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Number of items: 191.

A

Adrian, Francisco and Ding, Qiang and Sim, Taebo and Velentza, Anastasia and Sloan, Christine and Liu, Yi and Zhang, Guobao and Hur, Wooyoung and Ding, Sheng and Manley, Paul W. and Mestan, Juergen and Fabbro, Doriano and Gray, Nathanael (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nature Chemical Biology, 2 (2). pp. 95-102. ISSN 1552-4450

Alper, Phillip and Liu, Hong and Chatterjee, Arnab and Nguyen, Khanhlinh and Tully, David and Tumanut, Christine and Li, Jun and Harris, Jennifer and Tuntland, Tove and Chang, Jonathan and Gordon, Perry and Hollenbeck, Thomas and Karanewsky, Donald (2006) Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl. Bioorganic & Medicinal Chemistry Letters, 16 (6). pp. 1486-1490. ISSN 0960-894X

Altmann, Eva and Aichholz, Reiner and Betschart, Claudia and Buhl, Thomas and Green, Jonathan and Lattmann, Rene and Missbach, Martin (2006) Dipeptide nitrile inhibitors of cathepsin K. Bioorganic & Medicinal Chemistry Letters, 16 (9). pp. 2549-2554. ISSN 0960-894X

Ari, Nader and Westling, Lucas and Isbell, John (2006) Cherry-picking in an orchard: unattended LC/MS analysis from an autosampler with >32,000 samples online. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 11 (3). pp. 318-322. ISSN 1087-0571

B

Bakhtiarova, Adel and Taslimi, Paul and Elliman, Stephen and Kosinski, Penelope and Hubbard, Brian and Kavana, Michael and Kemp, Daniel (2006) Resveratrol inhibits firefly luciferase. Biochemical and Biophysical Research Communications, 351 (2). pp. 481-484. ISSN 0006-291X

Battram, Cliff and Charlton, Steven and Cuenoud, Bernard and Dowling, Mark and Fairhurst, Robin and Farr, David Colin and Fozard, John R. and Leighton-Davies, Juliet and Lewis, Christine A and McEvoy, Lorraine and Turner, Robert and Trifilieff, Alexandre (2006) In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action. The Journal of Pharmacology and Experimental Therapeutics, 317 (2). pp. 762-770. ISSN 0022-3565

Bavandi, Assadollah and Fahrngruber, Hermann and Aschauer, Heinrich and Hartmann, Boris and Meingassner, Josef and Kalthoff, Frank (2006) Pimecrolimus and tacrolimus differ in their inhibition of lymphocyte activation during the sensitization phase of contact hypersensitivity. Journal of Dermatological Science, 43 (2). pp. 117-126. ISSN 0923-1811

Beckmann, Nicolau and Cannet, Catherine and Zurbruegg, Stefan and Haberthuer, Reto and Li, Jianping and Pally, Charles and Bruns, Christian (2006) Macrophage infiltration detected at MR imaging in rat kidney allografts: early marker of chronic rejection? Radiology, 240 (3). pp. 717-724. ISSN 0033-8419

Bender, Andreas and Jenkins, Jeremy and Glick, Meir and Deng, Zhan and Nettles Jr., James and Davies, John (2006) "Bayes affinity fingerprints" improve retrieval rates in virtual screening and define orthogonal bioactivity space: when are multitarget drugs a feasible concept? Journal of Chemical Information and Modeling, 46 (6). pp. 2445-2456. ISSN 1549-9596

Benoit, Roger and Wilhelm, Ramon and Scherer-Becker, Daniela and Ostermeier, Christian (2006) An improved method for fast, robust, and seamless integration of DNA fragments into multiple plasmids. Protein Expression and Purification, 45 (1). pp. 66-71. ISSN 1046-5928

Benson, John and Chen, Ying-Nan and Cornell-Kennon, Susan and Dorsch, Marion and Kim, Sunkyu and Leszczyniecka, Magdalena and Sellers, William and Lengauer, Christoph (2006) Validating cancer drug targets. Nature, 441 (7092). pp. 451-456. ISSN 1476-4687

Berger, Cedric and Hiestand, Peter and Kindler-Baumann, Diana Rita and Rudin, Markus and Rausch, Martin (2006) Analysis of lesion development during acute inflammation and remission in a rat model of experimental autoimmune encephalomyelitis by visualization of macrophage infiltration, demyelination and blood-brain barrier damage. NMR in Biomedicine, 19 (1). pp. 101-107. ISSN 0952-3480

Berger, Cedric and Rausch, Martin and Schmidt, Philipp and Rudin, Markus (2006) Feasibility and limits of magnetically labeling primary cultured rat T cells with ferumoxides coupled with commonly used transfection agents. Molecular Imaging : official journal of the Society for Molecular Imaging, 5 (2). pp. 93-104. ISSN 1535-3508

Bertrand, Eric and Fritsch, Christine and Diether, Sigrid and Lambrou, George N. and Mueller, Dieter and Schaeffel, Frank and Schindler, Patrick and Schmid, Katharina and Van Oostrum, Jan and Voshol, Johannes (2006) Identification of apolipoprotein A-I as a "STOP" signal for myopia. Molecular & Cellular Proteomics : MCP, 5 (11). pp. 2158-2166. ISSN 1535-9476

Biedermann, Tilo and Lametschwandtner, Guenther and Tangemann, Kirsten and Kund, Juliana and Hinteregger, Sonja and Carballido-Perrig, Nicole and Rot, Antal and Schwaerzler, Christoph and Carballido, Jose (2006) IL-12 instructs skin homing of human Th2 cells. Journal of Immunology (Baltimore, Md. : 1950), 177 (6). pp. 3763-3770. ISSN 0022-1767

Bissiere, Stephanie and Mcallister, Kevin and Olpe, Hans-Rudolf and Cryan, John F. (2006) The rostral anterior cingulate cortex modulates depression but not anxiety-related behaviour in the rat. Behavioural Brain Research, 175 (1). pp. 195-199. ISSN 0166-4328

Boisvert, Christine and Morgan, Peter (2006) The Study Support Associate: an alternative to the traditional animal care position. Lab Animal, 35 (1). pp. 34-38. ISSN 0093-7355

Bold, Guido and Wojeik, Severine and Caravatti, Giorgio and Lindauer, Renate and Stierlin, Claire and Gertsch, Jurg and Wartmann, Markus and Altmann, Karl-Heinz (2006) Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom? ChemMedChem, 1 (1). pp. 37-40. ISSN 1860-7179

Bonenfant, Debora and Coulot, Michele and Towbin, Harry and Schindler, Patrick and Van Oostrum, Jan (2006) Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. Molecular & Cellular Proteomics : MCP, 5 (3). pp. 541-552. ISSN 1535-9476

Bonneau, Olivier and Wyss, Daniel and Ferretti, Stephane Raymond and Blaydon, Clare and Stevenson, Christopher and Trifilieff, Alexandre (2006) Effect of adenosine A2A receptor activation in murine models of respiratory disorders. American Journal of Physiology. Lung cellular and molecular physiology, 290 (5). L1036-L1043. ISSN 1040-0605

Bordone, Laura and Motta, Maria Carla and Picard, Frederic and Robinson, Ashley and Jhala, Ulupi and Apfeld, Javier and McDonagh, Thomas and Lemieux, Madeleine and McBurney, Michael and Szilvasi, Akos and Easlon, Erin and Lin, Su-Ju and Guarente, Leonard (2006) Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biology, 4 (2). e31. ISSN 1545-7885

Brinkmann, Volker and Baumruker, Thomas (2006) Pulmonary and vascular pharmacology of sphingosine 1-phosphate. Current Opinion in Pharmacology, 6 (3). pp. 244-250. ISSN 1471-4892

Brown, Nathan and Jacoby, Edgar (2006) On scaffolds and hopping in medicinal chemistry. Mini Reviews in Medicinal Chemistry, 6 (11). pp. 1217-1229. ISSN 1389-5575

Brown, Nathan and Lewis, Richard (2006) Exploiting QSAR methods in lead optimization. Current Opinion in Drug Discovery & Development, 9 (4). pp. 419-424. ISSN 1367-6733

Brown, Nathan and Zehender, Hartmut and Azzaoui, Kamal and Schuffenhauer, Ansgar and Mayr, Lorenz and Jacoby, Edgar (2006) A chemoinformatics analysis of hit lists obtained from high-throughput affinity-selection screening. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 11 (2). pp. 123-130. ISSN 1087-0571

Bruin, Gerardus and Waldmeier, Felix and Boernsen, K. Olaf and Pfaar, Ulrike and Gross, Gerhard and Zollinger, Markus (2006) A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: validation and applications. Journal of chromatography. A, 1133 (1-2). pp. 184-194. ISSN 0021-9673

Bruin, Gerardus and Waldmeier, Felix and Boernsen, K. Olaf and Pfaar, Ulrike and Gross, Gerhard and Zollinger, Markus (2006) A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: validation and applications. Journal of chromatography. A, 1133 (1-2). pp. 184-194. ISSN 0021-9673

C

Carballido, Jose and Carballido-Perrig, Nicole and Schwaerzler, Christoph and Lametschwandtner, Guenther (2006) Regulation of human T helper cell differentiation by antigen-presenting cells: the bee venom phospholipase A2 model. Chemical Immunology and Allergy, 91. pp. 147-158. ISSN 1660-2242

Cebe, Regis and Geiser, Martin (2006) Rapid and easy thermodynamic optimization of the 5'-end of mRNA dramatically increases the level of wild type protein expression in Escherichia coli. Protein Expression and Purification, 45 (2). pp. 374-380. ISSN 1046-5928

Cebe, Regis and Geiser, Martin (2006) Monitoring protein expression levels in E. coli using a high throughput approach. Microbial Cell Factories, 5 (Suppl ). P78. ISSN 1475-2859

Chen, Hong (2006) Cellular inflammatory responses: novel insights for obesity and insulin resistance. Pharmacological research : the official journal of the Italian Pharmacological Society, 53 (6). pp. 469-477. ISSN 1043-6618

Chen, T and Li, E (2006) Establishment and maintenance of DNA methylation patterns in mammals. Current Topics in Microbiology and Immunology, 301. pp. 179-201. ISSN 0070-217X

Chene, Patrick (2006) Drugs targeting protein-protein interactions. ChemMedChem, 1 (4). pp. 400-411. ISSN 1860-7179

Cho, Charles and Koo, Seung-Hoi and Wang, Yan and Callaway, Scott and Hedrick, Susan and Mak, Pui Ying and Orth, Anthony and Peters, Eric and Saez, Enrique and Montminy, Marc and Schultz, Peter and Chanda, Sumit (2006) Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metabolism, 3 (5). pp. 367-378. ISSN 1550-4131

Choi, Ha-Soon and Wang, Zhicheng and Richmond, Wendy and He, Xiaohui and Yang, Kunyong and Jiang, Tao and Karanewsky, Donald and Gu, Xiang-Ju and Zhou, Vicki and Liu, Yi and Che, Jianwei and Lee, Christian and Caldwell, Jeremy and Kanazawa, Takanori and Umemura, Ichiro and Matsuura, Naoko and Ohmori, Osamu and Honda, Toshiyuki and Gray, Nathanael and He, Yun (2006) Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2. Bioorganic & Medicinal Chemistry Letters, 16 (10). pp. 2689-2692. ISSN 0960-894X

Choi, Ha-Soon and Wang, Zhicheng and Richmond, Wendy and He, Xiaohui and Yang, Kunyong and Jiang, Tao and Sim, Taebo and Karanewsky, Donald and Gu, Xiang-Ju and Zhou, Vicki and Liu, Yi and Ohmori, Osamu and Caldwell, Jeremy and Gray, Nathanael and He, Yun (2006) Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (8). pp. 2173-2176. ISSN 0960-894X

Collins, Cynthia S and Hong, Jiyong and Sapinoso, Lisa and Zhou, Yingyao and Liu, Zheng and Micklash, Kenneth and Schultz, Peter G and Hampton, Garret M (2006) A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proceedings of the National Academy of Sciences of the United States of America, 103 (10). pp. 3775-3780. ISSN 0027-8424

Coppola, Gary and Damon Ii, Robert and Eskesen, J and France, Dennis and Paterniti, James (2006) Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 113-117. ISSN 0960-894X

Coupez, Bernard and Lewis, Richard (2006) Docking and scoring--theoretically easy, practically impossible? Current Medicinal Chemistry, 13 (25). pp. 2995-3003. ISSN 0929-8673

Culshaw, Andrew and Bevan, Stuart and Christiansen, Martin and Copp, Prafula and Davis, Andrew and Davis, Clare and Dyson, Alex and Dziadulewicz, Ed and Edwards, Lee and Eggelte, Hendrikus and Fox, Alyson and Gentry, Clive and Groarke, Alex and Hallett, Allan and Hart, Terry and Hughes, Glyn and Knights, Sally and Kotsonis, Peter and Lee, Wai and Lyothier, Isabelle and Mcbryde, Andrew and Mcintyre, Peter and Paloumbis, George and Panesar, Moh and Patel, Sadhana and Seiler, Max Peter and Yaqoob, Mo and Zimmermann, Kaspar (2006) Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain. Journal of Medicinal Chemistry, 49 (2). pp. 471-474. ISSN 0022-2623

D

Danahay, Henry and Atherton, Hazel and Jackson, Alan and Kreindler, James L and Poll, Chris and Bridges, Robert J (2006) Membrane capacitance and conductance changes parallel mucin secretion in the human airway epithelium. American Journal of Physiology. Lung cellular and molecular physiology, 290 (3). L558-L569. ISSN 1040-0605

Davies, John and Glick, Meir and Jenkins, Jeremy (2006) Streamlining lead discovery by aligning in silico and high-throughput screening. Current Opinion in Chemical Biology, 10 (4). pp. 343-351. ISSN 1367-5931

Dev, Kumlesh K (2006) Using RNAi in the clinic. IDrugs : the investigational drugs journal, 9 (4). pp. 279-282. ISSN 1369-7056

Dev, Kumlesh K. and Chatterjee, Sandipan and Osinde, Maribel and Stauffer, Daniela and Morgan, Hannah and Kobialko, Monika and Dengler, Uwe and Rueeger, Heinrich and Martoglio, Bruno and Rovelli, Giorgio (2006) Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals. European Journal of Pharmacology, 540 (1-3). pp. 10-17. ISSN 0014-2999

Dev, Kumlesh K. and Henley, Jeremy M. (2006) The schizophrenic faces of PICK1. Trends in Pharmacological Sciences, 27 (11). pp. 574-579. ISSN 0165-6147

Dowling, Mark and Charlton, Steven (2006) Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor. British Journal of Pharmacology, 148 (7). pp. 927-937. ISSN 0007-1188

Dubaele, Sandy and Jahnke, Wolfgang and Schoepfer, Joseph and Fuchs, Jean and Chene, Patrick (2006) Inhibition of DNA helicases with DNA-competitive inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (4). pp. 923-927. ISSN 0960-894X

Dubaele, Sandy and Lourdel, Claude and Chene, Patrick (2006) Study of the ATP-binding site of helicase IV from Escherichia coli. Biochemical and Biophysical Research Communications, 341 (3). pp. 828-836. ISSN 0006-291X

Dubois, Celine and Hengerer, Bastian and Mattes, Henri (2006) Identification of a potent agonist of the orphan nuclear receptor Nurr1. ChemMedChem, 1 (9). pp. 955-958. ISSN 1860-7179

Dupuis, Delphine and Relkovic, Dinko and Lhuillier, Loic and Mosbacher, Johannes and Kaupmann, Klemens (2006) Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit. Molecular Pharmacology, 70 (6). pp. 2027-2036. ISSN 0026-895X

E

Elliman, Stephen and Wu, Isaac and Kemp, Daniel (2006) Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. The Journal of Biological Chemistry, 281 (1). pp. 16-19. ISSN 0021-9258

Ellis, David and Kuhen, Kelli and Anaclerio, Beth and Wu, Baogen and Wolff, Karen and Yin, Hong and Bursulaya, Badry and Caldwell, Jeremy and Karanewsky, Donald and He, Yun (2006) Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4246-4251. ISSN 0960-894X

Engstrom, Par and Suzuki, Harukazu and Ninomiya, Noriko and Akalin, Altuna and Sessa, Luca and Lavorgna, Giovanni and Brozzi, Alessandro and Luzi, Lucilla and Tan, Sin Lam and Yang, Liang and Kunarso, Galih and Ng, Edwin Lian-Chong and Batalov, Sergei and Wahlestedt, Claes and Kai, Chikatoshi and Kawai, Jun and Carninci, Piero and Hayashizaki, Yoshihide and Wells, Christine and Bajic, Vladimir and Orlando, Valerio and Reid, James and Lenhard, Boris and Lipovich, Leonard (2006) Complex Loci in human and mouse genomes. PLoS Genetics, 2 (4). e47. ISSN 1553-7404

Epple, Robert and Azimioara, Mihai and Russo, Ross and Bursulaya, Badry and Tian, Shin-Shay and Gerken, Andrea and Iskandar, Maya (2006) 1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists. Bioorganic & Medicinal Chemistry Letters, 16 (11). pp. 2969-2973. ISSN 0960-894X

Epple, Robert and Azimioara, Mihai and Russo, Ross and Xie, Yongping and Wang, Xing and Cow, Christopher and Wityak, John and Karanewsky, Donald and Bursulaya, Badry and Kreusch, Andreas and Tuntland, Tove and Gerken, Andrea and Iskandar, Maya and Saez, Enrique and Seidel, Martin and Tian, Shin-Shay (2006) 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2. Bioorganic & Medicinal Chemistry Letters, 16 (21). pp. 5488-5492. ISSN 0960-894X

Epple, Robert and Russo, Ross and Azimioara, Mihai and Cow, Christopher and Xie, Yongping and Wang, Xing and Wityak, John and Karanewsky, Donald and Gerken, Andrea and Iskandar, Maya and Saez, Enrique and Seidel, Martin and Tian, Shin-Shay (2006) 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4376-4380. ISSN 0960-894X

Erbel, Paulus and Schiering, Nikolaus and D'Arcy, Allan and Renatus, Martin and Kroemer, Markus and Lim, Siew Pheng and Yin, Zheng and Keller, Thomas and Vasudevan, Subhash and Hommel, Ulrich (2006) Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nature Structural & Molecular Biology, 13 (4). pp. 372-373. ISSN 1545-9993

Ertl, Peter and Jelfs, Stephen and Mühlbacher, Jörg and Schuffenhauer, Ansgar and Selzer, Paul (2006) Quest for the rings. In silico exploration of ring universe to identify novel bioactive heteroaromatic scaffolds. Journal of Medicinal Chemistry, 49 (15). pp. 4568-4573. ISSN 0022-2623

Ettmayer, Peter and Baumruker, Thomas and Guerini, Danilo and Mechtcheriakova, Diana and Nussbaumer, Peter and Streiff, Markus and Billich, Andreas (2006) NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 84-87. ISSN 0960-894X

Ettmayer, Peter and Mayer, Peter and Kalthoff, Frank and Neruda, Wolfgang and Harrer, Nathalie and Hartmann, Gabriella and Epstein, Michelle M and Brinkmann, Volker and Heusser, Christoph and Woisetschlaeger, Maximilian (2006) A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation. American Journal of Respiratory and Critical Care Medicine, 173 (6). pp. 599-606. ISSN 1073-449X

F

Faller, Bernard and Wang, Jianling and Zimmerlin, Alfred Gilbert and Bell, Leslie and Hamon, Jacques and Whitebread, Steven and Azzaoui, Kamal and Bojanic, Dejan and Urban, Laszlo (2006) High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis. Expert Opinion on Drug Metabolism & Toxicology, 2 (6). pp. 823-833. ISSN 1742-5255

Feng, Wan Yong (2006) Metabolism of green tea catechins: an overview. Current Drug Metabolism, 7 (7). pp. 755-809. ISSN 1389-2002

Ferrara, Philippe and Curioni, A and Vangrevelinghe, Eric and Meyer, Thomas and Mordasini, T and Andreoni, W and Acklin, Pierre and Jacoby, Edgar (2006) New scoring functions for virtual screening from molecular dynamics simulations with a quantum-refined force-field (QRFF-MD). Application to cyclin-dependent kinase 2. Journal of Chemical Information and Modeling, 46 (1). pp. 254-263. ISSN 1549-9596

Fink, Joshua and Gu, Feng and Vasudevan, Subhash (2006) Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever. Reviews in Medical Virology, 16 (4). pp. 263-275. ISSN 1052-9276

Furet, Pascal and Bold, Guido and Meyer, Thomas and Roesel, Johannes and Guagnano, Vito (2006) Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. Journal of Medicinal Chemistry, 49 (15). pp. 4451-4454. ISSN 0022-2623

G

Galanello, Renzo and Piga, Antonio and Forni, Gian Luca and Bertrand, Yves and Foschini, Maria Loreta and Bordone, Elena and Leoni, Giovanbattista and Lavagetto, Antonella and Zappu, Antonietta and Longo, Filomena and Maseruka, Henry and Hewson, Nicola and Sechaud, Romain and Belleli, Rossella and Alberti, Daniele (2006) Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with beta-thalassemia major. Haematologica, 91 (10). pp. 1343-1351. ISSN 1592-8721

Galanello, Renzo and Piga, Antonio and Forni, Gian Luca and Bertrand, Yves and Foschini, Maria Loreta and Bordone, Elena and Leoni, Giovanbattista and Lavagetto, Antonella and Zappu, Antonietta and Longo, Filomena and Maseruka, Henry and Hewson, Nicola and Sechaud, Romain and Belleli, Rossella and Alberti, Daniele Maria (2006) Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with beta-thalassemia major. Haematologica, 91 (10). pp. 1343-1351. ISSN 1592-8721

Ganguly, Milan and Brown, Nathan and Schuffenhauer, Ansgar and Ertl, Peter and Gillet, Valerie J. and Greenidge, Paulette (2006) Introducing the consensus modeling concept in genetic algorithms: application to interpretable discriminant analysis. Journal of Chemical Information and Modeling, 46 (5). pp. 2110-2124. ISSN 1549-9596

Garcia-Echeverria, Carlos (2006) Medicinal chemistry approaches to target the kinase activity of IGF-1R. IDrugs : the investigational drugs journal, 9 (6). pp. 415-419. ISSN 1369-7056

Gasser, Juerg Andreas (2006) Coupled or uncoupled remodeling, is that the question? Journal of Musculoskeletal & Neuronal Interactions, 6 (2). pp. 128-133. ISSN 1108-7161

Gasser, Juerg Andreas (2006) The relative merits of anabolics versus anti-resorptive compounds: where our targets should be, and whether we are addressing them. Current Opinion in Pharmacology, 6 (3). pp. 313-318. ISSN 1471-4892

Gasser, Juerg Andreas and Green, Jonathan and Shen, Victor and Ingold, Peter and Rebmann, Andrea and Bhatnagar, Ajay and Evans, Dean Brent (2006) A single intravenous administration of zoledronic acid prevents the bone loss and mechanical compromise induced by aromatase inhibition in rats. Bone, 39 (4). pp. 787-795. ISSN 8756-3282

Gedeck, Peter and Rohde, Bernhard and Bartels, Christian (2006) QSAR--how good is it in practice? Comparison of descriptor sets on an unbiased cross section of corporate data sets. Journal of Chemical Information and Modeling, 46 (5). pp. 1924-1936. ISSN 1549-9596

Geierstanger, Bernhard and Saviranta, Petri and Brinker, Achim (2006) Antibody microarrays using resonance light-scattering particles for detection. Methods in Molecular Biology (Clifton, N.J.), 328. pp. 31-50. ISSN 1064-3745

Gerwin, Nicole and Hops, Caroline and Lucke, Andrea (2006) Intraarticular drug delivery in osteoarthritis. Advanced Drug Delivery Reviews, 58 (2). pp. 226-242. ISSN 0169-409X

Gjoni, Tina and Desrayaud, Sandrine and Imobersteg, Stefan and Urwyler, Stephan (2006) The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivo. Journal of Neurochemistry, 96 (5). pp. 1416-1422. ISSN 0022-3042

Glick, Meir and Jenkins, Jeremy and Nettles Jr., James and Hitchings, Hamilton and Davies, John (2006) Enrichment of high-throughput screening data with increasing levels of noise using support vector machines, recursive partitioning, and laplacian-modified naive bayesian classifiers. Journal of Chemical Information and Modeling, 46 (1). pp. 193-200. ISSN 1549-9596

Gromada, Jesper and Hughes, Thomas (2006) Ringing the dinner bell for insulin: muscarinic M3 receptor activity in the control of pancreatic beta cell function. Cell Metabolism, 3 (6). pp. 390-392. ISSN 1550-4131

Guintu, Christina and Kwok, Michael and Hanlon, James and Spalding, Tracy and Wolff, Karen and Yin, Hong and Kuhen, Kelli and Sasher, Kimberly and Calvin, Paul and Jiang, Shumei and Zhou, Yingyao and Isbell, John (2006) Just-in-time purification: an effective solution for cherry-picking and purifying active compounds from large legacy libraries. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 11 (8). pp. 933-939. ISSN 1087-0571

H

Harant, Hanna and Lettner, Nicole and Hofer, Lotte and Oberhauser, Berndt and De Vries, Jan Egbert and Lindley, Ivan-J.D. (2006) The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon. The Journal of Biological Chemistry, 281 (41). pp. 30492-30502. ISSN 0021-9258

Hasan, Samiul and Daugelat, Sabine and Rao, P S Srinivasa and Schreiber, Mark (2006) Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Computational Biology, 2 (6). e61. ISSN 1553-7358

Hasan, Samiul and Schreiber, Mark (2006) Recovering motifs from biased genomes: application of signal correction. Nucleic Acids Research, 34 (18). pp. 5124-5132. ISSN 1362-4962

Hofmann, Matthias and Brinkmann, Volker and Zerwes, Hans-Guenter (2006) FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs. International Immunopharmacology, 6 (13-14). pp. 1902-1910. ISSN 1567-5769

Hofmann, Matthias and Zerwes, Hans-Guenter (2006) Identification of organ-specific T cell populations by analysis of multiparameter flow cytometry data using DNA-chip analysis software. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 69 (6). pp. 533-540. ISSN 1552-4922

Hoover-Plow, Jane and Shchurin, Aleksey and Hart, Erika and Sha, Jingfeng and Hill, Annie and Singer, Jonathan and Nadeau, Joseph (2006) Genetic background determines response to hemostasis and thrombosis. BMC Blood Disorders, 6 (1). p. 6. ISSN 1471-2326

Hoyer, Daniel and Thakker, Deepak and Natt, Francois and Maier, Rainer and Huesken, Dieter and Mueller, Matthias and Flor, Peter Josef and Van Der Putten, P. Herman and Schmutz, Markus and Bilbe, Graeme and Cryan, John F. (2006) Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders. Journal of Receptor and Signal Transduction Research, 26 (5-6). pp. 527-547. ISSN 1079-9893

Huang, Yina Hsing and Barouch-Bentov, Rina and Herman, Ann and Walker, John and Sauer, Karsten (2006) Integrating traditional and postgenomic approaches to investigate lymphocyte development and function. Advances in Experimental Medicine and Biology, 584. pp. 245-276. ISSN 0065-2598

Hummel, Manfred and Yonan, Nizar and Ross, Heather and Miller, Leslie W and Sechaud, Romain and Balez, Sebastien and Koelle, Ernst Ulrich and Gerosa, Gino (2006) Pharmacokinetics and variability of mycophenolic acid from enteric-coated mycophenolate sodium compared with mycophenolate mofetil in de novo heart transplant recipients. Clinical transplantation, 21 (1). pp. 18-23. ISSN 0902-0063

J

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W

Waelchli, Rudolf and Bollbuck, Birgit and Bruns, Christian and Buhl, Thomas and Eder, Joerg and Feifel, Roland and Hersperger, Rene and Janser, Philipp and Revesz, Laszlo and Zerwes, Hans-Guenter and Schlapbach, Achim (2006) Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 108-112. ISSN 0960-894X

Walshmartin, Emily and Sabeti, Pardis and Hutcheson, Holli B and Fry, Ben and Schaffner, Stephen F and de Bakker, Paul I W and Varilly, Patrick and Palma, Alejandro and Roy, Jessica and Cooper, Richard and Winkler, Cheryl and Zeng, Yi and de The, Guy and Lander, Eric S and O'Brien, Stephen and Altshuler, David (2006) Searching for signals of evolutionary selection in 168 genes related to immune function. Human Genetics, 119 (1-2). pp. 92-102. ISSN 0340-6717

Wang, Shaowen and Yan-Neale, Yan and Cai, Richard and Alimov, Irina and Cohen, Dalia (2006) Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824. Cell Cycle, 5 (15). pp. 1662-1668. ISSN 1551-4005

Wang, Zhiwei and Wu, Baogen and Kuhen, Kelli and Bursulaya, Badry and Nguyen, Truc and Nguyen, Deborah and He, Yun (2006) Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4174-4177. ISSN 0960-894X

Wardle, Fiona and Odom, Duncan and Bell, George and Yuan, Bingbing and Danford, Timothy and Wiellette, Elizabeth and Herbolsheimer, Elizabeth and Sive, Hazel and Young, Richard and Smith, James (2006) Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome Biology, 7 (8). R71. ISSN 1465-6906

Watters, Amy A and Jones, Ronald N and Leeds, Jennifer A and Denys, Gerald and Sader, Helio S and Fritsche, Thomas R (2006) Antimicrobial activity of a novel peptide deformylase inhibitor, LBM415, tested against respiratory tract and cutaneous infection pathogens: a global surveillance report (2003-2004). The Journal of antimicrobial chemotherapy, 57 (5). pp. 914-923. ISSN 0305-7453

Weidensteiner, Claudia and Rausch, Martin and Mcsheehy, Paul M.J. and Allegrini, Peter Roland (2006) Quantitative dynamic contrast-enhanced MRI in tumor-bearing rats and mice with inversion recovery TrueFISP and two contrast agents at 4.7 T. Journal of Magnetic Resonance Imaging: JMRI, 24 (3). pp. 646-656. ISSN 1053-1807

Weiler, Jan and Hunziker, Juerg and Hall, Jeffrey (2006) Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Therapy, 13 (6). pp. 496-502. ISSN 0969-7128

Weiss, Markus and Fresneau, Marcel and Camenisch, Gian P. and Kretz, Olivier and Gross, Gerhard (2006) In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex Fe-[ICL670]2 for rat, marmoset, rabbit, mouse, dog, and human. Drug metabolism and disposition: the biological fate of chemicals, 34 (6). pp. 971-975. ISSN 0090-9556

Wu, Baogen and Kuhen, Kelli and Ngoc Nguyen, Truc and Ellis, David and Anaclerio, Beth and He, Xiaohui and Yang, Kunyong and Karanewsky, Donald and Yin, Hong and Wolff, Karen and Bieza, Kimberly and Caldwell, Jeremy and He, Yun (2006) Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (13). pp. 3430-3433. ISSN 0960-894X

Wu, Zhidan and Huang, Xueming and Feng, Yajun and Handschin, Christoph and Feng, Yan and Gullicksen, P. Scott and Bare, Olivia and Labow, Mark and Spiegelman, Bruce and Stevenson, Susan (2006) Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 103 (39). pp. 14379-14384. ISSN 0027-8424

Y

Yan, Frank and King, Frederick and He, Yun and Caldwell, Jeremy and Zhou, Yingyao (2006) Learning from the data: mining of large high-throughput screening databases. Journal of Chemical Information and Modeling, 46 (6). pp. 2381-2395. ISSN 1549-9596

Yang, X and Parker, David and Whitehead, Lewis and Ryder, Neil and Weidmann, Beat and Stabile-Harris, M and Kizer, D and McKinnon, M and Smellie, A and Powers, D (2006) A collaborative hit-to-lead investigation leveraging medicinal chemistry expertise with high throughput library design, synthesis and purification capabilities. Combinatorial Chemistry High Throughput Screening, 9 (2). pp. 123-130. ISSN 1386-2073

Yin, Zheng and Patel, Sejal and Wang, Wei and Chan, Wai Ling and Rao, Ranga and Wang, Gang and Ngew, Xinyi and Patel, Viral and Beer, David and Knox, John E and Ma, Ngai Ling and Ehrhardt, Claus and Lim, Siew Pheng and Vasudevan, Subhash and Keller, Thomas (2006) Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 40-43. ISSN 0960-894X

Z

Zemann, Barbara and Kinzel, Bernd and Mueller, Matthias and Reuschel, Roland and Mechtcheriakova, Diana and Urtz, Nicole and Bornancin, Frederic and Baumruker, Thomas and Billich, Andreas (2006) Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood, 107 (4). pp. 1454-1458. ISSN 0006-4971

Zhang, Qiong and Liu, Yi and Gao, Feng and Ding, Qiang and Cho, Charles and Hur, Wooyoung and Jin, Yunho and Uno, Tetsuo and Joazeiro, Claudio and Gray, Nathanael (2006) Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. Journal of the American Chemical Society, 128 (7). pp. 2182-2183. ISSN 0002-7863

Zollinger, Markus and Waldmeier, Felix and Hartmann, Stefan and Zenke, Gerhard and Zimmerlin, Alfred Gilbert and Glaenzel, Ulrike and Baldeck, Jean-Pierre and Schweitzer, Alain and Berthier, Stephane and Moenius, Thomas and Grassberger, Maximilian (2006) Pimecrolimus: absorption, distribution, metabolism, and excretion in healthy volunteers after a single oral dose and supplementary investigations in vitro. Drug metabolism and disposition: the biological fate of chemicals, 34 (5). pp. 765-774. ISSN 0090-9556

This list was generated on Mon Dec 9 05:23:52 2019 UTC.

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