Sandham, David, Barker, Lucy, Beattie, David, Beer, David, Bidlake, Louise, Bentley, David, Butler, Keith, Craig, Sarah, Farr, David Colin, Ffoulkes-Jones, Claire, Fozard, John R., Haberthuer, Sandra, Howes, Colin, Hynx, Deborah, Jeffers, Sarah, Keller, Thomas, Kirkham, Paul, Maas, Janet, Mazzoni, Lazzaro, Nicholls, Andy, Pilgrim, Gaynor, Schaebulin, Elisabeth, Spooner, Gillian M, Stringer, Rowan, Tranter, Pamela, Turner, Katharine, Tweed, Morris, Walker, Christoph, Watson, Simon and Cuenoud, Bernard (2004) Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters. Bioorganic & Medicinal Chemistry, 12 (19). pp. 5213-5224. ISSN 0968-0896

Abstract

A series of novel corticosteroid derivatives featuring C-17 furoate ester functionality have been synthesised. Profiling in vitro and in vivo has resulted in the identification of a compound with a longer duration of action and a lower oral side effect profile in rodents compared to budesonide.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmc.2004.06.027
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Glucocorticoids; Asthma; Duration of action; Side effects
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.bmc.2004.06.027
Date Deposited:	14 Dec 2009 13:55
Last Modified:	31 Jan 2013 01:08
URI:	https://oak.novartis.com/id/eprint/729