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Number of items: 468.

A

Abend, Johanna and Sathe, Atul and Changala, Marguerite and Casey, Fergal and Kistler, Amy and Chandran, Sindhu and Howard, Abigail and Wojciechowski, David (2016) Correlation of BK Virus Neutralizing Serostatus with the Incidence of BK Viremia in Kidney Transplant Recipients. Transplantation. p. 1. ISSN 0041-1337

Abramowski, Dorothee and Staufenbiel, Matthias (2016) Co-expression of truncated and full-length tau induces severe neurotoxicity. Mol Psychiatry. ISSN 1359-4184

Accart Gris, Nathalie and Dawson King, Janet and Kramer, Ina and Kolbinger, Frank and Beckmann, Nicolau (2016) NON-INVASIVE IMAGING DEMONSTRATES CLINICAL FEATURES OF THE PATHOLOGY IN A RAT ADJUVANT MODEL FOR ANKYLOSING SPONDYLITIS. European journal of histochemistry : EJH., 60 (4). p. 2667. ISSN 2038-8306

Achichi, Manel and Chetham, Michelle and Dragisic, Zlatan and Euzenat, Jerome and Faria, Daniel and Ferrara, Alfio and Flouris, Giorgios and Fundulaki, Irini and Harrow, Ian and Ivanova, Valentina and Jimenez-Ruiz, Ernesto and Kuss, Elena and Lambrix, Patrick and Leopold, Henrik and Meilicke, Christian and Montanelli, Stefano and Pesquita, Catia and Saveta, Tzanina (2016) Results of the Ontology Alignment Evaluation Initiative 2016. CEUR Proceedings, 1766. pp. 73-129. ISSN 1613-0073

Agarinis, Claudia and Orsini, Vanessa and Megel, Philippe and Abraham, Yann and Yang, Haidi and Mickanin, Craig and Bouwmeester, Antonius and Tchorz, Jan and Parker, Christian (2016) Activation of Yap Directed Transcription by Knock-down of Conserved Cellular Functions. Journal of Biomolecular Screening.

Agarinis, Claudia and Orsini, Vanessa and Megel, Philippe and Abraham, Yann and Yang, Haidi and Mickanin, Craig and Myer, Vic and Bouwmeester, Antonius and Tchorz, Jan and Parker, Christian (2016) Activation of Yap Directed Transcription by Knock-down of Conserved Cellular Functions. Journal of Biomolecular Screening.

Akahane, Koshi and Sanda, Takaomi and Mansour, Marc R. and Radimerski, Thomas and Weinstock, David M. and Letai, Anthony and Look, Thomas (2016) HSP90 Inhibition Leads to Degradation of the TYK2 Kinase and Apoptotic Cell Death in T-Cell Acute Lymphoblastic Leukemia. Leukemia, 30 (1). pp. 219-228. ISSN 1476-5551; 0887-6924

Akahori, Mizuki and Ayalasomayajula, Surya and Langenickel, Thomas Heiko and Pal, Parasar and Sunkara, Gangadhar (2016) Pharmacokinetics after single ascending dose, food effect, and safety of sacubitril/valsartan (LCZ696), a novel angiotensin receptor and neprilysin inhibitor, in healthy Japanese subjects. European Journal of Drug Metabolism and Pharmacokinetics, Epub a (NA). NA-NA. ISSN 2107-0180

Alper, Phillip and Ratnikov, Max (2016) GNF portion of an NSF GOALI grant proposal on flow photochemistry to be submitted with Professor Gary Molander from U Penn. NSF Review Committee, None (None). pp. 1-85. ISSN None

Althof, Erwin and Nijholt, Ralf (2016) Novartis & SiLA—Partners in Simplifying Lab Automation Implementations. Novartis & SiLA—Partners in Simplifying Lab Automation Implementations.

Altmann, Eva and Schlierf, Anita and Jefferson, AB and Renatus, Martin and Jones, Matthew and Hassiepen, Ulrich and Assenberg, Rene and Schaefer, Michael and Quancard, Jean and Kiffe, Michael and Weiss, Andreas and Wiesmann, Christian and Sedrani, Richard and Eder, Joerg and Martoglio, Bruno (2016) A first-in-class small molecule inhibitor of the COP9 signalosome subunit 5 for the treatment of cancer. Nature communications, 7. pp. 13166-13175. ISSN 2041-1723

Amaral, Adam and Saran, Chitra and Amin, Jakal and Hatsis, Panagiotis (2016) A Comparison of LC-MS/MS and a Fully Integrated Autosampler/Solid Phase Extraction System for the Analysis of Protein Binding Samples. Journal of Biomolecular Screening. ISSN 1552-454X

Anders, Gerd and Hassiepen, Ulrich and Theisgen, Stephan and Heymann, Stephan and Muller, Lionel and Panigada, Tania and Huster, Daniel and Samsonov, Sergey (2016) The Intrinsic Pepsin Resistance of Interleukin-8 Can be Explained from a Combined Bioinformatical and Experimental Approach. IEEE TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, PP (99). p. 1. ISSN 1545-5963

Andersen, ND and Nielsen, BE and Corradi, J and Tolosa, MF and Feuerbach, Dominik and Arias, HR and Bouzat, C (2016) Exploring the Positive Allosteric Modulation of Human α7 Nicotinic Receptors from a Single-Channel Perspective. Neuropharmacology.

Arenas-Amirez, Natalia and Zou, Chao and Popp, Simone and Zingg, Daniel and Brannetti, Barbara and Wirth, Emmanuelle and Calzascia, Thomas and Kovarik, Jiri and Sommer , Lukas and Zenke, Gerhard and Woytschak, Janine and Regnier, Catherine and Katopodis, Andreas and Boyman, Onur (2016) Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2. Science Translational Medicine, 8 (367). ISSN 1946-62341946-6242

Argikar, Upendra and Bushee, Jennifer and Dunne, Christine (2016) An in vitro approach to investigate ocular metabolism: Part I - Levobunolol. Drug metabolism and disposition, 44 (8). pp. 1304-1312. ISSN 1521-009X

Argikar, Upendra and Potter, Phil and Matthew, Hutzler and Punit, Marathe (2016) Challenges and Opportunities with Non-CYP Enzymes Aldehyde oxidase, Carboxyl esterase and UDP-glucuronosyl transferase. Focus on Reaction Phenotyping and Prediction of Human Clearance. AAPS Journal, 18 (6). pp. 1391-1405. ISSN N/A

Arias, HR and Ravazzini, F and Targowska-Duda, KM and Kaczor, AA and Feuerbach, Dominik and Boffi, JC and Draczkowski, P and Montag, D and Brown, BM and Elgoyhen, AB and Jozwiak, K and Puia, G (2016) Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. The International Journal of Biochemistry & Cell Biology.

Ashok, Yashwanth and Jaakola, Veli-Pekka (2016) Nanodisc-Tm: Rapid functional assessment of nanodisc reconstituted membrane proteins by CPM assay. MethodsX, 3. pp. 212-218. ISSN 22150161

Atienzar, Franck and Blomme, Eric and Chen, Minjun and Hewit , Philip and Kenna, Gerry and Labbe, Gilles and LeCluyse, Edward and Moulin, Frederic and Pognan, Francois and Roth, Adrian and Suter-Dick, Laura and Ukairo, Okechukwu and Weaver, Richard and Will, Yvonne and Dambach, Donna (2016) Key challenges and opportunities associated with the use of in vitro models to detect human DILI: integrated risk assessment and mitigation plans. BioMed Research International, 2016 (-). pp. 1-20. ISSN 10.1155

Auberson, Yves and Briard, Emmanuelle and Sykes, David and Reilly, John and Healy, Mark (2016) The Ligand Specific Efficiency (LSE) index for PET tracer optimization, illustrated with tracer candidates for imaging the prostacyclin receptor. ChemMedChem, 11 (13). pp. 1415-1427. ISSN don't know

Auld, Douglas (2016) Doug Auld—Interview for November 2016 issue of Assays and Drug Dev. Technologies (Mary Ann Liebert Inc., publishing). Assay and drug development technologies, 14 (9). pp. 518-523.

Auld, Douglas and Busby, Scott and Chen, Kiki and Jimenez, Marta and Yue, Qing and Bowes, Scott and Wendel, Gregory and Smith, Thomas and Zhang, Ji (2016) Matrix-Based Activity Pattern Classification as a Novel Method for the Characterization of Enzyme Inhibitors Derived from High-Throughput Screening. Journal of Biomolecular Screening, 21 (10). pp. 1075-1089. ISSN 1552-454X

Ayalasomayajula, Surya and Langenickel, Thomas Heiko and Priya, Chandra and Wolfson, Edward and Albrecht, Diego and Zhou, Wei and Pal, Parasar and Rajman, Iris and Sunkara, Gangadhar (2016) Effect of food on the oral bioavailability of the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan (LCZ696) in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics, 54 (12). pp. 1012-1018. ISSN 0946-1965

B

Bacioglu, Mehtap and Maia, Luis and Schelle, Juliane and Kaeser, Stephan and Schweighauser, Manuel and Shimshek, Derya and Neumann, Ulf and Preische, Oliver and Kahle, Philipp and Staufenbiel, Matthias and Neumann, Manuela and Kuhle, jens and Jucker, Mathias (2016) Neurofilament light chain in blood and CSF as marker of disease progression in mouse models of neurodegenerative diseases. Neuron, 91 (1). pp. 56-66. ISSN 08966273

Bakker, Maarten H. and Lee, Cameron and Meijer, E. W. and Dankers, Patricia Y. W. and Albertazzi, Lorenzo (2016) Supramolecular multicomponent BTA polymers as a modular platform for intracellular delivery. ACS Nano, 10 (2). pp. 1845-1852. ISSN 1936-08511936-086X

Balko, Justin M and Arteaga, Carlos L (2016) Tumors with amplifications of JAK2 at the 9p24 loci in TNBC demonstrate JAK2-specific dependency. Sci Transl Med., 8 (334). pp. 334-353. ISSN 1946-6242

Bastakoty, Dikshya and Saraswati, Sarika and Atkinson, James and Feoktistov, Igor and Liu, Jun and Harris, Jennifer and Young, Pampee (2016) Temporary, Systemic Inhibition of the WNT/β- Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, Stem cells and Regenerative Medicine, 2 (2). pp. 1-13. ISSN 2472-6990

Bauer, Daniel and Soon, Rachel and Kulmatycki, Kenneth and Chen, Yuming and Noe, Adele and Chen, Jin and Dosik, Jonathan and Meyers, Charles (2016) Photosensitizing potential of pradigastat in healthy subjects: a randomized controlled trial using three defined sunlight exposure conditions. Photochem. Photobiol. Sci., 15 (9). pp. 1155-1162. ISSN 1474-905X1474-9092

Bautista Mercader, Manuel and Tosini, Federico and Schneider, Marcel and Steigmiller, Stefan (2016) Transmission Raman Spectroscopy (TRS): how far can we go with the analysis of capsule based Dry Powder Inhalers? European Pharmaceutical Review, 21 (6). pp. 6-10.

Beckmann, Nicolau and Doelemeyer, Arno and Zurbruegg, Stefan and Bigot, Karine and Theil, Diethilde and Frieauff, Wilfried and Kolly, Carine and Neddermann, Daniel and Kreutzer, Robert and Perrot, Ludovic and Brzak, Irena and Jacobson, Laura and Staufenbiel, Matthias and Neumann, Ulf and Shimshek, Derya (2016) Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice. Neurobiology of Aging, 45. pp. 50-60. ISSN 01974580

Ben M'Barek, Mohamed and Redrup, Michael J and Igarashi, Harue and Schaefgen, Jay and Lin, Jenny and Geisler, Lisa and Ramachandran, Subramanian and Cardoso, Thales and Hillewaert, Vera (2016) Sample Management: Recommendation for best practices and harmonization from the Global Bioanalysis Consortium Harmonization Team. The AAPS Journal, Volume (Issue ). pp. 290-293. ISSN 1550-7416

Bende, Girish and Biswal, Shibadas and Bhad, Prafulla and Chen, Yuming and Salunke, Atish Azad and Winter, Serge and Wagner, Robert and Sunkara, Gangadhar (2016) Relative bioavailability of diclofenac potassium from softgel capsule versus powder for oral solution and immediate-release tablet formulation. Clinical Pharmacology in Drug Development, 5 (1). pp. 76-82. ISSN 2160-7648

Benoit, Roger and Ostermeier, Christian and Geiser, Martin and Widmer, Hans and Auer, Manfred and Li, Julia Su Zhou (2016) Seamless insert-plasmid assembly at high efficiency and low cost. PLOS ONE, April . pp. 1-13.

Berg, Daniela and Godau, Jana and Trenkwalder, Claudia and Eggert, Karla and Csoti, Ilona and Storch, Alexander and Huber, Heiko and Morelli-Canelo, Monica and Stamelou, Maria and Ries, Vincent and Wolz, Martin and Schneider, Christine and Di Paolo, Thérèse and Gasparini, Fabrizio and Hariry, Sam and Vandemeulebroecke, Marc and Gomez-Mancilla, Baltazar and Abi-Saab, Walid and Johns, Donald and Cooke, Katy (2016) AFQ056 treatment of levodopa-induced dyskinesias: results of two randomized controlled trials. Movement Disorders, 26 (7). pp. 1243-1250.

Bergeron, Sophie and Grant, James (2016) Validity Studies - Enhancing Patent Searches. Pharmaceutical patent analyst, Unknow (Unknow). XX-YY. ISSN 2046-8954

Berghausen, Joerg and Seiler, Frank Hans and Gobeau, Nathalie and Faller, Bernard (2016) Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range. ADMET&DMPK.

Bergsdorf, Christian and Fiez-Vandal, Cedric and Sykes, David and Bernet, Pascal and Aussenac, Sonia and Charlton, Steven and Schopfer, Ulrich and Ottl, Johannes and Duckely, Myriam (2016) An alternative thiol-reactive dye to analyze ligand interactions with the chemokine receptor CXCR2 using a new thermal shift assay format. Journal of Biomolecular Screening, 21 (3). pp. 243-251. ISSN 1087-05711552-454X

Bernasconi-Elias, Paula and Hu, Tiancen and Jenkins, David and Firestone, Brant and Gans, Sara and Kurth, Esther and Capodieci, Paola and Deplazes-Lauber, Joelle and Petropoulos, Konstantin and Thiel, Phillip and Ponsel, Dirk and Choi, Sung Hee and Lemotte, Peter and London, Anne and Goetcshkes, Margaret and Nolin, Erin and Jones, Michael and Slocum, Kelly and Kluk, Michael and Weinstock, David and Christodoulou, Alexandra and Weinberg, Olga and Jaehrling, Jan and Ettenberg, Seth and Buckler, Alan and Blacklow, Stephen and Aster, Jon and Fryer, Christy (2016) Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. ISSN 0950-92321476-5594

Beverly, Michael and Dell, Amy and Parmar, Parul and Houghton, Leslie (2016) Label-free analysis of mRNA capping efficiency using RNAse H probes and LC-MS. Analytical and Bioanalytical Chemistry, 408 (18). pp. 5021-5030. ISSN 1618-2650

Bhoumik, Priyasma and Del Rio Espinola, Alberto and Hahne, Florian and Moggs, Jonathan and Grenet, Olivier (2016) Translational Safety Genetics - Leveraging Genetic Variation for Enhanced Safety Assessment. Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Bhowmik, Shiva and Chiu, Hsien-Po and Jones, David and Chiu, Hsiu-Ju and Miller, Mitchell and Xu, Qingping and Farr, Carol Lynn and Ridlon, Jason M. and Wells, James E. and Elsliger, Marc-Andre and Wilson, Ian A. and Hylemon, Phillip B. and Lesley, Scott (2016) Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis. Proteins: Structure, Function and Bioinformatics, 84 (3). pp. 316-331. ISSN 10970134

Bidinosti, Michael and Botta, Paolo and Moreira Ramos Proenca, Catia and Stoehr, Natacha and Bernhard, Mario and Fruh, Isabelle and Mueller, Matthias and Bonenfant, Debora and Voshol, Johannes and Carbone, Walter and Neal, Sarah and Mctighe, Stephanie and Roma, Guglielmo and Dolmetsch, Ricardo and Porter, Jeffrey and Caroni, Pico and Bouwmeester, Antonius and Lüthi, Andreas and Galimberti, Ivan (2016) CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency. Science.

Bigaud, Marc and Dincer, Zuhal and Bollbuck, Birgit and Dawson King, Janet and Beckmann, Nicolau and Beerli, Christian and Cavelti, Gina and Nahler, Michaela and Angst, Daniela and Janser, Philipp and Otto, Heike and Rosner, Elisabeth and Hersperger, Rene and Bruns, Christian and Quancard, Jean (2016) Pathophysiological consequences of a break in S1P1-dependent homeostasis of vascular permeability revealed by S1P1 competitive antagonism. PLOS ONE.

Biosse Duplan, Martin and Komla-Ebri, Davide and Heuzé, Yann and Estibal, Valentin and Gaudas, Emilie and Kaci, Nabil and Benoist-Lasselin, Catherine and Zerah, Michel and Kramer, Ina and Kneissel, Michaela and Graus Porta, Diana and Di Rocco, Federico and Legeai-Mallet, Laurence (2016) Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible. Human molecular genetics. ISSN 1460-2083; 0964-6906

Bojkovic, Jade and Richie, Daryl and Six, David and Rath, Christopher and Sawyer, William and Hu, Daniel and Dean, Charles (2016) Characterization of an Acinetobacter baumannii lptD deletion strain: Permeability defects and response to inhibition of lipopolysaccharide and fatty acid biosynthesis. Journal of Bacteriology, 198 (4). pp. 731-741. ISSN 1098-5530

Bottos, Alessia and Gill, Jason W and Tzankov, Alexander and Wodnar-Filipowicz, Aleksandra and Hynes, Nancy E (2016) Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nature communications, 7 (12258). pp. 1-12. ISSN 2041-1723

Bottos, Alessia and Gotthardt, Dagmar and Gill, Jason W and Gattelli, Albana and Frei, Anna and Tzankov, Alexandar and Sexl, Veronika and Wodnar-Filipowicz, Aleksandra and Hynes, Nancy E (2016) Decreased NK cell-mediated anti-tumor immunity consequent to JAK pathway inhibition enhances metastasis in preclinical models of breast cancer. Nat Commun., 7 (12258). pp. 1-12. ISSN 2041-1723

Bouchez, Laure and Gerbeaux, Cyril and rusch, marion and Livendahl, madeleine and Patoor, Maude and Press, Neil (2016) Wake Up Call of A Sleeping Beauty”: Straightforward Synthesis of Functionalized β-(2-Pyridyl) Ketones from 2,6-Lutidine. Synlett.

Brandl, Trixi and Simic, Oliver and Skaanderup, Philip and Namoto, Kenji and Berst, Frederic and Ehrhardt, Claus and Schiering, Nikolaus and Mueller, Irene Renate and Woelcke, Julian (2016) Trypsin inhibitors for the treatment of pancreatitis. Bioorganic & Medicinal Chemistry Letters.

Brasa, Sarah and Rozenberg, Izabela and Zollinger, Tulipan and Hahne, Florian and Peters, Thomas and Manzella, Liliana and Decker, Jerry and He, Yunsheng and Johnson, Keith and Mccormack, Christine and Gasparini, Fabrizio and Chibout, Salah-Dine and Grenet, Olivier and Moggs, Jonathan and Gomez-Mancilla, Baltazar and Terranova, Remi and Jacquemont, Sebastien (2016) Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome. Clinical Epigenetics, 8 (1). ISSN 18687083

Brasa, Sarah and Sebastien, Jacquemont and Hahne, Florian and Rozenberg, Izabela and Peters, Thomas and He, Yunsheng and Mccormack, Christine and Gasparini, Fabrizio and Chibout, Salah-Dine and Grenet, Olivier and Moggs, Jonathan and Gomez-Mancilla, Baltazar and Terranova, Remi (2016) Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in Fragile X syndrome. Clinical Epigenetics (http://www.clinicalepigeneticsjournal.com/).

Brecht, Karin and Riebel, Virginie and Couttet, Philippe and Paech, Franziska and Wolf, Armin and Chibout, Salah-Dine and Pognan, Francois and Krähenbühl, Stephan and Uteng, Marianne (2016) Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin. Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin, 40. pp. 55-65.

Brian, William and Tremaine, Larry M. and Arefayene, Million and de Kanter, Ruben and Evers, Raymond and Guo, Yingying and Kalabus, James and Lin, Wen and Loi, Cho-Ming and Xiao, Guangqing (2016) Assessment of Drug Metabolism Enzyme and Transporter Pharmacogenetics in Drug Discovery and Early Development: Perspectives of the I-PWG. Pharmacogenomics, 17. pp. 615-631. ISSN 1744-8042

Brown, Alan and Drew, Philip and Knight, Brian and Marc, Philippe and Troth, Sean and Wuersch, Kuno and Zandee, Joyce (2016) Graphical display of histopathology data from toxicology studies for drug discovery and development: an industry perspective. Regulatory toxicology and pharmacology, 82. pp. 167-172.

Brunschweiger, Andreas and Gebert, Luca F. R. and Lucic, Matije and Pradère, Ugo and Jahns, Hartmut and Hunziker, Juerg and Hall, Jonathan (2016) Site-specific conjugation of drug-like fragments to anti-miRNA oligonucleotides: pros and cons of targeting miRNAs in RISC. Angewandte Chemie International Edition, 52 (1). pp. 156-159. ISSN 1359-73451364-548X

Brykczynska Kunzmann, Urszula and Vrieseling Pecho, Eline and Thiemeyer, Anke and Klein, Jessica and Fruh, Isabelle and Doll, Thierry and Manneville, Carole and Iazeolla, Mariavittoria and Beibel, Martin and Roma, Guglielmo and Naumann, Ulrike and Kelley, Nicholas and Oakeley, Edward James and Mueller, Matthias and Gomez-Mancilla, Baltazar and Buehler, Marc and Tabolacci, Elisabetta and Chiruazzi, Pietro and Neri, Giovanni and Bouwmeester, Antonius and Di Giorgio, Francesco and Fodor, Barna (2016) CGG Repeat-Induced FMR1 Silencing Depends on the Expansion Size in Human iPSCs and Neurons Carrying Unmethylated Full Mutations. Stem Cell Reports, 7 (6). pp. 1059-1071. ISSN 22136711

Brykczynska Kunzmann, Urszula and Vrieseling Pecho, Eline and Thiemeyer, Anke and Klein, Jessica and Fruh, Isabelle and Doll, Thierry and Manneville, Carole and Iazeolla, Mariavittoria and Beibel, Martin and Roma, Guglielmo and Naumann, Ulrike and Kelley, Nicholas and Oakeley, Edward James and Mueller, Matthias and Gomez-Mancilla, Baltazar and Buehler, Marc and Tabolacci, Elisabetta and Chiruazzi, Pietro and Neri, Giovanni and Bouwmeester, Antonius and Di Giorgio, Francesco and Fodor, Barna (2016) Human neurons carrying FMR1 unmethylated full mutations require large CGG repeat expansions for silencing and display neurodegenerative features. Cell Stem Cell.

Brzeszczyńska, Joanna and Johns, Neil and Schilb, Alain and Degen, Simone and Degen, Martin and Langen, Ramon and Schols, Annemie and Glass, David and Roubenoff, Ronenn and Greig, Carolyn A. and Jacobi, Carsten and Fearon, Kenneth C.H. and Ross, James A. (2016) Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not healthy elderly. Clinical Cancer Research, 8 (7). pp. 1-12. ISSN 1945-4589

Burmester, Gerd and Durez, Patrick and Shestakova, Galena and Genovese, Mark and Schulze-Koops, Hendrik and Li, Yue and Wang, Amanda and Lewitzky, Steven and Koroleva, Irina and Agarwal-Berneis, Anni and Lee, David M and Hueber, Wolfgang (2016) Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis. Rheumatology (United Kingdom), 55 (1). pp. 49-55. ISSN 14620332

C

Calonder, Claudio and Polus, Florine and Woessner, Ralph and Loesche, Christian and Cheng, Yi and Dragatin, Christian and Bodenlenz, Manfred and Aigner, Birgit and Tiffner, K and Mader , J and Ratzer , M and Pieber, Thomas and Bruin, Gerardus and Sinner, Frank (2016) Secukinumab Distributes into Dermal Interstitial Fluid of Psoriatic Patients as Demonstrated by Open Flow Microperfusion. Experimental dermatology, 25 (2). pp. 157-159. ISSN 09066705

Camenisch, Gian P. (2016) Drug disposition classification systems in discovery and development: A comparative review of the BDDCS, ECCS and ECCCS concepts. Pharmaceutical Research.

Campbell, Katie and Solovieff, Nadia and Morrissey, Michael and Leary, Rebecca and Mahan, Scott and Adamovich, Wendy and Murphy, Leon and Mirzaa, Ghayda and Jansen, Laura and Timms, Andrew and Conti, Valerio and Adams, Carissa and boyle, Evan and Collins, Sarah and ishak, gisele and poliachik, sandra and girisha, katta and yeung, kit san and chung, brain hon yin and rahikkala, elisa and gunter, sonya and martin, beth and weaver, molly and doerschner, michael and shendure, jay and saneto, russell and novotny, edward and hevner, robert and ojemann, jeffrey and guerrini, renzo and Sellers, William and dobyns, william (2016) Association of MTOR mutations with developmental brain disorders, including megalencephaly, focal cortical dysplasia, and pigmentary mosaicism. JAMA Neurology, 73 (7). pp. 836-845. ISSN 21686149

Caravatti, Giorgio and Guagnano, Vito and Aichholz, Reiner and Blanz, Joachim and Blasco, Francesca and Wipfli, Peter and Fritsch, Christine and Maira, Sauveur-Michel and Schnell, Christian and Seiler, Frank Hans (2016) Increasing metabolic stability via the deuterium kinetic isotope effect: an example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (19). pp. 4729-4734. ISSN 0960-894X

Carita, Guillaume and Frisch Dit Leitz, Estelle and Dahmani, Ahmed and Raymondie, Chloe and Cassoux, Nathalie and Piperno-Neumann, Sophie and Nemati, Fariba and Roman-Roman, Sergio and Wylie, Andrew and Emery, Caroline and Schoumacher, Marie and Decaudin, Didier (2016) Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma. Oncotarget, 7 (23). pp. 33542-33556. ISSN 1949-2553 (Electronic); 1949-2553 (Linking)

Carstens, Nadia and Williams, Sue and Goolam, Saadiah and Carmichael, Trevor and Zou, Chao and Cheung, Chi Ming and Buechmann-Moller, Stine and Sultan, Marc and Staedtler, Frank and Rice, Dennis and Lacoste, Arnaud and Paes, Kim and Swart, Peter and Ramsay , Michele (2016) Novel mutation in the CHST6 gene causes macular corneal dystrophy in a black South African family. BMC medical genetics, 17 (1). p. 47. ISSN 1471-2350

Cejka, Daniel and Parada-Rodriguez, Diego and Pichler, Stefanie and Marculescu, Rodrig and Kramer, Ina and Kneissel, Michaela and Gross, Thomas and Reisinger, Andreas and Pahr, Dieter and Monier-Faugere, Marie-Claude and Haas, Martin and Malluche, Hartmut H. (2016) Sclerostin knock-out does not protect from uremia-induced bone loss in a murine model of chronic renal failure. Kidney International.

Chaker, A and Shamji, MH and Dumitru, A and Calderon, M and Scadding, G and Makatsori, M and Jones, Ieuan and He, Ally and Subramanian, Kulandayan and Arm, Jonathan and Durham, SR and Schmidt-Weber, CB (2016) Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: a randomised controlled trial. Journal of Allergy and Clinical Immunology.

Chandra, Abhishek and Lin, Tiao and Young, Tiffany and Tong, Wei and Ma, Xiaoyuan and Tseng, Wei-Ju and Kramer, Ina and Kneissel, Michaela and Levine, Michael A. and Zhang, Yejia and Cengel, Keith and Liu, X. Sherry and Qin, Ling (2016) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of Bone & Mineral Research, 16. ISSN 1523-4681

Chapman, Victoria and Terranova, Remi and Moggs, Jonathan and Kimber, Ian and Dearman, Rebecca (2016) Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens. Toxicology, 340. pp. 17-26. ISSN 1879-3185

Chen, Chao and Zhu, Hugh and Stauffer, Frederic and Caravatti, Giorgio and Vollmer, Susanne and Machauer, Rainer and Holzer, Philipp and Moebitz, Henrik and Scheufler, Clemens and Klumpp, Martin and Tiedt, Ralph and Beyer, Kim and Calkins, Keith and Kiffe, Michael and Guthy, Daniel Alexander and Zhang, Jeff and Gaul, Christoph (2016) The Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Chen, Xiao-Hui and Hatsis, Panagiotis and Judge, Joyce and Argikar, Upendra and Ren, Xiaojun and Sarber, Jason and Mansfield, Keith and Liang, Guiqing and Adamal, Adam and Catoire, Alexandre and Bentley, Adam and Ramos, Luis and Moench, Paul and Hintermann, Samuel and Carcache, David and Glick, Jim and Flarakos, Jimmy (2016) Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry. Analytical Chemistry, 88 (23). pp. 11813-11820. ISSN 0003-27001520-6882

Chen, Ying-Nan P and LaMarche, Matthew J and Chan, Ho Man and Fekkes, Peter and Garcia-Fortanet, Jorge and Acker, Michael G and Antonakos, Brandon and Chen, Christine Hiu-Tung and Chen, Zhouliang and Cooke, Vesselina G and Dobson, Jason R and Deng, Zhan and Fei, Feng and Firestone, Brant and Fodor, Michelle and Fridrich, Cary and Gao, Hui and Grunenfelder, Denise and Hao, Huai-Xiang and Jacob, Jaison and Ho, Samuel and Hsiao, Kathy and Kang, Zhao B and Karki, Rajesh and Kato, Mitsunori and Larrow, Jay and La Bonte, Laura R and Lenoir, Francois and Liu, Gang and Liu, Shumei and Majumdar, Dyuti and Meyer, Matthew J and Palermo, Mark and Perez, Lawrence and Pu, Minying and Price, Edmund and Quinn, Christopher and Shakya, Subarna and Shultz, Michael D and Slisz, Joanna and Venkatesan, Kavitha and Wang, Ping and Warmuth, Markus and Williams, Sarah and Yang, Guizhi and Yuan, Jing and Zhang, Ji-Hu and Zhu, Ping and Ramsey, Timothy and Keen, Nicholas J and Sellers, William R and Stams, Travis and Fortin, Pascal D (2016) Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature, 535 (7610). pp. 148-152. ISSN 1476-4687

Cheng, Dai and Liu, Jun and Han, Dong and Zhang, Guobao and Hsieh, Hsin-I and Ng, Nicholas and Kasibhatla, Shailaja and Tompkins, Celin and Li, Jie and Steffy, Auzon and Seidel, Martin and Harris, Jennifer and Sun, Fangxian (2016) Discovery of a Novel Series of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med Chem Lett, 7 (7). pp. 676-680. ISSN 1948-5875

Chitnis, Shripad and Han, Yi and Yamaguchi, Masayuki and Nozaki, Sachiko and Zhao, Rong and Kulmatycki, Kenneth and Sunkara, Gangadhar (2016) Population pharmacokinetic modeling and noncompartmental analysis demonstrated bioequivalence between metformin component of metformin/vildagliptin fixed-dose combination products and metformin immediate-release tablet sourced from various countries. Clinical Pharmacology in Drug Development, 5 (1). pp. 40-51. ISSN 2160-7648

Christmann-Franck, Serge and van Westen, Gerard and Papadatos, George and Beltran Escudie, Fanny and Roberts, Alexander and Overington, John P and Domine, Daniel (2016) Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design? Journal of chemical information and modeling, asap (asap). 0-0. ISSN 1549-960X

Clark, Kirk (2016) Outcome of the first wwPDB/CCDC/D3R Ligand Validation Workshop. Structure, 24 (4). pp. 502-508. ISSN 09692126

Clark, Robert and Delise, Anthony and Youreneff, Maureen (2016) Developmental toxicity studies of lumefantrine and artemether in rats and rabbits. Birth defects research. Part B: developmental and reproductive toxicology, 107. pp. 243-257. ISSN 1542-9741; 1542-9733

Colleton, Curtis and Brewster, David and Chester, Anne and Clarke, David and Heining, Peter and Olaharski, Andrew (2016) THE USE OF MINIPIGS FOR PRECLINICAL SAFETY ASSESSMENT BY THE PHARMACEUTICAL INDUSTRY: Results of an IQ DruSafe Minipig Survey. THE USE OF MINIPIGS FOR PRECLINICAL SAFETY ASSESSMENT BY THE PHARMACEUTICAL INDUSTRY: Results of an IQ DruSafe Minipig Survey, 44 (3). pp. 458-466. ISSN 0192-62331533-1601

Colman, Karyn (2016) Impact of the Genetics and Source of Preclinical Safety Animal Models on Study Design, Results and Interpretation. Toxicologic pathology, ? (?). pp. 1-13. ISSN 1533-1601; 0192-6233

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Corey, Victoria and Fuchs, Olivia and Meister, Stephan and Goldgof, Greg and Winzeler, Elizabeth and Istvan, Eva and Goldberg, Daniel and Coburn-Flynn, Olivia and Gnadig, Nina and Lee, Marcus and Fidock, David and Sakata-Kato, Tomoyo and Lukens, Amanda and Magistrado, Pamela and Wirth, Dyann and Linares, Maria and Franco, Virginia and Gracia, Maria and Gamo, Francisco and Zhou, Yingyao and Tanaseichuk, Olga (2016) Comprehensive analysis of resistance development in the malaria parasite. Nature communications, 7 (1). pp. 1-9. ISSN 2041-1723

Craven, Timothy W. and Cho, Min-Kyu and Traaseth, Nathaniel J. and Bonneau, Richard and Kirshenbaum, Kent (2016) A Miniature Protein Stabilized by a Cation−π Interaction Network. Journal of the American Chemical Society, 138 (5). pp. 1543-1550. ISSN 0002-7863

Crick, Peter, J. and Griffiths, William, J. and Zhang, Juan and Beibel, Martin and Abdel-Khalik, Jonas and Kuhle, Jens and Sailer, Andreas and Wang, Yuqin (2016) Reduced plasma levels of 25‐hydroxycholesterol and increased CSF levels of bile acid precursors in multiple sclerosis patients. Molecular Neurobiology. ISSN 0893-7648; 1559-1182

Crutcher, Emeline and May, Ali and Harrison, John and Schaaf, Christian and Sovago, Judit and Gomez-Mancilla, Baltazar (2016) Assessment of cognitive outcome measures in teenagers with 15q13.3 microdeletion syndrome. Genetics in Medicine.

Cytrynbaum, Cheryl and Chong, Karen and Hannig, Vickie and Choufani, Sanaa and Shuman, Cheryl and Steele, Leslie and Morgan, Thomas and Scherer, Stephen W and Stavropoulos, Dimitri J and Basran, Raveen K and Weksberg, Rosanna (2016) Genomic imbalance in the centromeric 11p15 imprinting center in three families: Further evidence of a role for IC2 as a cause of Russell-Silver syndrome. American journal of medical genetics. Part A, 170 (10). pp. 2731-2739. ISSN 1552-4833

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D'Alessandro, Pier Luca and Furet, Pascal and Baysang, Frederic and Brunner, Reto and Vorherr, Thomas and Stachyra, Therese-Marie and Ottl, Johannes and Lizos, Dimitrios and Cobos-Correa, Amanda and Marzinzik, Andreas and Kaufmann, Markus (2016) Bioorthogonal Probes to study MDM2-p53 inhibitors in cells and to develop high content screening assays for drug discovery. Angewandte Chemie International Edition, 55 (52). pp. 16026-16030. ISSN 1433-7851

Dalvit, Claudio and Vulpetti, Anna (2016) Weak intermolecular hydrogen-bonds with fluorine: detection and implications for enzymatic/chemical reactions, for chemical physical properties and for ligand/protein fluorine NMR screening. Chemistry-a European Journal.

Daniels, Matthew and Tan, Kian (2016) Substrate and Catalyst Controlled Regioselective C-H Functionalization of Five-Membered Heterocycles. Organic Letters, 18 (14). pp. 3310-3313.

Dawson King, Janet (2016) GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis. no journal (9).

Deanna , Barch and Steve, Marder and Michael, Harms and Lars, Jarksog and Robert, Buchanan and Will, Cronenwett and Li-Shiun , Chen and Weiss, Markus and Maguire, Paul and Pezous, Nicole and Feuerbach, Dominik and Lopez Lopez, Cristina and Johns, Donald and Gomez-Mancilla, Baltazar (2016) Task-related fMRI responses to a nicotinic acetylcholine receptor agonist in schizophrenia: a randomized trial. Progress in Neuro-Psychiticpharmacology and Biol Psy.

Defontis, Myriam / MD and Cote, Serge and Ledieu, David (2016) A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety. Experimental and Toxicologic Pathology. ISSN 16181433

Dejesus, Rowena and Moretti, Francesca and Mcallister, Gregory and Wang, Zuncai and Bergman, Phil and Liu, Shanming and Frias, Elizabeth and Alford, John and Reece-Hoyes, John and Lindeman, Alicia and Kelliher, Jennifer and Russ, Carsten and Knehr, Judith and Carbone, Walter and Beibel, Martin and Roma, Guglielmo and Aylwin, Ng and Ramnik, Xavier and Mickanin, Craig and Murphy, Leon and Hoffman, Gregory and Nyfeler, Beat (2016) Functional CRISPR screening identifies the protein ufmylation pathway as a regulator of SQSTM1/p62. eLife, 5 (NA). NA-NA. ISSN 2050-084X

Delise, Anthony and Solomen, Howard M. and Makris, Susan L. and Alsaid, Hasan and Bermudex, Oscar and Beyer, Bruce K. and Chen, Antong and Chen, Connie L. and Chen, Zhou and Chmielewski, Gary and De Schaepdrijver, Luc and Dogdas, Belma and French, Julian and Harrouck, Waffa and Helfott, Jonathan and Henkelman, R. Mark and Hesterman, Jacob and Hew, Kok-Wah and Hoberman, Alan and Lo, Cecilia and McDougal, Andrew and Mink, Daniel and Scott, Lelia and Stewart, Jane and Sutherland, Vicki and Tatiparthi, Arun K. and Winkelmann, Christopher T. and Wise, L. David and Wood, Sandra L. and Ying, Xiaoyou (2016) Micro-CT Imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A Workshop Report. Regulatory Toxicology and Pharmacology, 77. pp. 100-108. ISSN 02732300

Descombes, Patrick and Oakeley, Edward James (2016) Landscape of Genomics Technology Platforms in Switzerland. International Journal for Chemistry (CHIMIA).

Diagana, Thierry Tidiane and Chavchich, Marina and Van Breda, Karin and Rowcliffe, Kerryn and Edstein, Michael (2016) The spiroindolone KAE609 does not induce dormant ring stages in Plasmodium falciparum parasites. Antimicrobial Agents and Chemotherapy, 60 (9). pp. 5167-5174. ISSN 1098-6596

Dickson, Callum and Hornak, Viktor and Pearlstein, Robert and Mckay, Daniel and Velez-Vega, Camilo and Duca, Jose and Sandham, David and Shaw, Duncan and Fairhurst, Robin and Reilly, John and Charlton, Steven and Sykes, David (2016) Uncoupling the structure-activity relationships of β2 adrenergic receptor ligands from membrane binding. Journal of Medicinal Chemistry, 59 (12). pp. 5780-5789. ISSN 0022-26231520-4804

Dodd, Stephanie and Sethuraman, Vijay and Panicucci, Riccardo and Garad, Sudhakar and Zhou, Liping and Capacci-Daniel, Christina (2016) Co-Crystal Formation Based on Structural Matching. European Journal of Pharmaceutical Sciences. ISSN 09280987

Dole, Kiran and Segal, Florencia and Feire, Adam and Magnusson, Baldur and Rondon, Juan C and Vemula, Janardhana Rao and Yu, Jing and Pang, Yinuo and Pertel, Peter (2016) A first-in-human study to assess the safety and pharmacokinetics of monoclonal antibodies against human cytomegalovirus in healthy volunteers. Antimicrobial Agents and Chemotherapy, 60 (5). pp. 2881-2887. ISSN 0066-4804; 1098-6596

Donner, Lili and Fälker, Knut and Klinker, Stefan and Gremer, Lothar and Pagani, Giulia and Gohlke, Holger and Willbold, Dieter and Lang, Florian and Grenegard, Magnus and Elvers, Margitta (2016) Blood platelets contribute to the formation of Amyloid deposits in cerebral vessels via integrin. Science Signaling, 9 (429). ra52-56. ISSN 1945-08771937-9145

Dovala, Dustin and Rath, Christopher and Hu, Qijun and Sawyer, William and Shia, Steven and Elling, Robert and Knapp, Mark and Metzger Iv, Louis (2016) Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism. Proceedings of the National Academy of Sciences of the United States of America, 28. ISSN 1091-6490

Dovala, Dustin and Sawyer, William and Rath, Christopher and Metzger Iv, Louis (2016) Rapid analysis of protein expression and solubility with the SpyTag-SpyCatcher system. Protein Expr Purif, 117. pp. 44-51. ISSN 1096-0279 (Electronic); 1046-5928 (Linking)

Drollmann, Anton Franz and Lowe, Phil and Meiser, Karin and Arm, Jonathan (2016) Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. Journal of Allergy and Clinical Immunology, 138 (4). pp. 1051-1059. ISSN 1097-6825

Dryja, Ted (2016) Early Insight Into Neovascular Age-Related Macular Degeneration. JAMA Ophthalmology, 134 (11). pp. 1281-1282. ISSN 2168-6173

Dubiknov, Tatyana and Hoepfner, Dominic and Cohen, Ehud (2016) The Triage of Misfolded Prion Molecules to Aggresomes Occurs Within the Endoplasmic Reticulum. Journal of cell science, 129 (19). pp. 3635-3647. ISSN 1477-9137; 0021-9533

de Zwart, Marcel and Lausecker, Berthold and Globig, Susanne and Neddermann, Daniel and Le Bras, Bruno and Guenzi, Alberto and White, Stephen and Scheel-Fjording, Marianne and Timmerman, Philip (2016) Co-medication and interference testing in bioanalysis: a European Bioanalysis Forum Recommendation. Bioanalysis, 8 (19). pp. 2065-2070. ISSN 1757-6180

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Einolf, Heidi and Chen, Jin and Meyers, Charles and Kulmatycki, Kenneth and Bretz, Angela and Wang, Lai and Palamar, Safet and Majumdar, Tapan and Tran, Phi (2016) Pradigastat disposition in humans: in vivo and in vitro investigations. Xenobiotica. ISSN 0049-8254

Ekmark-Lewen, S and Fridgeirsdottir, A and Kiwanuka, O and Hanell, A and Meyerson , B and Mir, Anis Khusro and Gram, Hermann and Lewen , A and Clausen, F and Hillered, L and Marklund, N (2016) Complex behavioral alterations after diffuse traumatic axonal injury in mice are normalized by post-injury neutralization of interleukin-1β. European Journal of Neuroscience, 43 (8). pp. 1016-1033. ISSN 0953816X

El Mouelhi, Mohamed and Roubenoff, Ronenn (2016) Drug Development and Challenges for Neuromuscular Clinical Trials. Journal of Molecular Neuroscience, 58 (3). pp. 374-378. ISSN 1559-1166

Eng , Christina and Wang, Zuncai and Tkach, Diane and Toral-Barzy, Lourdes and Ugwonali, Savuth and Liu, Shanming and Fitzgerald, Stephanie and George, Elizabeth and Frias, Elizabeth and Cochran, Nadire and Dejesus, Rowena and Mcallister, Gregory and Hoffman, Gregory and Bray, Kevin and Lemon, LuAnna and Lucas, Judy and Fantin, Valeria and Abraham, Robert and Murphy, Leon and Nyfeler, Beat (2016) Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. PNAS, 113 (1). pp. 182-187. ISSN 1091-6490

Erpenbeck, Veit and Popov, Todor A and Miller, David and Weinstein, Steven F and Spector, Sheldon and Magnusson, Baldur and Osuntokun, Wande and Goldsmith, Paul and Weiss, Markus and Beier, Jutta (2016) The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma. Pulmonary pharmacology & therapeutics, 39. pp. 54-63. ISSN 1522-9629; 1094-5539

Erpenbeck, Veit and Weiss, Markus and Sandham, David and Neelakantham, Srikanth Raju (2016) Pharmacokinetics, safety, and tolerability of QAW039 (fevipiprant), a novel CRTh2 receptor antagonist: Results from two randomized, phase I, placebo-controlled studies in healthy volunteers. Clinical Pharmacology in Drug Development.

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Fabrice, Andre and Hurvitz, Sara and Fasolo, Angelica and Tseng, Ling-Ming and Jerusalem, Guy and Wilks, Sharon and O'Regan, Ruth and Isaacs, Claudine and Toi, Masakazu and Burris, Howard and He, Wei and Riester, Markus and Taran, Tetiana and Chen, David and Slamon, Dennis (2016) Molecular Alterations and Everolimus Efficacy in HER2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3. JCO, 34 (18). pp. 2115-2124. ISSN 1527-7755

Faulkner, Lee and Gibson, Andrew and Sullivan, Andrew and Tailor, Arun and Usui, Toru and Alfirevic, Ana and Pirmohamed, Munir and Naisbitt, Dean J. and Park, B. Kevin (2016) Detection of primary T cell responses to drugs and chemicals in HLA-typed volunteers: implications for the prediction of drug immunogenicity. Toxicological Sciences, 154 (2). pp. 416-429. ISSN 1096-60801096-0929

Fenaux, Martijn and Lin, Xiaodong and Yokokawa, Fumiaki and Sweeney, Zachary and Saunders, Oliver and Xie, Lili and Lim, Siew Pheng and Uteng, Marianne and Uehara, Kyoko and Warne, Robert and Jones, Christopher and Yendluri, Satya and Gu, Helen and Mansfield, Keith and Boisclair, Julie and Heimbach, Tycho and Catoire, Alexandre and Bracken, Kathryn and Weaver, Margaret and Moser, Heinz and Zhong, Weidong (2016) Antiviral nucleotide incorporation by recombinant human mitochondrial RNA polymerase is predictive of increased in vivo mitochondrial toxicity risk. Antimicrobial Agents and Chemotherapy, 60 (12). pp. 7077-7085. ISSN 1098-6596

Ferreira Antunes, Marcia and Eggimann, Fabian and Kittelmann, Matthias and Luetz, Stephan and Hanlon, Steven Paul and Wirz, Beat and Bachler, Thorsten and Winkler, Margit (2016) Human xanthine oxidase recombinant in E. coli: a whole cell catalyst for preparative drug metabolites synthesis. Journal of Biotechnology. ISSN 01681656

Fischer, Jerome (2016) Rapport du stage de 2eme annee. Rapport du stage de 2eme annee..

Flarakos, Jimmy and Du, Yancy and Bedman, Timothy and Chandra, Priya and Al-Share, Qusai and Jordaan, Pierre and Wang, Lai and Gu, Helen and Mangold, James and Albrecht, Diego and Lin, Tsu-Han (2016) Disposition and metabolism of [14C]LCZ696, an angiotensin receptor neprilysin inhibitor, in healthy volunteers. Xenobiotica.

Forrester, William and Chen, Sheng-hong and Lahav, Galit (2016) Schedule-dependent interaction between anticancer treatments. Science, 351 (6278). pp. 1204-1208. ISSN 1095-9203

Forrester, William and Paek, Andrew L. and Liu, Julia C. and Loewer, Alexander and Lahav, Galit (2016) Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell, 165 (3). pp. 631-642. ISSN 10974172

Fouche, Marianne and Roth, Hans-Joerg and Schaefer, Michael and Berghausen, Joerg and Desrayaud, Sandrine and Blatter, Markus and Piechon, Philippe and Dix, Ina and Martin Garcia, Aimar (2016) Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure. ChemMedChem.

Fouche, Marianne and Schaefer, Michael and Berghausen, Joerg and Desrayaud, Sandrine and Roth, Hans-Joerg (2016) Pharmacokinetic Studies around the Mono- and Difunctionalization of a Bioavailable Cyclic Decapeptide Scaffold. ChemMedChem.

Francotte, Eric (2016) Practical Advances in SFC for the Purification of Pharmaceutical Molecules. LCGC Europe.

Frommlet, Alexandra and Blechschmidt, Anke and Lingel, Andreas and Peng, Chen and Perez, Manuel and Cobas, Carlos and Dominguez, Santiago (2016) An Automated Software Tool for Efficient Processing and Analysis of Ligand-Observed 1H and 19F NMR Binding Data. Journal of Medicinal Chemistry, 59 (7). pp. 3303-3310. ISSN 0022-26231520-4804

Fu, Yunlin and Li, Wenkui and Flarakos, Jimmy and Tse, Francis (2016) LC-MS/MS determination of Pasireotide (SOM230), a cyclic peptide, in monkey plasma. Journal of Chromatography B.

Fu, Yunlin and Xia, Yuan-qing and Flarakos, Jimmy and Tse, Francis and Miller, Jeffrey and Jones, Elliott and Li, Wenkui (2016) Deferential Mobility Spectrometry Coupled with Multiple Ion Monitoring in Regulated LC-MS/MS Bioanalysis of a Therapeutic Cyclic Peptide in Human Plasma. Analytical Chemistry.

Furet, Pascal and Masuya, Keiichi and Kallen, Joerg and Valat, Therese-Marie and Guagnano, Vito and Holzer, Philipp and Mah, Robert and Stutz, Stefan and Vaupel, Andrea and Chene, Patrick and Jeay, Sebastien and Ruetz, Stephan and Schlapbach, Achim (2016) Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument. Bioorganic and Medicinal Chemistry Letters, 26 (19). pp. 4837-4841. ISSN 1464-3405

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Gable, Jonathan and Lee, Gregory and Acker, Timothy and Hulce, Kaitlin and Gonzalez, Eric and Schweigler, Patrick and Melkko, Samu and Farady, Christopher and Craik, Charles (2016) Fragment-based protein-protein interaction antagonists of a viral dimeric protease. ChemMedChem.

Gadola, Stephan (2016) Primary Sjögren's Syndrome_Article for Patients (Lays) in German Language. Primäres Sjögren Syndrom.

Gallagher, Iain and Jacobi, Carsten and Tardif, Nicolas and Fearon, Kenneth (2016) Systems biology and cancer cachexia. Special Issue of SCDB .

Gallou, Fabrice (2016) A Deeper Shade of Green: Inspiring Sustainable Pharmaceutical API Manufacturing via the Green Aspiration Level. Green chemistry, 19. pp. 281-285.

Gallou, Fabrice (2016) EvanPhos. A New Ligand for ppm Level Pd-Catalyzed Suzuki-Miyaura Couplings in Either Organic Solvent or Water. Ang Chem Int Ed, 55 (16). pp. 4914-4918.

Gallou, Fabrice and Lipshutz, Bruce and Handa, Sachin (2016) The Evolution of Solvents in Organic Chemistry. ACS Sus. Chem., 4 (11). pp. 5838-5849.

Gallou, Fabrice and Parmentier, Michael and Lipshutz, Bruce and Gabriel , Christopher (2016) Sustainable and Scalable: Fe/ppm Pd Nanoparticle-catalyzed Nitro Group Reductions… in Water at Room Temperature. Org. Proc. Res. Dev..

Gampe, Christian and Hollis-Symynkywicz, Micah and Zecri, Frederic (2016) Covalent Chemical 5'-Functionalization of RNA with Diazo Reagents. Angewandte Chemie. International edition, 55 (35). pp. 10283-10286. ISSN 14337851

Gan, Lu and Jiang, Xuemin and Mendonza, Anisha and Swan, Therese and Reynolds, Christine and Nguyen, Joanne and Pal, Parasar and Neelakantham, Srikanth Raju and Dahlke, Marion and Langenickel, Thomas Heiko and Rajman, Iris and Akahori, Mizuki and Sunkara, Gangadhar (2016) Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects. Clinical Pharmacology in Drug Development, 5 (1). pp. 27-39. ISSN 2160-7648

Gan, Lu and Jiang, Xuemin and Mendonza, Anisha and Swan, Therese and Reynolds, Christine and Nguyen, Joanne and Pal, Parasar and Neelakantham, Srikanth Raju and Dahlke, Marion and Langenickel, Thomas Heiko and Rajman, Iris and Akahori, Mizuki and Zhou, Wei and Rebello, Sam and Sunkara, Gangadhar (2016) Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects. Clinical Pharmacology in Drug Development, 5 (1). pp. 27-39. ISSN 2160-7648

Gan, Lu and Langenickel, Thomas Heiko and Petruck, Jesika and Kode, Kiran Kumar and Rajman, Iris and Chandra, Priyamvada and Zhou, Wei and Rebello, Sam and Sunkara, Gangadhar (2016) Effects of age and gender on the pharmacokinetics of LCZ696, an angiotensin receptor neprilysin inhibitor. Journal of Clinical Pharmacology , 56 (1). pp. 78-86. ISSN 00912700

Gao, Jinhai and Wang, Bing and Rajan, Srinivasan (2016) In-tube Derivatization for the Determination of Absolute Configuration and Enantiomeric Purity of Chiral Compounds by NMR Spectroscopy. Magn Reson Chem.

Gao, Xinliu and Lin, Hui and Krantz, Carsten and Garnier, Arlette and Flarakos, Jimmy and Tse, Francis and Li, Wenkui (2016) Quantitative analysis of factor P (Properdin) in monkey serum using immunoaffinity capturing in combination with LC-MS/MS. Bioanalysis.

Garcia Fortanet, Jorge and Chen, Christine and Chen, Zhuoliang and Deng, Zhan and Firestone, Brant and Fekkes, Peter and Fodor, Michelle and Fortin, Pascal and Fridrich, Cary and Grunenfelder, Denise and Ho, Samuel and Kang, Zhao Bin and Karki, Rajesh and Kato, Mitsunori and Keen, Nicholas and Larrow, Jay and Lenoir, Francois and Liu, Gang and Liu, Shumei and Lombardo, Franco and Majumdar, Dyuti and Meyer, Matthew and Palermo, Mark and Perez, Lawrence and Pu, Minying and Ramsey, Timothy and Shultz, Michael and Stams, Travis and Towler, Christopher and Wang, Ping and Williams, Sarah and Zhang, Ji and Lamarche, Matthew and Sellers, William (2016) Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Gauvreau, Gail M and Arm, Jonathan P and Boulet, Louis-Philippe and Leigh, Richard and Cockcroft, Donald W and Davis, Beth E and Mayers, Irvin and FitzGerald, J Mark and Dahlen, Barbro and Killian, Kieran J and Laviolette, Michel and Carlsten, Christopher and Lazarinis, Nikolaos and Watson, Richard M and Milot, Joanne and Swystun, Veronica and Bowen, Miranda and Hui, Linda and Lantz, Ann-Sofie and Meiser, Karin and Maahs, Suzanne and Lowe, Philip J and Skerjanec, Andrej and Drollmann, Anton and O'Byrne, Paul M (2016) Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. The Journal of allergy and clinical immunology, in pre (in pre). 00-00. ISSN 1097-6825

Gedeck, Peter and Lu, Yipin and Skolnik, Suzanne and Rodde, Stephane and Dollinger, Gavin and Jia, Weiping and Berellini, Giuliano and Vianello, Riccardo and Faller, Bernard and Lombardo, Franco (2016) The benefit of retraining pKa models studied using internally measured data. Journal of Chemical Information and Modeling.

Gentile, Antonietta and Musella, Alessandra and Bullitta, Silvia and Fresegna, Diego and De Vito, Francesca and Piras, Eleanora and Gargano, Francesca and Borsellino, Giovanna and Battistini, Luca and Schubart Wellensiek, Anna and Mandolesi, Georgia and Centonze, Diego (2016) EFFECTS OF SIPONIMOD (BAF312) ON SYNAPTIC NEURODEGENERATIVE DAMAGE IN EXPERIMENTAL MULTIPLE SCLEROSIS. J Neuroinflammation, 13 (1). p. 207. ISSN 1742-2094

Ghode, Pramila Baban and Ramachandran, Sarath and Bifani, Juan Pablo and Sivaraman, Jayaraman (2016) Structure and mapping of spontaneous mutational sites of PyrR from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications, 471 (4). pp. 409-415. ISSN 1090-2104

Glatthar, Ralf and Stojanovic, Aleksandar and Troxler, Thomas J. and Mattes, Henri and Moebitz, Henrik and Beerli, Rene and Blanz, Joachim and Gassmann, Ernst and Drueckes, Peter and Fendrich, Gabriele and Gutmann, Sascha and Martiny-Baron, Georg and Spence, Fiona and Peel, John Edmondson and Sparrer, Helmut (2016) Discovery of imidazoquinolines as a novel class of potent, selective and in vivo efficacious COT kinase inhibitors. Journal of Medicinal Chemistry, 59 (16). pp. 7544-7560. ISSN 0022-2623

Glowienke, Susanne (2016) Aromatic amine data sharing for 2015. Aromatic amine data sharing, Not ap (Not ap). NA-NA. ISSN Not applicable

Glowienke, Susanne (2016) Assessing safety of extractables from materials and leachables in pharmaceuticals and biologics – current challenges and approaches. Regul Tox Pharm, 81 (?). pp. 201-211. ISSN not available

Glowienke, Susanne (2016) Intermediates mutagenicity data sharing for 2017. Intermediates data sharing.

Glowienke, Susanne (2016) "Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses". Regulatory Toxicology and Pharmacology .

Glowienke, Susanne (2016) Toxicological assessment report on excipients in xxx (formulation) for use in pediatric patients (age groups). Regulatory toxicology and pharmacology.

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Steffek, Micah (2016) Evaluation of PPAT Phosphopantetheine Site Inhibitors and Identification of Small Molecule Binders at the PPAT ATP site. Johns Hopkins Independent Research Proposal.

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Strobelt, Hendrik and Alsallakh, Bilal and Botros, Joseph and Peterson, Brant and Borowsky, Mark and Lex, Alexander and Pfister, Hanspeter (2016) Vials: Visualizing Alternative Splicing of Genes. IEEE transactions on visualization and computer graphics, 22 (1). pp. 399-408. ISSN 1941-0506

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Sugiyama, Ikuo and Murayama, Norie and Kuroki, Ayaka and Kota, Jagannath and Iwano, Shunsuke and Yamazaki, Hiroshi and Hirota, Takashi (2016) Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells. Xenobiotica, 46 (9). pp. 765-774. ISSN 1366-5928

Sun, Haiying and Machineni, Surendra Kumar and Ting, Lillian and Praestgaard, Jens and Kuemmell, Andreas and Stein, Daniel and Sunkara, Gangadhar and Kovacs, Steven and Villano, Stephen and Tanaka, Ken (2016) A Randomized, Open-label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects. Antimicrobial Agents and Chemotherapy, Online (Online). pp. 1-22. ISSN 1098-6596

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Surya , Ayalasomayajula and Schuehly, Uwe and Langenickel, Thomas Heiko and Pal, Parasar and Chen, Fabian and Chen, Zhen and Zhou, Wei and Sunkara, Gangadhar (2016) Effect of renal function on the pharmacokinetics of LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor. European Journal of Clinical Pharmacology, 72 (9). pp. 1065-1073. ISSN 1432-1041

Sutton, James and Mitra, Partha and Yang, Ren-Ming and Ramsay, Robert G. and Gonda, Thomas J (2016) CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression. Oncotarget, 7 (8). pp. 9069-9083. ISSN 1949-2553

Swann, Justine and plouffe, David and Winzeler, Elizabeth and Meister, Stephan (2016) A high-­‐throughput luciferase-­‐based assay for the discovery of therapeutics that prevent malaria. ACS Infectious Diseases.

Swart, Pieter Jacob and Lozac'H, Frederic and Faller, Thomas and Van De Kerkhof, Esther and Krauser, Joel and Natt, Francois and Hunziker, Juerg and Catoire, Alexandre and Garnier, Maxime and litherland, karine and christensen, Jesper (2016) ADME studies of [5-3H]-2′-O-methyluridine nucleoside in mice: A building block in siRNA therapeutics. Pharmacology Research and Perspectives, 4 (1). ISSN 2052-1707

Sykes, David and Bradley, Michelle and Reilly, John and Bauer, Carsten and Watson, Simon and Sandham, David and Dubois, Gerald and Charlton, Steven (2016) Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology, 89 (5). pp. 593-605. ISSN 1521-0111

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Tang, Hai-Ming and Ju, Haisong and Zhao, Shufang and Laduke, Carrie and Hahn, Suzette and Glick, Jim and Carey, Cynthia and Friedrichs, Gregory (2016) Translational assessment of cardiac contractility by echocardiography in the telemetered rat. Journal of Pharmacological Toxicololgical Methods, 77. pp. 24-32. ISSN 1056-8719

Tarselli, Mike (2016) NEXT CRO quick-reference guide. NEXT, NA (NA). pp. 1-6. ISSN NA

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Thomas, Jason and Harrington, Edmund and Murphy, Jason and Jain, Rishi and Schirle, Markus and Gower, Carrie and Chang, Matthew and Maly, Dustin (2016) GENERATION OF BIVALENT KINASE INHIBITORS STARTING FROM A SINGLE POLYPHARMACOLOGICAL COMPONENT FOR SELECTIVE TARGET MODULATION IN VIVO. ACS Chemical Biology.

Thomson, JP and Ottaviano, R and Unterberger, E and Lempiainen, H and Mueller, Arne and Terranova, Remi and Illingworth, RS and Webb, S and Kerr, AR and Drake, A and Lyall, M and Wolf, CR and Moggs, Jonathan and Schwarz, M and Meehan, R (2016) Loss of Tet1 associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer. Cancer Research.

Tian, Hua and Maciazek, Dawid and Postawa, Zbigniew and Garrison, Barbara and Winograd, Nicholas (2016) CO2-Cluster SIMS. Journal of American Society of Mass Spectrometry, 27 (9). pp. 1476-1482. ISSN 1879-1123

Tian, Hua and Wucher, Andrea and Winograd, Nicholas (2016) Reducing the matrix effect in organic cluster SIMS using dynamic reactive ionization. Journal of the American Society for Mass Spectrometry, 27 (2). pp. 2014-2024. ISSN 1879-1123

Tomic, Ivana and Vidis Millward, Ana and Mueller-Zsigmondy, Martin and Cardot, Jean-Michel (2016) Setting accelerated dissolution test for PLGA microspheres containing peptide, investigation of critical parameters affecting drug release rate and mechanism. International journal of pharmaceutics, 505 (1-2). pp. 42-51. ISSN 1873-3476

Torene, Rebecca and Nirmala, Nanguneri and Obici, Laura and Meini, Antonella and Tormey, Vincent and Caorsi, R. and Starck-Schwertz, Sandrine and Letzkus, Martin and Hartmann, Nicole and Abrams, Ken and Lachmann, Helen and Gattorno, Marco (2016) Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome. Annals of the Rheumatic Diseases, 29. ISSN 1468-2060

Toris, Carol and McLaughlin, Marsha and Dworak, Douglas and Fan, Shan and Havens, Shane and Zhan, Guilin and Horan, Nicholas and Prasanna, Ganesh (2016) Effects of rho kinase inhibitors on intraocular pressure and aqueous humor dynamics in nonhuman primates and rabbits. Journal of Ocular Pharmacology and Therapeutics, 32 (6). pp. 355-364. ISSN 1557-7732

Townsend, Elizabeth and Cooke, Vesselina and Firestone, Brant and Gao, Hui and Lees, Emma and Weinstock, David (2016) The Public Repository of Xenografts (ProXe) enables discovery and randomized phase II-like trials in mice. molecular cell.

Trendelenburg, Anne-Ulrike (2016) Frailty in mouse ageing: A conceptual approach. Mechanisms of Ageing and Development, 160. pp. 34-40. ISSN 18726216

Trenkwalder, Claudia and Berg, Daniela and Eggert, Karla and Oehlwein, Christian and Ceballos-Baumann, Andres and Feigin, Andrew and Coorvol, Jean Christophe and Rascol, Olivier and Stocchi, Fabrizio and Linazasoro, Gurutz and Di Paolo, Thérèse and Maruff, Paul and Feuerbach, Dominik and Sovago, Judit and Weiss, Markus and Rozenberg, Izabela and Johns, Donald and Gomez-Mancilla, Baltazar (2016) A multi-centre, randomized, double-blind, placebo-controlled, parallel-group, multiple oral dose study to assess the efficacy, safety and tolerability of AQW051 in Parkinson’s patients with L-dopa induced dyskinesias. Movement Disorders.

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Umehara, Ken-Ichi and Zollinger, Markus and Kigondu, Elizabeth and Witschi, Marc and Juif, Claire and Huth, Felix and Schiller, Hilmar and Chibale, Kelly and Camenisch, Gian P. (2016) Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors. Xenobiotica. pp. 1-6. ISSN 0049-82541366-5928

Urban, Laszlo and Nagy, Istvan and Varga, Angelika and Selvarajah, Srikumaran and Jenes, Agnes and Kulik, Akos and Brain, Susan and Baker, David and Valente, Joao and White, John and Mackie, Kenneth and Chen, Jie (2016) CAPSAICIN- AND ANANDAMIDE-SENSITIVITY OF PRIMARY SENSORY NEURONS IS CONTROLLED BY VARIOUS COMPONENTS OF CROSSTALK BETWEEN THE CANNABINOID TYPE 1 AND THE CAPSAICIN RECEPTORS. Scientific reports, 6 (33307). pp. 1-18. ISSN 2045-2322

Uteng, Marianne and Mahl, Joerg Andreas and Beckmann, Nicolau and Piaia, Alessandro and Ledieu, David and Dubost, Valerie and Tritto, Elaine and Wolf, Armin and Moulin, Pierre and Li, Li and Chibout, Salah-Dine and Pognan, Francois (2016) Comparative renal safety assessment of the hepatitis B drugs, adefovir, tenofovir, telbivudine and entecavir in rats. Comparative renal safety assessment of the hepatitis B drugs, adefovir, tenofovir, telbivudine and entecavir in rats, 155 (1). pp. 283-297.

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Vaidya, Soniya and Khindri, Sanjeev and Calder, Nicole and Hara, Hisanori and Majumdar, Tapan and Salvatore, Febbraro and Rainard , Fuhr and Woessner, Ralph (2016) Pharmacokinetics of indacaterol acetate and mometasone furoate delivered alone or in a free or fixed dose combination in healthy volunteers. Pulmonary Pharmacology and Therapeutics, 37. pp. 30-36. ISSN 10945539

Vaidya, Soniya and Khindri, Sanjeev and Maahs, Suzanne and Machineni, Surendra Kumar and Hara, Hisanori and Juan, Axel and Kaiser, Guenther (2016) Lung Delivery of Indacaterol and Mometasone Furoate Following Inhalation of QMF149 via the Twisthaler® Device in Healthy Volunteers. Clinical Pharmacology in Drug Development. ISSN 2160763X

Van, Linh and Floch, David and Jiang, Xuemin and Klein, Ulf and Abrams, Ken and Sunkara, Gangadhar (2016) Pharmacokinetic and Pharmacodynamics of Canakinumab in Patients with Systemic Juvenile Idiopathic Arthritis. The Journal of Clinical Pharmacology, Online (0(0)). pp. 1-12. ISSN 10.1002/jcph:754

Van Eldik, LJ and Carrillo, M and Cole, PE and Feuerbach, Dominik and Greenberg, BD and Hendrix, J and Kennedy, M and Kozauer, N and Mueller, R and Ransohoff, R and Wilcock, DM and Bain, L and Bales, K (2016) The Roles of Inflammation and Immune Mechanisms in Alzheimer's Disease. Alzheimers Dementia, 2 (2). pp. 99-100. ISSN http://dx.doi.org/10.1016/j.trci.2016.05.001

Vicini, P and Fields, O and Lai, E and Litwack, E D and Martin, A-M and Morgan, T M and Pacanowski, M A and Papaluca, M and Perez, O D and Ringel, M S and Robson, M and Sakul, H and Vockley, J and Zaks, T and Dolsten, M and Søgaard, M (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical pharmacology and therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Vicini, Paolo and Fields, Owen and Lai, Eric and Litwack, David and Martin, Anne-Marie and Morgan, Thomas and Pacanowski, Michael and Papaluca, Marisa and Perez, Omar and Ringel, Michael and Robson, Matthew and Sakul, Hakan and Vockley, Joseph and Zaks, Tal and Sogaard, Morten (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical Pharmacology and Therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Vicini, Paolo and Fields, Owen and Lai, Eric and Litwack, David and Martin, Anne-Marie and Morgan, Thomas and Pacanowski, Michael and Papaluca, Marisa and Perez, Omar and Ringel, Michael and Robson, Matthew and Sakul, Hakan and Vockley, Joseph and Zaks, Tal and Sogaard, Morten (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical Pharmacology and Therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Voegtle, Markus and Leforestier, Baptiste (2016) Safe Generation and Direct Use of Chlorine Azide in Flow Chemistry – 1,2‐Azidochlorination of Olefins and Access to Triazoles. Synlett, 27 (-). pp. 1957-1962. ISSN 0936-5214

Vrieseling Pecho, Eline (2016) Hunting cellular mechanisms underlying the spreading of misfolded protein pathology in the brain. Neuropathology and Applied Neurobiology, 42 (2). pp. 135-136. ISSN 1365-2990

Vuichoud, Basile and Bornet, Aurélien and de Nanteuil, Florian and Milani, Jonas and Canet, Estel and Ji, Xiao and Mieville, Pascal and Weber, Emmanuelle and Kurzbach, Dennis and Flamm, Andrea and Konrat, Robert and Gossert, Alvar and Jannin, Sami and Bodenhausen, Geoffrey (2016) Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins. Chemistry - a European journal, 22 (41). pp. 14696-14700. ISSN 09476539

van Overbeek, Megan and Capurso, Daniel and Carter, Mathew M. and Thompson, Mathew S. and Frias, Elizabeth and Reece-Hoyes, John and Nye, Christopher and Gradia, Scott and Vidal, Bastien and Zheng, Jiashun and Hoffman, Gregory and Fuller, Christopher K. and May, Andrew P. (2016) DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks. Molecular Cell, 63 (4). pp. 633-646. ISSN 1097-4164

van Overbeek, Megan and Capurso, Daniel and Carter, Matthew and Thompson, Matthew M. and Frias, Elizabeth and Russ, Carsten and Reece-Hoyes, John and Nye, Christopher and Gradia, Scott and Vidal, Bastien and Zheng, Jiashun and Hoffman, Gregory and Fuller, Christopher K. and May, Andrew P. (2016) DNA repair outcomes at Cas9-mediated double-strand breaks are non-random and sequence-dependent. Science.

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Walker, Dana and Ramiah, Shashi (2016) Veterinary Pathologists in Translational Pharmacology and Biomarker Integration in Drug Discovery and Development. Toxicologic Pathology.

Walles, Markus and Rudolph, Bettina and Peraus, Gisela and Wolf, Thierry and Bourgailh, Julien and Suetterlin, Martina and Moenius, Thomas and Heudi, Olivier and Elbast, Walid and Lanshoeft, Christian and Bilic, Sanela (2016) New Insights in Tissue Distribution, Metabolism and Excretion of [3H]-labeled Antibody Maytansoid Conjugates in Female Tumor Bearing Nude Rats. Drug Metabolism and Disposition.

Wang, Hui and Lu, Bo and Castillo, Johnny and Yang, Zinger and Mcallister, Gregory and Reece-Hoyes, John and Tallarico, John and Russ, Carsten and Hoffman, Gregory and Schirle, Markus and Cong, Feng (2016) Tankyrase inhibitor sensitizes lung cancer cells to endothelial growth factor receptor (EGFR) inhibition via stabilizing angiomotins and inhibiting yap signaling. Journal of Biological Chemistry, 291 (29). pp. 15256-15266. ISSN 1083-351X

Wang, Yuan and Cornett, Allen and King, Frederick and Mao, Yi and Nigsch, Florian and Paris, Greg and Mcallister, Gregory and Jenkins, Jeremy (2016) Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery. Cell Chemical Biology, 23 (7). pp. 862-874. ISSN 24519456

Wassermann, Anne and Borowsky, Mark and Partl, Christian and Lex, Alexander and Streit, Marc and Pfister, Hanspeter and Schmalstieg, Dieter (2016) Caleydo Entourage: analyzing experimental data across multiple pathways. IEEE Trans Vis Comput Graph. , 19 (12). pp. 2536-2545. ISSN 1077-2626

Weaver, Margaret and Blak Grossi, Anette and Parish, Joanna and Schützsack, Jorgen and Løgsted, Jeanet and Brück Bøgh, Ingrid and Cameron, David and Harvey, Warren and Festag, Matthias and Downes, Noel and Venturella, Silvana and Schlichtiger, Julia and Mhedhbi, Sofiene and Ross, Vanessa and Kissner, Thomas and Stark, Claudia and Milano, Stephane and Heining, Peter and Sanchez-Felix, Manuel (2016) Vehicle Systems and Excipients Used in Minipig Drug Development Studies. Toxicologic Pathology, 44 (3). pp. 367-372. ISSN 1533-1601

Weaver, Margaret and Grossi, AB and Schuetzsack, J and Parish , J and Loegsted, J and Boegh, IB and Cameron , D and Harvey, W and Festag, M and Downes, N and Venturella, S and Schlichtiger, J and Heining, Peter and Sanchez-Felix, Manuel (2016) Vehicle Systems and Excipients Used in Minipig Drug Development Studies. Toxicology Pathology.

Webster, Carl I. and Bryson, Christine J. and Cloake, Edward A. and Jones, Tim D. and Austin, Mark J. and Karle, Anette and Spindeldreher, Sebastian and Lowe, David C. and Baker, Matthew P. (2016) A comparison of the ability of the human IgG1 allotypes Gm1(3) and Gm1(1,17) to stimulate T-cells responses from allotype matched and mismatched donors. mAbs.

Weehuizen, T and Lankelma, J and de Jong, K and de Boer, O and Roelofs, J and Day, N and Gram, Hermann and de vos, j and Wiersinga, J (2016) THERAPEUTIC ADMINISTRATION OF A MONOCLONAL ANTI-IL-1Β ANTIBODY PROTECTS AGAINST EXPERIMENTAL MELIOIDOSIS. Shock : molecular, cellular, and systemic pathobiological aspects and therapeutic approaches : the official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies., 46. pp. 566-574. ISSN 1540-0514

Wehmeyer, Corinna and Frank, Svetlana and Beckmann, Denise and Böttcher, Martin and Cromme, Christoph and König, Ulrich and Fennen, Michelle and Held, Annelena and Paruzel, Peter and Hartmann, Christine and Stratis, Athanasios and Korb-Pap, Adelheid and Kramer, Ina and van den Berg, Wim and Kamradt, Thomas and Kneissel, Michaela and Pap, Thomas and Dankbar, Berno (2016) Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Science translational medicine. ISSN 1946-6242; 1946-6234

Weiskopf, Kipp and Anderson, Katie and Ito, Daisuke and Schnorr, Peter and Tomiyasu, Hirotaka and Ring, Aaron and Bloink, Kristin and Efe, Jem and Rue, Sarah and Lowery, David and Barkal, Amira and Prohaska, Susan and McKenna, Kelly and Cornax, Ingrid and O'Brien, Timothy and O'Sullivan, Gerard and Weissman, Irving and Modiano, Jaime (2016) Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20. Cancer immunology research, 4 (12). pp. 1072-1087. ISSN 2326-6074; 2326-6066

Wetzel, Kristie and Capodieci, Paola (2016) Dual ISH-IHC. Publication on website acdbio.com/dual-ISH-IHC.

Wharton Jr, Keith and Quigley, Catherine and Themeles, Marian and Dunstan, Robert W. and Doyle, Kathryn and Cahir-McFarland, Ellen and Wei, Jing and Buko, Alex and Reid, Carl E. and Sun, Chao and Carmillo, Paul and Sur, Gargi and Carulli, John P. and Mansfield, Keith and Westmoreland, Susan V. and Staugaitis, Susan M. and Fox, Robert J. and Meier, Werner and Goelz, Susan (2016) JC polyomavirus abundance and distribution in progressive multifocal leukoencephalopathy brain tissue implicates myelin sheath in intracerebral dissemination of infection. PLoS One.

Whibley, Natasha and Tritto, Elaine and Traggiai, Elisabetta and Kolbinger, Frank and Moulin, Pierre and Brees, Dominique and Coleman, Bianca M. and Mamo, Anna J. and Garg, Abhishek V. and Jaycox, Jillian R. and Siebenlist, Ulrich and Kammueller, Michael and Gaffen, Sarah L. (2016) IL-17A is the dominant IL-17-family cytokine required for immunity to acute murine oral mucosal candidiasis. Journal of Leukocyte Biology, 99 (?). ?.

White, John, P.M and Cibelli , Mario and Urban, Laszlo and Nilius, Bernd and McGeown, Graham and Nagy, Istvan (2016) TRPV4: MOLECULAR CONDUCTOR OF A DIVERSE ORCHESTRA. Physiological reviews, 96 (96). pp. 911-973. ISSN 1522-1210; 0031-9333

White, Nicholas and Thanh, Duong Tran and Uthaisin, Chirapong and Nosten, Francois and Phyo, Aung Pyae and Pukrittayakamee, Sasithon and Jittamala, Podjanee and Chuthasmit, Kittiphum and Cheung, Nicole and Feng, Elie and Li, Ruobing and Magnusson, Baldur and Sultan, Marc and Wieser, Daniela and Xun, Xiaolei and Zhao, Rong and Diagana, Thierry Tidiane and Pertel, Peter and Leong, Franz Joel Wen (2016) The novel imidazolopiperazine KAF156 clears parasitemia rapidly in falciparum and vivax malaria. New England journal of medicine : NEJM., 375 (12). pp. 1152-1160. ISSN 0028-4793

Whitebread, Steven and Dumotier, Berengere and Armstrong, Duncan and Fekete, Alexander and Chen, Shanni and Hartmann, Andreas and Mueller, Patrick and Urban, Laszlo (2016) Secondary Pharmacology: Screening and Interpretation of Off-target Activities – Focus on translation. Drug Discovery Today. ISSN 13596446

Wilcken, Rainer and Srinivas, Honnappa (2016) Mutational analysis of SGPL1: In silico modelling (The analysis results will be shared with Prof. Friedhelm Hildebrandt, Harvard medical school, Division of Nephrology Boston Children's Hospital). These results ( were approved in OAK before), that were shared with Prof. Friedhelm Hildebrandt is now a part of full manuscript for publication with Prof. Friedhelm Hildebrandt as corresponding author . Honnappa Srinivas and Rainer Wilken are the co-authors from NIBR. Please find attached the full manuscript. SGPL1 mutations cause nephrosis with ichthyosis and adrenal insufficiency.

Willadt, Silvia and Nash, Mark and Slater, Clarke (2016) Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragm. Scientific reports, 6. ISSN 2045-2322

Willard, Elizabeth and Sykes, David and Dubois, Gerald and Bradley, Michelle and Riddy, Darren and Sandham, David and Watson, Simon and Bauer, Carsten and Charlton, Steven (2016) Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology, 89 (5). pp. 593-605. ISSN 15210111

Winkler, Gian Christian and Lovsin Barle, Ester and Mirwald, Jens (2016) Tiered Banding Concept for Pharmaceutical Intermediates. Chimica oggi; chemistry today, 34 (4). pp. 32-36. ISSN ISSN 0392-839X, EISSN 1973-8250

Witek, Jagna and Keller, Bettina G. and Blatter, Markus and Meissner, Axel and Wagner, Beatrix and Riniker, Sereina (2016) Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States. Journal of Chemical Information & Modeling, 56 (8). pp. 1547-1562. ISSN 1549-960X

X

Xiuning, Le and Rajee, Anthony and Pedram, Razavi and Daniel J, Treacy and Flora, Luo and Mahmoud, Ghandi and Jose, Baselga and Levi A, Garraway (2016) Systematic functional characterization of resistance to PI3K inhibition in breast cancer. Cancer discovery, 6 (10). pp. 1134-1147. ISSN 2159-8290; 2159-8274

Xu, Jing and Li, Li and Xiong, Jie and Dekker, Aaron den and Ye, Andrew and Karatas , Hacer and Liu, Liu and Wang, He and Qin, Zhaohui S. and Wang, Shaomeng and Dou, Yali (2016) MLL1 and MLL1 fusion proteins play distinct roles in regulating leukemic transcription program. Cell discovery.

Y

Yang, Yang (2016) Expedient Synthesis of 4-Aryl Quinazoline Analogues via Direct Nucleophilic Arylation of 2-Chloroquinazoline. Synthesis, 48 (14). pp. 2255-2262. ISSN 0039-7881

Yokokawa, Fumiaki and Noble, Christian Guy and Lim, Siew Pheng and Rao, Ranga Rao K.R. and Tania, Stefani and Wang, Gang and Lee, Gladys and Hunziker, Juerg and Karuna, Ratnaningrum and Manjunatha, Ujjini Havaldar and Nilar, Shahul and Shi, Pei-Yong and Smith, Paul (2016) Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase From a Fragment Hit Using Structure-Based Drug Design. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Yu, Vionnie and Scadden, David (2016) Heterogeneity of the bone marrow niche. Current Opinion in Hematology, 23 (4). pp. 331-338. ISSN 2016 Jul;23(4):331-8

Yu, Yanyan and chen , Jiajia and Gao, Jun and Liao, Rijing and Oyang, Counde and Li, En and Jin, Hong and Yang, Pengyuan and Zhou, Shaolian and Yi, Wei (2016) A methodology paper for histone variant peptide quantitation. Quantitative Profiling of Combinational K27/K36 Modifications on Histone H3 Variants in Mouse Organs..

Z

Zeeman, Anne-Marie and Lakshminarayana, Suresh Bangalore and van der Werff, Nicole and Klooster, Els and Kondreddi, Ravinder Reddy and Bodenreider, Christophe and Simon, Oliver and Sauerwein, Robert and Yeung, Bryan King Sing and Diagana, Thierry Tidiane and Kocken, Clemens (2016) PI4K is a prophylactic, but not radical curative target in Plasmodium vivax-type malaria parasites. Antimicrobial Agents and Chemotherapy (AAC) .

Zhai, Yufeng and Chen, Kaisheng and Zhong, Yang and Zhou, Bin and Ainscow, Edward and Wu, Ying-Ta and Zhou, Yingyao (2016) An Automatic Quality Control Pipeline for High-throughput Screening Hit Identification. Journal of Molecular Screening, 21 (8). pp. 832-841. ISSN 10870571

Zhang, Jin and Heimbach, Tycho and Barve, Avantika and Li, Wenkui and He, Handan (2016) Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies with PBPK Modeling. Journal of Pharmaceutical Sciences, 105 (4). pp. 1398-1404. ISSN 1520-6017

Zhu, Andrew and Chen, David and He, Wei and Kanai, Masayuki and Voi, Maurizio and Chen, Li-Tzong and Daniele, Bruno and Vogel, Arndt and Chiang, Derek (2016) Integrative Biomarker Analyses Indicate Etiological Variations in c-Met and Tsc2 Alterations in Hepatocellular Carcinoma. Journal of Hepatology, 65 (2). pp. 296-304. ISSN 1600-0641

Zhu, Kaichuan and Xiang, Xianyuan and Dorostkar, Mario and Filser, Severin and Crux, Sophie and Marinkovic, Petar and Neumann, Ulf and Shimshek, Derya and Rammes, Gerhard and Haass, Christian and Lichtenthaler, Stefan and Herms, Jochen (2016) Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biological Psychiatry. ISSN 18732402

Zielman, Ronald and Postma, Rudmer and Verhoeven, Aswin and Bakels, Floor and van Oosterhout, Willebrordus P J and Meissner, Axel and van den Maagdenberg, Arn M J M and Terwindt, Gisela M and Mayboroda, Oleg A and Ferrari, Michel D (2016) Metabolomic changes in CSF of migraine patients measured with (1)H-NMR spectroscopy. Molecular bioSystems, 12 (12). pp. 3674-3682. ISSN 1742-2051

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