Baldwin, Helen M, Jamieson, Thomas, Nibbs, Robert J B, Carballido, Jose, Jaritz, Marcus and Graham, Gerard J (3276) Microarray analyses demonstrate the involvement of Type I Interferons in psoriasiform pathology development in D6 deficient mice. The Journal of Biological Chemistry, 288 (51). pp. 36473-36483. ISSN 0021-92581083-351X

Abstract

The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence or resolution inflammatory pathologies can emerge resulting in substantial morbidity and mortality. We had been studying the D6 chemokine scavenging receptor which played an indispensable role in the resolution phase of inflammatory responses and does so by facilitating removal of inflammatory CC chemokines. In D6 deficient mice, otherwise innocuous cutaneous inflammatory stimuli induce a grossly exaggerated inflammatory response that bears many similarities to human psoriasis. In the present study we have used transcriptomic approaches to define the molecular make up of this response. The data presented highlights a number of cytokines as playing potential role is in development of this psoriasis like pathology. Most compellingly, we provide data indicating a key role for the type I interferon pathway in the emergence of this pathology. Neutralising antibodies to type I interferons are able to ameliorate the psoriasis like pathology confirming a role in its development. Comparison of the data generated from this mouse model worth data from transcriptional analysis of human psoriasis further demonstrate their strong similarities. Finally, these transcriptional data provide insights into the cytokine network active in exaggerated inflammatory responses.

Item Type:	Article
Keywords:	Chemokines, Decoy Receptor, skin inflammation
Date Deposited:	10 May 2016 23:45
Last Modified:	25 May 2017 00:45
URI:	https://oak.novartis.com/id/eprint/9950