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New chemotypes for cathepsin K inhibitors.

Teno, Naoki and Irie, Osamu and Miyake, Takahiro and Gohda, Keigo and Horiuchi, Miyuki and Tada, Sachiyo and Nonomura, Kazuhiko and Kometani, Motohiko and Iwasaki, Genji and Betschart, Claudia (2008) New chemotypes for cathepsin K inhibitors. Bioorganic & Medicinal Chemistry Letters, 18 (8). pp. 2599-2603. ISSN 1464-3405


Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Cathepsin K; Non-peptidic inhibitors; New chemotype; Cyano pryrimidine acetylene; Cyano pyrimidine t-amine
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Date Deposited: 14 Dec 2009 13:52
Last Modified: 14 Dec 2009 13:52


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