Items where Year is 2008

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Number of items: 382.

A

Abdulla, Salim, Sagara, Issaka, Borrmann, Steffen, D'Alessandro, Umberto, González, Raquel, Hamel, Mary, Ogutu, Bernhards, Mårtensson, Andreas, Lyimo, John, Maiga, Hamma, Sasi, Philip, Nahum, Alain, Bassat, Quique, Juma, Elizabeth, Otieno, Lucas, Björkman, Anders, Beck, Hans Peter, Andriano, Kim, Cousin, Marc, Lefevre, Gilbert, Ubben, David and Premji, Zulfikarali (2008) Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial. Lancet, 372 (9652). pp. 1819-1827. ISSN 1474-547X

Abramowski, Dorothee, Wiederhold, Karl-Heinz, Furrer, Ulrich, Jaton, Anne-Lise, Neuenschwander, Anton, Runser, Marie-Josephine, Danner, Simone, Reichwald, Julia, Ammaturo, Domenico, Staab, Dieter, Stoeckli, Markus, Rueeger, Heinrich, Neumann, Ulf and Staufenbiel, Matthias (2008) Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition. The Journal of Pharmacology and Experimental Therapeutics, 327 (2). pp. 411-424. ISSN 1521-0103

Abudalu, Mohammed, Tyring, Stephen, Koltun, William, Bodsworth, Neil and Hamed, Kamal (2008) Single-day, patient-initiated famciclovir therapy versus 3-day valacyclovir regimen for recurrent genital herpes: a randomized, double-blind, comparative trial. Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America, 47 (5). pp. 651-658. ISSN 1537-6591

Almeida, M. Q., Fragoso, M. C. B. V., Lotfi, C. F. P., Santos, M. G., Nishi, M. Y., Costa, M. H. S., Lerario, A. M., Maciel, C. C., Mattos, G. E., Jorge, A. A. L., Mendonca, B. B. and Latronico, A. C. (2008) Expression of Insulin-Like Growth Factor-II and Its Receptor in Pediatric and Adult Adrenocortical Tumors. Journal of Clinical Endocrinology & Metabolism, 93 (9). pp. 3524-3531. ISSN 0021-972X

Alten, Rieke, Gram, Hermann, Joosten, Leo A, van den Berg, Wim B, Sieper, Joachim, Wassenberg, Siegfrid, Burmester, Gerd, van Riel, Piet, Diaz-Lorente, Maria, Bruin, Gerardus, Woodworth, Thasia G., Rordorf, Christiane, Batard, Yannick, Wright, Andrew and Jung, Thomas (2008) The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. Arthritis research & therapy, 10 (3). R67. ISSN 1478-6362

Alten, Rieke, Gram, Hermann, Joosten, Leo, Berg, Wim, Sieper, Joachim, Wassenberg, Siegfrid, Burmester, Gerd, van Riel, Piet, Diaz-Lorente, Maria, Bruin, Gerardus, Woodworth, Thasia G., Rordorf, Christiane, Batard, Yannick, Wright, Andrew and Jung, Thomas (2008) The human anti-IL-1ß monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. Arthritis Research & Therapy, 10 (3). R67. ISSN 1478-6354

Alvarez, Carlos (2008) On the origins of arrestin and rhodopsin. BMC Evolutionary Biology, 8 (1). p. 222. ISSN 1471-2148

Andreae, Marc, Steiner, Thomas, Hueber, Matthieu, Schopfer, Ulrich, Smith, Robert, Igo, Debra, Cantrell, Daryl, Hohos, Aaron and Kiwanuka, Andrew (2008) Closing the gap between centralized and decentralized compound management approaches. Combinatorial Chemistry & High Throughput Screening, 11 (10). pp. 825-833. ISSN 1386-2073

Atadja, Peter, Shao, Wenlin, Wang, Y, Growney, Joseph, Feng, Y, Yao, Yao, Wallace, A, Crisanti, C, Fawell, Stephen and Albelda, S (2008) Efficacy of panobinostat (LBH589) in lung cancer: potent anticancer activity in both in vitro and in vivo tumor models. European Journal of Cancer Supplements, 6 (12). pp. 48-49.

Ayalasomayajula, Surya, Tchaloyan, Stephanie, Yeh, Ching-Ming, Bizot, Marie-Noelle, Dieterich, Hans Armin, Howard, Danny and Dole, William (2008) A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with allopurinol, celecoxib and cimetidine in healthy subjects. Current Medical Research and Opinion, 24 (3). pp. 717-726. ISSN 1473-4877

Ayalasomayajula, Surya, Yeh, Ching-Ming, Vaidyanathan, Sujata, Flannery, Brian, Dieterich, Hans Armin, Howard, Danny, Bedigian, Martin and Dole, William (2008) Effects of aliskiren, a direct Renin inhibitor, on cardiac repolarization and conduction in healthy subjects. Journal of Clinical Pharmacology, 48 (7). pp. 799-811. ISSN 0091-2700

B

Bagnoli, Fabio, Moschioni, Monica, Donati, Claudio, Dimitrovska, Valentina, Ferlenghi, Ilaria, Facciotti, Claudia, Muzzi, Alessandro, Giusti, Fabiola, Emolo, Carla, Sinisi, Antonella, Hilleringmann, Markus, Pansegrau, Werner, Censini, Stefano, Rappuoli, Rino, Covacci, Antonello, Masignani, Vega and Barocchi, Michele A (2008) A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. Journal of Bacteriology, 190 (15). pp. 5480-5492. ISSN 1098-5530

Bardotti, Angela, Averani, Giovanni, Berti, Francesco, Berti, Stefania, Carinci, Valeria, D'Ascenzi, Sandro, Fabbri, Barbara, Giannini, Sara, Giannozzi, Aldo, Magagnoli, Claudia, Proietti, Daniela, Norelli, Francesco, Rappuoli, Rino, Ricci, Stefano and Costantino, Paolo (2008) Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases. Vaccine, 26 (18). pp. 2284-2296. ISSN 0264-410X

Barlaskar, F. M., Spalding, A. C., Heaton, J. H., Kuick, R., Kim, A. C., Thomas, D. G., Giordano, T. J., Ben-Josef, E. and Hammer, G. D. (2008) Preclinical Targeting of the Type I Insulin-Like Growth Factor Receptor in Adrenocortical Carcinoma. Journal of Clinical Endocrinology & Metabolism, 94 (1). pp. 204-212. ISSN 0021-972X

Bartholomaus, I, Schlager, C, Brinkmann, Volker, Wekerle, H and Flugel, A (2008) Intravital 2-photon imaging of encephalitogenic effector cells during fingolimod (FTY720) treatment of experimental autoimmune encephalomyelitis. Multiple Sclerosis, 14 (No 1 Supplement). S30-S31.

Beaud, Marie-Laure, Schmidlin, Eric, Wannier, Thierry, Freund, Patrick, Bloch, Jocelyne, Mir, Anis, Schwab, Martin E and Rouiller, Eric M (2008) Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion. BMC neuroscience, 9 (5). ISSN 1471-2202

Beierle, Elizabeth A, Trujillo, Angelica, Nagaram, Abhilasha, Golubovskaya, Vita M, Cance, William G and Kurenova, Elena V (2008) TAE226 inhibits human neuroblastoma cell survival. Cancer Investigation, 26 (2). pp. 145-151. ISSN 1532-4192

Bell, Leslie, Bickford, Shari, Nguyen, Phong, Wang, Jianling, He, Timothy, Zhang, Bailin, Friche, Yannick, Zimmerlin, Alfred Gilbert, Urban, Laszlo and Bojanic, Dejan (2008) Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 13 (5). pp. 343-353. ISSN 1087-0571

Bender, Andreas, Bojanic, Dejan, Davies, John, Crisman, Thomas, Mikhailov, Dmitri, Scheiber, Josef, Jenkins, Jeremy, Deng, Zhan, Hill, William, Popov, Maxim, Jacoby, Edgar and Glick, Meir (2008) Which aspects of HTS are empirically correlated with downstream success? Current Opinion in Drug Discovery & Development, 11 (3). pp. 327-337. ISSN 1367-6733

Berglund, Ken, Schleich, Wolfram, Wang, Hong, Feng, Guoping, Hall, William C, Kuner, Thomas and Augustine, George J (2008) Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. Brain Cell Biology, 36 (1-4). pp. 101-118. ISSN 1559-7113

Bergstroem, Mats, Monazzam, Azita, Razifar, Pasha, Ide, Susan, Josephsson, Raymond and Langstrom, Bengt (2008) Modeling spheroid growth, PET tracer uptake, and treatment effects of the Hsp90 inhibitor NVP-AUY922. Journal of Nuclear Medicine: official publication, Society of Nuclear Medicine, 49 (7). pp. 1204-1210. ISSN 0161-5505

Bingel-Erlenmeyer, Rouven, Kohler, Rebecca, Kramer, Guenter, Sandikci, Arzu, Antolic, Snjezana, Maier, Timm, Schaffitzel, Christiane, Wiedmann, Brigitte, Bukau, Bernd and Ban, Nenad (2008) A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing. Nature, 452 (7183). pp. 108-111. ISSN 1476-4687

Bingel-Erlenmeyer, Rouven, Kohler, Rebecca, Kramer, Günter, Sandikci, Arzu, Antolić, Snjezana, Maier, Timm, Schaffitzel, Christiane, Wiedmann, Brigitte, Bukau, Bernd and Ban, Nenad (2008) A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing. Nature, 452 (7183). pp. 108-111. ISSN 1476-4687

Biron, Eric, Chatterjee, Jayanta, Ovadia, Oded, Langenegger, Daniel, Brueggen, Josef, Hoyer, Daniel, Schmid, Herbert, Jelinek, Raz, Gilon, Chaim, Hoffman, Amnon and Kessler, Horst (2008) Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. Angewandte Chemie (International ed. in English), 47 (14). pp. 2595-2599. ISSN 1521-3773

Bissiere, Stephanie, Plachta, Nicolas, Hoyer, Daniel, Mcallister, Kevin, Olpe, Hans-Rudolf, Grace, Anthony and Cryan, John F. (2008) The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learning. Biological Psychiatry, 63 (9). pp. 821-831. ISSN 1873-2402

Blancafort, Pilar, Tschan, Mario P, Bergquist, Sharon, Guthy, Daniel Alexander, Brachat, Arndt Holger, Sheeter, Dennis A, Torbett, Bruce E, Erdmann, Dirk and Barbas, Carlos F (2008) Modulation of drug resistance by artificial transcription factors. Molecular Cancer Therapeutics, 7 (3). pp. 688-697. ISSN 1535-7163

Blanchard Rohner, Geraldine, Snape, Matthew D, Kelly, Dominic F, John, Tessa, Morant, Anita, Yu, Ly-Mee, Borkowski, Astrid, Ceddia, Francesca, Borrow, Ray, Siegrist, Claire-Anne and Pollard, Andrew J (2008) The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response. Journal of Immunology (Baltimore, Md. : 1950), 180 (4). pp. 2165-2173. ISSN 0022-1767

Blanchard Rohner, Geraldine, Snape, Matthew D, Kelly, Dominic F, John, Tessa, Morant, Anita, Yu, Ly-Mee, Borkowski, Astrid, Ceddia, Francesca, Borrow, Ray, Siegrist, Claire-Anne and Pollard, Andrew J (2008) The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response. The Journal of immunology : official journal of the American Association of Immunologists, 180 (4). pp. 2165-2173. ISSN 0022-1767

Ble, Francois-Xavier, Cannet, Catherine, Zurbruegg, Stefan, Karmouty Quintana, Harry, Bergmann, Reinhard, Frossard, Nelly, Trifilieff, Alexandre and Beckmann, Nicolau (2008) Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging. Radiology, 248 (3). pp. 834-843. ISSN 1527-1315

Boath, Alistair, Graf, Christine, Lidome, Emilie, Ullrich, Thomas, Nussbaumer, Peter and Bornancin, Frederic (2008) Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin. The Journal of Biological Chemistry, 283 (13). pp. 8517-8526. ISSN 0021-9258

Boehme, J, Suttorp, M, Fischer, R, Bornhaeuser, M and Gasser, Juerg Andreas (2008) Influence of Imatinib on Bone Remodeling in Juvenile Mice. Journal of Bone and Mineral Research, 23. S189.

Bowen, David G, Shoukry, Naglaa H, Grakoui, Arash, Fuller, Michael J, Cawthon, Andrew G, Dong, Christine, Hasselschwert, Dana L, Brasky, Kathleen M, Freeman, Gordon J, Seth, Nilufer P, Wucherpfennig, Kai W, Houghton, Mortimer and Walker, Christopher M (2008) Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. Journal of virology, 82 (10). pp. 5109-5114. ISSN 1098-5514

Breitling, Rainer, Li, Yang, Tesson, Bruno M, Fu, Jingyuan, Wu, Chunlei, Wiltshire, Tim, Gerrits, Alice, Bystrykh, Leonid V, de Haan, Gerald, Su, Andrew and Jansen, Ritsert C (2008) Genetical genomics: spotlight on QTL hotspots. PLoS Genetics, 4 (10). e1000232. ISSN 1553-7404

Broeker, Michael and Kollaritsch, Herwig (2008) After a tick bite in a tick-borne encephalitis virus endemic area: current positions about post-exposure treatment. Vaccine, 26 (7). pp. 863-868. ISSN 0264-410X

Brouwers, J E M, Lambers, F M, Gasser, Juerg Andreas, van Rietbergen, B and Huiskes, R (2008) Bone degeneration and recovery after early and late bisphosphonate treatment of ovariectomized wistar rats assessed by in vivo micro-computed tomography. Calcified Tissue International, 82 (3). pp. 202-211. ISSN 0171-967X

Brouwers, J E M, Lambers, F M, Gasser, Juerg Andreas, van Rietbergen, B and Huiskes, R (2008) Bone degeneration and recovery after early and late bisphosphonate treatment of ovariectomized wistar rats assessed by in vivo micro-computed tomography. Calcified tissue international, 82 (3). pp. 202-211. ISSN 0171-967X

Bruin, Gerardus, Faller, Thomas, Wiegand, Hansjoerg, Schweitzer, Alain, Nick, Hanspeter, Schneider, Josef, Boernsen, K. Olaf and Waldmeier, Felix (2008) Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats. Drug metabolism and disposition: the biological fate of chemicals, 36 (12). pp. 2523-2538. ISSN 1521-009X

Bruin, Gerardus, Faller, Thomas, Wiegand, Hansjoerg, Schweitzer, Alain, Nick, Hanspeter, Schneider, Josef, Boernsen, K. Olaf and Waldmeier, Felix (2008) Pharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and its Iron Complex in Rats. Drug Metabolism and Disposition, 36 (12). pp. 2523-2538. ISSN 1521-009X

Buechau, Amanda S, Schauber, Jürgen, Hultsch, Thomas, Stuetz, Anton and Gallo, Richard L (2008) Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. The Journal of Investigative Dermatology, 128 (11). pp. 2646-2654. ISSN 1523-1747

C

CHANKVETADZE, Bezhan and Francotte, Eric (2008) Preface: Enantioseparations - Dedicated to Wolfgang Lindner. Journal of Chromatography B, 875 (1). p. 1. ISSN 15700232

Calvo, Jennifer, Daniels, Thomas, Wang, Xiaomei, Paul, Angelika, Lin, Jiandie, Spiegelman, Bruce M, Stevenson, Susan and Rangwala, Shamina (2008) Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. Journal of Applied Physiology (Bethesda, Md. : 1985), 104 (5). pp. 1304-1312. ISSN 8750-7587

Campa, Cristiana, Baiutti, Edi and Flamigni, Anna (2008) Capillary electrophoresis of sugar acids. Methods in Molecular Biology (Clifton, N.J.), 384. pp. 307-355. ISSN 1064-3745

Cao, Weihuan, Song, Ho-Juhn, Gangi, Tina, Kelkar, Anju, Antani, Isha, Garza, Dan and Konsolaki, Mary (2008) Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. Genetics, 178 (3). pp. 1457-1471. ISSN 0016-6731

Caputo, Antonella, Brocca-Cofano, Egidio, Castaldello, Arianna, Voltan, Rebecca, Gavioli, Riccardo, Srivastava, Indresh K, Barnett, Susan W, Cafaro, Aurelio and Ensoli, Barbara (2008) Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 DeltaV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin. Vaccine, 26 (9). pp. 1214-1227. ISSN 0264-410X

Chen, Jian, Shi, Xiaoying, Padmanabhan, Ranjani, Wang, Qiong, Wu, Zhidan, Stevenson, Susan, Hild, Marc, Garza, Dan and Li, Hao (2008) Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Genome Research, 18 (1). pp. 123-136. ISSN 1088-9051

Chen, Yuefeng, Wei, Tao, Yan, Lei, Lawrence, Frank, Qian, Hui-Rong, Burkholder, Timothy P, Starling, James J, Yingling, Jonathan M and Shou, Jianyong (2008) Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model. BMC Genomics, 9. p. 264. ISSN 1471-2164

Chene, Patrick (2008) Challenges in design of biochemical assays for the identification of small molecules to target multiple conformations of protein kinases. Drug Discovery Today, 13 (11-12). pp. 522-529. ISSN 1359-6446

Chene, Patrick (2008) PcrA/UvrD/Rep DNA helicases in bacterial genomes. Biochemical Systematics and Ecology, 36 (2). pp. 101-109. ISSN 0305-1978

Chesko, James, Kazzaz, Jina, Ugozzoli, Mildred, Singh, Manmohan, O'Hagan, Derek T, Madden, Claire, Perkins, Mark and Patel, Nikin (2008) Characterization of antigens adsorbed to anionic PLG microparticles by XPS and TOF-SIMS. Journal of Pharmaceutical Sciences, 97 (4). pp. 1443-1453. ISSN 0022-3549

Chiba, Hatsune, Hirasawa, Ryutaro, Kaneda, Masahiro, Amakawa, Yuko, Li, En, Sado, Takashi and Sasaki, Hiroyuki (2008) De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes. Genesis (New York, N.Y. : 2000), 46 (12). pp. 768-774. ISSN 1526-968X

Chung, Yuen-Li, Troy, Helen, Kristeleit, Rebecca, Aherne, Wynne, Jackson, L Elizabeth, Atadja, Peter, Griffiths, John R, Judson, Ian R, Workman, Paul, Leach, Martin O and Beloueche-Babari, Mounia (2008) Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts. Neoplasia (New York, N.Y.), 10 (4). pp. 303-313. ISSN 1476-5586

Coers, Jörn, Bernstein-Hanley, Isaac, Grotsky, David, Parvanova, Iana, Howard, Jonathan C, Taylor, Gregory A, Dietrich, William and Starnbach, Michael N (2008) Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. Journal of Immunology (Baltimore, Md. : 1950), 180 (9). pp. 6237-6245. ISSN 0022-1767

Cooper, P J, Ayre, Gareth, Martin, Carmen, Rizzo, J A, Ponte, E V and Cruz, A A (2008) Geohelminth infections: a review of the role of IgE and assessment of potential risks of anti-IgE treatment. Allergy, 63 (4). pp. 409-417. ISSN 1398-9995

Coote, Kevin, Atherton, Hazel, Young, Alice, Sugar, Rosemary, Burrows, Rachel, Smith, Nicola, Schlaeppi, Jean-Marc, Groot-Kormelink, Paul, Gosling, Martin and Danahay, Henry (2008) The guinea-pig tracheal potential difference as an in vivo model for the study of epithelial sodium channel function in the airways. British Journal of Pharmacology, 155 (7). pp. 1025-1033. ISSN 1476-5381

Crisman, Thomas, Bender, Andreas, Milik, Mariusz, Jenkins, Jeremy, Scheiber, Josef, Sukuru, Sai Chetan, Fejzo, Jasna, Hommel, Ulrich, Davies, John and Glick, Meir (2008) "Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits. Journal of Medicinal Chemistry, 51 (8). pp. 2481-2491. ISSN 0022-2623

Crooks, Emma T, Jiang, Pengfei, Franti, Michael, Wong, Sharon, Zwick, Michael B, Hoxie, James A, Robinson, James E, Moore, Penny L and Binley, James M (2008) Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization. Virology, 377 (2). pp. 364-378. ISSN 0042-6822

Cross, N C P, Daley, G Q, Green, A R, Hughes, T P, Jamieson, C, Manley, Paul W., Mughal, T, Perrotti, D, Radich, J, Skoda, R, Soverini, S, Vainchenker, W, Verstovsek, S, Villeval, J-L and Goldman, J M (2008) BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features. Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 22 (11). pp. 1975-1989. ISSN 1476-5551

Croyle, Michelle, Akeno, Nagako, Knauf, Jeffrey A, Fabbro, Doriano, Chen, Xu, Baumgartner, Jacqueline E, Lane, Heidi and Fagin, James A (2008) RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR. Cancer Research, 68 (11). pp. 4183-4191. ISSN 1538-7445

Cunningham, Matthew, Thomas, Hilary, Christopher, Marks, Margaret, Green, Zhen, Fan and Helmout, Modjtahedi (2008) Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells. International Journal of Oncology, 33 (5). pp. 1107-1113. ISSN 1019-6439

D

D'Eon, Tara, Pierce, Kerry, Roix, Jeffrey, Tyler, Andrew, Chen, Hong and Teixeira, Sandra (2008) The role of adipocyte insulin resistance in the pathogenesis of obesity-related elevations in endocannabinoids. Diabetes, 57 (5). pp. 1262-1268. ISSN 1939-327X

De Bruyne, Elke, Bos, Tomas Jan, Asosingh, Kewal, Vande Broek, Isabelle, Menu, Eline, Van Valckenborgh, Els, Atadja, Peter, Coiteux, Valérie, Leleu, Xavier, Thielemans, Kris, Van Camp, Ben, Vanderkerken, Karin and Van Riet, Ivan (2008) Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 14 (10). pp. 2918-2926. ISSN 1078-0432

Del Vecchio, Mariangela and Balducci, Enrico (2008) Mono ADP-ribosylation inhibitors prevent inflammatory cytokine release in alveolar epithelial cells. Molecular and Cellular Biochemistry, 310 (1-2). pp. 77-83. ISSN 0300-8177

Demuth, Andreas, Aharonowitz, Yair, Bachmann, Till T, Blum-Oehler, Gabriele, Buchrieser, Carmen, Covacci, Antonello, Dobrindt, Ulrich, Emody, Levente, van der Ende, Arie, Ewbank, Jonathan, Fernandez, Luis Angel, Frosch, Matthias, Garcia-Del Portillo, Francisco, Gilmore, Michael S, Glaser, Philippe, Goebel, Werner, Hasnain, Seyed E, Heesemann, Juergen, Islam, Khalid, Korhonen, Timo, Maiden, Martin, Meyer, Thomas F, Montecucco, Cesare, Oswald, Eric, Parkhill, Julian, Pucciarelli, M Graciela, Ron, Eliora, Svanborg, Catharina, Uhlin, Bernt Eric, Wai, Sun Nyunt, Wehland, Juergen and Hacker, Joerg (2008) Pathogenomics: an updated European Research Agenda. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and evolutionary genetics in infectious diseases, 8 (3). pp. 386-393. ISSN 1567-1348

Dodeller, Francis, Gottar-Guillier, Marie, Huesken, Dieter, Iourgenko, Vadim and Cenni, Bruno (2008) The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways. The Journal of Biological Chemistry, 283 (31). pp. 21487-21494. ISSN 0021-9258

Ducray, Pierre, Gauvry, Noelle, Pautrat, Francois, Goebel, Thomas, Fruechtel, Joerg, Desaules, Yves, Schorderet Weber, Sandra, Bouvier, Jacques, Wagner, Beatrix, Froelich, Olivier and Kaminsky, Ronald (2008) Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. Bioorganic & Medicinal Chemistry Letters, 18 (9). pp. 2935-2938. ISSN 1464-3405

Dultz, Elisa, Hildenbeutel, Markus, Martoglio, Bruno, Hochman, Jacob, Dobberstein, Bernhard and Kapp, Katja (2008) The signal peptide of the mouse mammary tumor virus Rem protein is released from the endoplasmic reticulum membrane and accumulates in nucleoli. The Journal of Biological Chemistry, 283 (15). pp. 9966-9976. ISSN 0021-9258

Dunsmore, Colin J, Miller, Keith, Blake, Katy L, Patching, Simon G, Henderson, Peter J F, Garnett, James, Stubbings, William J, Phillips, Simon E V, Palestrant, Deborah, De Los Angeles, Joseph, Leeds, Jennifer, Chopra, Ian and Fishwick, Colin W G (2008) 2-Aminotetralones: novel inhibitors of MurA and MurZ. Bioorganic & Medicinal Chemistry Letters, 18 (5). pp. 1730-1734. ISSN 1464-3405

Dunsmore, Colin J, Miller, Keith, Blake, Katy L, Patching, Simon G, Henderson, Peter J F, Garnett, James A, Stubbings, William J, Phillips, Simon E V, Palestrant, Deborah J, Angeles, Joseph De Los, Leeds, Jennifer A, Chopra, Ian and Fishwick, Colin W G (2008) 2-Aminotetralones: novel inhibitors of MurA and MurZ. Bioorganic & medicinal chemistry letters, 18 (5). pp. 1730-1734. ISSN 1464-3405

Dutt, Amit, Salvesen, Helga B, Chen, Tzu-Hsiu, Ramos, Alex H, Onofrio, Robert C, Hatton, Charlie, Nicoletti, Richard, Winckler, Wendy, Grewal, Rupinder, Hanna, Megan, Wyhs, Nicolas, Ziaugra, Liuda, Richter, Daniel J, Trovik, Jone, Engelsen, Ingeborg B, Stefansson, Ingunn M, Fennell, Tim, Cibulskis, Kristian, Zody, Michael C, Akslen, Lars A, Gabriel, Stacey, Wong, Kwok-Kin, Sellers, William, Meyerson, Matthew and Greulich, Heidi (2008) Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proceedings of the National Academy of Sciences of the United States of America, 105 (25). pp. 8713-8717. ISSN 1091-6490

E

Ece Gamsiz, D, Shah, Lipa, Devalapally, Harikrishna, Amiji, Mansoor M and Carrier, Rebecca L (2008) A model predicting delivery of saquinavir in nanoparticles to human monocyte/macrophage (Mo/Mac) cells. Biotechnology and Bioengineering, 101 (5). pp. 1072-1082. ISSN 1097-0290

Elis, Winfried, Triantafellow, Ellen, Wolters, Natalie M, Sian, Katie R, Caponigro, Giordano, Borawski, Jason, Gaither, Larry, Murphy, Leo, Finan, Peter and Mackeigan, Jeff (2008) Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. Molecular Cancer Research : MCR, 6 (4). pp. 614-623. ISSN 1541-7786

Endres, Thomas and Fendt, Markus (2008) Inactivation of the lateral septum blocks fox odor-induced fear behavior. Neuroreport, 19 (6). pp. 667-670. ISSN 0959-4965

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Gulati, Pawan, Gaspers, Lawrence D, Dann, Stephen G, Joaquin, Manel, Nobukuni, Takahiro, Natt, Francois, Kozma, Sara C, Thomas, Andrew P and Thomas, George (2008) Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metabolism, 7 (5). pp. 456-465. ISSN 1932-7420

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Halin, Cornelia, Fahrngruber, Hermann, Meingassner, Josef, Bold, Guido, Littlewood-Evans, Amanda, Stuetz, Anton and Detmar, Michael (2008) Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. The American Journal of Pathology, 173 (1). pp. 265-277. ISSN 1525-2191

Hannon, Jason and Hoyer, Daniel (2008) Molecular biology of 5-HT receptors. Behavioural Brain Research, 195 (1). pp. 198-213. ISSN 1872-7549

Harris, Helen J, Farquhar, Michelle J, Mee, Christopher J, Davis, Christopher, Reynolds, Gary M, Jennings, Adam, Hu, Ke, Yuan, Fei, Deng, HongKui, Hubscher, Stefan G, Han, Jang H, Balfe, Peter and McKeating, Jane A (2008) CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry. Journal of Virology, 82 (10). pp. 5007-5020. ISSN 1098-5514

He, Yan-Ling, Flannery, Brian, Campestrini, Joelle, Leon Reyes, Selene, Zinny, Miguel A, Ligueros-Saylan, Monica and Jarugula, Venkateswar (2008) Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixed-dose combination tablet in healthy volunteers. Current Medical Research and Opinion, 24 (6). pp. 1703-1709. ISSN 1473-4877

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Heikenwalder, Mathias, Prinz, Marco, Zeller, Nicolas, Lang, Karl S, Junt, Tobias, Rossi, Simona, Tumanov, Alexei, Schmidt, Hauke, Priller, Josef, Flatz, Lukas, Rülicke, Thomas, Macpherson, Andrew J, Holländer, Georg A, Nedospasov, Sergei A and Aguzzi, Adriano (2008) Overexpression of lymphotoxin in T cells induces fulminant thymic involution. The American Journal of Pathology, 172 (6). pp. 1555-1570. ISSN 1525-2191

Hertig, Alexandre, Lefevre, Guillaume, Toumi, Karine, Rondeau, Eric, Capeau, Jacqueline, Uzan, Serge and Berkane, Nadia (2008) Soluble endoglin levels during normotensive and hypertensive pregnancies. European journal of obstetrics, gynecology, and reproductive biology, 140 (1). pp. 138-140. ISSN 0301-2115

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Hoegenauer, Klemens, Billich, Andreas, Pally, Charles, Streiff, Markus, Wagner, Beatrix, Welzenbach, Karl and Nussbaumer, Peter (2008) Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues. ChemMedChem, 3 (7). pp. 1027-1029. ISSN 1860-7187

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Holden, Neil, Squires, Paul E, Kaur, Manminder, Bland, Rosemary, Jones, Carol and Newton, Robert (2008) Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C. Cellular Signalling, 20 (7). pp. 1338-1348. ISSN 0898-6568

Holmes, Joseph, Martin, Daniel, Ramsay, C, Ypma, E and Oster, P (2008) Combined administration of serogroup B meningococcal vaccine and conjugated serogroup C meningococcal vaccine is safe and immunogenic in college students. Epidemiology and Infection, 136 (6). pp. 790-799. ISSN 0950-2688

Huang, Bing S, White, Roselyn A, Ahmad, Monir, Jeng, Arco and Leenen, Frans H H (2008) Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 295 (1). R166-R172. ISSN 0363-6119

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Huss, Jon, Orozco, Camilo, Goodale, James, Wu, Chunlei, Batalov, Sergei, Vickers, Tim, Valafar, Faramarz and Su, Andrew (2008) A gene wiki for community annotation of gene function. PLoS Biology, 6 (7). e175. ISSN 1545-7885

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Kawahara, E, Miyake, T, Matsuura, N, Umemura, I, Masuya, Keiichi, Kanazawa, T, Meyer, T, Mestan, Juergen, Hatakeyama, Shinji and Ohmori, Osamu (2008) Discovery of potent and selective focal adhesion kinase inhibitors. European Journal of Cancer Supplements, 6 (12). p. 43. ISSN 1359-6349

Klionsky, Daniel J, Abeliovich, Hagai, Agostinis, Patrizia, Agrawal, Devendra K, Aliev, Gjumrakch, Askew, David S, Baba, Misuzu, Baehrecke, Eric H, Bahr, Ben A, Ballabio, Andrea, Bamber, Bruce A, Bassham, Diane C, Bergamini, Ettore, Bi, Xiaoning, Biard-Piechaczyk, Martine, Blum, Janice S, Bredesen, Dale E, Brodsky, Jeffrey L, Brumell, John H, Brunk, Ulf T, Bursch, Wilfried, Camougrand, Nadine, Cebollero, Eduardo, Cecconi, Francesco, Chen, Yingyu, Chin, Lih-Shen, Choi, Augustine, Chu, Charleen T, Chung, Jongkyeong, Clarke, Peter G H, Clark, Robert S B, Clarke, Steven G, Clave, Corinne, Cleveland, John L, Codogno, Patrice, Colombo, Maria I, Coto-Montes, Ana, Cregg, James M, Cuervo, Ana Maria, Debnath, Jayanta, Demarchi, Francesca, Dennis, Patrick B, Dennis, Phillip A, Deretic, Vojo, Devenish, Rodney J, Di Sano, Federica, Dice, J Fred, Difiglia, Marian, Dinesh-Kumar, Savithramma, Distelhorst, Clark W, Djavaheri-Mergny, Mojgan, Dorsey, Frank C, Droge, Wulf, Dron, Michel, Dunn, William A, Duszenko, Michael, Eissa, N Tony, Elazar, Zvulun, Esclatine, Audrey, Eskelinen, Eeva-Liisa, Fesus, Laszlo, Finley, Kim D, Fuentes, Jose M, Fueyo, Juan, Fujisaki, Kozo, Galliot, Brigitte, Gao, Fen-Biao, Gewirtz, David A, Gibson, Spencer B, Gohla, Antje, Goldberg, Alfred L, Gonzalez, Ramon, González-Estévez, Cristina, Gorski, Sharon, Gottlieb, Roberta A, Haussinger, Dieter, He, You-Wen, Heidenreich, Kim, Hill, Joseph A, Hoyer-Hansen, Maria, Hu, Xun, Huang, Wei-Pang, Iwasaki, Akiko, Jaattela, Marja, Jackson, William T, Jiang, Xuejun, Jin, Shengkan, Johansen, Terje, Jung, Jae U, Kadowaki, Motoni, Kang, Chanhee, Kelekar, Ameeta, Kessel, David H, Kiel, Jan A K W, Kim, Hong Pyo, Kimchi, Adi, Kinsella, Timothy J, Kiselyov, Kirill, Kitamoto, Katsuhiko, Knecht, Erwin, Komatsu, Masaaki, Kominami, Eiki, Kondo, Seiji, Kovács, Attila L, Kroemer, Guido, Kuan, Chia-Yi, Kumar, Rakesh, Kundu, Mondira, Landry, Jacques, Laporte, Marianne, Le, Weidong, Lei, Huan-Yao, Lenardo, Michael J, Levine, Beth, Lieberman, Andrew, Lim, Kah-Leong, Lin, Fu-Cheng, Liou, Willisa, Liu, Leroy F, Lopez-Berestein, Gabriel, Lopez-Otin, Carlos, Lu, Bo, Macleod, Kay F, Malorni, Walter, Martinet, Wim, Matsuoka, Ken, Mautner, Josef, Meijer, Alfred J, Melendez, Alicia, Michels, Paul, Miotto, Giovanni, Mistiaen, Wilhelm P, Mizushima, Noboru, Mograbi, Baharia, Monastyrska, Iryna, Moore, Michael N, Moreira, Paula I, Moriyasu, Yuji, Motyl, Tomasz, Munz, Christian, Murphy, Leon, Naqvi, Naweed I, Neufeld, Thomas P, Nishino, Ichizo, Nixon, Ralph A, Noda, Takeshi, Nurnberg, Bernd, Ogawa, Michinaga, Oleinick, Nancy L, Olsen, Laura J, Ozpolat, Bulent, Paglin, Shoshana, Palmer, Glen E, Papassideri, Issidora, Parkes, Miles, Perlmutter, David H, Perry, George, Piacentini, Mauro, Pinkas-Kramarski, Ronit, Prescott, Mark, Proikas-Cezanne, Tassula, Raben, Nina, Rami, Abdelhaq, Reggiori, Fulvio, Rohrer, Bärbel, Rubinsztein, David C, Ryan, Kevin M, Sadoshima, Junichi, Sakagami, Hiroshi, Sakai, Yasuyoshi, Sandri, Marco, Sasakawa, Chihiro, Sass, Miklós, Schneider, Claudio, Seglen, Per O, Seleverstov, Oleksandr, Settleman, Jeffrey, Shacka, John J, Shapiro, Irving M, Sibirny, Andrei, Silva-Zacarin, Elaine C M, Simon, Hans-Uwe, Simone, Cristiano, Simonsen, Anne, Smith, Mark A, Spanel-Borowski, Katharina, Srinivas, Vickram, Steeves, Meredith, Stenmark, Harald, Stromhaug, Per E, Subauste, Carlos S, Sugimoto, Seiichiro, Sulzer, David, Suzuki, Toshihiko, Swanson, Michele S, Tabas, Ira, Takeshita, Fumihiko, Talbot, Nicholas J, Talloczy, Zsolt, Tanaka, Keiji, Tanaka, Kozo, Tanida, Isei, Taylor, Graham S, Taylor, J Paul, Terman, Alexei, Tettamanti, Gianluca, Thompson, Craig B, Thumm, Michael, Tolkovsky, Aviva M, Tooze, Sharon A, Truant, Ray, Tumanovska, Lesya V, Uchiyama, Yasuo, Ueno, Takashi, Uzcátegui, Néstor L, van der Klei, Ida, Vaquero, Eva C, Vellai, Tibor, Vogel, Michael W, Wang, Hong-Gang, Webster, Paul, Wiley, John W, Xi, Zhijun, Xiao, Gutian, Yahalom, Joachim, Yang, Jin-Ming, Yap, George, Yin, Xiao-Ming, Yoshimori, Tamotsu, Yu, Li, Yue, Zhenyu, Yuzaki, Michisuke, Zabirnyk, Olga, Zheng, Xiaoxiang, Zhu, Xiongwei and Deter, Russell L (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4 (2). pp. 151-175. ISSN 1554-8635

Klionsky, Daniel J, Abeliovich, Hagai, Agostinis, Patrizia, Agrawal, Devendra K, Aliev, Gjumrakch, Askew, David S, Baba, Misuzu, Baehrecke, Eric H, Bahr, Ben A, Ballabio, Andrea, Bamber, Bruce A, Bassham, Diane C, Bergamini, Ettore, Bi, Xiaoning, Biard-Piechaczyk, Martine, Blum, Janice S, Bredesen, Dale E, Brodsky, Jeffrey L, Brumell, John H, Brunk, Ulf T, Bursch, Wilfried, Camougrand, Nadine, Cebollero, Eduardo, Cecconi, Francesco, Chen, Yingyu, Chin, Lih-Shen, Choi, Augustine, Chu, Charleen T, Chung, Jongkyeong, Clarke, Peter G H, Clark, Robert S B, Clarke, Steven G, Clavé, Corinne, Cleveland, John L, Codogno, Patrice, Colombo, María I, Coto-Montes, Ana, Cregg, James M, Cuervo, Ana Maria, Debnath, Jayanta, Demarchi, Francesca, Dennis, Patrick B, Dennis, Phillip A, Deretic, Vojo, Devenish, Rodney J, Di Sano, Federica, Dice, J Fred, Difiglia, Marian, Dinesh-Kumar, Savithramma, Distelhorst, Clark W, Djavaheri-Mergny, Mojgan, Dorsey, Frank C, Dröge, Wulf, Dron, Michel, Dunn, William A, Duszenko, Michael, Eissa, N Tony, Elazar, Zvulun, Esclatine, Audrey, Eskelinen, Eeva-Liisa, Fésüs, László, Finley, Kim D, Fuentes, José M, Fueyo, Juan, Fujisaki, Kozo, Galliot, Brigitte, Gao, Fen-Biao, Gewirtz, David A, Gibson, Spencer B, Gohla, Antje, Goldberg, Alfred L, Gonzalez, Ramon, González-Estévez, Cristina, Gorski, Sharon, Gottlieb, Roberta A, Häussinger, Dieter, He, You-Wen, Heidenreich, Kim, Hill, Joseph A, Høyer-Hansen, Maria, Hu, Xun, Huang, Wei-Pang, Iwasaki, Akiko, Jäättelä, Marja, Jackson, William T, Jiang, Xuejun, Jin, Shengkan, Johansen, Terje, Jung, Jae U, Kadowaki, Motoni, Kang, Chanhee, Kelekar, Ameeta, Kessel, David H, Kiel, Jan A K W, Kim, Hong Pyo, Kimchi, Adi, Kinsella, Timothy J, Kiselyov, Kirill, Kitamoto, Katsuhiko, Knecht, Erwin, Komatsu, Masaaki, Kominami, Eiki, Kondo, Seiji, Kovács, Attila L, Kroemer, Guido, Kuan, Chia-Yi, Kumar, Rakesh, Kundu, Mondira, Landry, Jacques, Laporte, Marianne, Le, Weidong, Lei, Huan-Yao, Lenardo, Michael J, Levine, Beth, Lieberman, Andrew, Lim, Kah-Leong, Lin, Fu-Cheng, Liou, Willisa, Liu, Leroy F, Lopez-Berestein, Gabriel, López-Otín, Carlos, Lu, Bo, Macleod, Kay F, Malorni, Walter, Martinet, Wim, Matsuoka, Ken, Mautner, Josef, Meijer, Alfred J, Meléndez, Alicia, Michels, Paul, Miotto, Giovanni, Mistiaen, Wilhelm P, Mizushima, Noboru, Mograbi, Baharia, Monastyrska, Iryna, Moore, Michael N, Moreira, Paula I, Moriyasu, Yuji, Motyl, Tomasz, Münz, Christian, Murphy, Leon, Naqvi, Naweed I, Neufeld, Thomas P, Nishino, Ichizo, Nixon, Ralph A, Noda, Takeshi, Nürnberg, Bernd, Ogawa, Michinaga, Oleinick, Nancy L, Olsen, Laura J, Ozpolat, Bulent, Paglin, Shoshana, Palmer, Glen E, Papassideri, Issidora, Parkes, Miles, Perlmutter, David H, Perry, George, Piacentini, Mauro, Pinkas-Kramarski, Ronit, Prescott, Mark, Proikas-Cezanne, Tassula, Raben, Nina, Rami, Abdelhaq, Reggiori, Fulvio, Rohrer, Bärbel, Rubinsztein, David C, Ryan, Kevin M, Sadoshima, Junichi, Sakagami, Hiroshi, Sakai, Yasuyoshi, Sandri, Marco, Sasakawa, Chihiro, Sass, Miklós, Schneider, Claudio, Seglen, Per O, Seleverstov, Oleksandr, Settleman, Jeffrey, Shacka, John J, Shapiro, Irving M, Sibirny, Andrei, Silva-Zacarin, Elaine C M, Simon, Hans-Uwe, Simone, Cristiano, Simonsen, Anne, Smith, Mark A, Spanel-Borowski, Katharina, Srinivas, Vickram, Steeves, Meredith, Stenmark, Harald, Stromhaug, Per E, Subauste, Carlos S, Sugimoto, Seiichiro, Sulzer, David, Suzuki, Toshihiko, Swanson, Michele S, Tabas, Ira, Takeshita, Fumihiko, Talbot, Nicholas J, Tallóczy, Zsolt, Tanaka, Keiji, Tanaka, Kozo, Tanida, Isei, Taylor, Graham S, Taylor, J Paul, Terman, Alexei, Tettamanti, Gianluca, Thompson, Craig B, Thumm, Michael, Tolkovsky, Aviva M, Tooze, Sharon A, Truant, Ray, Tumanovska, Lesya V, Uchiyama, Yasuo, Ueno, Takashi, Uzcátegui, Néstor L, van der Klei, Ida, Vaquero, Eva C, Vellai, Tibor, Vogel, Michael W, Wang, Hong-Gang, Webster, Paul, Wiley, John W, Xi, Zhijun, Xiao, Gutian, Yahalom, Joachim, Yang, Jin-Ming, Yap, George, Yin, Xiao-Ming, Yoshimori, Tamotsu, Yu, Li, Yue, Zhenyu, Yuzaki, Michisuke, Zabirnyk, Olga, Zheng, Xiaoxiang, Zhu, Xiongwei and Deter, Russell L (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4 (2). pp. 151-175. ISSN 1554-8635

Koeberling, Oliver, Seubert, Anja and Granoff, Dan M (2008) Bactericidal antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed factor H-binding protein and genetically attenuated endotoxin. The Journal of Infectious Diseases, 198 (2). pp. 262-270. ISSN 0022-1899

Koehn, Jadranka, Fountoulakis, M and Krapfenbauer, Kurt (2008) Multiple drug resistance associated with function of ABC-transporters in diabetes mellitus: molecular mechanism and clinical relevance. Infectious Disorders Drug Targets, 8 (2). pp. 109-118. ISSN 1871-5265

Koenders, Marije I, Devesa, Isabel, Marijnissen, Renoud J, Abdollahi-Roodsaz, Shahla, Boots, Annemieke M H, Walgreen, Birgitte, Di Padova, Franco E., Nicklin, Martin J H, Joosten, Leo A B and van den Berg, Wim B (2008) Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis and Rheumatism, 58 (11). pp. 3461-3470. ISSN 0004-3591

Komatsu, Noriko, Waki, Michihiko, Sue, Mayumi, Tokuda, Chikashi, Kasaoka, Tatsuhiko, Nakajima, Motowo, Higashi, Nobuaki and Irimura, Tatsuro (2008) Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies. Journal of Immunological Methods, 331 (1-2). pp. 82-93. ISSN 0022-1759

Konig, H, Holtz, M, Modi, H, Manley, Paul W., Holyoake, T L, Forman, S J and Bhatia, R (2008) Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors. Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 22 (4). pp. 748-755. ISSN 1476-5551

Kovarik, John M., Riviere, Gilles-Jacques, Neddermann, Daniel, Maton, Steve, Hunt, Thomas L and Schmouder, Robert (2008) A mechanistic study to assess whether isoproterenol can reverse the negative chronotropic effect of fingolimod. Journal of Clinical Pharmacology, 48 (3). pp. 303-310. ISSN 0091-2700

Kovarik, John M., Riviere, Gilles-Jacques, Neddermann, Daniel, Maton, Steve, Hunt, Tom and Schmouder, Robert (2008) A mechanistic study to assess whether isoproterenol can reverse the negative chronotropic effect of fingolimod. Journal of Clinical Pharmacology, 48 (3). pp. 303-310. ISSN 0091-2700

Kovarik, John M., Slade, Alan, Riviere, Gilles-Jacques, Neddermann, Daniel, Maton, Steve, Hunt, Tom and Schmouder, Robert (2008) The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects. British Journal of Clinical Pharmacology, 66 (2). pp. 199-206. ISSN 1365-2125

Kulasingam, Vathany, Smith, Christopher, Batruch, Ihor, Buckler, Alan, Jeffery, Douglas and Diamandis, Eleftherios P (2008) "Product ion monitoring" assay for prostate-specific antigen in serum using a linear ion-trap. Journal of Proteome Research, 7 (2). pp. 640-647. ISSN 1535-3893

Kulasingam, Vathany, Smith, Christopher R, Batruch, Ihor, Buckler, Alan, Jeffery, Douglas and Diamandis, Eleftherios P (2008) "Product ion monitoring" assay for prostate-specific antigen in serum using a linear ion-trap. Journal of Proteome Research, 7 (2). pp. 640-647. ISSN 1535-3893

Kurabachew, Mekonnen, Lu, Stephen, Krastel, Philipp, Schmitt, Esther, Suresh, Bangalolore, Goh, Anne, Knox, John, Ma, Ngai Ling, Jiricek, Jan, Beer, David, Cynamon, Michael, Petersen, Frank, Dartois, Veronique, Keller, Thomas, Dick, Thomas and Sambandamurthy, Vasan (2008) Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis. The Journal of Antimicrobial Chemotherapy, 62 (4). pp. 713-719. ISSN 1460-2091

Kuramochi-Miyagawa, Satomi, Watanabe, Toshiaki, Gotoh, Kengo, Totoki, Yasushi, Toyoda, Atsushi, Ikawa, Masahito, Asada, Noriko, Kojima, Kanako, Yamaguchi, Yuka, Ijiri, Takashi W, Hata, Kenichiro, Li, En, Matsuda, Yoichi, Kimura, Tohru, Okabe, Masaru, Sakaki, Yoshiyuki, Sasaki, Hiroyuki and Nakano, Toru (2008) DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes & Development, 22 (7). pp. 908-917. ISSN 0890-9369

Kurash, Yuliya, Lei, Hong, Shen, Qiong, Marston, Wendy, Granda, Brian, Fan, Hong, Wall, Daniel, Li, En and Gaudet, Francois (2008) Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Molecular Cell, 29 (3). pp. 392-400. ISSN 1097-2765

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Lang, Sven Arke, Brecht, Isabel, Moser, Christian, Obed, Aiman, Batt, David, Schlitt, Hans Juergen, Geissler, Edward Kenneth and Stoeltzing, Oliver (2008) Dual inhibition of Raf and VEGFR2 reduces growth and vascularization of hepatocellular carcinoma in an experimental model. Langenbeck's Archives of Surgery / Deutsche Gesellschaft für Chirurgie, 393 (3). pp. 333-341. ISSN 1435-2451

Lazaro, Elisabet, Lowe, Philip, Briand, Xavier and Faller, Bernard (2008) New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin. Journal of Medicinal Chemistry, 51 (7). pp. 2009-2017. ISSN 0022-2623

Le Coutre, Philipp, Ottmann, Oliver G, Giles, Francis, Kim, Dong-Wook, Cortes, Jorge, Gattermann, Norbert, Apperley, Jane F, Larson, Richard A, Abruzzese, Elisabetta, O'Brien, Stephen G, Kuliczkowski, Kazimierz, Hochhaus, Andreas, Mahon, Francois-Xavier, Saglio, Giuseppe, Gobbi, Marco, Kwong, Yok-Lam, Baccarani, Michele, Hughes, Timothy, Martinelli, Giovanni, Radich, Jerald P, Zheng, Ming, Shou, Yaping and Kantarjian, Hagop (2008) Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia. Blood, 111 (4). pp. 1834-1839. ISSN 0006-4971

Lee, Seung-Hyo, Prince, Joseph E, Rais, Muhammad, Kheradmand, Farrah, Ballantyne, Christie M, Weitz Schmidt, Gabriele, Smith, C Wayne and Corry, David B (2008) Developmental control of integrin expression regulates Th2 effector homing. Journal of Immunology (Baltimore, Md. : 1950), 180 (7). pp. 4656-4667. ISSN 0022-1767

Lefevre, Gilbert, Pommier, Françoise, Sedek, Greg, Allison, Mark, Huang, Hsun-Lun Aaron, Kiese, Beate, Ho, Yu-Yun and Appel Dingemanse, Silke (2008) Pharmacokinetics and bioavailability of the novel rivastigmine transdermal patch versus rivastigmine oral solution in healthy elderly subjects. Journal of clinical pharmacology, 48 (2). pp. 246-252. ISSN 0091-2700

Lefevre, Gilbert, Sedek, Greg, Jhee, S S, Leibowitz, M T, Huang, H-La, Enz, Albert, Maton, Steve, Ereshefsky, L, Pommier, Francoise, Schmidli, Heinz and Appel Dingemanse, Silke (2008) Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients. Clinical pharmacology and therapeutics, 83 (1). pp. 106-114. ISSN 1532-6535

Li, Jing, Knee, Deborah, Wang, Youzhen, Zhang, Qingxiu, Johnson, Jennifer, Cheng, Jane, He, Helen, Miller, Christine, Li, Zhifang, Kowal, Colleen, Eckman Iii, Joseph, Tang, Betty, Yuan, Jing, Chen, Liqing, Deveraux, Quinn, Nasoff, Marc and Stover, David (2008) LBY135, a Novel Anti-DR5 Agonistic Antibody Induces Tumor Cell–Specific Cytotoxic Activity in Human Colon Tumor Cell Lines and Xenografts. Drug Development Research, 69 (2). pp. 69-82. ISSN 0272-4391

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Li, Li-Fu, Liao, Shuen-Kuei, Huang, Chung-Chi, Hung, Ming-Jui and Quinn, Deborah (2008) Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment. Critical care (London, England), 12 (4). R103. ISSN 1466-609X

Lietha, Daniel and Eck, Michael J (2008) Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PloS one, 3 (11). e3800. ISSN 1932-6203

Lim, Siew Pheng, Wen, Daying, Yap, Thai Leong, Yan, Chung Ka, Lescar, Julien and Vasudevan, Subhash (2008) A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses. Antiviral research, 80 (3). pp. 360-369. ISSN 1872-9096

Lisztwan, Joanna, Pornon, Astrid, Chen, Bin, Chen, Shiuan and Evans, Dean Brent (2008) The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer. Breast Cancer Research, 10 (4). R56. ISSN 1465-5411

Liu, Bo, Chang, Jonathan, Gordon, William, Isbell, John, Zhou, Yingyao and Tuntland, Tove (2008) Snapshot PK: a rapid rodent in vivo preclinical screening approach. Drug Discovery Today, 13 (7-8). pp. 360-367. ISSN 1359-6446

Liu, Xin, Wang, Ling, Zhao, Kehao, Thompson, Paul R, Hwang, Yousang, Marmorstein, Ronen and Cole, Philip A (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature, 451 (7180). pp. 846-850. ISSN 1476-4687

Liu, Andrew, Tran, Hien, Zhang, Eric, Priest, Aaron A, Welsh, David K and Kay, Steve A (2008) Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genetics, 4 (2). e1000023. ISSN 1553-7404

Lu, Qiang and An, W Frank (2008) Impact of novel screening technologies on ion channel drug discovery. Combinatorial Chemistry & High Throughput Screening, 11 (3). pp. 185-194. ISSN 1386-2073

Lu, Xiangdong, Kovalev, Grigoriy I, Chang, Hua, Kallin, Eric, Knudsen, Geoffrey, Xia, Li, Mishra, Nilamadhab, Ruiz, Phillip, Li, En, Su, Lishan and Zhang, Yi (2008) Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. The Journal of Biological Chemistry, 283 (20). pp. 13825-13833. ISSN 0021-9258

Lu, Hong, Rateri, Debra L, Feldman, David, Jr, Richard J Charnigo, Fukamizu, Akiyoshi, Ishida, Junji, Oesterling, Elizabeth G, Cassis, Lisa A and Daugherty, Alan (2008) Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. The Journal of Clinical Investigation, 118 (3). pp. 984-993. ISSN 0021-9738

Luo, Dahai, Xu, Ting, Watson, Randall, Scherer-Becker, Daniela, Sampath, Aruna, Jahnke, Wolfgang, Yeong, Sui Sum, Wang, Chern Hoe, Lim, Siew Pheng, Strongin, Alex, Vasudevan, Subhash and Lescar, Julien (2008) Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. The EMBO Journal, 27 (23). pp. 3209-3219. ISSN 1460-2075

Luqman, Mohammad, Klabunde, Sha, Lin, Karen, Georgakis, Georgios V., Cherukuri, Anu, Holash, Jocelyn, Goldbeck, Cheryl, Xu, Xiaomei, Kadel, Edward E., Lee, Sang Hoon, Aukerman, Sharon, Jallal, Bahija, Aziz, Natasha, Weng, Wen-Kai, Wierda, William, O'Brien, Susan and Younes, Anas (2008) The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood, 112 (3). pp. 711-720. ISSN 1528-0020

Lysaght, Michael J, Jaklenec, Ana and Deweerd, Elizabeth (2008) Great expectations: private sector activity in tissue engineering, regenerative medicine, and stem cell therapeutics. Tissue engineering. Part A, 14 (2). pp. 305-315. ISSN 1937-3341

Lyukmanova, Ekaterina N, Shenkarev, Zakhar O, Paramonov, Alexander S, Sobol, Alexander G, Ovchinnikova, Tatiana V, Chupin, Vladimir V, Kirpichnikov, Mikhail P, Blommers, Marcel J.J. and Arseniev, Alexander S (2008) Lipid-protein nanoscale bilayers: a versatile medium for NMR investigations of membrane proteins and membrane-active peptides. Journal of the American Chemical Society, 130 (7). pp. 2140-2141. ISSN 1520-5126

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Mac Sweeney, Aengus, Gil Parrado, Shirley, Vinzenz, Daniela, Bernardi, Anna, Hein, Andreas, Bodendorf, Ursula, Erbel, Paulus, Logel, Claude and Gerhartz, Bernd (2008) Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases. Journal of Molecular Biology, 384 (1). pp. 228-239. ISSN 1089-8638

Maira, Sauveur-Michel, Stauffer, Frederic, Brueggen, Josef, Furet, Pascal, Schnell, Christian, Fritsch, Christine, Brachmann, Saskia, Chene, Patrick, De Pover, Alain, Schoemaker, Kevin, Fabbro, Doriano, Gabriel, Daniela, Simonen, Marjo, Murphy, Leon, Finan, Peter, Sellers, William and Garcia-Echeverria, Carlos (2008) Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Molecular Cancer Therapeutics, 7 (7). pp. 1851-1863. ISSN 1535-7163

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Sechaud, Romain, Robeva, Anna, Belleli, Rossella and Balez, Sebastien (2008) Absence of an effect of a single-dose deferasirox on the steady-state pharmacokinetics of digoxin. International journal of clinical pharmacology and therapeutics, 46 (10). pp. 519-526. ISSN 0946-1965

Sechaud, Romain, Robeva, Anna, Belleli, Rossella and Balez, Sebastien (2008) Absolute oral bioavailability and disposition of deferasirox in healthy human subjects. Journal of clinical pharmacology, 48 (8). pp. 919-925. ISSN 0091-2700

Senechal, Yann, Kelly, Peter and Dev, Kumlesh K. (2008) Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning. Behavioural Brain Research, 186 (1). pp. 126-132. ISSN 0166-4328

Senechal, Yann, Prut, Laetitia, Kelly, Peter, Staufenbiel, Matthias, Natt, Francois, Hoyer, Daniel, Wiessner, Christoph and Dev, Kumlesh K. (2008) Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA. Brain Research, 1243. pp. 124-133. ISSN 1872-6240

Serluca-Aegerter, Fabrizio (2008) Development of the proepicardial organ in the zebrafish. Developmental Biology, 315 (1). pp. 18-27. ISSN 1095-564X

Serra, Alessandro, Nuti, Sandra, Tavarini, Simona, Sammicheli, Chiara, Rosa, Domenico, Saletti, Giulietta, Soldaini, Elisabetta, Abrignani, Sergio and Wack, Andreas (2008) Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function. Journal of Immunology (Baltimore, Md. : 1950), 181 (1). pp. 174-185. ISSN 0022-1767

Serra, Violeta, Markman, Ben, Scaltriti, Maurizio, Eichhorn, Pieter J A, Valero, Vanesa, Guzman, Marta, Botero, Maria Luisa, Llonch, Elisabeth, Atzori, Francesco, Di Cosimo, Serena, Maira, Michel, Garcia-Echeverria, Carlos, Parra, Josep Lluis, Arribas, Joaquin and Baselga, José (2008) NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Research, 68 (19). pp. 8022-8030. ISSN 1538-7445

Seubert, Anja, Monaci, Elisabetta, Pizza, Mariagrazia, O'Hagan, Derek T and Wack, Andreas (2008) The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. Journal of Immunology (Baltimore, Md. : 1950), 180 (8). pp. 5402-5412. ISSN 0022-1767

Shah, J Jina, Maloney, Susan A, Liu, Yecai, Flagg, Elaine W, Johnston, Stephanie P, Young, Suzanna A, Weston, Robert, Merritt, Samuel, Wilkins, Patricia P, Keane, Vincent, Calderon, Jaime, Sharp, Donald J, Causer, Louise, Maguire, James H and Cetron, Martin S (2008) Evaluation of the impact of overseas pre-departure treatment for infection with intestinal parasites among Montagnard refugees migrating from Cambodia to North Carolina. The American Journal of Tropical Medicine and Hygiene, 78 (5). pp. 754-759. ISSN 1476-1645

Shao, Wenlin, Growney, Joseph, O'Connor, Gregory, Feng, Yun, Scher, H, Yao, Yao, Fawell, Stephen and Atadja, Peter (2008) Potent anticancer activity of panobinostat (LBH589) in models of hormone-refractory prostate cancer (HRPC): targeting the androgen receptor. European Journal of Cancer Supplements, 6 (12). p. 52. ISSN 1359-6349

Shen, Xiaohua, Liu, Yingchun, Hsu, Yu-Jung, Fujiwara, Yuko, Kim, Jonghwan, Mao, Xiaohong, Yuan, Guo-Cheng and Orkin, Stuart H (2008) EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Molecular cell, 32 (4). pp. 491-502. ISSN 1097-4164

Shi, Leming, Jones, Wendell, Jensen, Roderick, Harris, Stephen, Perkins, Roger, Goodsaid, Federico, Guo, Lei, Croner, Lisa, Boysen, Cecilie, Fang, Hong, Qian, Feng, Amur, Shashi, Bao, Wenjun, Barbacioru, Catalin, Bertholet, Vincent, Cao, Xiaoxi, Chu, Tzu-Ming, Collins, Patrick, Fan, Xiao-hui, Frueh, Felix, Fuscoe, James, Han, jing, Guo, Xu, Herman, Damir, Hong, Huixiao, Kawasaki, Ernest, Li, Quan-Zhen, Luo, Yuling, Ma, Yunqing, Mei, Nan, Peterson, Ron and Puri, Raj (2008) The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics, 9 (Suppl ). S10. ISSN 1471-2105

Shibui, Takeo, Higo, Yukari, Tsutsui, Takeo W, Uchida, Minoru, Oshimura, Mitsuo, Barrett, James and Tsutsui, Takeki (2008) Changes in expression of imprinted genes following treatment of human cancer cell lines with non-mutagenic or mutagenic carcinogens. International Journal of Oncology, 33 (2). pp. 351-360. ISSN 1019-6439

Shua-Haim, Joshua, Smith, Juanita, Picard, Franck, Sedek, Greg, Athalye, Sandeep, Pommier, Françoise and Lefevre, Gilbert (2008) Steady-state pharmacokinetics of rivastigmine in patients with mild to moderate Alzheimer's disease not affected by co-administration of memantine: an open-label, crossover, single-centre study. Clinical drug investigation, 28 (6). pp. 361-374. ISSN 1173-2563

Siegl, Stephanie, Flor, Peter Josef and Fendt, Markus (2008) Amygdaloid metabotropic glutamate receptor subtype 7 is involved in the acquisition of conditioned fear. Neuroreport, 19 (11). pp. 1147-1150. ISSN 0959-4965

Siehler Wagner, Sandra (2008) Cell-based assays in GPCR drug discovery. Biotechnology Journal, 3 (4). pp. 471-483. ISSN 1860-7314

Siehler Wagner, Sandra, Nunn, Caroline, Hannon, Jason, Feuerbach, Dominik and Hoyer, Daniel (2008) Pharmacological profile of somatostatin and cortistatin receptors. Molecular and Cellular Endocrinology, 286 (1-2). pp. 26-34. ISSN 0303-7207

Simonen, Marjo, Ibig-Rehm, Yvonne, Hofmann, Gabriele, Zimmermann, Johann, Albrecht, Genevieve, Magnier, Maxime, Heidinger-Millot, Valerie and Gabriel, Daniela (2008) High-content assay to study protein prenylation. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 13 (6). pp. 456-467. ISSN 1087-0571

Skaanderup, Philip and Jensen, Thomas (2008) Synthesis of the macrocyclic core of (-)-pladienolide B. Organic Letters, 10 (13). pp. 2821-2824. ISSN 1523-7060

Song, Pingfang, Sekhon, Harmanjatinder S, Fu, Xiao Wen, Maier, Michelle, Jia, Yibing, Duan, Jie, Proskosil, Becky J, Gravett, Courtney, Lindstrom, Jon, Mark, Gregory P, Saha, Saurabh and Spindel, Eliot R (2008) Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer Research, 68 (12). pp. 4693-4700. ISSN 1538-7445

Soon, E, Holmes, Alan, Toshner, M, Treacy, C, Suntharalingam, J, Sheares, K, Budd, David, Pepke-Zaba, J and Morrell, N W (2008) Circulating Cytoking Profiles in Patients with Chronic Thromboembolic Pulmonary Hypertension and Response to Pulmonary Endarterectomy. Thorax, 63 (Supplement 7). A43. ISSN 0040-6376

Srivastava, Indresh K, Kan, Elaine, Sun, Yide, Sharma, Victoria A, Cisto, Jimna, Burke, Brian, Lian, Ying, Hilt, Susan, Biron, Zohar, Hartog, Karin, Stamatatos, Leonidas, Diaz-Avalos, Ruben, Cheng, R Holland, Ulmer, Jeffrey and Barnett, Susan W (2008) Comparative evaluation of trimeric envelope glycoproteins derived from subtype C and B HIV-1 R5 isolates. Virology, 372 (2). pp. 273-290. ISSN 0042-6822

Stansfeld, Phillip J, Grottesi, Alessandro, Sands, Zara A, Sansom, Mark S P, Gedeck, Peter, Gosling, Martin, Cox, Brian, Stanfield, Peter R, Mitcheson, John S and Sutcliffe, Michael J (2008) Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations. Biochemistry, 47 (28). pp. 7414-7422. ISSN 1520-4995

Stauffer, Frederic, Maira, Sauveur-Michel, Furet, Pascal and Garcia-Echeverria, Carlos (2008) Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 1027-1030. ISSN 1464-3405

Stauffer, Frederic, Maira, Sauveur-Michel, Furet, Pascal and García-Echeverría, Carlos (2008) Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 1027-3100. ISSN 1464-3405

Stickings, Paul, Peyre, Marisa, Coombes, Laura, Muller, Sylviane, Rappuoli, Rino, Del Giudice, Giuseppe, Partidos, Charalambos D and Sesardic, Dorothea (2008) Transcutaneous immunization with cross-reacting material CRM(197) of diphtheria toxin boosts functional antibody levels in mice primed parenterally with adsorbed diphtheria toxoid vaccine. Infection and Immunity, 76 (4). pp. 1766-1773. ISSN 1098-5522

Stringer, Rowan, Nicklin, Paul and Houston, J B (2008) Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance. Xenobiotica, 38 (10). pp. 1313-1329. ISSN 1366-5928

Sullivan, David and Martin, Eric (2008) Exploiting structure-activity relationships in docking. Journal of Chemical Information and Modeling, 48 (4). pp. 817-830. ISSN 1549-9596

Sullivan-Brown, Jessica, Schottenfeld, Jodi, Okabe, Noriko, Hostetter, Christine L, Serluca-Aegerter, Fabrizio, Thiberge, Stephan Y and Burdine, Rebecca D (2008) Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants. Developmental Biology, 314 (2). pp. 261-275. ISSN 1095-564X

Sumby, Paul, Zhang, Shizhen, Whitney, Adeline R, Falugi, Fabiana, Grandi, Guido, Graviss, Edward A, Deleo, Frank R and Musser, James M (2008) A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response. Infection and immunity, 76 (3). pp. 978-985. ISSN 1098-5522

Séchaud, R, Dutreix, C, Balez, S, Pommier, F, Dumortier, T, Morisson, S and Brun, E (2008) Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks. International journal of clinical pharmacology and therapeutics, 46 (2). pp. 102-108. ISSN 0946-1965

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Takahashi, Nozomi, de Jager, Victor C L, Glueck, Anton, Letzkus, Martin, Hartmann, Nicole, Staedtler, Frank, Ribeiro-Dias, Fatima, Heuvelmans-Jacobs, Marleen, van den Berg, Wim B and Joosten, Leo A B (2008) The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40. Arthritis and Rheumatism, 58 (11). pp. 3471-3484. ISSN 0004-3591

Tanner, Lukas, Schreiber, Mark, Low, Jenny, Ong, Adrian, Tolfvenstam, Thomas, Lai, Yee Ling, Ng, Lee Ching, Leo, Yee Sin, Thi Puong, Le, Vasudevan, Subhash, Simmons, Cameron P, Hibberd, Martin L and Ooi, Eng Eong (2008) Decision tree algorithms predict the diagnosis and outcome of dengue Fever in the early phase of illness. PLoS Neglected Tropical Diseases, 2 (3). e196. ISSN 1935-2735

Telford, John L (2008) Bacterial genome variability and its impact on vaccine design. Cell host & Microbe, 3 (6). pp. 408-416. ISSN 1934-6069

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Teno, Naoki, Irie, Osamu, Miyake, Takahiro, Gohda, Keigo, Horiuchi, Miyuki, Tada, Sachiyo, Nonomura, Kazuhiko, Kometani, Motohiko, Iwasaki, Genji and Betschart, Claudia (2008) New chemotypes for cathepsin K inhibitors. Bioorganic & Medicinal Chemistry Letters, 18 (8). pp. 2599-2603. ISSN 1464-3405

Thoma, Gebhard, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Cooke, Nigel Graham, Streiff, Markus and Zerwes, Hans-Guenter (2008) Reduced cardiac side-effect potential by introduction of polar groups: discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo. Bioorganic & Medicinal Chemistry letters, 18 (6). pp. 2000-2005. ISSN 1464-3405

Thoma, Gebhard, Streiff, Markus, Kovarik, Jiri, Glickman, Fraser, Wagner, Beatrix, Beerli, Christian and Zerwes, Hans-Guenter (2008) Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. Journal of Medicinal Chemistry, 51 (24). pp. 7915-7920. ISSN 1520-4804

Thomas, Matthew and Owen, Charles (2008) Inhibition of PI-3 kinase for treating respiratory disease: good idea or bad idea? Current Opinion in Pharmacology, 8 (3). pp. 267-274. ISSN 1471-4892

Tiao, Jim Yu-Hsiang, Bradaia, Amyaouch, Biermann, Barbara, Kaupmann, Klemens, Metz, Michaela, Haller, Corinne, Rolink, Antonius G, Pless, Elin, Barlow, Paul N, Gassmann, Martin and Bettler, Bernhard (2008) The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function. The Journal of Biological Chemistry, 283 (45). pp. 31005-31011. ISSN 0021-9258

Titz, Alexander, Patton, John, Alker, Andre M, Porro, Michele, Schwardt, Oliver Roland, Hennig, Michael, Francotte, Eric, Magnani, John L. and Ernst, Beat (2008) Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists? Bioorganic & Medicinal Chemistry, 16 (2). pp. 1046-1056. ISSN 1464-3391

Titz, Alexander, Patton, John, Alker, André M, Porro, Michele, Schwardt, Oliver, Hennig, Michael, Francotte, Eric, Magnani, John and Ernst, Beat (2008) Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists? Bioorganic & Medicinal Chemistry, 16 (2). pp. 1046-1056. ISSN 1464-3391

Troxler, Thomas J., Enz, Albert, Hoyer, Daniel, Langenegger, Daniel, Neumann, Peter, Pfaeffli, Paul, Schoeffter, Philippe and Hurth, Konstanze (2008) Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor. Bioorganic & Medicinal Chemistry Letters, 18 (3). pp. 979-982. ISSN 1464-3405

U

Umareddy, Indira, Tang, Kin Fai, Vasudevan, Subhash, Devi, Shamala, Hibberd, Martin L and Gu, Feng (2008) Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines. The Journal of General Virology, 89 (Pt 12). pp. 3052-3062. ISSN 0022-1317

V

Vajpai, Navratna, Strauss, Andre, Fendrich, Gabriele, Jacob, Sandra, Manley, Paul W., Grzesiek, Stephan and Jahnke, Wolfgang (2008) Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib. The Journal of biological chemistry, 283 (26). pp. 18292-18302. ISSN 0021-9258

Van Dijck, Annemie, Vloeberghs, Ellen, Van Dam, Debby, Staufenbiel, Matthias and De Deyn, Peter Paul (2008) Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory. Behavioural Brain Research, 190 (1). pp. 147-151. ISSN 0166-4328

Van Eis, Maurice, BICKELHAUPT, M, VANLOON, S, LUTZ, M, SPEK, A, DEWOLF, W, VAN ZEIST, W and BICKELHAUPT, F (2008) Tricarbonylchromium complexes of [5]- and [6]metacyclophane: an experimental and theoretical study. Tetrahedron, 64 (51). pp. 11641-11646. ISSN 0040-4020

Vanoni, Omar, Paganetti, Paolo and Molinari, Maurizio (2008) Consequences of individual N-glycan deletions and of proteasomal inhibition on secretion of active BACE. Molecular Biology of the Cell, 19 (10). pp. 4086-4098. ISSN 1939-4586

Verheul, Henk M W, Salumbides, Brenda, Van Erp, Karen, Hammers, Hans, Qian, David Z, Sanni, Tolib, Atadja, Peter and Pili, Roberto (2008) Combination strategy targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase inhibitors. Clinical Cancer Research: an official journal of the American Association for Cancer Research, 14 (11). pp. 3589-3597. ISSN 1078-0432

Vlkolinsky, Roman, Krucker, Thomas, Nelson, Gregory A and Obenaus, Andre (2008) (56)Fe-particle radiation reduces neuronal output and attenuates lipopolysaccharide-induced inhibition of long-term potentiation in the mouse hippocampus. Radiation Research, 169 (5). pp. 523-530. ISSN 0033-7587

van Meeteren, Laurens A, Brinkmann, Volker, Saulnier-Blache, Jean Sebastien, Lynch, Kevin and Moolenaar, Wouter H (2008) Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Letters, 266 (2). pp. 203-208. ISSN 0304-3835

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Wang, Biao, Goode, Jason, Best, Jennifer, Meltzer, Jodi, Schilman, Pablo E, Chen, Jian, Garza, Dan, Thomas, John B and Montminy, Marc (2008) The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metabolism, 7 (5). pp. 434-444. ISSN 1932-7420

Wang, Zhi Gang, Fukazawa, Takuya, Nishikawa, Toshio, Watanabe, Nobuyuki, Sakurama, Kazufumi, Motoki, Takayuki, Takaoka, Munenori, Hatakeyama, Shinji, Omori, Osamu, Ohara, Toshiaki, Tanabe, Shunsuke, Fujiwara, Yasuhiro, Shirakawa, Yasuhiro, Yamatsuji, Tomoki, Tanaka, Noriaki and Naomoto, Yoshio (2008) TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. Oncology Reports, 20 (6). pp. 1473-1477. ISSN 1021-335X

Wang, Ling, Montano, Monty, Rarick, Matt and Sebastiani, Paola (2008) Conditional clustering of temporal expression profiles. BMC Bioinformatics, 9. p. 147. ISSN 1471-2105

Wannier-Morino, P, Schmidlin, E, Freund, P, Belhaj-Saif, A, Bloch, J, Mir, Anis Khusro, Schwab, M E, Rouiller, E M and Wannier, T (2008) Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: effects of an antibody treatment neutralizing Nogo-A. Brain Research, 1217. pp. 96-109. ISSN 0006-8993

Watanabe, Nobuyuki, Takaoka, Munenori, Sakurama, Kazufumi, Tomono, Yasuko, Hatakeyama, Shinji, Ohmori, Osamu, Motoki, Takayuki, Shirakawa, Yasuhiro, Yamatsuji, Tomoki, Haisa, Minoru, Matsuoka, Junji, Beer, David G, Nagatsuka, Hitoshi, Tanaka, Noriaki and Naomoto, Yoshio (2008) Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo. Clinical Cancer Research : an official journal of the American Association for Cancer Research, 14 (14). pp. 4631-4639. ISSN 1078-0432

Wee, Susan, Lengauer, Christoph and Wiederschain, Dmitri (2008) Class IA phosphoinositide 3-kinase isoforms and human tumorigenesis: implications for cancer drug discovery and development. Current Opinion in Oncology, 20 (1). pp. 77-82. ISSN 1040-8746

Wee, Susan, Wiederschain, Dmitri, Maira, Sauveur-Michel, Loo, Alice, Miller, Christine, De Beaumont, Rosalie, Stegmeier, Frank, Yao, Yung-Mae and Lengauer, Christoph (2008) PTEN-deficient cancers depend on PIK3CB. Proceedings of the National Academy of Sciences of the United States of America, 105 (35). pp. 13057-13062. ISSN 0027-8424

Weiss, Andreas, Klein, Corinna, Woodman, Ben, Sathasivam, Kirupa, Bibel, Miriam, Regulier, Etienne, Bates, Gillian and Paganetti, Paolo (2008) Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease. Journal of Neurochemistry, 104 (3). pp. 846-858. ISSN 1471-4159

Weiss, Markus, Fresneau, Marcel, Moenius, Thomas, Stuetz, Anton and Billich, Andreas (2008) Binding of pimecrolimus and tacrolimus to skin and plasma proteins: implications for systemic exposure after topical application. Drug metabolism and disposition: the biological fate of chemicals, 36 (9). pp. 1812-1818. ISSN 1521-009X

Weiss, Markus, Pfaar, Ulrike, Schweitzer, Alain, Wiegand, Hansjörg, Skerjanec, Andrej and Schran, Horst (2008) Biodistribution and plasma protein binding of zoledronic acid. Drug metabolism and disposition: the biological fate of chemicals, 36 (10). pp. 2043-2049. ISSN 1521-009X

Wendorf, Janet, Chesko, James, Kazzaz, Jina, Ugozzoli, Mildred, Vajdy, Michael, O'Hagan, Derek and Singh, Manmohan (2008) A comparison of anionic nanoparticles and microparticles as vaccine delivery systems. Human Vaccines, 4 (1). pp. 44-49. ISSN 1554-8619

Wetzel, S, Renner, S, Nören-Müller, A, Schuffenhauer, Ansgar, Ertl, Peter and Waldmann, Herbert (2008) BIOS: Similarity-based design of natural product derived compound collections. Chemistry Central Journal, 2 (Suppl ). P48. ISSN 1752-153X

Wu, Chunlei, Delano, David, Mitro, Nico, Su, Stephen, Janes, Jeff, Mcclurg, Phillip, Batalov, Sergei, Welch, Genevieve, Zhang, Jie, Orth, Anthony, Walker, John, Glynne, Richard, Cooke, Michael, Takahashi, Joseph, Shimomura, Kazuhiro, Kohsaka, Akira, Bass, Joseph, Saez, Enrique, Wiltshire, Timothy and Su, Andrew (2008) Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genetics, 4 (5). e1000070. ISSN 1553-7404

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Yang, Lin, Clarke, Michelle J, Carlson, Brett L, Mladek, Ann C, Schroeder, Mark A, Decker, Paul, Wu, Wenting, Kitange, Gaspar J, Grogan, Patrick T, Goble, Jennie M, Uhm, Joon, Galanis, Evanthia, Giannini, Caterina, Lane, Heidi, James, C David and Sarkaria, Jann N (2008) PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel. Clinical Cancer Research: an official journal of the American Association for Cancer Research, 14 (12). pp. 3993-4001. ISSN 1078-0432

Yang, Lin, Clarke, Michelle J, Carlson, Brett L, Mladek, Ann C, Schroeder, Markus, Decker, Paul, Wu, Wenting, Kitange, Gaspar J, Grogan, Patrick T, Goble, Jennie M, Uhm, Joon, Galanis, Evanthia, Giannini, Caterina, Lane, Heidi, James, David and Sarkaria, Jann N (2008) PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel. Clinical Cancer Research : an official journal of the American Association for Cancer Research, 14 (12). pp. 3993-4001. ISSN 1078-0432

Yang, Yonghua, Rao, Rehka, Shen, Jie, Tang, Yun, Fiskus, Warren, Nechtman, John, Atadja, Peter and Bhalla, Kapil (2008) Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Research, 68 (12). pp. 4833-4842. ISSN 1538-7445

You, Taek, Lee, Mi, Jenkins, Jeremy, Alzate, Oscar and Dean, Donald (2008) Blocking binding of Bacillus thuringiensis Cry1Aa to Bombyx mori cadherin receptor results in only a minor reduction of toxicity. BMC Biochemistry, 9 (1). p. 3. ISSN 1471-2091

Young, Daniel, Bender, Andreas, Hoyt, Jonathan, McWhinnie, Elizabeth, Chirn, Gung-Wei, Tao, Charles, Tallarico, John, Labow, Mark, Jenkins, Jeremy, Mitchison, Timothy and Feng, Yan (2008) Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nature Chemical Biology, 4 (1). pp. 59-68. ISSN 1552-4469

Yu, Chunrong, Friday, Bret B, Yang, Lin, Atadja, Peter, Wigle, Dennis, Sarkaria, Jann and Adjei, Alex A (2008) Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro-Oncology, 10 (3). pp. 309-319. ISSN 1522-8517

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Zeggini, Eleftheria, Scott, Laura J, Saxena, Richa, Voight, Benjamin F, Marchini, Jonathan L, Hu, Tianle, de Bakker, Paul I W, Abecasis, Gonçalo R, Almgren, Peter, Andersen, Gitte, Ardlie, Kristin, Boström, Kristina Bengtsson, Bergman, Richard N, Bonnycastle, Lori L, Borch-Johnsen, Knut, Burtt, Noël P, Chen, Hong, Chines, Peter S, Daly, Mark J, Deodhar, Parimal, Ding, Chia-Jen, Doney, Alex S F, Duren, William L, Elliott, Katherine S, Erdos, Michael R, Frayling, Timothy M, Freathy, Rachel M, Gianniny, Lauren, Grallert, Harald, Grarup, Niels, Groves, Christopher J, Guiducci, Candace, Hansen, Torben, Herder, Christian, Hitman, Graham A, Hughes, Thomas, Isomaa, Bo, Jackson, Anne U, Jorgensen, Torben, Kong, Augustine, Kubalanza, Kari, Kuruvilla, Finny G, Kuusisto, Johanna, Langenberg, Claudia, Lango, Hana, Lauritzen, Torsten, Li, Yun, Lindgren, Cecilia M, Lyssenko, Valeriya, Marvelle, Amanda F, Meisinger, Christa, Midthjell, Kristian, Mohlke, Karen L, Morken, Mario A, Morris, Andrew D, Narisu, Narisu, Nilsson, Peter, Owen, Katharine R, Palmer, Colin N A, Payne, Felicity, Perry, John R B, Pettersen, Elin, Platou, Carl, Prokopenko, Inga, Qi, Lu, Qin, Li, Rayner, Nigel W, Rees, Matthew, Roix, Jeffrey, Sandbaek, Anelli, Shields, Beverley, Sjögren, Marketa, Steinthorsdottir, Valgerdur, Stringham, Heather M, Swift, Amy J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Timpson, Nicholas J, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Walker, Mark, Watanabe, Richard M, Weedon, Michael N, Willer, Cristen J, Illig, Thomas, Hveem, Kristian, Hu, Frank B, Laakso, Markku, Stefansson, Kari, Pedersen, Oluf, Wareham, Nicholas J, Barroso, Inês, Hattersley, Andrew T, Collins, Francis S, Groop, Leif, McCarthy, Mark I, Boehnke, Michael and Altshuler, David (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nature Genetics, 40 (5). pp. 638-645. ISSN 1546-1718

Zhang, Min, Fu, Wuxia, Prabhu, Sharmila, Moore, James C, Ko, Je, Kim, Jung Woo, Druker, Brian J, Trapp, Valerie, Fruehauf, John, Gram, Hermann, Fan, Hung Y and Ong, S Tiong (2008) Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance. Molecular and Cellular Biology, 28 (20). pp. 6496-6509. ISSN 1098-5549

Zhou, Liping, Skolnik, Suzanne, Yang, Linhong and Wang, Jianling (2008) Solubility-driven successful drug discovery. Solubility-driven successful drug discovery, Apr/Ma. pp. 20-22.

Zhou, Liping and Wang, Jianling (2008) Physio-chemical Characterization in Drug Discovery. Physio-chemical Characterization in Drug Discovery, 4. pp. 12-18.

Ziermann, Rainer and Sanchez-Guerrero, Sergio Arturo (2008) PROCLEIX West Nile virus assay based on transcription-mediated amplification. Expert Review of Molecular Diagnostics, 8 (3). pp. 239-245. ISSN 1744-8352

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