1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.
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Wattanasin, Sompong, Kallen, Joerg, Myers, Stewart, Guo, Qin, Sabio, Michael, Ehrhardt, Claus, Albert, Rainer, Hommel, Ulrich, Weckbecker, Gisbert, Welzenbach, Karl and Weitz Schmidt, Gabriele (2005) 1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1. Bioorganic & Medicinal Chemistry Letters, 15 (4). pp. 1217-1220. ISSN 0960-894X
Official URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
Abstract
1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.
Item Type: | Article |
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Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
Keywords: | Integrin; LFA-1; Diazepanediones; I-domain; L-site binding |
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Date Deposited: | 14 Dec 2009 13:56 |
Last Modified: | 31 Jan 2013 01:10 |
URI: | https://oak.novartis.com/id/eprint/672 |