Ducray, Pierre, Gauvry, Noelle, Pautrat, Francois, Goebel, Thomas, Fruechtel, Joerg, Desaules, Yves, Schorderet Weber, Sandra, Bouvier, Jacques, Wagner, Beatrix, Froelich, Olivier and Kaminsky, Ronald (2008) Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. Bioorganic & Medicinal Chemistry Letters, 18 (9). pp. 2935-2938. ISSN 1464-3405

Abstract

A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure-activity relationship and biological results are presented.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmcl.2008.03.071
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Amino-acetonitrile derivatives; AAD; Anthelmintic; Parasiticide; Nematocide; Haemonchus contortus
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmcl.2008.03.071
Date Deposited:	14 Dec 2009 13:52
Last Modified:	14 Dec 2009 13:52
URI:	https://oak.novartis.com/id/eprint/842