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New chemotypes for cathepsin K inhibitors.

Teno, Naoki, Irie, Osamu, Miyake, Takahiro, Gohda, Keigo, Horiuchi, Miyuki, Tada, Sachiyo, Nonomura, Kazuhiko, Kometani, Motohiko, Iwasaki, Genji and Betschart, Claudia (2008) New chemotypes for cathepsin K inhibitors. Bioorganic & Medicinal Chemistry Letters, 18 (8). pp. 2599-2603. ISSN 1464-3405


Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Cathepsin K; Non-peptidic inhibitors; New chemotype; Cyano pryrimidine acetylene; Cyano pyrimidine t-amine
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Date Deposited: 14 Dec 2009 13:52
Last Modified: 14 Dec 2009 13:52