Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.

Peukert, Stefan and Sun, Yingchuan and Zhang, Rui and Hurley, Brian and Sabio, Michael and Shen, Xiaoyu and Gray, Christen and Dzink-Fox, Joann and Tao, Jianshi and Cebula, Regina and Wattanasin, Sompong (2008) Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. Bioorganic & Medicinal Chemistry Letters, 18 (6). pp. 1840-1844. ISSN 1464-3405

Abstract

Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure-activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided.

Item Type: Article
Related URLs:
Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: UPPS inhibitor; Undecaprenyl pyrophosphate synthase; Antibacterial
Related URLs:
Date Deposited: 14 Dec 2009 13:51
Last Modified: 31 Jan 2013 01:03
URI: https://oak.novartis.com/id/eprint/910

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.