Furet, Pascal, Imbach, Patricia, Noorani, Maria, Koeppler, Juergen, Laumen, Kurt, Lang, Marc, Guagnano, Vito, Fuerst, Peter, Roesel, Johannes, Zimmermann, Johann and Garcia-Echeverria, Carlos (2004) Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design. Journal of Medicinal Chemistry, 47 (20). pp. 4810-4813. ISSN 0022-2623

Abstract

Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
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Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 13:55
Last Modified:	31 Jan 2013 01:08
URI:	https://oak.novartis.com/id/eprint/728