Amine Resistance Locus (PfCARL) confer multi-drug resistance. mBio, 7 (4). 00696-00716. ISSN 2161-2129; 2150-7511

LaRochelle, Jonathan, Fodor, Michelle, Durzynska, Izabela, Xu, Xiang, Fan, Lixing, Stams, Travis, Chan, Ho Man, Lamarche, Matthew, Chopra, Rajiv, Wang, Ping, Fortin, Pascal, Acker, Michael and Blacklow, Stephen (2016) Structural and functional consequences of three cancer-associated mutations of the oncogenic phosphatase SHP2. Biochemistry, 55 (15). pp. 2269-2277. ISSN 1520-4995

LaRochelle, Jonathan R., Fodor, Michelle, Durzynska, Izabela, Xu, Xiang, Fan, Lixin, Stams, Travis, Chan, Ho Man, Lamarche, Matthew, Chopra, Raj, Wang, Ping, Fortin, Pascal, Acker, Michael and Blacklow, Stephen C. (2016) Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55 (15). pp. 2269-2277. ISSN 1520-4995

Laffitte, Bryan, Shen, Weijun, Glynne, Richard and Mcnamara, Peter (2016) Inhibition of the NFAT kinases, GSK3beta and Dyrk1a, increases human beta cell proliferation and islet mass. Nature Communications.

Langenickel, Thomas Heiko, Jordaan, Pierre, Jesika, Petruck, Kode, Kiran Kumar, Pal, Parasar, Vaidya, Soniya, Priya, Chandra and Rajman, Iris (2016) Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization. European Journal of Clinical Pharmacology, 72 (8). pp. 917-924. ISSN 1432-1041

Lanshoeft, Christian, Heudi, Olivier and Cianférani, Sarah (2016) SMART Digest™ compared with pellet digestion for analysis of human immunoglobulin G1 in rat serum by liquid chromatography tandem mass spectrometry. Analytical Biochemistry, 501. pp. 23-25.

Lanshoeft, Christian, Heudi, Olivier, Cianférani, Sarah, Warren, Andrew Paul, Picard, Franck and Kretz, Olivier (2016) Quantitative analysis of hIgG1 in monkey serum by LC-MS/MS using mass spectrometric immunoassay. Bioanalysis.

Lanshoeft, Christian, Stutz, Gerhard, Elbast, Walid, Wolf, Thierry, Walles, Markus, Stoeckli, Markus, Picard, Franck and Kretz, Olivier (2016) Analysis of small molecule antibody-drug conjugate catabolites in rat liver and tumor tissue by liquid extraction surface analysis micro-capillary liquid chromatography tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 30 (7). pp. 823-832.

Lanshoeft, Christian, Wolf, Thierry, Heudi, Olivier, Cianferani, Sarah, Barteau, Samuel, Walles, Markus, Picard, Franck and Kretz, Olivier (2016) The use of generic surrogate peptides for the quantitative analysis of immunoglobulin G1 in pre-clinical species with high-resolution mass spectrometry. Analytical and bioanalytical Chemistry.

Lanshoeft, Christian, Wolf, Thierry, Walles, Markus, Barteau, Samuel, Picard, Franck, Kretz, Olivier, Cianférani, Sarah and Heudi, Olivier (2016) The flexibility of a generic LC-MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies. Journal of Pharmaceutical and Biomedical Analysis, 131 (-). pp. 214-222. ISSN 0731-7085

Larraufie, Marie-Helene, Rusch, Marion and Bouchez, Laure (2016) Diels-Alder Cycloaddition in Medicinal Chemistry. Current Organic chemistry - bentham science.

Laurent, Didier, Laurent, Vinet, Smaragda, Lamprianou, Marie , Daval, Gaelle, Filhoulaud, Haiyan, Wang, Sabine, Sewing, Hans-Paul, Juretschke, Heiner, Glombik, Paolo, Meda, Raphael, Boisgard, Duc Loc, Nguyen, Graeme J, Stasiuk, Nicholas J, Long, Xavier, Montet, Peter, Hecht, Werner, Kramer, Guy, Rutter and Jacob, Hecksher-Sorensen (2016) Pancreatic β-cell imaging in humans: Fiction or option? Diabetes, Obesity and Metabolism, 18 (1). pp. 6-15. ISSN 1463-1326

Lee, Patrick and Schlesinger, Ann (2016) Stanford-NIBR Mentoring Program Pilot. n/a.

Leeds, Jennifer, Brewer, Jason, Dean, Karl, Ding, Jian, Gamber, Gabriel, Jain, Akash, Kerrigan, John, Krastel, Philipp, Lee, Kwangho, Lombardo, Franco, Mckenney, David, Neckermann, Georg, Osborne, Colin, Palestrant, Deborah, Patane, Michael, Rann, Elin, Robinson, Zach, Schmitt, Esther, Stams, Travis, Yu, Donghui and Whitehead, Lewis (2016) Antibacterial and Solubility Optimization of Thiomuracin A. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Legangneux, Eric, Shakeri-Nejad, Kasra, Aslanis, Vassilios, Sagkriotis, Alexandros, Pezous, Nicole, Brendani, Bruno and Behrje, Rhett (2016) Cardiac Effects of Siponimod (BAF312) Re-initiation after Variable Periods of Drug Discontinuation in Healthy Subjects. Clinical Therapeutics, 38 (3). 631-645e1. ISSN 1879-114X

Legangneux, Eric, Shakeri-Nejad, Kasra, Aslanis, Vassilios, Sagkriotis, Alexandros, Pezous, Nicole, Brendani, Bruno, Behrje, Rhett and Gutierrez, MJ (2016) Cardiac Effects of Siponimod (BAF312) Re-initiation after Variable Periods of Drug Discontinuation in Healthy Subjects. Clinical Therapeutics, 38 (3). 631-645e1. ISSN 1879-114X

Lehmann, Hansjoerg (2016) A scalable and safe continuous flow procedure for in-line generation of Diazomethane and its precursor MNU. Green chemistry.

Leite, Leticia N, Gonzaga, Natalia A, Simplicio, Janaina A, do Vale, Gabriel T, Carballido, Jose, Alves_Filho, José C and Tirapelli, Carlos R (2016) Pharmacological characterization of the mechanisms underlying the vascular effects of succinate. European Journal of Pharmacology, 789 (Jul 27). pp. 334-343. ISSN 00142999

Lelais, Gerald, Epple, Robert, Marsilje, Thomas, Long, Yun, Mcneill, Matthew, Chen, Bei, Lu, Wenshuo, Anumolu, Jaganmohan, Badiger, Sangamesh, Bursulaya, Badry, Didonato, Michael, Fong, Rina, Juarez, Jose, Li, Jie, Manuia, Mari, Mason, Daniel, Gordon, William, Groessl, Todd, Johnson, Kevin, Jia, Yong, Kasibhatla, Shailaja, Li, Chun, Isbell, John, Spraggon, Glen, Bender, Steven and Michellys, Pierre (2016) Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small Cell Lung Cancers. Journal of Medicinal Chemistry, 59 (14). pp. 6671-6689. ISSN 0022-26231520-4804

Lelais, Gerald, Epple, Robert, Marsilje, Thomas, Long, Yun, Mcneill, Matthew, Chen, Bei, Lu, Wenshuo, Anumolu, Jaganmohan, Badiger, Sangamesh, Bursulaya, Badry, Didonato, Michael, Fong, Rina, Juarez, Jose, Li, Jie, Manuia, Mari, Mason, Daniel, Gordon, William, Groessl, Todd, Johnson, Kevin, Jia, Yong, Kasibhatla, Shailaja, Li, Chun, Isbell, John, Spraggon, Glen, Bender, Steven and Michellys, Pierre (2016) Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small Cell Lung Cancers. Journal of Medicinal Chemistry, 59 (14). pp. 6671-6689. ISSN 10.1021/acs.jmedchem.5b01985

Lelais, Gerald, Epple, Robert, Marsilje, Thomas, Long, Yun, Mcneill, Matthew, Chen, Bei, Lu, Wenshuo, Anumolu, Jaganmohan, Badiger, Sangamesh, Bursulaya, Badry, Didonato, Michael, Fong, Rina, Juarez, Jose, Li, Jie, Manuia, Mari, Mason, Daniel, Gordon, William, Groessl, Todd, Johnson, Kevin, Jia, Yong, Kasibhatla, Shailaja, Li, Chun, Isbell, John, Spraggon, Glen, Bender, Steven and Michellys, Pierre (2016) Discovery of a Novel and Potent Mutant Selective EGFR Inhibitor (EGF816) for the Treatment of EGFR mutant Non-Small Cell Lung Cancers. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Leong, Franz Joel Wen, Zhao, Rong and Magnusson, Baldur (2016) Study protocol CKAF156X2201: A proof-of-concept, open label study to assess efficacy, safety, tolerability and pharmacokinetics of KAF156 in adult patients with acute, uncomplicated Plasmodium falciparum or vivax malaria mono-infection. New England journal of medicine : NEJM., 375 (12). pp. 1152-1160. ISSN 0028-4793

Leroy, Cedric, Ramos, Pedro, Cornille, Karen, Fritsch, Christine, Bonenfant, Debora, Voshol, Johannes and Bentires-Alj, Mohamed (2016) Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition. Breast Cancer Research.

Levell, Julian, Cho, Young, Caferro, Thomas, Chenail, Gregg, Dix, Ina, Dooley, Julie, Firestone, Brant, Fortin, Pascal, Giraldes, John, Gould, Ty, Herlihy, Kara, Hood, Tami, Kulathila, Raviraj, Lin, Fallon, Liu, Gang, Van Der Plas, Simon, Slocum, Kelly, Smith, Troy, Toure, Bakary-Barry, Wagner, Beatrix, Xie, Xiaoling, Yang, Fan, Pagliarini, Raymond, Xu, Ming and Zhou, Liping (2016) Identification and Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Medicinal Chemistry Letters, 8 (2). pp. 151-156. ISSN 1948-5875

Lewis, Richard, Duca, Jose, Sherbourne, Brad, Manas, Eric, Christ, Clara, Shanmugasundaram, Veer, Cheng, Alan, DesJarlais, Renee, McGaughey, Georgia and van Vlijmen, Herman (2016) Collaborating to improve the use of free-energy and other quantitative methods in drug discovery. Journal of Computer-Aided Molecular Design, 30 (12). pp. 1139-1141. ISSN 15734951

Li, Yanran and Smolke, Christina (2016) Elucidating and Engineering the Biosynthesis of Noscapine in Saccharomyces cerevisiae. Nature Communications, 7 (N/A). p. 12137. ISSN 2041-1723

Lim, Siew Pheng, Noble, Christian Guy, Seh, Cheah Chen, Soh, Sherryl, Julien, Lescar, Shahul, Nilar, Manjunatha, Ujjini Havaldar, Arora, Rishi, Benson, Timothy, Wan, Kah Fei, Dong, Hongping, xie, Xuping, Pei-Yong, Shi and Yokokawa, Fumiaki (2016) Potent allosteric dengue virus NS5 polymerase inhibitors: mechanism of action and resistance profiling. PLOS Pathogens, 12 (8). e1005737. ISSN 1553-7374; 1553-7366

Lin, Wen, Heimbach, Tycho, Jain, Jay Prakash, Hamed, Kamal, Sunkara, Gangadhar and He, Handan (2016) A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients. Journal of Pharmaceutical Sciences, 105 (10). pp. 3205-3213. ISSN 1520-6017

Lionakis, Michail S., Albert, Nathaniel D., Swamydas, Muthulekha , Lee, Richard C. C., Loetscher, Pius and Kontoyiannis, Dimitrios P. (2016) Pharmacological blockade of the chemokine receptor CCR1 protects mice from systemic candidiasis of hematogenous o. Antimicrobial agents and chemotherapy.

Littlewood-Evans, Amanda, Sarret, Sophie, Apfel, Verena, Fuchs-Loesle, Perrine, Dawson King, Janet, Zhang, Juan, Muller, Alban, Tigani, Bruno, Kneuer, Rainer, Patel, Saijel, Gommermann, Nina, Rubic-Schneider, Tina, Junt, Tobias, Carballido, Jose and Valeaux, Stephanie (2016) GPR91 exacerbates rheumatoid arthritis via extracellular succinate released by intact inflammatory macrophages. Journal of Experimental Medicine.

Liu, Bo, Gordon, William and Richmond, Wendy (2016) Use of Solubilizers in Preclinical Formulations: Effect of Cremophor EL on the Pharmacokinetic Properties on Early Discovery Compounds. European Journal of Pharmaceutical Sciences , 87 (87). pp. 52-57. ISSN 0928-0987

Liu, Jun, Harris, Jennifer and Hsieh, Hsin-I (2016) Head and Neck Squamous Cancer Stem Cells and Metastasis in vitro and in vivo in the Chick Chorioallantoic Membrane Assay. Journal of Otolaryngology - Head and Neck Surgery, 45 (26). pp. 1-8. ISSN NA

Liu, Kevin, O'Donnell, Christopher, Flick, Andrew, Ding , Hong, Leverett, Carolyn, Kyne, Robert and Fink, Sarah (2016) Synthetic approaches to the 2014 new drugs. Bioorganic and Medicinal Chemistry, 24 (9). pp. 1937-1980. ISSN 0968-0896; 1464-3391

Lo, Michael K., Shi, Pei-Yong, Chen, Yen Liang, Flint, Mike and Spiropoulou, Christina F. (2016) In vitro Antiviral Activity of Adenosine Analog NITD008 against Tick-borne Flaviviruses. Antiviral Research, 130 (June 2). pp. 46-49. ISSN 1872-9096

Lovsin Barle, Ester, Crevoisier, Michel, Flueckiger, Andreas, Ader, Allan and Walsh, Andy (2016) Cleaning Limits: Why Should We Abandon Using the 10 ppm Criterion. Cleaning Limits: Why We Should Abandon Using the 10 ppm Criterion, 40 (1). pp. 52-56.

Lovsin Barle, Ester, Winkler, Gian Christian, Glowienke, Susanne, Elhajouji, Azeddine, Nunic, Jana and Martus, Hans-Joerg (2016) Setting occupational exposure limits (OELs) for genotoxic substances in pharmaceutical industry. Setting occupational exposure limits (OELs) for genotoxic substances in pharmaceutical industry.

Low, Ivan, Blasco, Francesca and Vachaspati, Prakash (2016) Optimised Method to Estimate Octanol Water Distribution Coefficient (logD) in a High Throughput Format. European Journal of Pharmaceutical Sciences, 92. pp. 110-116. ISSN 0928-0987

Ludwig, Marie-Gabrielle (2016) Interleukin-4 clicked surfaces drive M2 macrophage polarization. ChemBioChem, 17 (22). pp. 2123-2128.

Ludwig, Marie-Gabrielle (2016) Proton detection and breathing regulation by the retrotrapezoid nucleus. Journal of Physiology of London, 594 (6). pp. 1529-1551. ISSN 00223751

Mahl, Joerg Andreas, Dincer, Zuhal and Heining, Peter (2016) The potential of minipigs in the development of anti-cancer therapeutics: species comparison and examples of special applications. Toxicologic Pathology, 44 (3). pp. 391-397.

Maibaum, Juergen Klaus, Liao, Sha-Mei, Vulpetti, Anna, Ostermann, Nils, Randl, Stefan, Ruedisser, Simon, Lorthiois, Edwige, Erbel, Paulus, Kinzel, Bernd, Kolb, Fabrice, Barbieri, Samuel, Wagner, Julia, Durand, Corinne, Fettis, Kamal, Dussauge, Solene, Aubin, Nicola, Delgado, Omar, Hommel, Ulrich, Gould, Ty, Mac Sweeney, Aengus, Gerhartz, Bernd, Cumin, Frederic, Flohr, Stefanie, Schubart Wellensiek, Anna, Jaffee, Bruce, Harrison, Richard, Risitano, Antonio Maria, Eder, Joerg and Anderson, Karen (2016) Discovery of small-molecule reversible Factor D inhibitors targeting the alternative complement pathway. Nature Chemical Biology, 12 (12). pp. 1105-1110. ISSN 1552-4450

Mainolfi, Nello, Karki, Rajeshri, Liu, Fang and Anderson, Karen (2016) Evolution of a New Class of VEGFR-2 Inhibitors from Scaffold Morphing and Redesign. ACS Med Chem Letters, 7 (4). pp. 363-367. ISSN 1948-58751948-5875

Mainolfi, Nello, Powers, James, Meredith, Erik, Elliott, Jason, Poor, Stephen, Liu, Fang and Anderson, Karen (2016) Core Replacements in a Potent Series of VEGFR-2 Inhibitors and Their Impact on Potency, Solubility, and hERG. ACS Medicinal Chemistry Letters, 7 (4). pp. 357-362. ISSN 1948-5875

Manara, Maria Cristina, Terracciano, Mario, Mancarella, Caterina, Sciandra, Marika, Guerzoni, Clara, Pasello, Michela, Grilli, Andrea, Zini, Nicoletta, Picci, Piero, Colombo, Mario / P, Morrione, Andrea and Scotlandi, Katia (2016) CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling. Oncotarget, 7 (48). pp. 79925-79942. ISSN 19492553

Mancuso, Riccardo V., Welzenbach, Karl, Steinberger, Peter, Krähenbühl, Stephan and Weitz-Schmidt, Gabriele (2016) Downstream effect profiles discern different mechanisms of integrin LFA-1 inhibition. Biochemical pharmacology, Sept (6). ?-?. ISSN 1873-2968; 0006-2952

Mandrelli, Francesca, Buco, Alessia, Piccioni , Lorenzo, Renner, Florian, Guelat, Bertrand, Martin, Benjamin, Schenkel, Berthold and Venturoni, Francesco (2016) Scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions: methodology and reactor design. Green Chem.. ISSN 1463-92621463-9270

Mangold, James, Wu, Fan and Rebello, Sam (2016) Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4beta-Hydroxycholesterol and Changes in Midazolam Exposure. Clinical Pharmacology in Drug Development, 5 (4). pp. 245-249. ISSN 2160-7648

Manjunatha, Ujjini Havaldar, Diagana, Thierry Tidiane, Leong, Franz Joel Wen and Chao, Alexander (2016) Cryptosporidiosis drug discovery: Opportunities and Challenges. ACS Infectious Diseases, 2 (8). pp. 530-537. ISSN 10.1021

Mansour, Salah, Tocheva, Anna, Cave-Ayland, Chris, Machelett, Moritz, Sander, Barbara, Lissin, Nikolai, Molloy, Peter, Baird, Mark, Stübs, Gunthard, Schröder, Nicolas, Schumann, Ralf, Rademann, Jörg, Postle, Anthony, Jakobsen, Bent, Marshall, Ben, Gosain, Rajendra, Elkington, Paul, Elliott, Tim, Skylaris, Chris, Essex, Jonathan, Tews, Ivo and Gadola, Stephan (2016) CD1c antigen presentation. Cholesteryl esters stabilise human CD1c conformations for recognition by self-reactive T cells.

Manthiram, Kalpana, Nesbitt, Emily, Morgan, Thomas and Edwards, Kathryn M (2016) Family History in Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. Pediatrics, 138 (3). pp. 4572-4578. ISSN 1098-4275

Marsilje, Thomas, Stutz, Stefan, Boos, Andreas, Niklaus, Michel, Chen, Bei, Jiang, Songchun, Furet, Pascal, Mccarthy, Clive, Stauffer, Frederic, Guagnano, Vito, Vaupel, Andrea, Michellys, Pierre, Schnell, Christian, Jeay, Sebastien and Lu, Wenshuo (2016) Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (8). pp. 2057-2064. ISSN 0960-894X

Martin, Ivan, Centola, Matteo and Piccinini, Elia (2016) In Memoriam: Paolo Bianco. Current Stem Cell Reports, 2 (1). p. 1.

Martus, Hans-Joerg (2016) Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 795. pp. 7-30. ISSN 1879-3592

Marusyk, Andriy and Polyak, Kornelia (2016) Spatial proximity to fibroblasts increases heterogeneity in breast tumors and impacts therapeutic sensitivity and clinical outcome. Cancer research, Epub a (Epub a). pp. 1-29. ISSN 1538-7445; 0008-5472

Mavrakis, Konstantinos and Mcdonald Iii, Earl (2016) Collateral loss of MTAP in CDKN2A deleted cancers leads to selective dependence on PRMT5. Science, 351 (6278). pp. 1208-1213. ISSN 0036-80751095-9203

McDermott, Deborah, Fong, Jamie C and Basson, Craig (2016) Holt-roam Syndrome. Gene Reviews.

Mcdonald Iii, Earl and Mavrakis, Konstantinos (2016) Working Title: Collateral loss of MTAP in CDKN2A deleted cancers leads to increased sensitivity to PRMT5 inhibition. Science, Vol. 3 (Issue ). pp. 1208-1213. ISSN 0228-9806; 0036-8075

Mead, Andy N., Amouzadeh, Hamid R., Chapman, Kathryn, Ewart, Lorna, Giarola, Alessandro, Jackson, Sam, Jarvis, Philip, Jordaan, Pierre, Redfern, Will, Traebert, Martin, Valentin, Jean-Pierre and Vargas, Hugo M. (2016) THE PREDICTIVE VALUE OF THE RODENT NEUROFUNCTIONAL ASSESSMENT FOR CENTRAL NERVOUS SYSTEM EVENTS IN PHASE I CLINICAL TRIALS. Toxicological Sciences.

Meeske, Alexander J., Riley, Eammon P., Robins, William P., Uehara, Tsuyoshi, Mekalanos, John J., Kahne, Daniel, Walker, Suzanne, Kruse, Andrew C., Bernhardt, Thomas G. and Rudner, David Z. (2016) SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature, Epub (Epub). epub-Epub. ISSN 0028-0836

Meiser, Karin, Jordaan, Pierre, Latypova, Sasha and Darpo, Borje (2016) Comparing QT interval variability of semi-automated and high precision ECG methodologies in 7 thorough QT studies - implications for the power of studies intended for definitive evaluation of a drug's QT effect. Annals of noninvasive electrocardiology (22). pp. 1-8. ISSN 1082720X

Memmert, Klaus and Mielke, Anna-Lena (2016) Optimierung von Kulturbedingungen zur mikrobiellen Herstellung von Ascomycin Derivaten. Student Thesis, University of Dresden, n.a. (n.a.). pp. 1-48. ISSN n.a.

Merz-Stoeckle, Christina, Geering, Barbara, Yousefi, Shida, Rožman, Saša, Andina, Nicola, Benarafa, Charaf and Simon, Hans-Uwe (2016) RhoH is a negative regulator of eosinophilopoiesis. Cell death and differentiation, 23 (12). pp. 1961-1972. ISSN 1476-5403

Mesrouze, Yannick, Erdmann, Dirk, Fontana, Patrizia, Meyerhofer, Marco, Zimmermann, Catherine, Schmelzle, Tobias and Chene, Patrick (2016) Different recognition of TEAD transcription factor by the conserved β-strand:loop:α-helix motif of the TEAD binding site of YAP and VGLL1. Chemistry Select, 1. pp. 2993-2997.

Metcalfe, Hannah, Lea, Simon, Plumb, Jonathan, Beerli, Christian, Poll, Chris, Singh, Dave and Abbott-Banner, Katharine (2016) Neutral Sphingomyelinase-2, Acid Sphingomyelinase and Ceramide Levels in COPD patients compared to controls. International journal of chronic obstructive pulmonary disease, Volume (2016). pp. 2139-2147. ISSN 1178-2005

Metzler, Barbara, Gfeller, Patrick and Guinet, Elisabeth (2016) Restricting Glutamine or Glutamine-dependent purine and pyrimidine synthesis promotes human T regulator cells. The Journal of Immunology.

Michellys, Pierre, Chen, Bei, Jiang, Tao, Jin, Yunho, Marsilje, Thomas, Pei, Wei, Uno, Tetsuo, Wu, Baogen, Bursulaya, Badry, Lee, Christian, Li, Nanxin, Lu, Wenshuo, Zhu, Xuefeng, Nguyen, Truc, Kim, Sungjoon, Tuntland, Tove, Liu, Bo, Steffy, Auzon, Hood, Tami and Sun, Frank (2016) Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (3). pp. 1090-1096. ISSN 1464-3405

Moench, Paul, Catoire, Alexandre, Glick, Jim and Flarakos, Jimmy (2016) Determination of tissue-specific ion suppression by liquid extraction surface analysis mass spectrometry. Rapid Commun. Mass Spectrom, 30 (2). pp. 340-342. ISSN 09514198

Moggs, Jonathan, Maclachlan, Timothy, Martus, Hans-Joerg and Bentley, Philip (2016) Derisking drug-induced carcinogenicity for novel therapeutics. Trends in Cancer, 2 (8). pp. 398-408. ISSN 2405-8033

Moriguchi, Shigeki, Ishizuka, Toru, Yabuki, Yasushi, Shioda, Norifumi, Sasaki, Yuzuru, Takashira, Hideaki, Yeh, Jay Z, Narahashi, Toshio, Sakagami, Hiroyuki and Fukunaga, Kohji (2016) The KATP channel Kir6.2 is new target for Alzheimer’s disease therapy. Molecular Psychiatry, 00 (00). pp. 1-11. ISSN 1359-41841476-5578

Morris, Melody, David, Clarke, Lindsey, Osimiri and Douglas, Lauffenburger (2016) Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks. CPT: Pharmacometrics and Systems Pharmacology, 5 (10). pp. 544-553. ISSN 21638306

Moutsatsos, Ioannis, Hossain, Imtiaz, Agarinis, Claudia, Harbinski, Fred, Abraham, Yann, Dobler, Luc, Zhang, Xian, Wilson, Chris, Jenkins, Jeremy, Holway, Nicholas, Myer, Vic, Tallarico, John, Mickanin, Craig and Parker, Christian (2016) Jenkins-CI, an open source continuous integration system, as a scientific data and image processing platform. Journal of Biomolecular Screening, publis (2016 N). pp. 1-24. ISSN PMID: 27899692

Muller, Tony Andreas, Zwick, Anabel, Decker, Sarah, Klein, Claudius, Rister, Benjamin, Rudorf, Alina, Kissel, Sandra, Follo, Marie, Wasch, Ralph, Illert, Anna Lena, Oostendorp, Robert, Waskow, Claudia, Dierks, Christine and Duyster, Justus (2016) PIM1 inhibition effectively enhances Plerixafor-induced HSC mobilization. Blood, 128. p. 655. ISSN 1528-0020; 0006-4971

Munoz, Diana, Cassiani, Pamela, Li, Li, Billy, Eric, Wan, Jessica, Korn, Joshua, Jones, Michael, Golji, Javad, Ruddy, David, Yu, Kristine, Mcallister, Gregory, Hofmann, Francesco, Keen, Nicholas, Sellers, William, Schmelzle, Tobias, Stegmeier, Frank and Schlabach, Michael (2016) CRISPR screens provide a comprehensive assessment of cancer vulnerabilities but generate false-positive hits for highly amplified genomic regions. Cancer discovery.

Ng, Jia Tsing, Dekker, Carien, Reardon, Paul and von Delft, Frank (2016) Lessons from 10 Years of Crystallization Experiments at the SGC. Acta Crystallographica Section D, 72 (2). pp. 224-235. ISSN 2059-7983

Ng, Pearly and Bates, Roderick W. (2016) Synthesis of hydroxylated pyrrolidines by allenic cyclisation. Tetrahedron, 72 (41). pp. 6356-6362. ISSN 1464-5416; 0040-4020

Nilar, Shahul Hameed, Lakshminarayana, Suresh Bangalore, Ma, Ngai Ling, Keller, Thomas H., Blasco, Francesca and Smith, Paul William (2016) Artificial neural network analysis of pharmacokinetic and toxicity properties of lead molecules for Dengue fever, Tuberculosis and Malaria. Current Computer-Aided Drug Design, 12 (1). pp. 52-61. ISSN 18756697

Nishiguchi, Gisele, Burger, Matthew, Han, Wooseok, Tamez Jr., Victoriano, Lindvall, Mika, Bellamacina, Cornelia, Feucht, Paul, Wong, Kent, Lan, Jiong, Atallah, Gordana, Ding, Yu, Garcia, Pablo, Zavorotinskaya, Tatiana and Dai, Yumin (2016) Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. Bioorganic and Medicinal Chemistry Letters, 26 (9). pp. 2328-2332. ISSN 1464-3405

Njuguna, Nicholas, Umehara, Ken-Ichi, Huth, Felix, Schiller, Hilmar, Chibale, Kelly and Camenisch, Gian P. (2016) Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction. Drug Metabolism and Personalized Therapy.

Noble, Christian Guy, Lim, Siew Pheng, Arora, Rishi, Yokokawa, Fumiaki, Nilar, Shahul Hameed, Seh, Cheah Chen, Wright, Kirk, Benson, Timothy, Smith, Paul William and Shi, Pei-Yong (2016) A Conserved Pocket in the Dengue Virus Polymerase Identified Through Fragment-Based Screening. Journal of Biological Chemistry, 291 (16). pp. 8541-8548. ISSN 1083-351X

Novkovic, Mario, Onder, Lucas, Cupovic, Jovana, Abe, Jun, Bomze, David, Cremasco, Viviana, Scandella, Elke, Stein, Jens, Bocharov, Jennadi, Turley, Shannon and Ludewig, Burkhard (2016) Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality. PLoS Biology, 14 (7). ISSN 1545-7885

Nozaki, Sachiko, Yamaguchi, Masayuki and Lefevre, Gilbert (2016) Pharmacokinetic Modeling to Simulate the Concentration-Time Profiles Following Dermal Application of Rivastigmine Patch. Journal of Pharmaceutical Sciences. ISSN 00223549

Nyfeler, Beat and Eng, Christina H. (2016) Revisiting autophagy addiction of tumor cells. Autophagy Journal. ISSN 1554-8635

O'Sullivan, Catherine, Schubart Wellensiek, Anna, Mir, Anis Khusro and Dev, Kumlesh K (2016) The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Journal of Neuroinflammation, 13 (1). ISSN 17422094

O'Sullivan, Sinead, Gasparini, Fabrizio, Mir, Anis Khusro and Dev, Kumlesh (2016) Cytokine mediated liberation of soluble Fractalkine (sCX3CL1) in Human Astrocytes is dependent on ADAM10 and p38/NF-κB signalling. Journal of neuroinflammation, 13. p. 189. ISSN 1742-2094

Oakeley, Edward James (2016) Brief summary of history of your core platforms. Chimia, 70 (12). pp. 883-888.

Ogese, Monday O., Ahmed, Shaheda, Alferivic, Ana, Betts, Catherine J., Dickinson, Anne , Faulkner, Lee , French, Neil, Gibson, Andrew , Hirschfield, Gideon M., Kammueller, Michael, Meng, Xiaoli, Martin, Stefan F., Musette, Philippe, Norris, Alan, Pirmohamed, Munir, Park, B. Kevin, Purcell, Anthony W., Spraggs, Colin F., Whritenour, Jessica and Naisbitt, Dean J. (2016) New approaches to investigate drug-induced hypersensitivity. Chemical Research in Toxicology, 30. ISSN 0893-228X1520-5010

Orts, Julien, Marielle, Wälti, Gossert, Alvar, Peter, Güntert and Roland, Riek (2016) NMR-Based Determination of the 3D Structure of the Ligand-Protein Interaction Site without Protein Resonance Assignment. JACS, 138 (13). pp. 4393-4400. ISSN 0002-78631520-5126

Osorio, Fernando / G, Soria-Valles, Clara, Santiago-Fernández, Olaya, Bernal, Teresa, Mittelbrunn, María, Colado, Enrique, Rodriguez, Francisco, Bonzon-Kulichenko, Elena, Vázquez, Jesús, Fueyo, Antonio, Freije, José / MP and López-Otín, Carlos (2016) Loss of the proteostasis modulator AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Nature Medicine.

Ozcelik, Sefika, Skachokova, Zhiva, Fraser, Graham, Abramowski, Dorothee, Sprenger, Frederik, Clavaguera, Florence, Probst, Alphonse, Kappos, Ludwig, Frank, Stephan, Müller, Mathias, Staufenbiel, Matthias, Goedert, Michel, Tolnay, Markus and Winkler, David T (2016) Co-expression of truncated and full-length tau induces severe neurotoxicity. Molecular Psychiatry.

Page, Guy, Ratchada, Phachareeya, Miron, Yannick, Steiner, Guido, Ghetti, Andre, Miller, Paul E, Reynolds, Jack A, Wang, Ken, Greiter-Wilke, Andrea, Polonchuk, Liudmila, Traebert, Martin, Gintant, Gary A and Abi-Gerges , Najah (2016) Human ex-vivo action potential model for pro-arrhythmia risk assessment. Journal of Pharmacological and Toxicological Methods, http:/ (http:/). pp. 12-25. ISSN PM-06368

Pannirselvam, Malar , Brabham, Tiffini, Botchway, Alfred W. , Hodges, Donald B. , Traebert, Martin and Pugsley, Michael K. (2016) The Northeast Regional SPS Meeting Update: Safety Pharmacology Innovations and Applications. Journal of pharmacological and toxicological methods, 16. pp. 30152-30156. ISSN 10568719

Papillon, Julien, Pan, Meihui, Brousseau, Margaret, Gilchrist, Mark, Singh, Alok, Stawicki, Todd, Lou, Changgang and Thompson, Jed (2016) Synthetic Phospholipids as Specific Substrates for Plasma Endothelial Lipase. Bioorganic & Medicinal Chemistry Letters, 26 (15). pp. 3514-3517. ISSN 0960894X

Paricharak, Shardul, IJzerman, Adriaan P., Jenkins, Jeremy, Bender, Andreas and Nigsch, Florian (2016) Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening. Journal of chemical information and modeling, 56 (9). pp. 1622-1630. ISSN 1549-960X

Paricharak, Shardul, Ijzerman, Adriaan P, Bender, Andreas and Nigsch, Florian (2016) Analysis of Iterative Screening with Stepwise Compound Selection Based on Novartis in-house HTS Data. ACS Chemical Biology. ISSN 1554-89291554-8937

Parker, Christian (2016) Essential Biological Pathways Modulate Many Different Aspects of Cell Biology. www.atlasofscience.org, not ap (http:/). pp. 1-2. ISSN unknown

Pearson, David, Jin, Yi, Erpenbeck, Veit, Woessner, Ralph, Camenisch, Gian P. and Weiss, Markus (2016) Absorption, metabolism and excretion of fevipiprant (QAW039) investigated in vivo and in vitro. European Respiratory Journal, 48. ISSN 1399-3003

Perner , Florian and Heidel, Florian (2016) Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function. Leukemia, 30 (4). pp. 991-995. ISSN 1476-5551; 0887-6924

Peterlik, Daniel, Stangl, Christina, Bludau, Anna, Grabski, Dominik, Strasser, Robert, Schmidt, Dominic, Reber, Stefan O., Flor, Peter J. and Uschold-Schmidt, Nicole (2016) Relief from detrimental consequences of chronic psychosocial stress in mice deficient for the metabotropic glutamate receptor subtype 7. Neuropharmacology.

Peters, Tara L., Li, Lingxiao, Tula-Sanchez, Ana A., Pongtornpipat, Praechompoo and Schatz, Jonathan H. (2016) Control of Translational Activation by PIM Kinase in Activated B-Cell Diffuse Large B-Cell Lymphoma Confers Sensitivity to Inhibition by PIM447. Oncotarget, 7 (39). pp. 63362-63373. ISSN 1949-2553

Plotkin, Benjamin, Sampath, Srinath, Sampath, Srihari and Motamedi, Kambiz (2016) MRI and Ultrasound of the Wrist Tendons. Radiographics, 36 (6). pp. 1688-1700. ISSN 1527-1323

Plouffe, David, Wree, Melanie, Du, Alan Y, Li, Fengwu, Patra, Kailash, Lubar, Aristea, Okitsu, Shinji, Flannery, Erika L, Kato, Nobutaka, Tanaseichuk, Olga, Comer, Eamon, Zhou, Bin, Zhou, Yingyao, Leroy, Didier, Schreiber, Stuart L, Dechering, Koen, Sauerwein, Robert, Scherer, Christina A, Vinetz, Joseph and Winzeler, Elizabeth (2016) SaLSSA—a low cost method for assessing the malaria transmission-blocking potential of small molecules. Cell host & microbe, 19 (1). pp. 114-126. ISSN 1934-6069

Posey, AD, Schwab, RD, Boesteanu, AC, Steentoft, C, Mandel, U, Engels, Boris, Stone, JD, Madsen, TD, Schreiber, K, Haines, KM, Cogdill, AP, Chen, TJ, Song, D, Scholler, J, Young, R, Keith, B, Schreiber, H, Clausen, H, Johnson, LA and June, CH (2016) Validation of Abnormal Self-Antigens as Targets for Tumor Rejection by CAR T Cells. Science Translational Medicine, 44 (6). pp. 1444-1454. ISSN 1097-4180

Prabhala, Rao, Munschi, Nikhil, Ettenberg, Seth and Di Padova, Franco E. (2016) Targeting IL-17A in Multiple Myeloma: 2 A Potential Novel Therapeutic Approach in Myeloma. 3 (Running title: Th17 pathway in myeloma) 4. Leukemia.

Prasanna, Ganesh, Li, Byron, Mogi, Muneto and Rice, Dennis (2016) Pharmacology of novel intraocular pressure-lowering targets that enhance conventional outflow facility: Pitfalls, promises and what lies ahead? European Journal of Pharmacology, 787. pp. 47-56. ISSN 1879-0712

Prescher, Horst, Koch, Guido, Schuhmann, Tim, Ertl, Peter, Bussenault, Alex, Glick, Meir, Dix, Ina and Lizos, Dimitrios (2016) Construction of a 3D-shaped, natural product like fragment library by fragmentation and diversification of natural products. Bioorganic and medicinal chemistry. ISSN 09680896

Proudfoot, Andrew, Frank, Andreas, Ruggiu, Fiorella and Lingel, Andreas (2016) Facilitating Unambiguous NMR Assignment and Enabling Higher Probe Density by Selective Labeling of all Methyl Containing Amino Acids. Journal of Biomolecular NMR.

Puvanenthiran, Soozana, Essapen, Sharadah, Seddon, Alan / M and Modjtahedi, Helmout (2016) Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs. International Journal of Oncology, 49 (5). pp. 1825-1838. ISSN 17912423

Ramage, Michael I, Johns, Neil, Deans, Christopher D A, Ross, James A, Preston, Thomas, Skipworth, Richard J E, Jacobi, Carsten and Fearon, Kenneth C H (2016) The relationship between muscle protein content and CT-derived muscle radio-density in patients with upper GI cancer. Clinical nutrition.

Rathbun, Alan M, Shardell, Michelle, Orwig, Denise, Gruber-Baldini, Ann L, Ostir, Glenn, Hicks, Gregory E, Miller, Ram R, Hochberg, Marc C and Magaziner, Jay (2016) Effects of Prefracture Depressive Illness and Postfracture Depressive Symptoms on Physical Performance After Hip Fracture. Journal of the American Geriatrics Society, 64 (11). e171-e176. ISSN 1532-5415

Reece-Hoyes, John and Chen, Aye (2016) Miniaturisation of molecular biology reaction volumes: use of mosquito HTS for Gateway® cloning PCR amplification and Nextera library generation. TTP LabTech Application Note, na (na). na-na. ISSN na

Reilly, John, Liu, Qian, Boss, Kelly, Shin, Brian, Palermo, Mark, Larrow, Jay, Mann, Thierry and Howson, Christopher (2016) Reproducible Pharmaceutical Flash Purification Method Development by uPLC and HPLC. Chromatography Today. pp. 2-5.

Reuter, Björn, Venus, A, Grudenski, S, Heiler, P, Schad, L, Staufenbiel, Matthias, Hennerici, G and Fatar, M (2016) Statin therapy and the development of cerebral amyloid angiopathy – a rodent in-vivo approach. Int. J. Mol. Sci..

Riccardi, Sabrina, Bergling, Sebastian, Sigoillot, Frederic, Beibel, Martin, Werner, Annick, Leighton-Davies, Juliet, Knehr, Judith, Bouwmeester, Antonius, Parker, Christian, Roma, Guglielmo and Kinzel, Bernd (2016) Mir-210 promotes sensory hair cell formation in the organ of Corti. BMC Genomics, 17 (309). pp. 1-14. ISSN 1471-2164

Richie, Daryl (2016) Cell: Career Under A Microscope. Career Under A Microscope.

Richie, Daryl, Dean, Charles and Wang, Lisha (2016) Perils of an industrial job interview, don't forget to bring a water. Cell Press - Careers Under the Microscope.

Richie, Daryl, Takeoka, Ken, Bojkovic, Jade, Metzger Iv, Louis, Rath, Christopher, Sawyer, William and Dean, Charles (2016) Toxic accumulation of LPS pathway intermediates underlies the requirement of LpxH for growth of Acinetobacter baumannii ATCC 19606. Plos One, 11 (8). pp. 1-22. ISSN 1932-6203

Richie, Daryl, Takeoka, Ken, Bojkovic, Jade, Rath, Christopher, Sawyer, William, Wei, Jun-Rong and Dean, Charles (2016) Toxic accumulation of LPS pathway intermediates underlies the essentiality of LpxH in Acinetobacter baumannii ATCC19606. PLOS one, 11 (8). pp. 1-22. ISSN 1932-6203

Riede, Julia, Poller, Birk, Umehara, Ken-Ichi, Huwyler, Jörg and Camenisch, Gian P. (2016) New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data. European Journal of Pharmaceutical Sciences, 86. pp. 96-102. ISSN 1879-0720

Riester, Markus, Singh, Angad, Brannon, Rose, Yu, Kun, Campbell, Katie, Chiang, Derek and Morrissey, Michael (2016) PureCN: copy number calling and SNV classification using targeted short read sequencing. Source code for biology and medicine, 11. p. 13. ISSN 1751-0473

Ritter, Anett, Nuciforo, Sandro, Schulze, Axel, Oertli, Mevion, Rauschert, Tatjana, Voedisch, Bernd, Geisse, Sabine, Jostock, Thomas and Laux, Holger (2016) Fam60A plays a role for production stabilities of recombinant CHO cell lines. Biotechnology and bioengineering, n.a. (n.a.). n.a.-n.a.. ISSN 00063592

Ritter, Anett, Rauschert, Tatjana, Oertli, Mevion, Piehlmaier, Daniel, Mantas, Panagiotis, Kuntzelmann, Genevieve, Lageyre, Nadine, Brannetti, Barbara, Voedisch, Bernd, Geisse, Sabine, Jostock, Thomas and Laux, Holger (2016) Disruption of the gene C12orf35 leads to increased productivities in recombinant CHO cell lines. Biotechnology and Bioengineering.

Roessle, Matthias, Cathomas, Gieri, Bonapace, Laura, Sachs, Melanie, Dehler, Silvia, Storz, Martina, Huber, Gerhard, Moch, Holger, Junt, Tobias and Mertz, Kirsten D. (2016) Interleukin-33 expression indicates a favorable prognosis in malignant salivary gland tumors. Int J Surg Pathol.

Roest, Susan, Kapps-Fouthier, Sandra, Klopp, Julia, Rieffel, Sebastien, Gerhartz, Bernd and Shrestha, Binesh (2016) Transfection of insect cell in suspension for efficient baculovirus generation. MethodsX, 3. pp. 371-377.

Roffe, Gavin, Boonseng, Sarote, Baltus, Christine, Coles, Simon, Day, Iain, Jones, Rhiannon, Press, Neil, Ruiz, Mario, Tizzard, Graham, Cox, Hazel and Spencer, John (2016) A Synthetic, Catalytic and Theoretical Investigation of an Unsymmetrical SCN Pincer Palladacycle. Royal Society Open Science, 3 (4). p. 150656. ISSN 2054-5703

Roffe, Gavin, Boonseng, Sarote, Baltus, Christine, Coles, Simon, Jones, Rhiannon, Press, Neil, Ruiz, Mario, Cox, Hazel and Spencer, John (2016) A Robust Synthesis, DFT Investigation, and Catalytic Evaluation of an Unsymmetrical SCN Pincer Palladacycle. R. Soc. open science, 3 (n/a). 150656 . ISSN 2054-5703

Rokka, Johanna, Snellman, Anniina, Kaasalainen, Martti, Salonen, Jarno, Zona, Critiano, La Ferla, Barbara, Re, Francesca, Masserini, Massimo, Forsback, Sarita, Lopez-Picon, Francisco, Rinne, Joha O, Haaparanta Solin, Merja and Solin, Olof (2016) Synthesis and preclinical evaluation of functionalized 18F-nanoliposomes for Alzheimer’s disease. European Journal of Pharmaceutical Sciences.

Rubic-Schneider, Tina, Carballido-Perrig, Nicole, Regairaz Kalenga Kapiamba, Camille, Raad, Layla, Jost, Sandra, Christen, Brigitte, Wieczorek, Grazyna, Kreutzer, Robert, Dawson King, Janet, Lametschwandner, Guenther, Littlewood-Evans, Amanda and Carballido, Jose (2016) GPR91 deletion enhances mast cell activation while preventing arthritic disease. Allergy, DO - (DO - ). pp. 1-9. ISSN 1398-9995

Rubic-Schneider, Tina, Christen, Brigitte, Brees, Dominique and Kammueller, Michael (2016) Assessing immunocompetence in minipigs in translational safety sciences – a perspective. Experimental and Toxicologic Pathology, 44 (3). pp. 315-324. ISSN 0192-62331533-1601

Rubic-Schneider, Tina, Christen, Brigitte, Brees, Dominique and Kammueller, Michael (2016) Minipigs in translational immunosafety sciences – a perspective. Toxicologic Pathology (2016 special issue "Swine in translational research with emphasis on nonclinical safety testing in the minipig").

Rutkowska, Aleksandra, Dev, Kumlesh and Sailer, Andreas (2016) The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems. Current drug targets, 17 (16). pp. 1851-1860. ISSN 1873-5592

Salick, Max, Ihry, Robert, Worringer, Katie, Bilican, Bilada, Kommineni, Sravya and Ye, Chaoyang (2016) Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection. Cell Stem Cell, 19 (6). pp. 703-708. ISSN 18759777

Sampath, Srihari, Sampath, Srinath, Bredella, Miriam, Cypess, Aaron and Torriani, Martin (2016) State of the Art: Imaging of Brown Adipose Tissue. Radiology, 280 (1). pp. 4-19. ISSN 1527-1315

Sandham, David, Bauer, Carsten, Charlton, Steven, Sykes, David, Dubois, Gerald, Bradley, Michelle, Miah, Asadh, Riddy, Darren, Willard, Elizabeth and Watson, Simon (2016) Fevipiprant (QAW039) a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology.

Sborgi, Lorenzo, Ruehl, Sebastian, Mulvihill, Estefania, Pipercevic, Joka, Heilig, Rosalie, Stahlberg, Henning, Farady, Christopher, Bueller, Daniel, Broz, Petr and Hiller, Sebastian (2016) GSDMD pore formation in the plasma membrane constitutes the mechanism of pyroptotic cell death. EMBO Journal, 35 (16). pp. 1766-1778. ISSN 1460-2075

Schachter, Asher (2016) Advances and Unmet Needs in Genetics, Basic and Clinical Science in Alport syndrome Report from the 2015 International Workshop on Alport Syndrome. Nephrology Dialysis Transplantation.

Schachter, Asher (2016) Advances and Unmet Needs in Genetics, Basic and Clinical Science in Alport syndrome Report from the 2015 International Workshop on Alport Syndrome. Nephrology Dialysis Transplantation, NA (NA). pp. 1-9. ISSN 1460-2385

Schadt, Heiko, Wolf, Armin, Pognan, Francois, Chibout, Salah-Dine, Merz, Michael and Kullak-Ublick, Gerd (2016) Bile acids in drug induced liver injury: key players and surrogate markers. Clinics and Research in Hepatology and Gastroenterology.

Schelle, Juliane, Häsler, Lisa, Göpfert, Jens C, Joos, Thomas O, Vanderstichele, Hugo, Stoops, Erik, Neumann, Ulf, Shimshek, Derya, Staufenbiel, Matthias, Jucker, Mathias and Kaeser, Stephan A (2016) Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition. Alzheimer's & dementia. ISSN 15525260

Schiering, Nikolaus, D'Arcy, Allan, Villard, Frederic, Ramage, Paul, Logel, Claude, Cumin, Frederic, Ksander, Gary, Wiesmann, Christian, Karki, Rajeshri and Mogi, Muneto (2016) Structure of neprilysin in complex with the active metabolite of sacubitril. Nature Scientific Reports, 6 (27909 ). pp. 1-5. ISSN 2045-2322

Schmitt, Esther, Hoepfner, Dominic and Krastel, Philipp (2016) Natural products as probes in pharmaceutical research. Journal of Industrial Microbiology and Biotechnology, 43 (2-3). pp. 249-260.

Schmitt, Georg, Ridings, James, De Schaepdrijver, Luc, van Dosesum-Wolters, Ciska, Cappon, G and Hartmann, Andreas (2016) Non-clinical safety considerations for development of medicines targeted primarily at pediatric use: An industry view. Regulatory Toxicology .

Schneider, Nadine, Lowe, Daniel, Sayle, Roger, Tarselli, Mike and Landrum, Greg (2016) Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists Bread and Butter. Journal of Medicinal Chemistry, 59 (9). pp. 4385-4402. ISSN 1520-4804

Schneider, Nadine, Lowe, Daniel, Sayle, Roger, Tarselli, Mike and Landrum, Gregory (2016) Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists Bread and Butter. Journal of Medicinal Chemistry, 59 (9). pp. 4385-4402. ISSN 1520-4804

Schneider, Nadine, Stiefl, Nikolaus and Landrum, Gregory (2016) What's What: The (Nearly) Definitive Guide to Reaction Role Assignment. Journal of chemical information and modeling, 56 (12). pp. 2336-2346. ISSN 1549-960X

Schuierer, Sven and Roma, Guglielmo (2016) The Exon Quantification Pipeline (EQP): a comprehensive approach to the quantification of gene, exon, and junction expression from RNA-seq data. Nucleic Acids Research, 44 (16). e132. ISSN 0305-10481362-4962

Sedelmeier, Joerg Mathias, Sedelmeier, Gottfried, Schenkel, Berthold, Lima, Fabio, Kabeshov, Mikhail, Tran, Duc, Battilocchio, Claudio and Ley, Steven (2016) Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)–C(sp3) Cross-Couplings in Flow. Angew Chem Int Ed, 55 (55). pp. 1-6. ISSN 1055-0143

Segueni, Noria, Tritto, Elaine, Bourigault, Marie-Laure, Rose, Stephanie, Erard, Francois, Le Bert, Marc, Jacobs, Muazzam, Di Padova, Franco E., Moulin, Pierre, Brees, Dominique, Chibout, Salah-Dine, Ryffel, Bernhard, Kammueller, Michael and Quesniaux, Valerie (2016) Controlled acute M. tuberculosis infection in mice under treatment with IL-17A or IL-17F antibodies, in contrast to TNFα neutralization. Scientific reports, 6 (36923). pp. 1-17. ISSN 2045-2322

Semrau, Katherine, Hirschhorn, Lisa, Kodkany, Bhala, Spector, Jonathan, Tuller, Danielle, King, Gary, Lipsitz, Stuart, Sharma, Narender, Singh, Vinay, Kumar, Bharath, Ringer, Steven, Dhingra-Kumar, Neelam, Firestone, Rebecca, Kumar, Vishwajeet and Gawande, Atul (2016) Effectiveness of the WHO Safe Childbirth Checklist program in reducing severe maternal, fetal, and newborn harm in Uttar Pradesh, India: Study protocol for a matched-pair, cluster-randomized controlled trial. Trials, 17 (1). ISSN 1745-6215

Shakeri-Nejad, Kasra, Aslanis, Vassilios, Veldandi, Uday Kiran, Zaehringer, Andreas, Dodman, Angela, Su, Frank and Legangneux, Eric (2016) Pharmacokinetics, safety, and tolerability of siponimod (BAF312) in subjects with different levels of hepatic impairment: a single-dose, open-label, parallel-group study. Journal of Clinical Pharmacology.

Shaw, Duncan, Baig, Ferheen, Bruce, Ian, Chamoin, Sylvie, Collingwood, Stephen, Cross, Sarah, Dayal, Satish, Drueckes, Peter, Furet, Pascal, Furminger, Vikki, Haggart, Deborah, Hussey, Martin, Konstantinova, Irena, Loren, Jon, Molteni, Valentina, Roberts, Sonia, Reilly, John, Saunders, Alex, Stringer, Rowan, Sviridenko, Lilya, Thomas, Matthew, Thomson, Christopher, Tomlins, Christine, Wen, Ben, Yeh, Vince and Pearce, Andrew (2016) Optimization of PDGFR inhibitors for duration of action, as an inhaled therapy for lung remodeling in pulmonary arterial hypertension. Journal of Medicinal chemistry, 59 (17). pp. 7901-7914. ISSN DOI: 10.1021/acs.jmedchem.6b00703

Shimshek, Derya, Jacobson, Laura, Kolly, Carine, Zamurovic Ribrioux, Natasa, Balavenkatraman, Kamal Kumar, Morawiec, Laurent, Kreutzer, Robert, Schelle, Juliane, Jucker, Mathias, Bertschi, Barbara, Theil, Diethilde, Heier, Annabelle, Bigot, Karine, Beltz, Karen, Machauer, Rainer, Brzak, Irena, Perrot, Ludovic and Neumann, Ulf (2016) Pharmacological BACE1 and BACE2 inhibition induces hair hypopigmentation by inhibiting PMEL17 processing in mice. Scientific Reports, 6. p. 21917. ISSN 2045-2322

Smith, M. C., Mader, M. M., Cook, J. A., Iversen, P., Ajamie, R., Perkins, E., Bloem, L., Yip, Y. Y., Barda, D. A., Waid, P. P., Zeckner, D. J., Young, D. A., Sanchez-Felix, M., Donoho, G. P. and Wacheck, V. (2016) Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth. Molecular Cancer Therapeutics. ISSN 1535-7163

Smith, Troy, Sprague, Elizabeth, Wang, Kate, Mathieu, Simon, Chen, Zhuoliang, Mishina, Yuji, Feng, Yun, Shakya, Subarna, Chen, Dongshu, Meyer, Matthew, Brazell, Tres, Straub, Christopher, Sage, David, Wright, Kirk, Chen, Xin, Duca, Jose, Kim, Sean, Tian, Li, Martin, Eric, Hurov, Kristen, Shao, Wenlin and Yan-Neale, Yan (2016) Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. Journal of Medicinal Chemistry, 59 (10). pp. 4711-4723. ISSN 1520-4804

Soutter, Holly H., Centrella, Paolo, Clark, Matthew A., Cuozzo, John, Dumelin, Christoph, Guie, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Kennedy, Kaitlyn, Sigel, Eric, Troast, Dawn, Zhang, Ying, Ferguson, Andrew, Davies, Gareth, Stead, Eleanor, Breed, Jason, Madhavapeddi, Prashanti and Read, Jon A. (2016) Discovery of novel, co-factor specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology. Proceedings of the National Academy of Sciences.

Stauffer, Frederic, Jacob, Sandra, Scheufler, Clemens and Furet, Pascal (2016) Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors. Bioorganic & Medicinal Chemistry Letters, 26. pp. 2065-2067.

Stauffer, Frederic, Scheufler, Clemens, Moebitz, Henrik, Gaul, Christoph, Ragot, Christian, Be, Celine, Fernandez, Cesar, Beyer, Kim and Tiedt, Ralph (2016) Optimization of a fragment-based screening hit towards potent DOT1L inhibitors interacting in an induced binding pocket. ACS Medicinal Chemistry Letters, 7 (8). pp. 730-734. ISSN DOI: 10.1021/acsmedchemlett.6b00168

Steffek, Micah (2016) Characterization of PPAT Resistance Mutants and Identification of Small Molecule Binders at the PPAT ATP site. Independent Research Project Johns Hopkins University.

Steffek, Micah (2016) Evaluation of PPAT Phosphopantetheine Site Inhibitors and Identification of Small Molecule Binders at the PPAT ATP site. Johns Hopkins Independent Research Proposal.

Stewart, Neil J, Horn, Felix C, Norquay, Graham, Collier, Guilhem J, Yates, Denise, Lawson, Rod, Marshall, Helen and Wild, Jim M (2016) Reproducibility of Quantitative Indices of Lung Function and Microstructure from 129Xe Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy. Magnetic Resonance in Medicine, 000 (000). pp. 1-7. ISSN 10.1002/mrm.26310

Stringer, Rowan, Rose, Jonathan, Ferreira, Suzie and Ronseaux, Sebastien (2016) Application of osmotic pumps for sustained release of 1-aminobenzotriazole and inhibition of cytochrome P450 enzymes in mice: Model comparison with the hepatic P450 reductase null mouse. Drug Metabolism and Disposition, 44 (8). pp. 1213-1216. ISSN 0090-9556; 1521-009X

Strobelt, Hendrik, Alsallakh, Bilal, Botros, Joseph, Peterson, Brant, Borowsky, Mark, Lex, Alexander and Pfister, Hanspeter (2016) Vials: Visualizing Alternative Splicing of Genes. IEEE transactions on visualization and computer graphics, 22 (1). pp. 399-408. ISSN 1941-0506

Strobelt, Hendrik, Alsallakh, Bilal, Botros, Joseph, Peterson, Brant, Borowsky, Mark, Lex, Alexander and Pfister, Hanspeter (2016) Vials: Visualizing Alternative Splicing of Genes. IEEE transactions on visualization and computer graphics, 22 (1). pp. 399-408. ISSN 1941-0506

Stuart, Webb, Gabrelow, Chase, Pierce, James, Edwin , Gibb and Elliott, Jimmy (2016) Retinoic Acid Receptor (RAR) signaling preserves tendon stem cells characteristics and prevents spontaneous differentiation in vitro. Stem Cell Research and Therapy.

Stuart, Webb, Gabrelow, Chase, Pierce, James, Edwin , Gibb and Elliott, Jimmy (2016) Retinoic Acid Receptor (RAR) signaling preserves tendon stem cells characteristics and prevents spontaneous differentiation in vitro. Stem Cell Research and Therapy, 7 (45). pp. 1-11. ISSN 10.1186/s13287-016-0306-3

Sugiyama, Ikuo, Murayama, Norie, Kuroki, Ayaka, Kota, Jagannath, Iwano, Shunsuke, Yamazaki, Hiroshi and Hirota, Takashi (2016) Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells. Xenobiotica, 46 (9). pp. 765-774. ISSN 1366-5928

Sun, Haiying, Machineni, Surendra Kumar, Ting, Lillian, Praestgaard, Jens, Kuemmell, Andreas, Stein, Daniel, Sunkara, Gangadhar, Kovacs, Steven, Villano, Stephen and Tanaka, Ken (2016) A Randomized, Open-label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects. Antimicrobial Agents and Chemotherapy, Online (Online). pp. 1-22. ISSN 1098-6596

Sun, Yishan and Dolmetsch, Ricardo (2016) How induced pluripotent stem cells (iPSCs) are changing drug discovery in psychiatry. Swiss Medical Weekly.

Sun, Yishan, Pasca, Sergiu P., Portmann, Thomas, Goold, Carleton, Worringer, Katie, Guan, Wendy, Chan, Karen C., Gai, Hui, Vogt, Daniel, Chen, Ying-Jiun J., Mao, Rong, Chan, Karrie, Rubenstein, John L.R., Madison, Daniel V., Hallmayer, Joachim, Froehlich-Santino, Wendy M., Bernstein, Jon A. and Dolmetsch, Ricardo (2016) A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients. eLife, 5 (e13073). pp. 1-26. ISSN 2050-084X

Surya , Ayalasomayajula, Schuehly, Uwe, Langenickel, Thomas Heiko, Pal, Parasar, Chen, Fabian, Chen, Zhen, Zhou, Wei and Sunkara, Gangadhar (2016) Effect of renal function on the pharmacokinetics of LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor. European Journal of Clinical Pharmacology, 72 (9). pp. 1065-1073. ISSN 1432-1041

Sutton, James, Mitra, Partha, Yang, Ren-Ming, Ramsay, Robert G. and Gonda, Thomas J (2016) CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression. Oncotarget, 7 (8). pp. 9069-9083. ISSN 1949-2553

Swann, Justine, plouffe, David, Winzeler, Elizabeth and Meister, Stephan (2016) A high-­‐throughput luciferase-­‐based assay for the discovery of therapeutics that prevent malaria. ACS Infectious Diseases.

Swart, Pieter Jacob, Lozac'H, Frederic, Faller, Thomas, Van De Kerkhof, Esther, Krauser, Joel, Natt, Francois, Hunziker, Juerg, Catoire, Alexandre, Garnier, Maxime, litherland, karine and christensen, Jesper (2016) ADME studies of [5-3H]-2′-O-methyluridine nucleoside in mice: A building block in siRNA therapeutics. Pharmacology Research and Perspectives, 4 (1). ISSN 2052-1707

Sykes, David, Bradley, Michelle, Reilly, John, Bauer, Carsten, Watson, Simon, Sandham, David, Dubois, Gerald and Charlton, Steven (2016) Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology, 89 (5). pp. 593-605. ISSN 1521-0111

Tang, Hai-Ming, Ju, Haisong, Zhao, Shufang, Laduke, Carrie, Hahn, Suzette, Glick, Jim, Carey, Cynthia and Friedrichs, Gregory (2016) Translational assessment of cardiac contractility by echocardiography in the telemetered rat. Journal of Pharmacological Toxicololgical Methods, 77. pp. 24-32. ISSN 1056-8719

Tarselli, Mike (2016) NEXT CRO quick-reference guide. NEXT, NA (NA). pp. 1-6. ISSN NA

Tarselli, Mike (2016) Response to Science Magazine NextGen special issue, 20 May. Science NextGen 20 May 2016, 352 (6288). pp. 886-889. ISSN 0036-80751095-9203

Tarselli, Mike (2016) Tarselli Response to Science Mag InGenuity Survey, Nov 2016. Science, 354 (6315). pp. 964-966.

Thomas, Jason, Harrington, Edmund, Murphy, Jason, Jain, Rishi, Schirle, Markus, Gower, Carrie, Chang, Matthew and Maly, Dustin (2016) GENERATION OF BIVALENT KINASE INHIBITORS STARTING FROM A SINGLE POLYPHARMACOLOGICAL COMPONENT FOR SELECTIVE TARGET MODULATION IN VIVO. ACS Chemical Biology.

Thomson, JP, Ottaviano, R, Unterberger, E, Lempiainen, H, Mueller, Arne, Terranova, Remi, Illingworth, RS, Webb, S, Kerr, AR, Drake, A, Lyall, M, Wolf, CR, Moggs, Jonathan, Schwarz, M and Meehan, R (2016) Loss of Tet1 associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer. Cancer Research.

Tian, Hua, Maciazek, Dawid, Postawa, Zbigniew, Garrison, Barbara and Winograd, Nicholas (2016) CO2-Cluster SIMS. Journal of American Society of Mass Spectrometry, 27 (9). pp. 1476-1482. ISSN 1879-1123

Tian, Hua, Wucher, Andrea and Winograd, Nicholas (2016) Reducing the matrix effect in organic cluster SIMS using dynamic reactive ionization. Journal of the American Society for Mass Spectrometry, 27 (2). pp. 2014-2024. ISSN 1879-1123

Tomic, Ivana, Vidis Millward, Ana, Mueller-Zsigmondy, Martin and Cardot, Jean-Michel (2016) Setting accelerated dissolution test for PLGA microspheres containing peptide, investigation of critical parameters affecting drug release rate and mechanism. International journal of pharmaceutics, 505 (1-2). pp. 42-51. ISSN 1873-3476

Torene, Rebecca, Nirmala, Nanguneri, Obici, Laura, Meini, Antonella, Tormey, Vincent, Caorsi, R., Starck-Schwertz, Sandrine, Letzkus, Martin, Hartmann, Nicole, Abrams, Ken, Lachmann, Helen and Gattorno, Marco (2016) Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome. Annals of the Rheumatic Diseases, 29. ISSN 1468-2060

Toris, Carol, McLaughlin, Marsha, Dworak, Douglas, Fan, Shan, Havens, Shane, Zhan, Guilin, Horan, Nicholas and Prasanna, Ganesh (2016) Effects of rho kinase inhibitors on intraocular pressure and aqueous humor dynamics in nonhuman primates and rabbits. Journal of Ocular Pharmacology and Therapeutics, 32 (6). pp. 355-364. ISSN 1557-7732

Townsend, Elizabeth, Cooke, Vesselina, Firestone, Brant, Gao, Hui, Lees, Emma and Weinstock, David (2016) The Public Repository of Xenografts (ProXe) enables discovery and randomized phase II-like trials in mice. molecular cell.

Trendelenburg, Anne-Ulrike (2016) Frailty in mouse ageing: A conceptual approach. Mechanisms of Ageing and Development, 160. pp. 34-40. ISSN 18726216

Trenkwalder, Claudia , Berg, Daniela, Eggert, Karla , Oehlwein, Christian , Ceballos-Baumann, Andres , Feigin, Andrew, Coorvol, Jean Christophe , Rascol, Olivier, Stocchi, Fabrizio , Linazasoro, Gurutz, Di Paolo, Thérèse , Maruff, Paul, Feuerbach, Dominik, Sovago, Judit, Weiss, Markus, Rozenberg, Izabela, Johns, Donald and Gomez-Mancilla, Baltazar (2016) A multi-centre, randomized, double-blind, placebo-controlled, parallel-group, multiple oral dose study to assess the efficacy, safety and tolerability of AQW051 in Parkinson’s patients with L-dopa induced dyskinesias. Movement Disorders.

Umehara, Ken-Ichi, Zollinger, Markus, Kigondu, Elizabeth, Witschi, Marc, Juif, Claire, Huth, Felix, Schiller, Hilmar, Chibale, Kelly and Camenisch, Gian P. (2016) Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors. Xenobiotica. pp. 1-6. ISSN 0049-82541366-5928

Urban, Laszlo, Nagy, Istvan, Varga, Angelika, Selvarajah, Srikumaran, Jenes, Agnes, Kulik, Akos, Brain, Susan, Baker, David, Valente, Joao, White, John, Mackie, Kenneth and Chen, Jie (2016) CAPSAICIN- AND ANANDAMIDE-SENSITIVITY OF PRIMARY SENSORY NEURONS IS CONTROLLED BY VARIOUS COMPONENTS OF CROSSTALK BETWEEN THE CANNABINOID TYPE 1 AND THE CAPSAICIN RECEPTORS. Scientific reports, 6 (33307). pp. 1-18. ISSN 2045-2322

Uteng, Marianne, Mahl, Joerg Andreas, Beckmann, Nicolau, Piaia, Alessandro, Ledieu, David, Dubost, Valerie, Tritto, Elaine, Wolf, Armin, Moulin, Pierre, Li, Li, Chibout, Salah-Dine and Pognan, Francois (2016) Comparative renal safety assessment of the hepatitis B drugs, adefovir, tenofovir, telbivudine and entecavir in rats. Comparative renal safety assessment of the hepatitis B drugs, adefovir, tenofovir, telbivudine and entecavir in rats, 155 (1). pp. 283-297.

Vaidya, Soniya, Khindri, Sanjeev, Calder, Nicole, Hara, Hisanori, Majumdar, Tapan, Salvatore, Febbraro, Rainard , Fuhr and Woessner, Ralph (2016) Pharmacokinetics of indacaterol acetate and mometasone furoate delivered alone or in a free or fixed dose combination in healthy volunteers. Pulmonary Pharmacology and Therapeutics, 37. pp. 30-36. ISSN 10945539

Vaidya, Soniya, Khindri, Sanjeev, Maahs, Suzanne, Machineni, Surendra Kumar, Hara, Hisanori, Juan, Axel and Kaiser, Guenther (2016) Lung Delivery of Indacaterol and Mometasone Furoate Following Inhalation of QMF149 via the Twisthaler® Device in Healthy Volunteers. Clinical Pharmacology in Drug Development. ISSN 2160763X

Van, Linh, Floch, David, Jiang, Xuemin, Klein, Ulf, Abrams, Ken and Sunkara, Gangadhar (2016) Pharmacokinetic and Pharmacodynamics of Canakinumab in Patients with Systemic Juvenile Idiopathic Arthritis. The Journal of Clinical Pharmacology, Online (0(0)). pp. 1-12. ISSN 10.1002/jcph:754

Van Eldik, LJ, Carrillo, M, Cole, PE, Feuerbach, Dominik, Greenberg, BD, Hendrix, J, Kennedy, M, Kozauer, N, Mueller, R, Ransohoff, R, Wilcock, DM, Bain, L and Bales, K (2016) The Roles of Inflammation and Immune Mechanisms in Alzheimer's Disease. Alzheimers Dementia, 2 (2). pp. 99-100. ISSN http://dx.doi.org/10.1016/j.trci.2016.05.001

Vicini, P, Fields, O, Lai, E, Litwack, E D, Martin, A-M, Morgan, T M, Pacanowski, M A, Papaluca, M, Perez, O D, Ringel, M S, Robson, M, Sakul, H, Vockley, J, Zaks, T, Dolsten, M and Søgaard, M (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical pharmacology and therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Vicini, Paolo, Fields, Owen, Lai, Eric, Litwack, David, Martin, Anne-Marie, Morgan, Thomas, Pacanowski, Michael, Papaluca, Marisa, Perez, Omar, Ringel, Michael, Robson, Matthew, Sakul, Hakan, Vockley, Joseph, Zaks, Tal and Sogaard, Morten (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical Pharmacology and Therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Vicini, Paolo, Fields, Owen, Lai, Eric, Litwack, David, Martin, Anne-Marie, Morgan, Thomas, Pacanowski, Michael, Papaluca, Marisa, Perez, Omar, Ringel, Michael, Robson, Matthew, Sakul, Hakan, Vockley, Joseph, Zaks, Tal and Sogaard, Morten (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical Pharmacology and Therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Voegtle, Markus and Leforestier, Baptiste (2016) Safe Generation and Direct Use of Chlorine Azide in Flow Chemistry – 1,2‐Azidochlorination of Olefins and Access to Triazoles. Synlett, 27 (-). pp. 1957-1962. ISSN 0936-5214

Vrieseling Pecho, Eline (2016) Hunting cellular mechanisms underlying the spreading of misfolded protein pathology in the brain. Neuropathology and Applied Neurobiology, 42 (2). pp. 135-136. ISSN 1365-2990

Vuichoud, Basile, Bornet, Aurélien, de Nanteuil, Florian, Milani, Jonas, Canet, Estel, Ji, Xiao, Mieville, Pascal, Weber, Emmanuelle, Kurzbach, Dennis, Flamm, Andrea, Konrat, Robert, Gossert, Alvar, Jannin, Sami and Bodenhausen, Geoffrey (2016) Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins. Chemistry - a European journal, 22 (41). pp. 14696-14700. ISSN 09476539

Walker, Dana and Ramiah, Shashi (2016) Veterinary Pathologists in Translational Pharmacology and Biomarker Integration in Drug Discovery and Development. Toxicologic Pathology.

Walles, Markus, Rudolph, Bettina, Peraus, Gisela, Wolf, Thierry, Bourgailh, Julien, Suetterlin, Martina, Moenius, Thomas, Heudi, Olivier, Elbast, Walid, Lanshoeft, Christian and Bilic, Sanela (2016) New Insights in Tissue Distribution, Metabolism and Excretion of [3H]-labeled Antibody Maytansoid Conjugates in Female Tumor Bearing Nude Rats. Drug Metabolism and Disposition.

Wang, Hui, Lu, Bo, Castillo, Johnny, Yang, Zinger, Mcallister, Gregory, Reece-Hoyes, John, Tallarico, John, Russ, Carsten, Hoffman, Gregory, Schirle, Markus and Cong, Feng (2016) Tankyrase inhibitor sensitizes lung cancer cells to endothelial growth factor receptor (EGFR) inhibition via stabilizing angiomotins and inhibiting yap signaling. Journal of Biological Chemistry, 291 (29). pp. 15256-15266. ISSN 1083-351X

Wang, Yuan, Cornett, Allen, King, Frederick, Mao, Yi, Nigsch, Florian, Paris, Greg, Mcallister, Gregory and Jenkins, Jeremy (2016) Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery. Cell Chemical Biology, 23 (7). pp. 862-874. ISSN 24519456

Wassermann, Anne, Borowsky, Mark, Partl, Christian, Lex, Alexander, Streit, Marc, Pfister, Hanspeter and Schmalstieg, Dieter (2016) Caleydo Entourage: analyzing experimental data across multiple pathways. IEEE Trans Vis Comput Graph. , 19 (12). pp. 2536-2545. ISSN 1077-2626

Weaver, Margaret, Blak Grossi, Anette , Parish, Joanna , Schützsack, Jorgen , Løgsted, Jeanet , Brück Bøgh, Ingrid , Cameron, David , Harvey, Warren , Festag, Matthias , Downes, Noel , Venturella, Silvana , Schlichtiger, Julia , Mhedhbi, Sofiene , Ross, Vanessa , Kissner, Thomas , Stark, Claudia , Milano, Stephane , Heining, Peter and Sanchez-Felix, Manuel (2016) Vehicle Systems and Excipients Used in Minipig Drug Development Studies. Toxicologic Pathology, 44 (3). pp. 367-372. ISSN 1533-1601

Weaver, Margaret, Grossi, AB, Schuetzsack, J, Parish , J, Loegsted, J, Boegh, IB, Cameron , D, Harvey, W, Festag, M, Downes, N, Venturella, S, Schlichtiger, J, Heining, Peter and Sanchez-Felix, Manuel (2016) Vehicle Systems and Excipients Used in Minipig Drug Development Studies. Toxicology Pathology.

Webster, Carl I., Bryson, Christine J., Cloake, Edward A., Jones, Tim D., Austin, Mark J., Karle, Anette, Spindeldreher, Sebastian, Lowe, David C. and Baker, Matthew P. (2016) A comparison of the ability of the human IgG1 allotypes Gm1(3) and Gm1(1,17) to stimulate T-cells responses from allotype matched and mismatched donors. mAbs.

Weehuizen, T, Lankelma, J, de Jong, K, de Boer, O, Roelofs, J, Day, N, Gram, Hermann, de vos, j and Wiersinga, J (2016) THERAPEUTIC ADMINISTRATION OF A MONOCLONAL ANTI-IL-1Β ANTIBODY PROTECTS AGAINST EXPERIMENTAL MELIOIDOSIS. Shock : molecular, cellular, and systemic pathobiological aspects and therapeutic approaches : the official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies., 46. pp. 566-574. ISSN 1540-0514

Wehmeyer, Corinna, Frank, Svetlana, Beckmann, Denise, Böttcher, Martin, Cromme, Christoph, König, Ulrich, Fennen, Michelle, Held, Annelena, Paruzel, Peter, Hartmann, Christine, Stratis, Athanasios, Korb-Pap, Adelheid, Kramer, Ina, van den Berg, Wim, Kamradt, Thomas, Kneissel, Michaela, Pap, Thomas and Dankbar, Berno (2016) Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Science translational medicine. ISSN 1946-6242; 1946-6234

Weiskopf, Kipp, Anderson, Katie, Ito, Daisuke, Schnorr, Peter, Tomiyasu, Hirotaka, Ring, Aaron, Bloink, Kristin, Efe, Jem, Rue, Sarah, Lowery, David, Barkal, Amira, Prohaska, Susan, McKenna, Kelly, Cornax, Ingrid, O'Brien, Timothy, O'Sullivan, Gerard, Weissman, Irving and Modiano, Jaime (2016) Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20. Cancer immunology research, 4 (12). pp. 1072-1087. ISSN 2326-6074; 2326-6066

Wetzel, Kristie and Capodieci, Paola (2016) Dual ISH-IHC. Publication on website acdbio.com/dual-ISH-IHC.

Wharton Jr, Keith, Quigley, Catherine, Themeles, Marian, Dunstan, Robert W., Doyle, Kathryn, Cahir-McFarland, Ellen, Wei, Jing, Buko, Alex, Reid, Carl E., Sun, Chao, Carmillo, Paul, Sur, Gargi, Carulli, John P., Mansfield, Keith, Westmoreland, Susan V., Staugaitis, Susan M., Fox, Robert J., Meier, Werner and Goelz, Susan (2016) JC polyomavirus abundance and distribution in progressive multifocal leukoencephalopathy brain tissue implicates myelin sheath in intracerebral dissemination of infection. PLoS One.

Whibley, Natasha, Tritto, Elaine, Traggiai, Elisabetta, Kolbinger, Frank, Moulin, Pierre, Brees, Dominique, Coleman, Bianca M., Mamo, Anna J., Garg, Abhishek V., Jaycox, Jillian R., Siebenlist, Ulrich, Kammueller, Michael and Gaffen, Sarah L. (2016) IL-17A is the dominant IL-17-family cytokine required for immunity to acute murine oral mucosal candidiasis. Journal of Leukocyte Biology, 99 (?). ?.

White, John, P.M, Cibelli , Mario, Urban, Laszlo, Nilius, Bernd, McGeown, Graham and Nagy, Istvan (2016) TRPV4: MOLECULAR CONDUCTOR OF A DIVERSE ORCHESTRA. Physiological reviews, 96 (96). pp. 911-973. ISSN 1522-1210; 0031-9333

White, Nicholas, Thanh, Duong Tran, Uthaisin, Chirapong, Nosten, Francois, Phyo, Aung Pyae, Pukrittayakamee, Sasithon, Jittamala, Podjanee, Chuthasmit, Kittiphum, Cheung, Nicole, Feng, Elie, Li, Ruobing, Magnusson, Baldur, Sultan, Marc, Wieser, Daniela, Xun, Xiaolei, Zhao, Rong, Diagana, Thierry Tidiane, Pertel, Peter and Leong, Franz Joel Wen (2016) The novel imidazolopiperazine KAF156 clears parasitemia rapidly in falciparum and vivax malaria. New England journal of medicine : NEJM., 375 (12). pp. 1152-1160. ISSN 0028-4793

Whitebread, Steven, Dumotier, Berengere, Armstrong, Duncan, Fekete, Alexander, Chen, Shanni, Hartmann, Andreas, Mueller, Patrick and Urban, Laszlo (2016) Secondary Pharmacology: Screening and Interpretation of Off-target Activities – Focus on translation. Drug Discovery Today. ISSN 13596446

Wilcken, Rainer and Srinivas, Honnappa (2016) Mutational analysis of SGPL1: In silico modelling (The analysis results will be shared with Prof. Friedhelm Hildebrandt, Harvard medical school, Division of Nephrology Boston Children's Hospital). These results ( were approved in OAK before), that were shared with Prof. Friedhelm Hildebrandt is now a part of full manuscript for publication with Prof. Friedhelm Hildebrandt as corresponding author . Honnappa Srinivas and Rainer Wilken are the co-authors from NIBR. Please find attached the full manuscript. SGPL1 mutations cause nephrosis with ichthyosis and adrenal insufficiency.

Willadt, Silvia, Nash, Mark and Slater, Clarke (2016) Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragm. Scientific reports, 6. ISSN 2045-2322

Willard, Elizabeth, Sykes, David, Dubois, Gerald, Bradley, Michelle, Riddy, Darren, Sandham, David, Watson, Simon, Bauer, Carsten and Charlton, Steven (2016) Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology, 89 (5). pp. 593-605. ISSN 15210111

Winkler, Gian Christian, Lovsin Barle, Ester and Mirwald, Jens (2016) Tiered Banding Concept for Pharmaceutical Intermediates. Chimica oggi; chemistry today, 34 (4). pp. 32-36. ISSN ISSN 0392-839X, EISSN 1973-8250

Witek, Jagna, Keller, Bettina G., Blatter, Markus, Meissner, Axel, Wagner, Beatrix and Riniker, Sereina (2016) Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States. Journal of Chemical Information & Modeling, 56 (8). pp. 1547-1562. ISSN 1549-960X

Xiuning, Le, Rajee, Anthony, Pedram, Razavi, Daniel J, Treacy, Flora, Luo, Mahmoud, Ghandi, Jose, Baselga and Levi A, Garraway (2016) Systematic functional characterization of resistance to PI3K inhibition in breast cancer. Cancer discovery, 6 (10). pp. 1134-1147. ISSN 2159-8290; 2159-8274

Xu, Jing, Li, Li, Xiong, Jie, Dekker, Aaron den, Ye, Andrew, Karatas , Hacer, Liu, Liu, Wang, He, Qin, Zhaohui S., Wang, Shaomeng and Dou, Yali (2016) MLL1 and MLL1 fusion proteins play distinct roles in regulating leukemic transcription program. Cell discovery.

Yamada, Ken, Park, Hyi-Man, Rigel, Dean, Monovich, Lauren, Whalen, Erin, Anisowicz, Anthony, Beil, Michael, Berstler, James, Brocklehurst, Cara, Burdick, Debra, Caplan, Shari, Capparelli, Michael, Chen, Guanjing, Chen, Wei, Dale, Bethany, Deng, Lin, Fu, Fumin, Hamamatsu, Norio, Harasaki, Kouki, Herr, Tracey, Hoffmann, Peter, Hu, Qi-Ying, Huang, Waanjeng, Idamakanti, Neeraja, Imase, Hidetomo, Iwaki, Yuki, Jain, Monish, Jeyaseelan, Jey, Kato, Mitsunori, Kaushik, Virendar, Kohls, Darcy, Kunjathoor, Vidya, Lasala, Daniel, Lee, Jongchan, Liu, Jing, Luo, Yang, Ma, Fupeng, Mo, Ruowei, Mowbray, Sarah, Mogi, Muneto, Ossola, Flavio, Pandey, Pramod, Patel, Sejal, Raghavan, Swetha, Salem, Bahaa, Shanado, Yuka, Trakshel, Gary, Turner, Gordon, Wakai, Hiromichi, Wang, Chunhua, Weldon, Stephen, Wielicki, Jennifer, Xie, Xiaoling, Xu, Lingfei, Yagi, Yukiko, Yasoshima, Kayo, Yin, Jianning, Yowe, David, Zhang, Ji, Zheng, Gang and Dipetrillo, Keith (2016) Small-molecule WNK inhibition regulates cardiovascular and renal function. Nature Chemical Biology, 12 (11). pp. 896-898. ISSN 15524469

Yamada, Ken, Zhang, Ji, Xie, Xiaoling, Reinhardt, Juergen, Xie, Amy, LaSala, Daniel, Kohls, Darcy, Yowe, David, Burdick, Debra, Yoshisue, Hajime, Wakai, Hiromichi, Schmidt, Isabel, Yasoshima, Kayo, Yue, Qing, Kato, Mitsunori, Mogi, Muneto, Idamakanti, Neeraja, Kreder, Natasha, Drueckes, Peter, Pandey, Pramod, Kawanami, Toshio, Huang, Waanjeng, Yagi, Yukiko, Deng, Zhan, Park, Hyi-Man and Gunawan, Jason (2016) Discovery and Characterization of Allosteric WNK Kinase Inhibitors. ACS chemical biology, 11 (12). pp. 3338-3346. ISSN 1554-8937

Yang, Yang (2016) Expedient Synthesis of 4-Aryl Quinazoline Analogues via Direct Nucleophilic Arylation of 2-Chloroquinazoline. Synthesis, 48 (14). pp. 2255-2262. ISSN 0039-7881

Yokokawa, Fumiaki, Noble, Christian Guy, Lim, Siew Pheng, Rao, Ranga Rao K.R., Tania, Stefani, Wang, Gang, Lee, Gladys, Hunziker, Juerg, Karuna, Ratnaningrum, Manjunatha, Ujjini Havaldar, Nilar, Shahul, Shi, Pei-Yong and Smith, Paul (2016) Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase From a Fragment Hit Using Structure-Based Drug Design. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Yu, Vionnie and Scadden, David (2016) Heterogeneity of the bone marrow niche. Current Opinion in Hematology, 23 (4). pp. 331-338. ISSN 2016 Jul;23(4):331-8

Yu, Yanyan, chen , Jiajia, Gao, Jun, Liao, Rijing, Oyang, Counde, Li, En, Jin, Hong, Yang, Pengyuan, Zhou, Shaolian and Yi, Wei (2016) A methodology paper for histone variant peptide quantitation. Quantitative Profiling of Combinational K27/K36 Modifications on Histone H3 Variants in Mouse Organs..

Zeeman, Anne-Marie, Lakshminarayana, Suresh Bangalore, van der Werff, Nicole, Klooster, Els, Kondreddi, Ravinder Reddy, Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan King Sing, Diagana, Thierry Tidiane and Kocken, Clemens (2016) PI4K is a prophylactic, but not radical curative target in Plasmodium vivax-type malaria parasites. Antimicrobial Agents and Chemotherapy (AAC) .

Zhai, Yufeng, Chen, Kaisheng, Zhong, Yang, Zhou, Bin, Ainscow, Edward, Wu, Ying-Ta and Zhou, Yingyao (2016) An Automatic Quality Control Pipeline for High-throughput Screening Hit Identification. Journal of Molecular Screening, 21 (8). pp. 832-841. ISSN 10870571

Zhang, Jin, Heimbach, Tycho, Barve, Avantika, Li, Wenkui and He, Handan (2016) Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies with PBPK Modeling. Journal of Pharmaceutical Sciences, 105 (4). pp. 1398-1404. ISSN 1520-6017

Zhu, Andrew, Chen, David, He, Wei, Kanai, Masayuki, Voi, Maurizio, Chen, Li-Tzong, Daniele, Bruno, Vogel, Arndt and Chiang, Derek (2016) Integrative Biomarker Analyses Indicate Etiological Variations in c-Met and Tsc2 Alterations in Hepatocellular Carcinoma. Journal of Hepatology, 65 (2). pp. 296-304. ISSN 1600-0641

Zhu, Kaichuan, Xiang, Xianyuan, Dorostkar, Mario, Filser, Severin, Crux, Sophie, Marinkovic, Petar, Neumann, Ulf, Shimshek, Derya, Rammes, Gerhard, Haass, Christian, Lichtenthaler, Stefan and Herms, Jochen (2016) Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biological Psychiatry. ISSN 18732402

Zielman, Ronald, Postma, Rudmer, Verhoeven, Aswin, Bakels, Floor, van Oosterhout, Willebrordus P J, Meissner, Axel, van den Maagdenberg, Arn M J M, Terwindt, Gisela M, Mayboroda, Oleg A and Ferrari, Michel D (2016) Metabolomic changes in CSF of migraine patients measured with (1)H-NMR spectroscopy. Molecular bioSystems, 12 (12). pp. 3674-3682. ISSN 1742-2051

de Zwart, Marcel, Lausecker, Berthold, Globig, Susanne, Neddermann, Daniel, Le Bras, Bruno, Guenzi, Alberto, White, Stephen, Scheel-Fjording, Marianne and Timmerman, Philip (2016) Co-medication and interference testing in bioanalysis: a European Bioanalysis Forum Recommendation. Bioanalysis, 8 (19). pp. 2065-2070. ISSN 1757-6180

van Overbeek, Megan, Capurso, Daniel, Carter, Mathew M., Thompson, Mathew S., Frias, Elizabeth, Reece-Hoyes, John, Nye, Christopher, Gradia, Scott, Vidal, Bastien, Zheng, Jiashun, Hoffman, Gregory, Fuller, Christopher K. and May, Andrew P. (2016) DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks. Molecular Cell, 63 (4). pp. 633-646. ISSN 1097-4164

van Overbeek, Megan , Capurso, Daniel , Carter, Matthew , Thompson, Matthew M. , Frias, Elizabeth, Russ, Carsten, Reece-Hoyes, John, Nye, Christopher , Gradia, Scott, Vidal, Bastien , Zheng, Jiashun, Hoffman, Gregory, Fuller, Christopher K. and May, Andrew P. (2016) DNA repair outcomes at Cas9-mediated double-strand breaks are non-random and sequence-dependent. Science.