Synthesis of sterically hindered enamides via a Ti-mediated condensation of amides with aldehydes and ketones
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Genovino, Julien, Lagu, Bharat, Toure, Bakary-Barry and Wang, Kate (2012) Synthesis of sterically hindered enamides via a Ti-mediated condensation of amides with aldehydes and ketones. Chemical Communications, 48 (53). pp. 6735-6737. ISSN 1359-7345
Official URL: http://pubs.rsc.org/en/journals/journalissues/cc
Abstract
The first TiCl(4)-mediated condensation of secondary amides with aldehydes and ketones has been achieved. The reaction proceeds at room temperature and is complete within 5 h in most cases. The optimized procedure used 5 equiv of an amine base hinting that the in situ activation of both the amide and the Lewis acid is required. The reaction affords polysubstituted (E)-enamides.
| Item Type: | Article |
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| Keywords: | enamides, titanium tetrachloride, carbonyl compounds, amides |
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| Date Deposited: | 13 Oct 2015 13:14 |
| Last Modified: | 13 Oct 2015 13:14 |
| URI: | https://oak.novartis.com/id/eprint/8040 |