Van Dijck, Annemie, Vloeberghs, Ellen, Van Dam, Debby, Staufenbiel, Matthias and De Deyn, Peter Paul (2008) Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory. Behavioural Brain Research, 190 (1). pp. 147-151. ISSN 0166-4328

Abstract

The APP23 model is a transgenic mouse model for Alzheimer's disease. Cognitive performance in the APP23-model was assessed by Morris Water Maze (MWM) and passive avoidance learning, but the latter failed to show any difference between the genotypes. In search of a non-spatial alternative for assessment of hippocampus-dependent memory, we evaluated an odour paired-associate test, which is based on learning an association between two sets of odours. The protocol includes a shaping phase, in which the animals learn to dig up a reward, a preliminary training phase and a training phase, where the actual association is learned. Subsequently, mice are tested for transitive inference and subjected to a symmetry test. Impairment was seen in the APP23 mice, in comparison with wild type mice, in training; however, both groups failed the transitivity and symmetry test. Possible explanations for this discrepancy with earlier published results are the advanced age of the mice or the C57Bl/6J background, in which the model was established.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bbr.2008.02.014
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	APP23; Alzheimer's disease; Memory; Paired-associate test; Cognitive; Non-spatial; Odour
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bbr.2008.02.014
Date Deposited:	14 Dec 2009 13:52
Last Modified:	31 Jan 2013 01:04
URI:	https://oak.novartis.com/id/eprint/883