Block, Stan L, Yogev, Ram, Waldmeier, Felix and Hamed, Kamal (2011) Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis. The Pediatric infectious disease journal, 30 (6). pp. 525-528. ISSN 1532-0987

Abstract

An open-label study evaluated the safety (n = 53) and pharmacokinetics (n = 8) of single-dose therapy with 1500 mg famciclovir (prodrug of penciclovir) for recurrent herpes labialis in adolescents. Mean Cmax, mean AUC0-∞, and clearance for penciclovir were 9.37 μg/mL, 31.8 μg · h/mL, and 38.2 L/h, respectively, and within the range extrapolated from data in adults. Adverse events were generally mild and transient.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	28 Jan 2012 00:45
Last Modified:	01 Feb 2013 00:45
URI:	https://oak.novartis.com/id/eprint/6805