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Alper, Phillip, Liu, Hong, Chatterjee, Arnab, Nguyen, Khanhlinh, Tully, David, Tumanut, Christine, Li, Jun, Harris, Jennifer, Tuntland, Tove, Chang, Jonathan, Gordon, Perry, Hollenbeck, Thomas and Karanewsky, Donald (2006) Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl. Bioorganic & Medicinal Chemistry Letters, 16 (6). pp. 1486-1490. ISSN 0960-894X

Altmann, Eva, Aichholz, Reiner, Betschart, Claudia, Buhl, Thomas, Green, Jonathan, Lattmann, Rene and Missbach, Martin (2006) Dipeptide nitrile inhibitors of cathepsin K. Bioorganic & Medicinal Chemistry Letters, 16 (9). pp. 2549-2554. ISSN 0960-894X

Ari, Nader, Westling, Lucas and Isbell, John (2006) Cherry-picking in an orchard: unattended LC/MS analysis from an autosampler with >32,000 samples online. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 11 (3). pp. 318-322. ISSN 1087-0571

Bakhtiarova, Adel, Taslimi, Paul, Elliman, Stephen, Kosinski, Penelope, Hubbard, Brian, Kavana, Michael and Kemp, Daniel (2006) Resveratrol inhibits firefly luciferase. Biochemical and Biophysical Research Communications, 351 (2). pp. 481-484. ISSN 0006-291X

Battram, Cliff, Charlton, Steven, Cuenoud, Bernard, Dowling, Mark, Fairhurst, Robin, Farr, David Colin, Fozard, John R., Leighton-Davies, Juliet, Lewis, Christine A, McEvoy, Lorraine, Turner, Robert and Trifilieff, Alexandre (2006) In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action. The Journal of Pharmacology and Experimental Therapeutics, 317 (2). pp. 762-770. ISSN 0022-3565

Bavandi, Assadollah, Fahrngruber, Hermann, Aschauer, Heinrich, Hartmann, Boris, Meingassner, Josef and Kalthoff, Frank (2006) Pimecrolimus and tacrolimus differ in their inhibition of lymphocyte activation during the sensitization phase of contact hypersensitivity. Journal of Dermatological Science, 43 (2). pp. 117-126. ISSN 0923-1811

Beckmann, Nicolau, Cannet, Catherine, Zurbruegg, Stefan, Haberthuer, Reto, Li, Jianping, Pally, Charles and Bruns, Christian (2006) Macrophage infiltration detected at MR imaging in rat kidney allografts: early marker of chronic rejection? Radiology, 240 (3). pp. 717-724. ISSN 0033-8419

Bender, Andreas, Jenkins, Jeremy, Glick, Meir, Deng, Zhan, Nettles Jr., James and Davies, John (2006) "Bayes affinity fingerprints" improve retrieval rates in virtual screening and define orthogonal bioactivity space: when are multitarget drugs a feasible concept? Journal of Chemical Information and Modeling, 46 (6). pp. 2445-2456. ISSN 1549-9596

Benoit, Roger, Wilhelm, Ramon, Scherer-Becker, Daniela and Ostermeier, Christian (2006) An improved method for fast, robust, and seamless integration of DNA fragments into multiple plasmids. Protein Expression and Purification, 45 (1). pp. 66-71. ISSN 1046-5928

Benson, John, Chen, Ying-Nan, Cornell-Kennon, Susan, Dorsch, Marion, Kim, Sunkyu, Leszczyniecka, Magdalena, Sellers, William and Lengauer, Christoph (2006) Validating cancer drug targets. Nature, 441 (7092). pp. 451-456. ISSN 1476-4687

Berger, Cedric, Hiestand, Peter, Kindler-Baumann, Diana Rita, Rudin, Markus and Rausch, Martin (2006) Analysis of lesion development during acute inflammation and remission in a rat model of experimental autoimmune encephalomyelitis by visualization of macrophage infiltration, demyelination and blood-brain barrier damage. NMR in Biomedicine, 19 (1). pp. 101-107. ISSN 0952-3480

Berger, Cedric, Rausch, Martin, Schmidt, Philipp and Rudin, Markus (2006) Feasibility and limits of magnetically labeling primary cultured rat T cells with ferumoxides coupled with commonly used transfection agents. Molecular Imaging : official journal of the Society for Molecular Imaging, 5 (2). pp. 93-104. ISSN 1535-3508

Bertrand, Eric, Fritsch, Christine, Diether, Sigrid, Lambrou, George N., Mueller, Dieter, Schaeffel, Frank, Schindler, Patrick, Schmid, Katharina, Van Oostrum, Jan and Voshol, Johannes (2006) Identification of apolipoprotein A-I as a "STOP" signal for myopia. Molecular & Cellular Proteomics : MCP, 5 (11). pp. 2158-2166. ISSN 1535-9476

Biedermann, Tilo, Lametschwandtner, Guenther, Tangemann, Kirsten, Kund, Juliana, Hinteregger, Sonja, Carballido-Perrig, Nicole, Rot, Antal, Schwaerzler, Christoph and Carballido, Jose (2006) IL-12 instructs skin homing of human Th2 cells. Journal of Immunology (Baltimore, Md. : 1950), 177 (6). pp. 3763-3770. ISSN 0022-1767

Bissiere, Stephanie, Mcallister, Kevin, Olpe, Hans-Rudolf and Cryan, John F. (2006) The rostral anterior cingulate cortex modulates depression but not anxiety-related behaviour in the rat. Behavioural Brain Research, 175 (1). pp. 195-199. ISSN 0166-4328

Boisvert, Christine and Morgan, Peter (2006) The Study Support Associate: an alternative to the traditional animal care position. Lab Animal, 35 (1). pp. 34-38. ISSN 0093-7355

Bold, Guido, Wojeik, Severine, Caravatti, Giorgio, Lindauer, Renate, Stierlin, Claire, Gertsch, Jurg, Wartmann, Markus and Altmann, Karl-Heinz (2006) Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom? ChemMedChem, 1 (1). pp. 37-40. ISSN 1860-7179

Bonenfant, Debora, Coulot, Michele, Towbin, Harry, Schindler, Patrick and Van Oostrum, Jan (2006) Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. Molecular & Cellular Proteomics : MCP, 5 (3). pp. 541-552. ISSN 1535-9476

Bonneau, Olivier, Wyss, Daniel, Ferretti, Stephane Raymond, Blaydon, Clare, Stevenson, Christopher and Trifilieff, Alexandre (2006) Effect of adenosine A2A receptor activation in murine models of respiratory disorders. American Journal of Physiology. Lung cellular and molecular physiology, 290 (5). L1036-L1043. ISSN 1040-0605

Bordone, Laura, Motta, Maria Carla, Picard, Frederic, Robinson, Ashley, Jhala, Ulupi, Apfeld, Javier, McDonagh, Thomas, Lemieux, Madeleine, McBurney, Michael, Szilvasi, Akos, Easlon, Erin, Lin, Su-Ju and Guarente, Leonard (2006) Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biology, 4 (2). e31. ISSN 1545-7885

Brinkmann, Volker and Baumruker, Thomas (2006) Pulmonary and vascular pharmacology of sphingosine 1-phosphate. Current Opinion in Pharmacology, 6 (3). pp. 244-250. ISSN 1471-4892

Brown, Nathan and Jacoby, Edgar (2006) On scaffolds and hopping in medicinal chemistry. Mini Reviews in Medicinal Chemistry, 6 (11). pp. 1217-1229. ISSN 1389-5575

Brown, Nathan and Lewis, Richard (2006) Exploiting QSAR methods in lead optimization. Current Opinion in Drug Discovery & Development, 9 (4). pp. 419-424. ISSN 1367-6733

Brown, Nathan, Zehender, Hartmut, Azzaoui, Kamal, Schuffenhauer, Ansgar, Mayr, Lorenz and Jacoby, Edgar (2006) A chemoinformatics analysis of hit lists obtained from high-throughput affinity-selection screening. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 11 (2). pp. 123-130. ISSN 1087-0571

Bruin, Gerardus, Waldmeier, Felix, Boernsen, K. Olaf, Pfaar, Ulrike, Gross, Gerhard and Zollinger, Markus (2006) A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: validation and applications. Journal of chromatography. A, 1133 (1-2). pp. 184-194. ISSN 0021-9673

Bruin, Gerardus, Waldmeier, Felix, Boernsen, K. Olaf, Pfaar, Ulrike, Gross, Gerhard and Zollinger, Markus (2006) A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: validation and applications. Journal of chromatography. A, 1133 (1-2). pp. 184-194. ISSN 0021-9673

Carballido, Jose, Carballido-Perrig, Nicole, Schwaerzler, Christoph and Lametschwandtner, Guenther (2006) Regulation of human T helper cell differentiation by antigen-presenting cells: the bee venom phospholipase A2 model. Chemical Immunology and Allergy, 91. pp. 147-158. ISSN 1660-2242

Cebe, Regis and Geiser, Martin (2006) Rapid and easy thermodynamic optimization of the 5'-end of mRNA dramatically increases the level of wild type protein expression in Escherichia coli. Protein Expression and Purification, 45 (2). pp. 374-380. ISSN 1046-5928

Cebe, Regis and Geiser, Martin (2006) Monitoring protein expression levels in E. coli using a high throughput approach. Microbial Cell Factories, 5 (Suppl ). P78. ISSN 1475-2859

Chen, Hong (2006) Cellular inflammatory responses: novel insights for obesity and insulin resistance. Pharmacological research : the official journal of the Italian Pharmacological Society, 53 (6). pp. 469-477. ISSN 1043-6618

Chen, T and Li, E (2006) Establishment and maintenance of DNA methylation patterns in mammals. Current Topics in Microbiology and Immunology, 301. pp. 179-201. ISSN 0070-217X

Chene, Patrick (2006) Drugs targeting protein-protein interactions. ChemMedChem, 1 (4). pp. 400-411. ISSN 1860-7179

Cho, Charles, Koo, Seung-Hoi, Wang, Yan, Callaway, Scott, Hedrick, Susan, Mak, Pui Ying, Orth, Anthony, Peters, Eric, Saez, Enrique, Montminy, Marc, Schultz, Peter and Chanda, Sumit (2006) Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metabolism, 3 (5). pp. 367-378. ISSN 1550-4131

Choi, Ha-Soon, Wang, Zhicheng, Richmond, Wendy, He, Xiaohui, Yang, Kunyong, Jiang, Tao, Karanewsky, Donald, Gu, Xiang-Ju, Zhou, Vicki, Liu, Yi, Che, Jianwei, Lee, Christian, Caldwell, Jeremy, Kanazawa, Takanori, Umemura, Ichiro, Matsuura, Naoko, Ohmori, Osamu, Honda, Toshiyuki, Gray, Nathanael and He, Yun (2006) Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2. Bioorganic & Medicinal Chemistry Letters, 16 (10). pp. 2689-2692. ISSN 0960-894X

Choi, Ha-Soon, Wang, Zhicheng, Richmond, Wendy, He, Xiaohui, Yang, Kunyong, Jiang, Tao, Sim, Taebo, Karanewsky, Donald, Gu, Xiang-Ju, Zhou, Vicki, Liu, Yi, Ohmori, Osamu, Caldwell, Jeremy, Gray, Nathanael and He, Yun (2006) Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (8). pp. 2173-2176. ISSN 0960-894X

Collins, Cynthia S, Hong, Jiyong, Sapinoso, Lisa, Zhou, Yingyao, Liu, Zheng, Micklash, Kenneth, Schultz, Peter G and Hampton, Garret M (2006) A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proceedings of the National Academy of Sciences of the United States of America, 103 (10). pp. 3775-3780. ISSN 0027-8424

Coppola, Gary, Damon Ii, Robert, Eskesen, J, France, Dennis and Paterniti, James (2006) Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 113-117. ISSN 0960-894X

Coupez, Bernard and Lewis, Richard (2006) Docking and scoring--theoretically easy, practically impossible? Current Medicinal Chemistry, 13 (25). pp. 2995-3003. ISSN 0929-8673

Culshaw, Andrew, Bevan, Stuart, Christiansen, Martin, Copp, Prafula, Davis, Andrew, Davis, Clare, Dyson, Alex, Dziadulewicz, Ed, Edwards, Lee, Eggelte, Hendrikus, Fox, Alyson, Gentry, Clive, Groarke, Alex, Hallett, Allan, Hart, Terry, Hughes, Glyn, Knights, Sally, Kotsonis, Peter, Lee, Wai, Lyothier, Isabelle, Mcbryde, Andrew, Mcintyre, Peter, Paloumbis, George, Panesar, Moh, Patel, Sadhana, Seiler, Max Peter, Yaqoob, Mo and Zimmermann, Kaspar (2006) Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain. Journal of Medicinal Chemistry, 49 (2). pp. 471-474. ISSN 0022-2623

Danahay, Henry, Atherton, Hazel, Jackson, Alan, Kreindler, James L, Poll, Chris and Bridges, Robert J (2006) Membrane capacitance and conductance changes parallel mucin secretion in the human airway epithelium. American Journal of Physiology. Lung cellular and molecular physiology, 290 (3). L558-L569. ISSN 1040-0605

Davies, John, Glick, Meir and Jenkins, Jeremy (2006) Streamlining lead discovery by aligning in silico and high-throughput screening. Current Opinion in Chemical Biology, 10 (4). pp. 343-351. ISSN 1367-5931

Dev, Kumlesh K (2006) Using RNAi in the clinic. IDrugs : the investigational drugs journal, 9 (4). pp. 279-282. ISSN 1369-7056

Dev, Kumlesh K., Chatterjee, Sandipan, Osinde, Maribel, Stauffer, Daniela, Morgan, Hannah, Kobialko, Monika, Dengler, Uwe, Rueeger, Heinrich, Martoglio, Bruno and Rovelli, Giorgio (2006) Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals. European Journal of Pharmacology, 540 (1-3). pp. 10-17. ISSN 0014-2999

Dev, Kumlesh K. and Henley, Jeremy M. (2006) The schizophrenic faces of PICK1. Trends in Pharmacological Sciences, 27 (11). pp. 574-579. ISSN 0165-6147

Dowling, Mark and Charlton, Steven (2006) Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor. British Journal of Pharmacology, 148 (7). pp. 927-937. ISSN 0007-1188

Dubaele, Sandy, Jahnke, Wolfgang, Schoepfer, Joseph, Fuchs, Jean and Chene, Patrick (2006) Inhibition of DNA helicases with DNA-competitive inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (4). pp. 923-927. ISSN 0960-894X

Dubaele, Sandy, Lourdel, Claude and Chene, Patrick (2006) Study of the ATP-binding site of helicase IV from Escherichia coli. Biochemical and Biophysical Research Communications, 341 (3). pp. 828-836. ISSN 0006-291X

Dubois, Celine, Hengerer, Bastian and Mattes, Henri (2006) Identification of a potent agonist of the orphan nuclear receptor Nurr1. ChemMedChem, 1 (9). pp. 955-958. ISSN 1860-7179

Dupuis, Delphine, Relkovic, Dinko, Lhuillier, Loic, Mosbacher, Johannes and Kaupmann, Klemens (2006) Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit. Molecular Pharmacology, 70 (6). pp. 2027-2036. ISSN 0026-895X

Elliman, Stephen, Wu, Isaac and Kemp, Daniel (2006) Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. The Journal of Biological Chemistry, 281 (1). pp. 16-19. ISSN 0021-9258

Ellis, David, Kuhen, Kelli, Anaclerio, Beth, Wu, Baogen, Wolff, Karen, Yin, Hong, Bursulaya, Badry, Caldwell, Jeremy, Karanewsky, Donald and He, Yun (2006) Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4246-4251. ISSN 0960-894X

Engstrom, Par, Suzuki, Harukazu, Ninomiya, Noriko, Akalin, Altuna, Sessa, Luca, Lavorgna, Giovanni, Brozzi, Alessandro, Luzi, Lucilla, Tan, Sin Lam, Yang, Liang, Kunarso, Galih, Ng, Edwin Lian-Chong, Batalov, Sergei, Wahlestedt, Claes, Kai, Chikatoshi, Kawai, Jun, Carninci, Piero, Hayashizaki, Yoshihide, Wells, Christine, Bajic, Vladimir, Orlando, Valerio, Reid, James, Lenhard, Boris and Lipovich, Leonard (2006) Complex Loci in human and mouse genomes. PLoS Genetics, 2 (4). e47. ISSN 1553-7404

Epple, Robert, Azimioara, Mihai, Russo, Ross, Bursulaya, Badry, Tian, Shin-Shay, Gerken, Andrea and Iskandar, Maya (2006) 1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists. Bioorganic & Medicinal Chemistry Letters, 16 (11). pp. 2969-2973. ISSN 0960-894X

Epple, Robert, Azimioara, Mihai, Russo, Ross, Xie, Yongping, Wang, Xing, Cow, Christopher, Wityak, John, Karanewsky, Donald, Bursulaya, Badry, Kreusch, Andreas, Tuntland, Tove, Gerken, Andrea, Iskandar, Maya, Saez, Enrique, Seidel, Martin and Tian, Shin-Shay (2006) 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2. Bioorganic & Medicinal Chemistry Letters, 16 (21). pp. 5488-5492. ISSN 0960-894X

Epple, Robert, Russo, Ross, Azimioara, Mihai, Cow, Christopher, Xie, Yongping, Wang, Xing, Wityak, John, Karanewsky, Donald, Gerken, Andrea, Iskandar, Maya, Saez, Enrique, Seidel, Martin and Tian, Shin-Shay (2006) 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4376-4380. ISSN 0960-894X

Erbel, Paulus, Schiering, Nikolaus, D'Arcy, Allan, Renatus, Martin, Kroemer, Markus, Lim, Siew Pheng, Yin, Zheng, Keller, Thomas, Vasudevan, Subhash and Hommel, Ulrich (2006) Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nature Structural & Molecular Biology, 13 (4). pp. 372-373. ISSN 1545-9993

Ertl, Peter, Jelfs, Stephen, Mühlbacher, Jörg, Schuffenhauer, Ansgar and Selzer, Paul (2006) Quest for the rings. In silico exploration of ring universe to identify novel bioactive heteroaromatic scaffolds. Journal of Medicinal Chemistry, 49 (15). pp. 4568-4573. ISSN 0022-2623

Ettmayer, Peter, Baumruker, Thomas, Guerini, Danilo, Mechtcheriakova, Diana, Nussbaumer, Peter, Streiff, Markus and Billich, Andreas (2006) NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 84-87. ISSN 0960-894X

Ettmayer, Peter, Mayer, Peter, Kalthoff, Frank, Neruda, Wolfgang, Harrer, Nathalie, Hartmann, Gabriella, Epstein, Michelle M, Brinkmann, Volker, Heusser, Christoph and Woisetschlaeger, Maximilian (2006) A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation. American Journal of Respiratory and Critical Care Medicine, 173 (6). pp. 599-606. ISSN 1073-449X

Faller, Bernard, Wang, Jianling, Zimmerlin, Alfred Gilbert, Bell, Leslie, Hamon, Jacques, Whitebread, Steven, Azzaoui, Kamal, Bojanic, Dejan and Urban, Laszlo (2006) High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis. Expert Opinion on Drug Metabolism & Toxicology, 2 (6). pp. 823-833. ISSN 1742-5255

Feng, Wan Yong (2006) Metabolism of green tea catechins: an overview. Current Drug Metabolism, 7 (7). pp. 755-809. ISSN 1389-2002

Ferrara, Philippe, Curioni, A, Vangrevelinghe, Eric, Meyer, Thomas, Mordasini, T, Andreoni, W, Acklin, Pierre and Jacoby, Edgar (2006) New scoring functions for virtual screening from molecular dynamics simulations with a quantum-refined force-field (QRFF-MD). Application to cyclin-dependent kinase 2. Journal of Chemical Information and Modeling, 46 (1). pp. 254-263. ISSN 1549-9596

Fink, Joshua, Gu, Feng and Vasudevan, Subhash (2006) Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever. Reviews in Medical Virology, 16 (4). pp. 263-275. ISSN 1052-9276

Furet, Pascal, Bold, Guido, Meyer, Thomas, Roesel, Johannes and Guagnano, Vito (2006) Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. Journal of Medicinal Chemistry, 49 (15). pp. 4451-4454. ISSN 0022-2623

Galanello, Renzo, Piga, Antonio, Forni, Gian Luca, Bertrand, Yves, Foschini, Maria Loreta, Bordone, Elena, Leoni, Giovanbattista, Lavagetto, Antonella, Zappu, Antonietta, Longo, Filomena, Maseruka, Henry, Hewson, Nicola, Sechaud, Romain, Belleli, Rossella and Alberti, Daniele (2006) Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with beta-thalassemia major. Haematologica, 91 (10). pp. 1343-1351. ISSN 1592-8721

Galanello, Renzo, Piga, Antonio, Forni, Gian Luca, Bertrand, Yves, Foschini, Maria Loreta, Bordone, Elena, Leoni, Giovanbattista, Lavagetto, Antonella, Zappu, Antonietta, Longo, Filomena, Maseruka, Henry, Hewson, Nicola, Sechaud, Romain, Belleli, Rossella and Alberti, Daniele Maria (2006) Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with beta-thalassemia major. Haematologica, 91 (10). pp. 1343-1351. ISSN 1592-8721

Ganguly, Milan, Brown, Nathan, Schuffenhauer, Ansgar, Ertl, Peter, Gillet, Valerie J. and Greenidge, Paulette (2006) Introducing the consensus modeling concept in genetic algorithms: application to interpretable discriminant analysis. Journal of Chemical Information and Modeling, 46 (5). pp. 2110-2124. ISSN 1549-9596

Garcia-Echeverria, Carlos (2006) Medicinal chemistry approaches to target the kinase activity of IGF-1R. IDrugs : the investigational drugs journal, 9 (6). pp. 415-419. ISSN 1369-7056

Gasser, Juerg Andreas (2006) Coupled or uncoupled remodeling, is that the question? Journal of Musculoskeletal & Neuronal Interactions, 6 (2). pp. 128-133. ISSN 1108-7161

Gasser, Juerg Andreas (2006) The relative merits of anabolics versus anti-resorptive compounds: where our targets should be, and whether we are addressing them. Current Opinion in Pharmacology, 6 (3). pp. 313-318. ISSN 1471-4892

Gasser, Juerg Andreas, Green, Jonathan, Shen, Victor, Ingold, Peter, Rebmann, Andrea, Bhatnagar, Ajay and Evans, Dean Brent (2006) A single intravenous administration of zoledronic acid prevents the bone loss and mechanical compromise induced by aromatase inhibition in rats. Bone, 39 (4). pp. 787-795. ISSN 8756-3282

Gedeck, Peter, Rohde, Bernhard and Bartels, Christian (2006) QSAR--how good is it in practice? Comparison of descriptor sets on an unbiased cross section of corporate data sets. Journal of Chemical Information and Modeling, 46 (5). pp. 1924-1936. ISSN 1549-9596

Geierstanger, Bernhard, Saviranta, Petri and Brinker, Achim (2006) Antibody microarrays using resonance light-scattering particles for detection. Methods in Molecular Biology (Clifton, N.J.), 328. pp. 31-50. ISSN 1064-3745

Gerwin, Nicole, Hops, Caroline and Lucke, Andrea (2006) Intraarticular drug delivery in osteoarthritis. Advanced Drug Delivery Reviews, 58 (2). pp. 226-242. ISSN 0169-409X

Gjoni, Tina, Desrayaud, Sandrine, Imobersteg, Stefan and Urwyler, Stephan (2006) The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivo. Journal of Neurochemistry, 96 (5). pp. 1416-1422. ISSN 0022-3042

Glick, Meir, Jenkins, Jeremy, Nettles Jr., James, Hitchings, Hamilton and Davies, John (2006) Enrichment of high-throughput screening data with increasing levels of noise using support vector machines, recursive partitioning, and laplacian-modified naive bayesian classifiers. Journal of Chemical Information and Modeling, 46 (1). pp. 193-200. ISSN 1549-9596

Gromada, Jesper and Hughes, Thomas (2006) Ringing the dinner bell for insulin: muscarinic M3 receptor activity in the control of pancreatic beta cell function. Cell Metabolism, 3 (6). pp. 390-392. ISSN 1550-4131

Guintu, Christina, Kwok, Michael, Hanlon, James, Spalding, Tracy, Wolff, Karen, Yin, Hong, Kuhen, Kelli, Sasher, Kimberly, Calvin, Paul, Jiang, Shumei, Zhou, Yingyao and Isbell, John (2006) Just-in-time purification: an effective solution for cherry-picking and purifying active compounds from large legacy libraries. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 11 (8). pp. 933-939. ISSN 1087-0571

Harant, Hanna, Lettner, Nicole, Hofer, Lotte, Oberhauser, Berndt, De Vries, Jan Egbert and Lindley, Ivan-J.D. (2006) The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon. The Journal of Biological Chemistry, 281 (41). pp. 30492-30502. ISSN 0021-9258

Hasan, Samiul, Daugelat, Sabine, Rao, P S Srinivasa and Schreiber, Mark (2006) Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Computational Biology, 2 (6). e61. ISSN 1553-7358

Hasan, Samiul and Schreiber, Mark (2006) Recovering motifs from biased genomes: application of signal correction. Nucleic Acids Research, 34 (18). pp. 5124-5132. ISSN 1362-4962

Hofmann, Matthias, Brinkmann, Volker and Zerwes, Hans-Guenter (2006) FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs. International Immunopharmacology, 6 (13-14). pp. 1902-1910. ISSN 1567-5769

Hofmann, Matthias and Zerwes, Hans-Guenter (2006) Identification of organ-specific T cell populations by analysis of multiparameter flow cytometry data using DNA-chip analysis software. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 69 (6). pp. 533-540. ISSN 1552-4922

Hoover-Plow, Jane, Shchurin, Aleksey, Hart, Erika, Sha, Jingfeng, Hill, Annie, Singer, Jonathan and Nadeau, Joseph (2006) Genetic background determines response to hemostasis and thrombosis. BMC Blood Disorders, 6 (1). p. 6. ISSN 1471-2326

Hoyer, Daniel, Thakker, Deepak, Natt, Francois, Maier, Rainer, Huesken, Dieter, Mueller, Matthias, Flor, Peter Josef, Van Der Putten, P. Herman, Schmutz, Markus, Bilbe, Graeme and Cryan, John F. (2006) Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders. Journal of Receptor and Signal Transduction Research, 26 (5-6). pp. 527-547. ISSN 1079-9893

Huang, Yina Hsing, Barouch-Bentov, Rina, Herman, Ann, Walker, John and Sauer, Karsten (2006) Integrating traditional and postgenomic approaches to investigate lymphocyte development and function. Advances in Experimental Medicine and Biology, 584. pp. 245-276. ISSN 0065-2598

Hummel, Manfred, Yonan, Nizar, Ross, Heather, Miller, Leslie W, Sechaud, Romain, Balez, Sebastien, Koelle, Ernst Ulrich and Gerosa, Gino (2006) Pharmacokinetics and variability of mycophenolic acid from enteric-coated mycophenolate sodium compared with mycophenolate mofetil in de novo heart transplant recipients. Clinical transplantation, 21 (1). pp. 18-23. ISSN 0902-0063

Jacob, Sandra (2006) Structural biology of protein tyrosine kinases. Cellular and Molecular Life Sciences : CMLS, 63 (22). pp. 2608-2625. ISSN 1420-682X

Jacobson, Laura, Bettler, Bernhard, Kaupmann, Klemens and Cryan, John F. (2006) GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice. The Journal of Pharmacology and Experimental Therapeutics, 319 (3). pp. 1317-1326. ISSN 0022-3565

Jacobson, Laura, Kelly, Peter, Bettler, Bernhard, Kaupmann, Klemens and Cryan, John F. (2006) GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories. The Journal of Neuroscience : the official journal of the Society for Neuroscience, 26 (34). pp. 8800-8803. ISSN 1529-2401

Jacoby, Edgar, Bouhelal, Rochdi, Gerspacher, Marc and Seuwen, Klaus (2006) The 7 TM G-protein-coupled receptor target family. ChemMedChem, 1 (8). pp. 761-782. ISSN 1860-7179

Janser, Philipp, Neumann, Ulf, Miltz, Wolfgang, Feifel, Roland and Buhl, Thomas (2006) A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (10). pp. 2632-2636. ISSN 0960-894X

Jiang, Tao, Kuhen, Kelli, Wolff, Karen, Yin, Hong, Bieza, Kimberly, Caldwell, Jeremy, Bursulaya, Badry, Tuntland, Tove, Zhang, Kanyin, Karanewsky, Donald and He, Yun (2006) Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2. Bioorganic & Medicinal Chemistry Letters, 16 (8). pp. 2109-2112. ISSN 0960-894X

Jiang, Tao, Kuhen, Kelli, Wolff, Karen, Yin, Hong, Bieza, Kimberly, Caldwell, Jeremy, Bursulaya, Badry, Wu, Tom and He, Yun (2006) Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I. Bioorganic & Medicinal Chemistry Letters, 16 (8). pp. 2105-2108. ISSN 0960-894X

Jost, Lorenz M, Gschwind, Hans-Peter, Jalava, Tarja, Wang, Yongyu, Guenther, Clemens, Souppart, Claire, Rottmann, Antje, Denner, Karsten, Waldmeier, Felix, Gross, Gerhard, Masson, Eric and Laurent, Dirk (2006) Metabolism and disposition of vatalanib (PTK787/ZK-222584) in cancer patients. Drug metabolism and disposition: the biological fate of chemicals, 34 (11). pp. 1817-1828. ISSN 0090-9556

Karmouty Quintana, Harry, Cannet, Catherine, Zurbruegg, Stefan, Ble, Francois-Xavier, Fozard, John R., Page, Clive P. and Beckmann, Nicolau (2006) Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats. Magnetic Resonance in Medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 56 (6). pp. 1242-1250. ISSN 0740-3194

Keller, Thomas, Chen, Yen Liang, Knox, John, Lim, Siew Pheng, Ma, Ngai Ling, Patel, Sejal, Sampath, Aruna, Wang, Qing Yin, Yin, Zheng and Vasudevan, Subhash (2006) Finding new medicines for flaviviral targets. Novartis Foundation Symposium, 277. pp. 102-114. ISSN 1528-2511

Keller, Thomas, Pichota, Arkadius and Yin, Zheng (2006) A practical view of 'druggability'. Current Opinion in Chemical Biology, 10 (4). pp. 357-361. ISSN 1367-5931

Kidgell, Claire, Volkman, Sarah K, Daily, Johanna, Borevitz, Justin O, Plouffe, David, Zhou, Yingyao, Johnson, Jeffrey R, Leroche, Karine, Sarr, Ousmane, Ndir, Omar, Mboup, Soulyemane, Batalov, Sergei, Wirth, Dyann F and Winzeler, Elizabeth (2006) A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathogens, 2 (6). e57. ISSN 1553-7374

Kirkham, Paul and Rahman, Irfan (2006) Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacology & Therapeutics, 111 (2). pp. 476-494. ISSN 0163-7258

Klumpp, Martin, Boettcher, Andreas, Becker, Damaris, Meder, Gabriele, Blank, Jutta, Leder, Lukas, Forstner, Michael, Ottl, Johannes and Mayr, Lorenz (2006) Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 11 (6). pp. 617-633. ISSN 1087-0571

Knochenmuss, Richard (2006) Ion formation mechanisms in UV-MALDI. Analyst, 131 (9). pp. 966-986. ISSN 0003-2654

Knox, John E, Ma, Ngai Ling, Yin, Zheng, Patel, Sejal, Wang, Wei, Chan, Wai Ling, Rao, Ranga, Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Lim, Siew Pheng, Vasudevan, Subhash and Keller, Thomas (2006) Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors. Journal of Medicinal Chemistry, 49 (22). pp. 6585-6590. ISSN 0022-2623

La Montagne, Kenneth, Littlewood-Evans, Amanda, Schnell, Christian, O'Reilly, Terence, Wyder, Lorenza, Sanchez, Teresa, Probst, Beatrice, Butler, Jeannene, Wood, Alexander, Liau, Gene, Billy, Eric, Theuer, Andreas, Hla, Timothy and Wood, Jeanette (2006) Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Research, 66 (1). pp. 221-231. ISSN 0008-5472

Landrum, Gregory, Penzotti, Julie E and Putta, Santosh (2006) Feature-map vectors: a new class of informative descriptors for computational drug discovery. Journal of Computer-Aided Molecular Design, 20 (12). pp. 751-762. ISSN 0920-654X

Lane, Heidi and Lebwohl, David (2006) Future directions in the treatment of hormone-sensitive advanced breast cancer: the RAD001 (Everolimus)-letrozole clinical program. Seminars in Oncology, 33 (2 Suppl 7). S18-S25. ISSN 0093-7754

Laurent, Didier, O'Byrne, Elizabeth, Wasvary, James and Pellas, Theodore (2006) In vivo MRI of cartilage pathogenesis in surgical models of osteoarthritis. Skeletal Radiology, 35 (8). pp. 555-564. ISSN 0364-2348

Lecourtier, Lucas, Deschaux, O, Arnaud, C, Chessel, A, Kelly, Peter and Garcia, R (2006) Habenula lesions alter synaptic plasticity within the fimbria-accumbens pathway in the rat. Neuroscience, 141 (2). pp. 1025-1032. ISSN 0306-4522

Lee, Jee and Kemp, Daniel (2006) Human adipose-derived stem cells display myogenic potential and perturbed function in hypoxic conditions. Biochemical and Biophysical Research Communications, 341 (3). pp. 882-888. ISSN 0006-291X

Leeds, Jennifer and Dean, Charles (2006) Peptide deformylase as an antibacterial target: a critical assessment. Current Opinion in Pharmacology, 6 (5). pp. 445-452. ISSN 1471-4892

Leeds, Jennifer, Schmitt, Esther and Krastel, Philipp (2006) Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic. Expert Opinion on Investigational Drugs, 15 (3). pp. 211-226. ISSN 1744-7658

Leeds, Jennifer A and Dean, Charles R (2006) Peptide deformylase as an antibacterial target: a critical assessment. Current opinion in pharmacology, 6 (5). pp. 445-452. ISSN 1471-4892

Leeds, Jennifer A, Schmitt, Esther K and Krastel, Philipp (2006) Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic. Expert opinion on investigational drugs, 15 (3). pp. 211-226. ISSN 1744-7658

Lehmann, Hansjoerg (2006) Scale-up in microwave-accelerated organic synthesis. Ernst Schering Foundation Symposium Proceedings (3). pp. 133-149.

Lloyd, David, Bohan, Sandy and Gekakis, Nicholas (2006) Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice. Human Molecular Genetics, 15 (11). pp. 1884-1893. ISSN 0964-6906

Ma, Sue, Boerner, Joanne E., Tiong Yip, Choi Lai, Weidmann, Beat, Ryder, Neil, Cooreman, Michael and Lin, Kai (2006) NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon. Antimicrobial Agents and Chemotherapy, 50 (9). pp. 2976-2982. ISSN 0066-4804

Mader, Robert, Kocher, Thomas, Haier, Joerg, Wieczorek, Grazyna, Pfannkuche, Hans-Juergen and Ito, Moriko (2006) Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples. European Journal of Gastroenterology & Hepatology, 18 (9). pp. 945-950. ISSN 0954-691X

Maeda, Norihiro, Kasukawa, Takeya, Oyama, Rieko, Gough, Julian, Frith, Martin, Engström, Pär G, Lenhard, Boris, Aturaliya, Rajith N, Batalov, Sergei, Beisel, Kirk W, Bult, Carol J, Fletcher, Colin, Forrest, Alistair R R, Furuno, Masaaki, Hill, David, Itoh, Masayoshi, Kanamori-Katayama, Mutsumi, Katayama, Shintaro, Katoh, Masaru, Kawashima, Tsugumi, Quackenbush, John, Ravasi, Timothy, Ring, Brian Z, Shibata, Kazuhiro, Sugiura, Koji, Takenaka, Yoichi, Teasdale, Rohan D, Wells, Christine A, Zhu, Yunxia, Kai, Chikatoshi, Kawai, Jun, Hume, David A, Carninci, Piero and Hayashizaki, Yoshihide (2006) Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genetics, 2 (4). e62. ISSN 1553-7404

Mahnke, Marion, Schlaeppi, Jean-Marc, Pouliquen, Yann, Barys, Louise, Rolvering, Catherine, Henke, Mario, Schmitz, Rita, Geisse, Sabine and Kolbinger, Frank (2006) Automation for higher throughput in protein expression: visions, facts and fictions. Microbial Cell Factories, 5 (Suppl ). P60. ISSN 1475-2859

Mattes, Henri, Lingenhoehl, Kurt, Kalkman, Hans O., Auberson, Yves, Renaud, Johanne, Schmutz, Markus and Orain, David (2006) AMPA receptor antagonists: potential therapeutic applications. Recent patents on CNS drug discovery, 1 (3). pp. 247-259. ISSN 1574-8898

Mccleverty, Clare, Koesema, Eric, Patapoutian, Ardem, Lesley, Scott and Kreusch, Andreas (2006) Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Science : a publication of the Protein Society, 15 (9). pp. 2201-2206. ISSN 0961-8368

Medini, Duccio, Covacci, Antonello and Donati, Claudio (2006) Protein homology network families reveal step-wise diversification of Type III and Type IV secretion systems. PLoS Computational Biology, 2 (12). e173. ISSN 1553-7358

Melnick, Jonathan, Janes, Jeff, Kim, Sungjoon, Chang, Jim, Sipes, Daniel, Gunderson, Andrew, Jarnes, Laura, Matzen, Jason, Garcia, Michael, Hood, Tami, Beigi, Ronak, Xia, Gang, Harig, Richard, Asatryan, Hayk, Yan, Frank, Zhou, Yingyao, Gu, Xiang-Ju, Saadat, Alham, Zhou, Vicki, King, Frederick, Shaw, Christopher, Su, Andrew, Downs, Robert, Gray, Nathanael, Schultz, Peter, Warmuth, Markus and Caldwell, Jeremy (2006) An efficient rapid system for profiling the cellular activities of molecular libraries. Proceedings of the National Academy of Sciences of the United States of America, 103 (9). pp. 3153-3158. ISSN 0027-8424

Meyers, Charles, McCarren, Madeline, Wong, Nathan, Abraira, Carlos, Duckworth, William and Kashyap, Moti (2006) Baseline achievement of lipid goals and usage of lipid medications in patients with diabetes mellitus (from the Veterans Affairs Diabetes Trial). The American Journal of Cardiology, 98 (1). pp. 63-65. ISSN 0002-9149

Millard, Annabelle and Gentsch, Conrad (2006) Competition for sucrose pellets in tetrads of male Wistar, Fischer or Sprague-Dawley rats: is intra-group ranking reflected in the level of anxiety? Behavioural Brain Research, 168 (2). pp. 243-254. ISSN 0166-4328

Mitsukawa, Kayo, Mombereau, Cedric, Loetscher, Erika, Uzunov, Doncho, Van Der Putten, P. Herman, Flor, Peter Josef and Cryan, John F. (2006) Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 31 (6). pp. 1112-1122. ISSN 0893-133X

Murphy, Leon and Blenis, John (2006) MAPK signal specificity: the right place at the right time. Trends in Biochemical Sciences, 31 (5). pp. 268-275. ISSN 0968-0004

Nagle, Advait, Hur, Wooyoung and Gray, Nathanael (2006) Antimitotic agents of natural origin. Current Drug Targets, 7 (3). pp. 305-326. ISSN 1389-4501

Nettles Jr., James, Jenkins, Jeremy, Bender, Andreas, Deng, Zhan, Davies, John and Glick, Meir (2006) Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors. Journal of medicinal chemistry, 49 (23). pp. 6802-6810. ISSN 0022-2623

Nguyen, Deborah, Wolff, Karen, Yin, Hong, Caldwell, Jeremy and Kuhen, Kelli (2006) "UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection. Journal of Virology, 80 (1). pp. 130-137. ISSN 0022-538X

Osborne, Colin, Leitner, Ingrid, Hofbauer, Bettina, Fielding, Ceri A, Favre, Bertrand and Ryder, Neil (2006) Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. Antimicrobial Agents and Chemotherapy, 50 (6). pp. 2234-2236. ISSN 0066-4804

Ostermann, Nils, Eder, Joerg, Eidhoff, Ulf, Zink, Florence, Hassiepen, Ulrich, Worpenberg-Pietruk, Susanne, Maibaum, Juergen Klaus, Simic, Oliver, Hommel, Ulrich and Gerhartz, Bernd (2006) Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. Journal of Molecular Biology, 355 (2). pp. 249-261. ISSN 0022-2836

Pan, Shifeng, Mi, Yuan, Pally, Charles, Beerli, Christian, Chen, Alice, Guerini, Danilo, Hinterding, Klaus, Nuesslein-Hildesheim, Barbara, Tuntland, Tove, Lefebvre, Sophie, Liu, Yi, Gao, Wenqi, Chu, Alan, Brinkmann, Volker, Bruns, Christian, Streiff, Markus, Cannet, Catherine, Cooke, Nigel Graham and Gray, Nathanael (2006) A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chemistry & Biology, 13 (11). pp. 1227-1234. ISSN 1074-5521

Piga, Antonio, Galanello, Renzo, Forni, Gian Luca, Cappellini, Maria Domenica, Origa, Raffaella, Zappu, Antonietta, Donato, Guido, Bordone, Elena, Lavagetto, Antonella, Zanaboni, Laura, Sechaud, Romain, Hewson, Nicola, Ford, John M, Opitz, Herbert and Alberti, Daniele (2006) Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica, 91 (7). pp. 873-880. ISSN 1592-8721

Piga, Antonio, Galanello, Renzo, Forni, Gian Luca, Cappellini, Maria Domenica, Origa, Raffaella, Zappu, Antonietta, Donato, Guido, Bordone, Laura, Lavagetto, Antonella, Zanaboni, Laura, Sechaud, Romain, Hewson, Nicola, Ford, John Malcolm, Opitz, Herbert and Alberti, Daniele Maria (2006) Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica, 91 (7). pp. 873-880. ISSN 1592-8721

Porter, Dale, Yao, Jun and Polyak, Kornelia (2006) SAGE and related approaches for cancer target identification. Drug Discovery Today, 11 (3-4). pp. 110-118. ISSN 1359-6446

Pouliquen, Yann, Kolbinger, Frank, Geisse, Sabine and Mahnke, Marion (2006) Automated baculovirus titration assay based on viable cell growth monitoring using a colorimetric indicator. BioTechniques, 40 (3). pp. 282-292. ISSN 0736-6205

Pruenster, Monika and Rot, Antal (2006) Throwing light on DARC. Biochemical Society Transactions, 34 (Pt 6). pp. 1005-1008. ISSN 0300-5127

Quintana, Harry Karmouty, Cannet, Catherine, Schaeublin, Elisabeth, Zurbruegg, Stefan, Sugar, Rosemary, Mazzoni, Lazzaro, Page, Clive P, Fozard, John R. and Beckmann, Nicolau (2006) Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat. American Journal of Physiology. Lung cellular and molecular physiology, 291 (4). L651-L657. ISSN 1040-0605

Renatus, Martin, Parrado, Shirley Gil, D'Arcy, Allan, Eidhoff, Ulf, Gerhartz, Bernd, Hassiepen, Ulrich, Pierrat, Benoit, Riedl, Ralph, Vinzenz, Daniela, Worpenberg-Pietruk, Susanne and Kroemer, Markus (2006) Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure (London, England : 1993), 14 (8). pp. 1293-1302. ISSN 0969-2126

Revesz, Laszlo, Blum, Ernst, Di Padova, Franco E., Buhl, Thomas, Feifel, Roland, Gram, Hermann, Hiestand, Peter, Manning, Ute, Neumann, Ulf and Rucklin, Gerard (2006) Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity. Bioorganic & Medicinal Chemistry Letters, 16 (2). pp. 262-266. ISSN 0960-894X

Ricke, Darrell, Wang, Shaowen, Cai, Richard and Cohen, Dalia (2006) Genomic approaches to drug discovery. Current Opinion in Chemical Biology, 10 (4). pp. 303-308. ISSN 1367-5931

Rines, Daniel, Tu, Buu, Miraglia, Loren, Welch, Genevieve, Zhang, Jia, Hull, Mitchell, Orth, Anthony and Chanda, Sumit (2006) High-content screening of functional genomic libraries. Methods in Enzymology, 414. pp. 530-565. ISSN 0076-6879

Rondeau, Jean-Michel, Bitsch, Francis, Bourgier, Emmanuelle, Geiser, Martin, Hemmig, Rene, Kroemer, Markus, Lehmann, Sylvie, Ramage, Paul, Rieffel, Sebastien, Strauss, Andre, Green, Jonathan and Jahnke, Wolfgang (2006) Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. ChemMedChem, 1 (2). pp. 267-273. ISSN 1860-7179

Rovina, Philipp, Jaritz, Markus, Hoefinger, Siegfried, Graf, Christine, Devay, Piroska, Billich, Andreas, Baumruker, Thomas and Bornancin, Frederic (2006) A critical beta6-beta7 loop in the pleckstrin homology domain of ceramide kinase. The Biochemical Journal, 400 (2). pp. 255-265. ISSN 1470-8728

Sato, Trey, Yamada, Rikuhiro, Ukai, Hideki, Baggs, Julie, Miraglia, Loren, Kobayashi, Tetsuya J, Welsh, David K, Kay, Steve A, Ueda, Hiroki R and Hogenesch, John (2006) Feedback repression is required for mammalian circadian clock function. Nature Genetics, 38 (3). pp. 312-319. ISSN 1061-4036

Schlaeppi, Jean-Marc, Henke, Mario, Mahnke, Marion, Hartmann, Steffen, Schmitz, Rita, Pouliquen, Yann, Kerins, Brendan, Weber, Erich, Kolbinger, Frank and Kocher, Hans P. (2006) A semi-automated large-scale process for the production of recombinant tagged proteins in the Baculovirus expression system. Protein Expression and Purification, 50 (2). pp. 185-195. ISSN 1046-5928

Schuffenhauer, Ansgar, Brown, Nathan, Selzer, Paul, Ertl, Peter and Jacoby, Edgar (2006) Relationships between Molecular Complexity, Biological Activity, and Structural Diversity. Journal of Chemical Information and Modeling, 46 (2). pp. 525-535. ISSN 1549-9596

Selzer, Paul and Ertl, Peter (2006) Applications of self-organizing neural networks in virtual screening and diversity selection. Journal of Chemical Information and Modeling, 46 (6). pp. 2319-2323. ISSN 1549-9596

Senechal, Yann, Larmet, Yves and Dev, Kumlesh K. (2006) Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies. Neuro-Degenerative Diseases, 3 (3). pp. 134-147. ISSN 1660-2854

Serluca, Fabrizio C and Fishman, Mark (2006) Big, bad hearts: from flies to man. Proceedings of the National Academy of Sciences of the United States of America, 103 (11). pp. 3947-3948. ISSN 0027-8424

Seuwen, Klaus, Ludwig, Marie-Gabrielle and Wolf, Romain (2006) Receptors for protons or lipid messengers or both? Journal of Receptor and Signal Transduction Research, 26 (5-6). pp. 599-610. ISSN 1079-9893

Siehler Wagner, Sandra and Guerini, Danilo (2006) Novel GPCR screening approach: indirect identification of S1P receptor agonists in antagonist screening using a calcium assay. Journal of Receptor and Signal Transduction Research, 26 (5-6). pp. 549-575. ISSN 1079-9893

Solbach, Christine, Roller, Marc, Eckerdt, Frank, Peters, Silke and Knecht, Rainald (2006) Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck. BMC Cancer, 6 (1). p. 242. ISSN 1471-2407

Spalding, Tracy and Burstein, Ethan (2006) Constitutive activity of muscarinic acetylcholine receptors. Journal of receptor and signal transduction research, 26 (1-2). pp. 61-85. ISSN 1079-9893

Stevenson, Christopher, Koch, Lauren Gerard and Britton, Steven L (2006) Aerobic capacity, oxidant stress, and chronic obstructive pulmonary disease--a new take on an old hypothesis. Pharmacology & Therapeutics, 110 (1). pp. 71-82. ISSN 0163-7258

Stoeckli, Markus, Knochenmuss, Richard, Mccombie, Gregor, Mueller, Dieter, Rohner, Tatiana, Staab, Dieter and Wiederhold, Karl-Heinz (2006) MALDI MS imaging of amyloid. Methods in Enzymology, 412. pp. 94-106. ISSN 0076-6879

Stuetz, Anton, Baumann, Karl, Grassberger, Max, Wolff, Klaus and Meingassner, Josef (2006) Discovery of topical calcineurin inhibitors and pharmacological profile of pimecrolimus. International Archives of Allergy and Immunology, 141 (3). pp. 199-212. ISSN 1018-2438

Szustakowski, Joseph, Lee, Jee, Marrese, Christine, Kosinski, Penelope, Nirmala, Nanguneri and Kemp, Daniel (2006) Identification of novel pathway regulation during myogenic differentiation. Genomics, 87 (1). pp. 129-138. ISSN 0888-7543

Teo, Jeanette, Thayalan, Pamela, Beer, David, Yap, Amelia, Nanjundappa, Mahesh, Ngew, Xinyi, Duraiswamy, Jeyaraj, Liung, Sarah, Dartois, Veronique, Schreiber, Mark, Hasan, Samiul, Cynamon, Michael, Ryder, Neil, Yang, Xia, Weidmann, Beat, Bracken, Kathryn, Dick, Thomas and Mukherjee, Kakoli (2006) Peptide deformylase inhibitors as potent antimycobacterial agents. Antimicrobial Agents and Chemotherapy, 50 (11). pp. 3665-3673. ISSN 0066-4804

Thakker, Deepak, Hoyer, Daniel and Cryan, John F. (2006) Interfering with the brain: use of RNA interference for understanding the pathophysiology of psychiatric and neurological disorders. Pharmacology & Therapeutics, 109 (3). pp. 413-438. ISSN 0163-7258

Tintelnot-Blomley, Marina and Lewis, Richard A (2006) A critical appraisal of structure-based drug design. IDrugs : the investigational drugs journal, 9 (2). pp. 114-118. ISSN 1369-7056

Tirat-Boeuf, Aline, Freuler, Felix, Stettler, Thomas, Mayr, Lorenz and Leder, Lukas (2006) Evaluation of two novel tag-based labelling technologies for site-specific modification of proteins. International Journal of Biological Macromolecules, 39 (1-3). pp. 66-76. ISSN 0141-8130

Tsao, Jeffrey, Boesiger, Peter and Pruessmann, Klaas P (2006) Lattice permutation for reducing motion artifacts in radial and spiral dynamic imaging. Magnetic Resonance in Medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 55 (1). pp. 116-125. ISSN 0740-3194

Tsao, Jeffrey, Hansen, Michael and Kozerke, Sebastian (2006) Accelerated parallel imaging by transform coding data compression with k-t SENSE. Conference Proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 1. p. 372. ISSN 1557-170X

Tully, David, Liu, Hong, Alper, Phillip, Chatterjee, Arnab, Epple, Robert, Roberts, Michael, Williams, Jennifer, Nguyen, Khanhlinh, Woodmansee, David, Tumanut, Christine, Li, Jun, Spraggon, Glen, Chang, Jonathan, Tuntland, Tove, Harris, Jennifer and Karanewsky, Donald (2006) Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3. Bioorganic & medicinal chemistry letters, 16 (7). pp. 1975-1980. ISSN 0960-894X

Tully, David, Liu, Hong, Chatterjee, Arnab, Alper, Phillip, Epple, Robert, Williams, Jennifer, Roberts, Michael, Woodmansee, David, Masick, Brian, Tumanut, Christine, Li, Jun, Spraggon, Glen, Hornsby, Michael, Chang, Jonathan, Tuntland, Tove, Hollenbeck, Thomas, Gordon, P., Harris, Jennifer and Karanewsky, Donald (2006) Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. Bioorganic & Medicinal Chemistry Letters, 16 (19). pp. 5112-5117. ISSN 0960-894X

Tully, David, Liu, Hong, Chatterjee, Arnab, Alper, Phillip, Williams, Jennifer, Roberts, Michael, Mutnick, Daniel, Woodmansee, David, Hollenbeck, Thomas, Gordon, P., Chang, Jonathan, Tuntland, Tove, Tumanut, Christine, Li, Jun, Harris, Jennifer and Karanewsky, Donald (2006) Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (19). pp. 5107-5111. ISSN 0960-894X

Tutter, Antonin and Walter, Johannes C (2006) Chromosomal DNA replication in a soluble cell-free system derived from Xenopus eggs. Methods in Molecular Biology (Clifton, N.J.), 322. pp. 121-137. ISSN 1064-3745

Tutter, Antonin V, Baltus, Gretchen A and Kadam, Shilpa (2006) Embryonic stem cells: a great hope for a new era of medicine. Current Opinion in Drug Discovery & Development, 9 (2). pp. 169-175. ISSN 1367-6733

Umareddy, Indira, Chao, Alex, Sampath, Aruna, Gu, Feng and Vasudevan, Subhash (2006) Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. The Journal of General Virology, 87 (Pt 9). pp. 2605-2614. ISSN 0022-1317

Urbina, Hugo, Debaene, François, Jost, Bernard, Bole-Feysot, Christine, Mason, Daniel, Kuzmic, Petr, Harris, Jennifer and Winssinger, Nicolas (2006) Self-assembled small-molecule microarrays for protease screening and profiling. Chembiochem : a European journal of chemical biology, 7 (11). pp. 1790-1797. ISSN 1439-4227

Uzunov, Veska, Sampson, Luther and Uzunov, Doncho (2006) Relevance of endogenous 3alpha-reduced neurosteroids to depression and antidepressant action. Psychopharmacology, 186 (3). pp. 351-361. ISSN 0033-3158

Waelchli, Rudolf, Bollbuck, Birgit, Bruns, Christian, Buhl, Thomas, Eder, Joerg, Feifel, Roland, Hersperger, Rene, Janser, Philipp, Revesz, Laszlo, Zerwes, Hans-Guenter and Schlapbach, Achim (2006) Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 108-112. ISSN 0960-894X

Walshmartin, Emily, Sabeti, Pardis, Hutcheson, Holli B, Fry, Ben, Schaffner, Stephen F, de Bakker, Paul I W, Varilly, Patrick, Palma, Alejandro, Roy, Jessica, Cooper, Richard, Winkler, Cheryl, Zeng, Yi, de The, Guy, Lander, Eric S, O'Brien, Stephen and Altshuler, David (2006) Searching for signals of evolutionary selection in 168 genes related to immune function. Human Genetics, 119 (1-2). pp. 92-102. ISSN 0340-6717

Wang, Shaowen, Yan-Neale, Yan, Cai, Richard, Alimov, Irina and Cohen, Dalia (2006) Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824. Cell Cycle, 5 (15). pp. 1662-1668. ISSN 1551-4005

Wang, Zhiwei, Wu, Baogen, Kuhen, Kelli, Bursulaya, Badry, Nguyen, Truc, Nguyen, Deborah and He, Yun (2006) Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4174-4177. ISSN 0960-894X

Wardle, Fiona, Odom, Duncan, Bell, George, Yuan, Bingbing, Danford, Timothy, Wiellette, Elizabeth, Herbolsheimer, Elizabeth, Sive, Hazel, Young, Richard and Smith, James (2006) Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome Biology, 7 (8). R71. ISSN 1465-6906

Watters, Amy A, Jones, Ronald N, Leeds, Jennifer A, Denys, Gerald, Sader, Helio S and Fritsche, Thomas R (2006) Antimicrobial activity of a novel peptide deformylase inhibitor, LBM415, tested against respiratory tract and cutaneous infection pathogens: a global surveillance report (2003-2004). The Journal of antimicrobial chemotherapy, 57 (5). pp. 914-923. ISSN 0305-7453

Weidensteiner, Claudia, Rausch, Martin, Mcsheehy, Paul M.J. and Allegrini, Peter Roland (2006) Quantitative dynamic contrast-enhanced MRI in tumor-bearing rats and mice with inversion recovery TrueFISP and two contrast agents at 4.7 T. Journal of Magnetic Resonance Imaging: JMRI, 24 (3). pp. 646-656. ISSN 1053-1807

Weiler, Jan, Hunziker, Juerg and Hall, Jeffrey (2006) Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Therapy, 13 (6). pp. 496-502. ISSN 0969-7128

Weiss, Markus, Fresneau, Marcel, Camenisch, Gian P., Kretz, Olivier and Gross, Gerhard (2006) In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex Fe-[ICL670]2 for rat, marmoset, rabbit, mouse, dog, and human. Drug metabolism and disposition: the biological fate of chemicals, 34 (6). pp. 971-975. ISSN 0090-9556

Wu, Baogen, Kuhen, Kelli, Ngoc Nguyen, Truc, Ellis, David, Anaclerio, Beth, He, Xiaohui, Yang, Kunyong, Karanewsky, Donald, Yin, Hong, Wolff, Karen, Bieza, Kimberly, Caldwell, Jeremy and He, Yun (2006) Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1. Bioorganic & Medicinal Chemistry Letters, 16 (13). pp. 3430-3433. ISSN 0960-894X

Wu, Zhidan, Huang, Xueming, Feng, Yajun, Handschin, Christoph, Feng, Yan, Gullicksen, P. Scott, Bare, Olivia, Labow, Mark, Spiegelman, Bruce and Stevenson, Susan (2006) Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America, 103 (39). pp. 14379-14384. ISSN 0027-8424

Yan, Frank, King, Frederick, He, Yun, Caldwell, Jeremy and Zhou, Yingyao (2006) Learning from the data: mining of large high-throughput screening databases. Journal of Chemical Information and Modeling, 46 (6). pp. 2381-2395. ISSN 1549-9596

Yang, X, Parker, David, Whitehead, Lewis, Ryder, Neil, Weidmann, Beat, Stabile-Harris, M, Kizer, D, McKinnon, M, Smellie, A and Powers, D (2006) A collaborative hit-to-lead investigation leveraging medicinal chemistry expertise with high throughput library design, synthesis and purification capabilities. Combinatorial Chemistry High Throughput Screening, 9 (2). pp. 123-130. ISSN 1386-2073

Yin, Zheng, Patel, Sejal, Wang, Wei, Chan, Wai Ling, Rao, Ranga, Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Knox, John E, Ma, Ngai Ling, Ehrhardt, Claus, Lim, Siew Pheng, Vasudevan, Subhash and Keller, Thomas (2006) Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors. Bioorganic & Medicinal Chemistry Letters, 16 (1). pp. 40-43. ISSN 0960-894X

Zemann, Barbara, Kinzel, Bernd, Mueller, Matthias, Reuschel, Roland, Mechtcheriakova, Diana, Urtz, Nicole, Bornancin, Frederic, Baumruker, Thomas and Billich, Andreas (2006) Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood, 107 (4). pp. 1454-1458. ISSN 0006-4971

Zhang, Qiong, Liu, Yi, Gao, Feng, Ding, Qiang, Cho, Charles, Hur, Wooyoung, Jin, Yunho, Uno, Tetsuo, Joazeiro, Claudio and Gray, Nathanael (2006) Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. Journal of the American Chemical Society, 128 (7). pp. 2182-2183. ISSN 0002-7863

Zollinger, Markus, Waldmeier, Felix, Hartmann, Stefan, Zenke, Gerhard, Zimmerlin, Alfred Gilbert, Glaenzel, Ulrike, Baldeck, Jean-Pierre, Schweitzer, Alain, Berthier, Stephane, Moenius, Thomas and Grassberger, Maximilian (2006) Pimecrolimus: absorption, distribution, metabolism, and excretion in healthy volunteers after a single oral dose and supplementary investigations in vitro. Drug metabolism and disposition: the biological fate of chemicals, 34 (5). pp. 765-774. ISSN 0090-9556