Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Exploiting structure-activity relationships in docking.

Sullivan, David and Martin, Eric (2008) Exploiting structure-activity relationships in docking. Journal of Chemical Information and Modeling, 48 (4). pp. 817-830. ISSN 1549-9596


From the perspective of 2D chemical descriptors, error in docking activity predictions is separated into noise and systematic components. This error framework explains how fitting docking scores to a 2D-QSAR equation often improves accuracy as well as its logical limits. Intriguingly, in examined cases where multiple docking models (e.g., multiple crystal structures or multiple scoring functions) are available for an enzyme, the noise component of error dominates the difference between the more accurate and less accurate docking models. When this is true, the QSAR equation fit statistics can rank each docking-score set's accuracy in the absence of experimental activity data.

Item Type: Article
Related URLs:
Additional Information: archiving not formally supported by this publisher
Related URLs:
Date Deposited: 14 Dec 2009 13:52
Last Modified: 14 Dec 2009 13:52


Email Alerts

Register with OAK to receive email alerts for saved searches.