Making protein interactions druggable: targeting PDZ domains.
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Dev, Kumlesh K. (2004) Making protein interactions druggable: targeting PDZ domains. Nature Reviews Drug Discovery, 3 (12). pp. 1047-1056. ISSN 1474-1776
Abstract
Modulating protein-protein interactions involved in disease pathways is an attractive strategy for developing drugs, but remains a challenge to achieve. One approach is to target certain domains within proteins that mediate these interactions. One example of such a domain is the PDZ domain, which is involved in interactions between many different proteins in a variety of cellular contexts. Because PDZ domains have well-defined binding sites, they are promising targets for drug discovery. However, there is still much to learn about the function of these domains before drugs targeting PDZ interactions can become a reality.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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| Date Deposited: | 14 Dec 2009 13:55 |
| Last Modified: | 14 Dec 2009 13:55 |
| URI: | https://oak.novartis.com/id/eprint/706 |