Teno, Naoki and Irie, Osamu and Miyake, Takahiro and Gohda, Keigo and Horiuchi, Miyuki and Tada, Sachiyo and Nonomura, Kazuhiko and Kometani, Motohiko and Iwasaki, Genji and Betschart, Claudia (2008) New chemotypes for cathepsin K inhibitors. Bioorganic & Medicinal Chemistry Letters, 18 (8). pp. 2599-2603. ISSN 1464-3405

Abstract

Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmcl.2008.03.036
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Cathepsin K; Non-peptidic inhibitors; New chemotype; Cyano pryrimidine acetylene; Cyano pyrimidine t-amine
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmcl.2008.03.036
Date Deposited:	14 Dec 2009 13:52
Last Modified:	14 Dec 2009 13:52
URI:	https://oak.novartis.com/id/eprint/882