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Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice.

Goddyn, Hannelore and Callaerts-Vegh, Zsuzsanna and Stroobants, Stijn and Dirikx, Trinette and Vansteenwegen, Debora and Hermans, Dirk and Van Der Putten, P. Herman and D'Hooge, Rudi (2008) Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice. Neurobiology of Learning and Memory, 90 (1). pp. 103-111. ISSN 1095-9564

Abstract

Metabotropic glutamate receptor 7 (mGluR7) is expressed in brain regions implicated in emotional learning and working memory, and previous behavioral experiments indicated contributions of mGluR7 to various complex behaviors. In the present study, we investigated the specific effects of mGluR7 deletion on a variety of conditioning paradigms that model crucial neurocognitive and psychopathological behavioral phenomena. Null-mutant mGluR7(-/-) mice displayed defects during scheduled appetitive conditioning, acquisition and extinction of appetitive odor conditioning, extinction of response suppression-based conditioned emotional responding (CER), acquisition of discriminative CER, and contextual fear conditioning. mGluR7(-/-) animals were slower to acquire the association between a conditioned stimulus and a positive or negative reinforcer, but eventually reached similar performance levels to their wildtype littermates. Notably, extinction learning of conditioned responses was slower in mGluR7(-/-) compared to wildtype animals. The observed delays in the acquisition of complicated stimulus associations across conditioning procedures may suggest a critical role for mGluR7 in neurocognitive functions and psychopathology.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Metabotropic glutamate receptors; mGluR7; Extinction; Learning and memory
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Date Deposited: 14 Dec 2009 13:53
Last Modified: 31 Jan 2013 01:06
URI: https://oak.novartis.com/id/eprint/796

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