Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.
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Altmann, Eva, Jacob, Sandra and Missbach, Martin (2004) Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. Journal of Medicinal Chemistry, 47 (24). pp. 5833-5836. ISSN 0022-2623
Official URL: http://pubs.acs.org/doi/abs/10.1021/jm0493111
Abstract
Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.
| Item Type: | Article |
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| Additional Information: | archiving not formally supported by this publisher |
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| Date Deposited: | 14 Dec 2009 13:55 |
| Last Modified: | 31 Jan 2013 01:08 |
| URI: | https://oak.novartis.com/id/eprint/718 |