A

Abend, Johanna, Sathe, Atul, Changala, Marguerite, Casey, Fergal, Kistler, Amy, Chandran, Sindhu, Howard, Abigail and Wojciechowski, David (2016) Correlation of BK Virus Neutralizing Serostatus with the Incidence of BK Viremia in Kidney Transplant Recipients. Transplantation. p. 1. ISSN 0041-1337

Abramowski, Dorothee and Staufenbiel, Matthias (2016) Co-expression of truncated and full-length tau induces severe neurotoxicity. Mol Psychiatry. ISSN 1359-4184

Accart Gris, Nathalie, Dawson King, Janet, Kramer, Ina, Kolbinger, Frank and Beckmann, Nicolau (2016) NON-INVASIVE IMAGING DEMONSTRATES CLINICAL FEATURES OF THE PATHOLOGY IN A RAT ADJUVANT MODEL FOR ANKYLOSING SPONDYLITIS. European journal of histochemistry : EJH., 60 (4). p. 2667. ISSN 2038-8306

Achichi, Manel, Chetham, Michelle, Dragisic, Zlatan, Euzenat, Jerome, Faria, Daniel, Ferrara, Alfio, Flouris, Giorgios, Fundulaki, Irini, Harrow, Ian, Ivanova, Valentina, Jimenez-Ruiz, Ernesto, Kuss, Elena, Lambrix, Patrick, Leopold, Henrik, Meilicke, Christian, Montanelli, Stefano, Pesquita, Catia and Saveta, Tzanina (2016) Results of the Ontology Alignment Evaluation Initiative 2016. CEUR Proceedings, 1766. pp. 73-129. ISSN 1613-0073

Agarinis, Claudia, Orsini, Vanessa, Megel, Philippe, Abraham, Yann, Yang, Haidi, Mickanin, Craig, Bouwmeester, Antonius, Tchorz, Jan and Parker, Christian (2016) Activation of Yap Directed Transcription by Knock-down of Conserved Cellular Functions. Journal of Biomolecular Screening.

Agarinis, Claudia, Orsini, Vanessa, Megel, Philippe, Abraham, Yann, Yang, Haidi, Mickanin, Craig, Myer, Vic, Bouwmeester, Antonius, Tchorz, Jan and Parker, Christian (2016) Activation of Yap Directed Transcription by Knock-down of Conserved Cellular Functions. Journal of Biomolecular Screening.

Akahane, Koshi, Sanda, Takaomi, Mansour, Marc R., Radimerski, Thomas, Weinstock, David M., Letai, Anthony and Look, Thomas (2016) HSP90 Inhibition Leads to Degradation of the TYK2 Kinase and Apoptotic Cell Death in T-Cell Acute Lymphoblastic Leukemia. Leukemia, 30 (1). pp. 219-228. ISSN 1476-5551; 0887-6924

Akahori, Mizuki, Ayalasomayajula, Surya, Langenickel, Thomas Heiko, Pal, Parasar and Sunkara, Gangadhar (2016) Pharmacokinetics after single ascending dose, food effect, and safety of sacubitril/valsartan (LCZ696), a novel angiotensin receptor and neprilysin inhibitor, in healthy Japanese subjects. European Journal of Drug Metabolism and Pharmacokinetics, Epub a (NA). NA-NA. ISSN 2107-0180

Alper, Phillip and Ratnikov, Max (2016) GNF portion of an NSF GOALI grant proposal on flow photochemistry to be submitted with Professor Gary Molander from U Penn. NSF Review Committee, None (None). pp. 1-85. ISSN None

Althof, Erwin and Nijholt, Ralf (2016) Novartis & SiLA—Partners in Simplifying Lab Automation Implementations. Novartis & SiLA—Partners in Simplifying Lab Automation Implementations.

Altmann, Eva, Schlierf, Anita, Jefferson, AB, Renatus, Martin, Jones, Matthew, Hassiepen, Ulrich, Assenberg, Rene, Schaefer, Michael, Quancard, Jean, Kiffe, Michael, Weiss, Andreas, Wiesmann, Christian, Sedrani, Richard, Eder, Joerg and Martoglio, Bruno (2016) A first-in-class small molecule inhibitor of the COP9 signalosome subunit 5 for the treatment of cancer. Nature communications, 7. pp. 13166-13175. ISSN 2041-1723

Amaral, Adam, Saran, Chitra, Amin, Jakal and Hatsis, Panagiotis (2016) A Comparison of LC-MS/MS and a Fully Integrated Autosampler/Solid Phase Extraction System for the Analysis of Protein Binding Samples. Journal of Biomolecular Screening. ISSN 1552-454X

Anders, Gerd, Hassiepen, Ulrich, Theisgen, Stephan, Heymann, Stephan, Muller, Lionel, Panigada, Tania, Huster, Daniel and Samsonov, Sergey (2016) The Intrinsic Pepsin Resistance of Interleukin-8 Can be Explained from a Combined Bioinformatical and Experimental Approach. IEEE TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, PP (99). p. 1. ISSN 1545-5963

Andersen, ND, Nielsen, BE, Corradi, J, Tolosa, MF, Feuerbach, Dominik, Arias, HR and Bouzat, C (2016) Exploring the Positive Allosteric Modulation of Human α7 Nicotinic Receptors from a Single-Channel Perspective. Neuropharmacology.

Arenas-Amirez, Natalia, Zou, Chao, Popp, Simone, Zingg, Daniel, Brannetti, Barbara, Wirth, Emmanuelle, Calzascia, Thomas, Kovarik, Jiri, Sommer , Lukas, Zenke, Gerhard, Woytschak, Janine, Regnier, Catherine, Katopodis, Andreas and Boyman, Onur (2016) Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2. Science Translational Medicine, 8 (367). ISSN 1946-62341946-6242

Argikar, Upendra, Bushee, Jennifer and Dunne, Christine (2016) An in vitro approach to investigate ocular metabolism: Part I - Levobunolol. Drug metabolism and disposition, 44 (8). pp. 1304-1312. ISSN 1521-009X

Argikar, Upendra, Potter, Phil, Matthew, Hutzler and Punit, Marathe (2016) Challenges and Opportunities with Non-CYP Enzymes Aldehyde oxidase, Carboxyl esterase and UDP-glucuronosyl transferase. Focus on Reaction Phenotyping and Prediction of Human Clearance. AAPS Journal, 18 (6). pp. 1391-1405. ISSN N/A

Arias, HR, Ravazzini, F, Targowska-Duda, KM, Kaczor, AA, Feuerbach, Dominik, Boffi, JC, Draczkowski, P, Montag, D, Brown, BM, Elgoyhen, AB, Jozwiak, K and Puia, G (2016) Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. The International Journal of Biochemistry & Cell Biology.

Ashok, Yashwanth and Jaakola, Veli-Pekka (2016) Nanodisc-Tm: Rapid functional assessment of nanodisc reconstituted membrane proteins by CPM assay. MethodsX, 3. pp. 212-218. ISSN 22150161

Atienzar, Franck, Blomme, Eric, Chen, Minjun, Hewit , Philip, Kenna, Gerry, Labbe, Gilles, LeCluyse, Edward, Moulin, Frederic, Pognan, Francois, Roth, Adrian, Suter-Dick, Laura, Ukairo, Okechukwu, Weaver, Richard, Will, Yvonne and Dambach, Donna (2016) Key challenges and opportunities associated with the use of in vitro models to detect human DILI: integrated risk assessment and mitigation plans. BioMed Research International, 2016 (-). pp. 1-20. ISSN 10.1155

Auberson, Yves, Briard, Emmanuelle, Sykes, David, Reilly, John and Healy, Mark (2016) The Ligand Specific Efficiency (LSE) index for PET tracer optimization, illustrated with tracer candidates for imaging the prostacyclin receptor. ChemMedChem, 11 (13). pp. 1415-1427. ISSN don't know

Auld, Douglas (2016) Doug Auld—Interview for November 2016 issue of Assays and Drug Dev. Technologies (Mary Ann Liebert Inc., publishing). Assay and drug development technologies, 14 (9). pp. 518-523.

Auld, Douglas, Busby, Scott, Chen, Kiki, Jimenez, Marta, Yue, Qing, Bowes, Scott, Wendel, Gregory, Smith, Thomas and Zhang, Ji (2016) Matrix-Based Activity Pattern Classification as a Novel Method for the Characterization of Enzyme Inhibitors Derived from High-Throughput Screening. Journal of Biomolecular Screening, 21 (10). pp. 1075-1089. ISSN 1552-454X

Ayalasomayajula, Surya, Langenickel, Thomas Heiko, Priya, Chandra, Wolfson, Edward, Albrecht, Diego, Zhou, Wei, Pal, Parasar, Rajman, Iris and Sunkara, Gangadhar (2016) Effect of food on the oral bioavailability of the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan (LCZ696) in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics, 54 (12). pp. 1012-1018. ISSN 0946-1965

B

Bacioglu, Mehtap, Maia, Luis, Schelle, Juliane, Kaeser, Stephan, Schweighauser, Manuel, Shimshek, Derya, Neumann, Ulf, Preische, Oliver, Kahle, Philipp, Staufenbiel, Matthias, Neumann, Manuela, Kuhle, jens and Jucker, Mathias (2016) Neurofilament light chain in blood and CSF as marker of disease progression in mouse models of neurodegenerative diseases. Neuron, 91 (1). pp. 56-66. ISSN 08966273

Bakker, Maarten H., Lee, Cameron, Meijer, E. W., Dankers, Patricia Y. W. and Albertazzi, Lorenzo (2016) Supramolecular multicomponent BTA polymers as a modular platform for intracellular delivery. ACS Nano, 10 (2). pp. 1845-1852. ISSN 1936-08511936-086X

Balko, Justin M and Arteaga, Carlos L (2016) Tumors with amplifications of JAK2 at the 9p24 loci in TNBC demonstrate JAK2-specific dependency. Sci Transl Med., 8 (334). pp. 334-353. ISSN 1946-6242

Bastakoty, Dikshya , Saraswati, Sarika , Atkinson, James , Feoktistov, Igor, Liu, Jun, Harris, Jennifer and Young, Pampee (2016) Temporary, Systemic Inhibition of the WNT/β- Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, Stem cells and Regenerative Medicine, 2 (2). pp. 1-13. ISSN 2472-6990

Bauer, Daniel, Soon, Rachel, Kulmatycki, Kenneth, Chen, Yuming, Noe, Adele, Chen, Jin, Dosik, Jonathan and Meyers, Charles (2016) Photosensitizing potential of pradigastat in healthy subjects: a randomized controlled trial using three defined sunlight exposure conditions. Photochem. Photobiol. Sci., 15 (9). pp. 1155-1162. ISSN 1474-905X1474-9092

Bautista Mercader, Manuel, Tosini, Federico, Schneider, Marcel and Steigmiller, Stefan (2016) Transmission Raman Spectroscopy (TRS): how far can we go with the analysis of capsule based Dry Powder Inhalers? European Pharmaceutical Review, 21 (6). pp. 6-10.

Beckmann, Nicolau, Doelemeyer, Arno, Zurbruegg, Stefan, Bigot, Karine, Theil, Diethilde, Frieauff, Wilfried, Kolly, Carine, Neddermann, Daniel, Kreutzer, Robert, Perrot, Ludovic, Brzak, Irena, Jacobson, Laura, Staufenbiel, Matthias, Neumann, Ulf and Shimshek, Derya (2016) Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice. Neurobiology of Aging, 45. pp. 50-60. ISSN 01974580

Ben M'Barek, Mohamed, Redrup, Michael J, Igarashi, Harue , Schaefgen, Jay , Lin, Jenny , Geisler, Lisa , Ramachandran, Subramanian , Cardoso, Thales and Hillewaert, Vera (2016) Sample Management: Recommendation for best practices and harmonization from the Global Bioanalysis Consortium Harmonization Team. The AAPS Journal, Volume (Issue ). pp. 290-293. ISSN 1550-7416

Bende, Girish, Biswal, Shibadas, Bhad, Prafulla, Chen, Yuming, Salunke, Atish Azad, Winter, Serge, Wagner, Robert and Sunkara, Gangadhar (2016) Relative bioavailability of diclofenac potassium from softgel capsule versus powder for oral solution and immediate-release tablet formulation. Clinical Pharmacology in Drug Development, 5 (1). pp. 76-82. ISSN 2160-7648

Benoit, Roger, Ostermeier, Christian, Geiser, Martin, Widmer, Hans, Auer, Manfred and Li, Julia Su Zhou (2016) Seamless insert-plasmid assembly at high efficiency and low cost. PLOS ONE, April . pp. 1-13.

Berg, Daniela, Godau, Jana, Trenkwalder, Claudia, Eggert, Karla, Csoti, Ilona, Storch, Alexander, Huber, Heiko, Morelli-Canelo, Monica, Stamelou, Maria, Ries, Vincent, Wolz, Martin, Schneider, Christine, Di Paolo, Thérèse, Gasparini, Fabrizio, Hariry, Sam, Vandemeulebroecke, Marc, Gomez-Mancilla, Baltazar, Abi-Saab, Walid, Johns, Donald and Cooke, Katy (2016) AFQ056 treatment of levodopa-induced dyskinesias: results of two randomized controlled trials. Movement Disorders, 26 (7). pp. 1243-1250.

Bergeron, Sophie and Grant, James (2016) Validity Studies - Enhancing Patent Searches. Pharmaceutical patent analyst, Unknow (Unknow). XX-YY. ISSN 2046-8954

Berghausen, Joerg, Seiler, Frank Hans, Gobeau, Nathalie and Faller, Bernard (2016) Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range. ADMET&DMPK.

Bergsdorf, Christian, Fiez-Vandal, Cedric, Sykes, David, Bernet, Pascal, Aussenac, Sonia, Charlton, Steven, Schopfer, Ulrich, Ottl, Johannes and Duckely, Myriam (2016) An alternative thiol-reactive dye to analyze ligand interactions with the chemokine receptor CXCR2 using a new thermal shift assay format. Journal of Biomolecular Screening, 21 (3). pp. 243-251. ISSN 1087-05711552-454X

Bernasconi-Elias, Paula, Hu, Tiancen, Jenkins, David, Firestone, Brant, Gans, Sara, Kurth, Esther, Capodieci, Paola, Deplazes-Lauber, Joelle, Petropoulos, Konstantin, Thiel, Phillip, Ponsel, Dirk, Choi, Sung Hee, Lemotte, Peter, London, Anne, Goetcshkes, Margaret, Nolin, Erin, Jones, Michael, Slocum, Kelly, Kluk, Michael, Weinstock, David, Christodoulou, Alexandra, Weinberg, Olga, Jaehrling, Jan, Ettenberg, Seth, Buckler, Alan, Blacklow, Stephen, Aster, Jon and Fryer, Christy (2016) Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. ISSN 0950-92321476-5594

Beverly, Michael, Dell, Amy, Parmar, Parul and Houghton, Leslie (2016) Label-free analysis of mRNA capping efficiency using RNAse H probes and LC-MS. Analytical and Bioanalytical Chemistry, 408 (18). pp. 5021-5030. ISSN 1618-2650

Bhoumik, Priyasma, Del Rio Espinola, Alberto, Hahne, Florian, Moggs, Jonathan and Grenet, Olivier (2016) Translational Safety Genetics - Leveraging Genetic Variation for Enhanced Safety Assessment. Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Bhowmik, Shiva, Chiu, Hsien-Po, Jones, David, Chiu, Hsiu-Ju, Miller, Mitchell, Xu, Qingping, Farr, Carol Lynn, Ridlon, Jason M., Wells, James E., Elsliger, Marc-Andre, Wilson, Ian A., Hylemon, Phillip B. and Lesley, Scott (2016) Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis. Proteins: Structure, Function and Bioinformatics, 84 (3). pp. 316-331. ISSN 10970134

Bidinosti, Michael, Botta, Paolo, Moreira Ramos Proenca, Catia, Stoehr, Natacha, Bernhard, Mario, Fruh, Isabelle, Mueller, Matthias, Bonenfant, Debora, Voshol, Johannes, Carbone, Walter, Neal, Sarah, Mctighe, Stephanie, Roma, Guglielmo, Dolmetsch, Ricardo, Porter, Jeffrey, Caroni, Pico, Bouwmeester, Antonius, Lüthi, Andreas and Galimberti, Ivan (2016) CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency. Science.

Bigaud, Marc, Dincer, Zuhal, Bollbuck, Birgit, Dawson King, Janet, Beckmann, Nicolau, Beerli, Christian, Cavelti, Gina, Nahler, Michaela, Angst, Daniela, Janser, Philipp, Otto, Heike, Rosner, Elisabeth, Hersperger, Rene, Bruns, Christian and Quancard, Jean (2016) Pathophysiological consequences of a break in S1P1-dependent homeostasis of vascular permeability revealed by S1P1 competitive antagonism. PLOS ONE.

Biosse Duplan, Martin, Komla-Ebri, Davide, Heuzé, Yann, Estibal, Valentin, Gaudas, Emilie, Kaci, Nabil, Benoist-Lasselin, Catherine, Zerah, Michel, Kramer, Ina, Kneissel, Michaela, Graus Porta, Diana, Di Rocco, Federico and Legeai-Mallet, Laurence (2016) Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible. Human molecular genetics. ISSN 1460-2083; 0964-6906

Bojkovic, Jade, Richie, Daryl, Six, David, Rath, Christopher, Sawyer, William, Hu, Daniel and Dean, Charles (2016) Characterization of an Acinetobacter baumannii lptD deletion strain: Permeability defects and response to inhibition of lipopolysaccharide and fatty acid biosynthesis. Journal of Bacteriology, 198 (4). pp. 731-741. ISSN 1098-5530

Bottos, Alessia, Gill, Jason W, Tzankov, Alexander, Wodnar-Filipowicz, Aleksandra and Hynes, Nancy E (2016) Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nature communications, 7 (12258). pp. 1-12. ISSN 2041-1723

Bottos, Alessia, Gotthardt, Dagmar, Gill, Jason W, Gattelli, Albana, Frei, Anna, Tzankov, Alexandar, Sexl, Veronika, Wodnar-Filipowicz, Aleksandra and Hynes, Nancy E (2016) Decreased NK cell-mediated anti-tumor immunity consequent to JAK pathway inhibition enhances metastasis in preclinical models of breast cancer. Nat Commun., 7 (12258). pp. 1-12. ISSN 2041-1723

Bouchez, Laure, Gerbeaux, Cyril, rusch, marion, Livendahl, madeleine, Patoor, Maude and Press, Neil (2016) Wake Up Call of A Sleeping Beauty”: Straightforward Synthesis of Functionalized β-(2-Pyridyl) Ketones from 2,6-Lutidine. Synlett.

Brandl, Trixi, Simic, Oliver, Skaanderup, Philip, Namoto, Kenji, Berst, Frederic, Ehrhardt, Claus, Schiering, Nikolaus, Mueller, Irene Renate and Woelcke, Julian (2016) Trypsin inhibitors for the treatment of pancreatitis. Bioorganic & Medicinal Chemistry Letters.

Brasa, Sarah, Rozenberg, Izabela, Zollinger, Tulipan, Hahne, Florian, Peters, Thomas, Manzella, Liliana, Decker, Jerry, He, Yunsheng, Johnson, Keith, Mccormack, Christine, Gasparini, Fabrizio, Chibout, Salah-Dine, Grenet, Olivier, Moggs, Jonathan, Gomez-Mancilla, Baltazar, Terranova, Remi and Jacquemont, Sebastien (2016) Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome. Clinical Epigenetics, 8 (1). ISSN 18687083

Brasa, Sarah, Sebastien, Jacquemont, Hahne, Florian, Rozenberg, Izabela, Peters, Thomas, He, Yunsheng, Mccormack, Christine, Gasparini, Fabrizio, Chibout, Salah-Dine, Grenet, Olivier, Moggs, Jonathan, Gomez-Mancilla, Baltazar and Terranova, Remi (2016) Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in Fragile X syndrome. Clinical Epigenetics (http://www.clinicalepigeneticsjournal.com/).

Brecht, Karin, Riebel, Virginie, Couttet, Philippe, Paech, Franziska, Wolf, Armin, Chibout, Salah-Dine, Pognan, Francois, Krähenbühl, Stephan and Uteng, Marianne (2016) Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin. Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin, 40. pp. 55-65.

Brian, William, Tremaine, Larry M., Arefayene, Million, de Kanter, Ruben, Evers, Raymond, Guo, Yingying, Kalabus, James, Lin, Wen, Loi, Cho-Ming and Xiao, Guangqing (2016) Assessment of Drug Metabolism Enzyme and Transporter Pharmacogenetics in Drug Discovery and Early Development: Perspectives of the I-PWG. Pharmacogenomics, 17. pp. 615-631. ISSN 1744-8042

Brown, Alan, Drew, Philip, Knight, Brian, Marc, Philippe, Troth, Sean, Wuersch, Kuno and Zandee, Joyce (2016) Graphical display of histopathology data from toxicology studies for drug discovery and development: an industry perspective. Regulatory toxicology and pharmacology, 82. pp. 167-172.

Brunschweiger, Andreas, Gebert, Luca F. R., Lucic, Matije, Pradère, Ugo, Jahns, Hartmut, Hunziker, Juerg and Hall, Jonathan (2016) Site-specific conjugation of drug-like fragments to anti-miRNA oligonucleotides: pros and cons of targeting miRNAs in RISC. Angewandte Chemie International Edition, 52 (1). pp. 156-159. ISSN 1359-73451364-548X

Brykczynska Kunzmann, Urszula, Vrieseling Pecho, Eline, Thiemeyer, Anke, Klein, Jessica, Fruh, Isabelle, Doll, Thierry, Manneville, Carole, Iazeolla, Mariavittoria, Beibel, Martin, Roma, Guglielmo, Naumann, Ulrike, Kelley, Nicholas, Oakeley, Edward James, Mueller, Matthias, Gomez-Mancilla, Baltazar, Buehler, Marc, Tabolacci, Elisabetta, Chiruazzi, Pietro, Neri, Giovanni, Bouwmeester, Antonius, Di Giorgio, Francesco and Fodor, Barna (2016) CGG Repeat-Induced FMR1 Silencing Depends on the Expansion Size in Human iPSCs and Neurons Carrying Unmethylated Full Mutations. Stem Cell Reports, 7 (6). pp. 1059-1071. ISSN 22136711

Brykczynska Kunzmann, Urszula, Vrieseling Pecho, Eline, Thiemeyer, Anke, Klein, Jessica, Fruh, Isabelle, Doll, Thierry, Manneville, Carole, Iazeolla, Mariavittoria, Beibel, Martin, Roma, Guglielmo, Naumann, Ulrike, Kelley, Nicholas, Oakeley, Edward James, Mueller, Matthias, Gomez-Mancilla, Baltazar, Buehler, Marc, Tabolacci, Elisabetta, Chiruazzi, Pietro, Neri, Giovanni, Bouwmeester, Antonius, Di Giorgio, Francesco and Fodor, Barna (2016) Human neurons carrying FMR1 unmethylated full mutations require large CGG repeat expansions for silencing and display neurodegenerative features. Cell Stem Cell.

Brzeszczyńska, Joanna, Johns, Neil, Schilb, Alain, Degen, Simone, Degen, Martin, Langen, Ramon, Schols, Annemie, Glass, David, Roubenoff, Ronenn, Greig, Carolyn A., Jacobi, Carsten, Fearon, Kenneth C.H. and Ross, James A. (2016) Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not healthy elderly. Clinical Cancer Research, 8 (7). pp. 1-12. ISSN 1945-4589

Burmester, Gerd, Durez, Patrick, Shestakova, Galena, Genovese, Mark, Schulze-Koops, Hendrik, Li, Yue, Wang, Amanda, Lewitzky, Steven, Koroleva, Irina, Agarwal-Berneis, Anni, Lee, David M and Hueber, Wolfgang (2016) Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis. Rheumatology (United Kingdom), 55 (1). pp. 49-55. ISSN 14620332

C

Calonder, Claudio, Polus, Florine, Woessner, Ralph, Loesche, Christian, Cheng, Yi, Dragatin, Christian, Bodenlenz, Manfred, Aigner, Birgit, Tiffner, K, Mader , J, Ratzer , M, Pieber, Thomas, Bruin, Gerardus and Sinner, Frank (2016) Secukinumab Distributes into Dermal Interstitial Fluid of Psoriatic Patients as Demonstrated by Open Flow Microperfusion. Experimental dermatology, 25 (2). pp. 157-159. ISSN 09066705

Camenisch, Gian P. (2016) Drug disposition classification systems in discovery and development: A comparative review of the BDDCS, ECCS and ECCCS concepts. Pharmaceutical Research.

Campbell, Katie, Solovieff, Nadia, Morrissey, Michael, Leary, Rebecca, Mahan, Scott, Adamovich, Wendy, Murphy, Leon, Mirzaa, Ghayda, Jansen, Laura, Timms, Andrew, Conti, Valerio, Adams, Carissa, boyle, Evan, Collins, Sarah, ishak, gisele, poliachik, sandra, girisha, katta, yeung, kit san, chung, brain hon yin, rahikkala, elisa, gunter, sonya, martin, beth, weaver, molly, doerschner, michael, shendure, jay, saneto, russell, novotny, edward, hevner, robert, ojemann, jeffrey, guerrini, renzo, Sellers, William and dobyns, william (2016) Association of MTOR mutations with developmental brain disorders, including megalencephaly, focal cortical dysplasia, and pigmentary mosaicism. JAMA Neurology, 73 (7). pp. 836-845. ISSN 21686149

Caravatti, Giorgio, Guagnano, Vito, Aichholz, Reiner, Blanz, Joachim, Blasco, Francesca, Wipfli, Peter, Fritsch, Christine, Maira, Sauveur-Michel, Schnell, Christian and Seiler, Frank Hans (2016) Increasing metabolic stability via the deuterium kinetic isotope effect: an example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (19). pp. 4729-4734. ISSN 0960-894X

Carita, Guillaume, Frisch Dit Leitz, Estelle, Dahmani, Ahmed, Raymondie, Chloe, Cassoux, Nathalie, Piperno-Neumann, Sophie, Nemati, Fariba, Roman-Roman, Sergio, Wylie, Andrew, Emery, Caroline, Schoumacher, Marie and Decaudin, Didier (2016) Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma. Oncotarget, 7 (23). pp. 33542-33556. ISSN 1949-2553 (Electronic); 1949-2553 (Linking)

Carstens, Nadia, Williams, Sue, Goolam, Saadiah, Carmichael, Trevor, Zou, Chao, Cheung, Chi Ming, Buechmann-Moller, Stine, Sultan, Marc, Staedtler, Frank, Rice, Dennis, Lacoste, Arnaud, Paes, Kim, Swart, Peter and Ramsay , Michele (2016) Novel mutation in the CHST6 gene causes macular corneal dystrophy in a black South African family. BMC medical genetics, 17 (1). p. 47. ISSN 1471-2350

Cejka, Daniel, Parada-Rodriguez, Diego, Pichler, Stefanie, Marculescu, Rodrig, Kramer, Ina, Kneissel, Michaela, Gross, Thomas, Reisinger, Andreas, Pahr, Dieter, Monier-Faugere, Marie-Claude, Haas, Martin and Malluche, Hartmut H. (2016) Sclerostin knock-out does not protect from uremia-induced bone loss in a murine model of chronic renal failure. Kidney International.

Chaker, A, Shamji, MH, Dumitru, A, Calderon, M, Scadding, G, Makatsori, M, Jones, Ieuan, He, Ally, Subramanian, Kulandayan, Arm, Jonathan, Durham, SR and Schmidt-Weber, CB (2016) Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: a randomised controlled trial. Journal of Allergy and Clinical Immunology.

Chandra, Abhishek, Lin, Tiao, Young, Tiffany, Tong, Wei, Ma, Xiaoyuan, Tseng, Wei-Ju, Kramer, Ina, Kneissel, Michaela, Levine, Michael A., Zhang, Yejia, Cengel, Keith, Liu, X. Sherry and Qin, Ling (2016) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of Bone & Mineral Research, 16. ISSN 1523-4681

Chapman, Victoria, Terranova, Remi, Moggs, Jonathan, Kimber, Ian and Dearman, Rebecca (2016) Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens. Toxicology, 340. pp. 17-26. ISSN 1879-3185

Chen, Chao, Zhu, Hugh, Stauffer, Frederic, Caravatti, Giorgio, Vollmer, Susanne, Machauer, Rainer, Holzer, Philipp, Moebitz, Henrik, Scheufler, Clemens, Klumpp, Martin, Tiedt, Ralph, Beyer, Kim, Calkins, Keith, Kiffe, Michael, Guthy, Daniel Alexander, Zhang, Jeff and Gaul, Christoph (2016) The Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Chen, Xiao-Hui, Hatsis, Panagiotis, Judge, Joyce, Argikar, Upendra, Ren, Xiaojun, Sarber, Jason, Mansfield, Keith, Liang, Guiqing, Adamal, Adam , Catoire, Alexandre, Bentley, Adam, Ramos, Luis, Moench, Paul, Hintermann, Samuel, Carcache, David, Glick, Jim and Flarakos, Jimmy (2016) Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry. Analytical Chemistry, 88 (23). pp. 11813-11820. ISSN 0003-27001520-6882

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Dickson, Callum, Hornak, Viktor, Pearlstein, Robert, Mckay, Daniel, Velez-Vega, Camilo, Duca, Jose, Sandham, David, Shaw, Duncan, Fairhurst, Robin, Reilly, John, Charlton, Steven and Sykes, David (2016) Uncoupling the structure-activity relationships of β2 adrenergic receptor ligands from membrane binding. Journal of Medicinal Chemistry, 59 (12). pp. 5780-5789. ISSN 0022-26231520-4804

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Dole, Kiran, Segal, Florencia, Feire, Adam, Magnusson, Baldur, Rondon, Juan C, Vemula, Janardhana Rao, Yu, Jing, Pang, Yinuo and Pertel, Peter (2016) A first-in-human study to assess the safety and pharmacokinetics of monoclonal antibodies against human cytomegalovirus in healthy volunteers. Antimicrobial Agents and Chemotherapy, 60 (5). pp. 2881-2887. ISSN 0066-4804; 1098-6596

Doll, Thierry, Fruh, Isabelle, Mueller, Matthias, Marcellin, David, Russell, Oliver, Rai, Pavendeep, Taylor, Robert, Lightowlers, Robert, Turnbull, Douglass, Bastien, Julie, Germain, Mitchel, Rygiel, Karolina, Majlinda, Lako and Amy, Reeve (2016) Unanticipated increase in mtDNA deletion heteroplasmy in an in vivo environment. Nature Genetics.

Donner, Lili, Fälker, Knut, Klinker, Stefan, Gremer, Lothar, Pagani, Giulia, Gohlke, Holger, Willbold, Dieter, Lang, Florian, Grenegard, Magnus and Elvers, Margitta (2016) Blood platelets contribute to the formation of Amyloid deposits in cerebral vessels via integrin. Science Signaling, 9 (429). ra52-56. ISSN 1945-08771937-9145

Dovala, Dustin, Rath, Christopher, Hu, Qijun, Sawyer, William, Shia, Steven, Elling, Robert, Knapp, Mark and Metzger Iv, Louis (2016) Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism. Proceedings of the National Academy of Sciences of the United States of America, 28. ISSN 1091-6490

Dovala, Dustin, Sawyer, William, Rath, Christopher and Metzger Iv, Louis (2016) Rapid analysis of protein expression and solubility with the SpyTag-SpyCatcher system. Protein Expr Purif, 117. pp. 44-51. ISSN 1096-0279 (Electronic); 1046-5928 (Linking)

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Dryja, Ted (2016) Early Insight Into Neovascular Age-Related Macular Degeneration. JAMA Ophthalmology, 134 (11). pp. 1281-1282. ISSN 2168-6173

Dubiknov, Tatyana, Hoepfner, Dominic and Cohen, Ehud (2016) The Triage of Misfolded Prion Molecules to Aggresomes Occurs Within the Endoplasmic Reticulum. Journal of cell science, 129 (19). pp. 3635-3647. ISSN 1477-9137; 0021-9533

de Zwart, Marcel, Lausecker, Berthold, Globig, Susanne, Neddermann, Daniel, Le Bras, Bruno, Guenzi, Alberto, White, Stephen, Scheel-Fjording, Marianne and Timmerman, Philip (2016) Co-medication and interference testing in bioanalysis: a European Bioanalysis Forum Recommendation. Bioanalysis, 8 (19). pp. 2065-2070. ISSN 1757-6180

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Ekmark-Lewen, S, Fridgeirsdottir, A, Kiwanuka, O, Hanell, A, Meyerson , B, Mir, Anis Khusro, Gram, Hermann, Lewen , A, Clausen, F, Hillered, L and Marklund, N (2016) Complex behavioral alterations after diffuse traumatic axonal injury in mice are normalized by post-injury neutralization of interleukin-1β. European Journal of Neuroscience, 43 (8). pp. 1016-1033. ISSN 0953816X

El Mouelhi, Mohamed and Roubenoff, Ronenn (2016) Drug Development and Challenges for Neuromuscular Clinical Trials. Journal of Molecular Neuroscience, 58 (3). pp. 374-378. ISSN 1559-1166

Eng , Christina, Wang, Zuncai, Tkach, Diane, Toral-Barzy, Lourdes, Ugwonali, Savuth, Liu, Shanming, Fitzgerald, Stephanie, George, Elizabeth, Frias, Elizabeth, Cochran, Nadire, Dejesus, Rowena, Mcallister, Gregory, Hoffman, Gregory, Bray, Kevin, Lemon, LuAnna, Lucas, Judy, Fantin, Valeria, Abraham, Robert, Murphy, Leon and Nyfeler, Beat (2016) Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. PNAS, 113 (1). pp. 182-187. ISSN 1091-6490

Erpenbeck, Veit, Popov, Todor A, Miller, David, Weinstein, Steven F, Spector, Sheldon, Magnusson, Baldur, Osuntokun, Wande, Goldsmith, Paul, Weiss, Markus and Beier, Jutta (2016) The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma. Pulmonary pharmacology & therapeutics, 39. pp. 54-63. ISSN 1522-9629; 1094-5539

Erpenbeck, Veit, Weiss, Markus, Sandham, David and Neelakantham, Srikanth Raju (2016) Pharmacokinetics, safety, and tolerability of QAW039 (fevipiprant), a novel CRTh2 receptor antagonist: Results from two randomized, phase I, placebo-controlled studies in healthy volunteers. Clinical Pharmacology in Drug Development.

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Faulkner, Lee, Gibson, Andrew, Sullivan, Andrew, Tailor, Arun, Usui, Toru, Alfirevic, Ana, Pirmohamed, Munir, Naisbitt, Dean J. and Park, B. Kevin (2016) Detection of primary T cell responses to drugs and chemicals in HLA-typed volunteers: implications for the prediction of drug immunogenicity. Toxicological Sciences, 154 (2). pp. 416-429. ISSN 1096-60801096-0929

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Fouche, Marianne, Roth, Hans-Joerg, Schaefer, Michael, Berghausen, Joerg, Desrayaud, Sandrine, Blatter, Markus, Piechon, Philippe, Dix, Ina and Martin Garcia, Aimar (2016) Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure. ChemMedChem.

Fouche, Marianne, Schaefer, Michael, Berghausen, Joerg, Desrayaud, Sandrine and Roth, Hans-Joerg (2016) Pharmacokinetic Studies around the Mono- and Difunctionalization of a Bioavailable Cyclic Decapeptide Scaffold. ChemMedChem.

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Frommlet, Alexandra, Blechschmidt, Anke, Lingel, Andreas, Peng, Chen, Perez, Manuel, Cobas, Carlos and Dominguez, Santiago (2016) An Automated Software Tool for Efficient Processing and Analysis of Ligand-Observed 1H and 19F NMR Binding Data. Journal of Medicinal Chemistry, 59 (7). pp. 3303-3310. ISSN 0022-26231520-4804

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Furet, Pascal, Masuya, Keiichi, Kallen, Joerg, Valat, Therese-Marie, Guagnano, Vito, Holzer, Philipp, Mah, Robert, Stutz, Stefan, Vaupel, Andrea, Chene, Patrick, Jeay, Sebastien, Ruetz, Stephan and Schlapbach, Achim (2016) Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument. Bioorganic and Medicinal Chemistry Letters, 26 (19). pp. 4837-4841. ISSN 1464-3405

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Gable, Jonathan , Lee, Gregory , Acker, Timothy , Hulce, Kaitlin , Gonzalez, Eric , Schweigler, Patrick, Melkko, Samu, Farady, Christopher and Craik, Charles (2016) Fragment-based protein-protein interaction antagonists of a viral dimeric protease. ChemMedChem.

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Gallagher, Iain, Jacobi, Carsten, Tardif, Nicolas and Fearon, Kenneth (2016) Systems biology and cancer cachexia. Special Issue of SCDB .

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Gampe, Christian, Hollis-Symynkywicz, Micah and Zecri, Frederic (2016) Covalent Chemical 5'-Functionalization of RNA with Diazo Reagents. Angewandte Chemie. International edition, 55 (35). pp. 10283-10286. ISSN 14337851

Gan, Lu, Jiang, Xuemin, Mendonza, Anisha, Swan, Therese, Reynolds, Christine, Nguyen, Joanne, Pal, Parasar, Neelakantham, Srikanth Raju, Dahlke, Marion, Langenickel, Thomas Heiko, Rajman, Iris, Akahori, Mizuki and Sunkara, Gangadhar (2016) Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects. Clinical Pharmacology in Drug Development, 5 (1). pp. 27-39. ISSN 2160-7648

Gan, Lu, Jiang, Xuemin, Mendonza, Anisha, Swan, Therese, Reynolds, Christine, Nguyen, Joanne, Pal, Parasar, Neelakantham, Srikanth Raju, Dahlke, Marion, Langenickel, Thomas Heiko, Rajman, Iris, Akahori, Mizuki, Zhou, Wei, Rebello, Sam and Sunkara, Gangadhar (2016) Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects. Clinical Pharmacology in Drug Development, 5 (1). pp. 27-39. ISSN 2160-7648

Gan, Lu, Langenickel, Thomas Heiko, Petruck, Jesika, Kode, Kiran Kumar, Rajman, Iris, Chandra, Priyamvada, Zhou, Wei, Rebello, Sam and Sunkara, Gangadhar (2016) Effects of age and gender on the pharmacokinetics of LCZ696, an angiotensin receptor neprilysin inhibitor. Journal of Clinical Pharmacology , 56 (1). pp. 78-86. ISSN 00912700

Gao, Jinhai, Wang, Bing and Rajan, Srinivasan (2016) In-tube Derivatization for the Determination of Absolute Configuration and Enantiomeric Purity of Chiral Compounds by NMR Spectroscopy. Magn Reson Chem.

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Garcia Fortanet, Jorge, Chen, Christine, Chen, Zhuoliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao Bin, Karki, Rajesh, Kato, Mitsunori, Keen, Nicholas, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Shultz, Michael, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah, Zhang, Ji, Lamarche, Matthew and Sellers, William (2016) Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Gauvreau, Gail M, Arm, Jonathan P, Boulet, Louis-Philippe, Leigh, Richard, Cockcroft, Donald W, Davis, Beth E, Mayers, Irvin, FitzGerald, J Mark, Dahlen, Barbro, Killian, Kieran J, Laviolette, Michel, Carlsten, Christopher, Lazarinis, Nikolaos, Watson, Richard M, Milot, Joanne, Swystun, Veronica, Bowen, Miranda, Hui, Linda, Lantz, Ann-Sofie, Meiser, Karin, Maahs, Suzanne, Lowe, Philip J, Skerjanec, Andrej, Drollmann, Anton and O'Byrne, Paul M (2016) Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. The Journal of allergy and clinical immunology, in pre (in pre). 00-00. ISSN 1097-6825

Gedeck, Peter, Lu, Yipin, Skolnik, Suzanne, Rodde, Stephane, Dollinger, Gavin, Jia, Weiping, Berellini, Giuliano, Vianello, Riccardo, Faller, Bernard and Lombardo, Franco (2016) The benefit of retraining pKa models studied using internally measured data. Journal of Chemical Information and Modeling.

Gentile, Antonietta, Musella, Alessandra, Bullitta, Silvia, Fresegna, Diego, De Vito, Francesca, Piras, Eleanora, Gargano, Francesca, Borsellino, Giovanna, Battistini, Luca, Schubart Wellensiek, Anna, Mandolesi, Georgia and Centonze, Diego (2016) EFFECTS OF SIPONIMOD (BAF312) ON SYNAPTIC NEURODEGENERATIVE DAMAGE IN EXPERIMENTAL MULTIPLE SCLEROSIS. J Neuroinflammation, 13 (1). p. 207. ISSN 1742-2094

Ghode, Pramila Baban, Ramachandran, Sarath , Bifani, Juan Pablo and Sivaraman, Jayaraman (2016) Structure and mapping of spontaneous mutational sites of PyrR from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications, 471 (4). pp. 409-415. ISSN 1090-2104

Glatthar, Ralf, Stojanovic, Aleksandar, Troxler, Thomas J., Mattes, Henri, Moebitz, Henrik, Beerli, Rene, Blanz, Joachim, Gassmann, Ernst, Drueckes, Peter, Fendrich, Gabriele, Gutmann, Sascha, Martiny-Baron, Georg, Spence, Fiona, Peel, John Edmondson and Sparrer, Helmut (2016) Discovery of imidazoquinolines as a novel class of potent, selective and in vivo efficacious COT kinase inhibitors. Journal of Medicinal Chemistry, 59 (16). pp. 7544-7560. ISSN 0022-2623

Glowienke, Susanne (2016) Aromatic amine data sharing for 2015. Aromatic amine data sharing, Not ap (Not ap). NA-NA. ISSN Not applicable

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Glowienke, Susanne (2016) Intermediates mutagenicity data sharing for 2017. Intermediates data sharing.

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Shaw, Duncan, Baig, Ferheen, Bruce, Ian, Chamoin, Sylvie, Collingwood, Stephen, Cross, Sarah, Dayal, Satish, Drueckes, Peter, Furet, Pascal, Furminger, Vikki, Haggart, Deborah, Hussey, Martin, Konstantinova, Irena, Loren, Jon, Molteni, Valentina, Roberts, Sonia, Reilly, John, Saunders, Alex, Stringer, Rowan, Sviridenko, Lilya, Thomas, Matthew, Thomson, Christopher, Tomlins, Christine, Wen, Ben, Yeh, Vince and Pearce, Andrew (2016) Optimization of PDGFR inhibitors for duration of action, as an inhaled therapy for lung remodeling in pulmonary arterial hypertension. Journal of Medicinal chemistry, 59 (17). pp. 7901-7914. ISSN DOI: 10.1021/acs.jmedchem.6b00703

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Smith, Troy, Sprague, Elizabeth, Wang, Kate, Mathieu, Simon, Chen, Zhuoliang, Mishina, Yuji, Feng, Yun, Shakya, Subarna, Chen, Dongshu, Meyer, Matthew, Brazell, Tres, Straub, Christopher, Sage, David, Wright, Kirk, Chen, Xin, Duca, Jose, Kim, Sean, Tian, Li, Martin, Eric, Hurov, Kristen, Shao, Wenlin and Yan-Neale, Yan (2016) Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. Journal of Medicinal Chemistry, 59 (10). pp. 4711-4723. ISSN 1520-4804

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Stewart, Neil J, Horn, Felix C, Norquay, Graham, Collier, Guilhem J, Yates, Denise, Lawson, Rod, Marshall, Helen and Wild, Jim M (2016) Reproducibility of Quantitative Indices of Lung Function and Microstructure from 129Xe Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy. Magnetic Resonance in Medicine, 000 (000). pp. 1-7. ISSN 10.1002/mrm.26310

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